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ONTOLOGY REPORT - ANNOTATIONS

Term:canonical NF-kappaB signal transduction
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Accession:GO:0007249 term browser browse the term
Definition:An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).
Synonyms:exact_synonym: I-kappaB kinase/NF-kappaB signal transduction;   I-kappaB kinase/NF-kappaB signaling;   NF-kappaB cascade;   canonical NF-kappaB signaling cascade
 related_synonym: I-kappaB kinase/NF-kappaB cascade;   p50-dependent NF-kappaB signaling


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canonical NF-kappaB signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18025176) Ensembl
MGI		 PMID:18025176 GO_REF:0000107 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675 		JBrowse link
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of ISO (PMID:18025176) MGI PMID:18025176 NCBI chr 1:179,099,330...179,229,677
Ensembl chr 1:179,099,330...179,229,684 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 involved_in IMP (PMID:26514923) CAFA PMID:26514923 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G BCL10 BCL10 immune signaling adaptor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:85,265,776...85,276,632
Ensembl chr 1:85,265,776...85,276,632 		JBrowse link
G BCL3 BCL3 transcription coactivator involved_in IDA (PMID:8196632) UniProt PMID:8196632 NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 involved_in TAS Reactome Reactome:R-HSA-5357956 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 involved_in TAS Reactome Reactome:R-HSA-5357956 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G CARD11 caspase recruitment domain family member 11 involved_in IMP (PMID:28628108) UniProt PMID:28628108 NCBI chr 7:2,906,142...3,043,867
Ensembl chr 7:2,906,142...3,044,228 		JBrowse link
G CD74 CD74 molecule involved_in ISO (PMID:23736979) AgBase PMID:23736979 NCBI chr 5:150,401,639...150,412,910
Ensembl chr 5:150,401,637...150,412,969 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in TAS
IDA
IMP		 (PMID:18626576)
(PMID:20434986), (PMID:9244310), (PMID:9252186), (PMID:9346484)
(PMID:26514923)		 UniProt
CAFA		 PMID:9244310 PMID:9252186 PMID:9346484 PMID:18626576 PMID:20434986 More... NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CREBBP CREB binding protein involved_in IDA (PMID:16135789) UniProt PMID:16135789 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713 		JBrowse link
G DEFB124 defensin beta 124 involved_in IDA
IBA		 (PMID:24955228) UniProt
GO_Central		 PMID:24955228 GO_REF:0000033 NCBI chr20:31,465,471...31,475,127
Ensembl chr20:31,465,471...31,476,757 		JBrowse link
G EP300 E1A binding protein p300 involved_in IDA (PMID:23811396) ARUK-UCL PMID:23811396 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077 		JBrowse link
G HACD3 3-hydroxyacyl-CoA dehydratase 3 involved_in TAS (PMID:10747961) PINC PMID:10747961 NCBI chr15:65,530,463...65,578,349
Ensembl chr15:65,530,418...65,578,349 		JBrowse link
G IFT80 intraflagellar transport 80 acts_upstream_of_or_within ISO (PMID:35733270) MGI PMID:35733270 NCBI chr 3:160,256,986...160,399,225
Ensembl chr 3:160,256,986...160,399,880 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta involved_in IMP
IDA
TAS		 (PMID:15383541), (PMID:25816133)
(PMID:20434986), (PMID:9346484)
(PMID:18626576)		 UniProt PMID:9346484 PMID:15383541 PMID:18626576 PMID:20434986 PMID:25816133 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in TAS
IDA		 (PMID:18626576), (PMID:9927690)
(PMID:20434986)		 PINC
ComplexPortal		 PMID:9927690 PMID:18626576 PMID:20434986 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in IMP (PMID:25515214) ARUK-UCL PMID:25515214 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902 		JBrowse link
G IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 6:78,867,551...78,979,411
Ensembl chr 6:78,867,551...78,946,440 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 involved_in TAS
IDA		 (PMID:9374458)
(PMID:17878161)		 PINC
UniProt		 PMID:9374458 PMID:17878161 NCBI chr 3:10,164,919...10,243,745
Ensembl chr 3:10,164,919...10,243,745 		JBrowse link
G IRF1 interferon regulatory factor 1 ISO RGD PMID:15141302 RGD:5128786 NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719 		JBrowse link
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:45,263,119...45,317,020
Ensembl chr17:45,263,119...45,317,029 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in TAS
IDA		 (PMID:10882101), (PMID:19675569), (PMID:34871740), (PMID:35952808) Reactome
UniProt		 PMID:10882101 PMID:19675569 PMID:34871740 PMID:35952808 Reactome:R-HSA-9014325 Reactome:R-HSA-937072 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MIR146A microRNA 146a involved_in IMP (PMID:20937840) ARUK-UCL PMID:20937840 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
G MYO18A myosin XVIIIA involved_in IDA (PMID:9918798) UniProt PMID:9918798 NCBI chr17:29,071,122...29,180,398
Ensembl chr17:29,071,122...29,180,398 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IDA
IBA		 (PMID:23811396), (PMID:34721373) ARUK-UCL
GO_Central		 PMID:23811396 PMID:34721373 GO_REF:0000033 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 involved_in IDA
IBA		 (PMID:37816088) UniProt
GO_Central		 PMID:37816088 GO_REF:0000033 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524 		JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in IDA (PMID:1493333), (PMID:25038658) CAFA PMID:1493333 PMID:25038658 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NFKBIL1 NFKB inhibitor like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:31,546,851...31,558,829
