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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:exact_synonym: Reactome:R-HSA-1059683
 related_synonym: Il-6 signaling pathway;   PID:200146

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interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:6484113
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:5686846
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:5686834
RGD:5686846
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6484113
G Cebpd CCAAT/enhancer binding protein delta JBrowse link 11 89,008,008 89,009,146 RGD:6484113
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6484113
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:6484113
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6484113
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6484113
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
G Gab2 GRB2-associated binding protein 2 JBrowse link 1 162,082,876 162,283,379 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:5686834
RGD:6484113
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:6484113
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:6484113
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1580493
RGD:11062097
RGD:6484113
RGD:5686839
RGD:5686834
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:5686834
RGD:6484113
RGD:5686839
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:5686834
RGD:6484113
RGD:5686900
RGD:5686839
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:6484113
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:5686839
RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5686839
RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Junb JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link 19 26,092,972 26,094,756 RGD:6484113
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:6484113
G Lmo4 LIM domain only 4 JBrowse link 2 250,218,635 250,235,435 RGD:6484113
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6484113
G Mitf melanocyte inducing transcription factor JBrowse link 4 130,172,484 130,425,496 RGD:6484113
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6484113
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:6484113
G Pias3 protein inhibitor of activated STAT, 3 JBrowse link 2 198,821,377 198,831,533 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:5686834
RGD:6484113
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6484113
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6484113
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:5686834
RGD:6484113
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:5686834
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:5686834
RGD:6484113
RGD:5686839
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:5686834
RGD:6484113
RGD:5686839
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6484113
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6484113
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:5686839
RGD:6484113
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:6484113

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Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      cytokine and chemokine mediated signaling pathway 558
        cytokine mediated signaling pathway 473
          Interleukin mediated signaling pathway 245
            interleukin-6 family mediated signaling pathway 48
              interleukin-6 signaling pathway 48
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.