Ensembl chr 6:31,546,870...31,558,829 		JBrowse link
G NLRC3 NLR family CARD domain containing 3 involved_in
acts_upstream_of		 IDA
ISO		 (PMID:15705585)
(PMID:22863753)		 UniProt
MGI		 PMID:15705585 PMID:22863753 NCBI chr16:3,539,033...3,577,403
Ensembl chr16:3,539,033...3,577,403 		JBrowse link
G PRDX1 peroxiredoxin 1 involved_in
acts_upstream_of_negative_effect		 IEA
ISO		 (PMID:15858817) Ensembl
MGI		 PMID:15858817 GO_REF:0000107 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732 		JBrowse link
G RASSF2 Ras association domain family member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22227519) Ensembl
MGI		 PMID:22227519 GO_REF:0000107 NCBI chr20:4,780,023...4,823,608
Ensembl chr20:4,780,023...4,823,608 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IMP
IDA
IBA
IEA
IGI		 (PMID:23619365)
(PMID:12048232), (PMID:1406630), (PMID:21343177), (PMID:23811396), (PMID:23878390)
(PMID:21343177)		 BHF-UCL
ARUK-UCL
GO_Central
TreeGrafter
CAFA		 PMID:1406630 PMID:12048232 PMID:21343177 PMID:23619365 PMID:23811396 More... GO_REF:0000033 GO_REF:0000118 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr19:45,001,464...45,038,192
Ensembl chr19:45,001,461...45,038,192 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:89,757,816...89,791,064
Ensembl chr 8:89,757,806...89,791,064 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IMP (PMID:25816133) UniProt PMID:25816133 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IMP (PMID:25816133) UniProt PMID:25816133 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:161,136,963...161,236,230
Ensembl chr 2:161,136,908...161,236,230 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in TAS (PMID:10581243), (PMID:21042276) UniProt PMID:10581243 PMID:21042276 NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114 		JBrowse link
G TIFA TRAF interacting protein with forkhead associated domain involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:112,274,537...112,285,904
Ensembl chr 4:112,272,968...112,285,955 		JBrowse link
G TLR7 toll like receptor 7 involved_in IMP
IEA
IBA		 (PMID:35477763) UniProt
TreeGrafter
GO_Central		 PMID:35477763 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:12,867,072...12,890,361
Ensembl chr  X:12,867,072...12,890,361 		JBrowse link
G TLR8 toll like receptor 8 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:12,906,620...12,923,169
Ensembl chr  X:12,906,620...12,923,169 		JBrowse link
G TLR9 toll like receptor 9 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645 		JBrowse link
G TRADD TNFRSF1A associated via death domain involved_in IMP (PMID:25732226) ARUK-UCL PMID:25732226 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IEA
IMP
IDA
TAS		 (PMID:25515214)
(PMID:20038579), (PMID:26839314)		 Ensembl
ARUK-UCL
UniProt
Reactome		 PMID:20038579 PMID:25515214 PMID:26839314 GO_REF:0000107 Reactome:R-HSA-937072 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G TRIM8 tripartite motif containing 8 involved_in IDA (PMID:27995356) UniProt PMID:27995356 NCBI chr10:102,644,479...102,658,319
Ensembl chr10:102,642,503...102,658,318 		JBrowse link
I-kappaB phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELP1 elongator acetyltransferase complex subunit 1 ISO RGD PMID:12133632 RGD:1626124 NCBI chr 9:108,867,517...108,934,124
Ensembl chr 9:108,866,898...108,934,328 		JBrowse link
negative regulation of canonical NF-kappaB signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IDA (PMID:10982546) BHF-UCL PMID:10982546 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ARRB2 arrestin beta 2 involved_in IDA (PMID:26839314) UniProt PMID:26839314 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G AZI2 5-azacytidine induced 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:28,321,047...28,348,824
Ensembl chr 3:28,315,003...28,349,050 		JBrowse link
G CACTIN cactin, spliceosome C complex subunit involved_in IDA (PMID:26363554) UniProt PMID:26363554 NCBI chr19:3,610,645...3,626,790
Ensembl chr19:3,610,645...3,626,815 		JBrowse link
G CARD19 caspase recruitment domain family member 19 involved_in NAS (PMID:15637807) UniProt PMID:15637807 NCBI chr 9:93,096,217...93,113,283
Ensembl chr 9:93,096,217...93,113,283 		JBrowse link
G CARD8 caspase recruitment domain family member 8 involved_in IDA (PMID:11551959) HGNC-UCL PMID:11551959 NCBI chr19:48,179,825...48,255,946
Ensembl chr19:48,180,770...48,255,946 		JBrowse link
G CASP8 caspase 8 involved_in IMP (PMID:17047155) UniProt PMID:17047155 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CCDC22 coiled-coil domain containing 22 involved_in IMP (PMID:23563313) UniProt PMID:23563313 NCBI chr  X:49,235,470...49,250,520
Ensembl chr  X:49,235,470...49,250,520 		JBrowse link
G CORO1A coronin 1A involved_in ISO (PMID:25093672) AgBase PMID:25093672 NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IDA (PMID:15310755), (PMID:17389591) BHF-UCL PMID:15310755 PMID:17389591 NCBI chr 9:121,567,074...121,785,530
Ensembl chr 9:121,567,057...121,785,530 		JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 involved_in IDA (PMID:11927590) UniProt PMID:11927590 NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775 		JBrowse link
G ESR1 estrogen receptor 1 involved_in IDA (PMID:16043358), (PMID:7651415) UniProt PMID:7651415 PMID:16043358 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HDAC1 histone deacetylase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19805123) Ensembl
MGI		 PMID:19805123 GO_REF:0000107 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635 		JBrowse link
G IRGM immunity related GTPase M involved_in IDA (PMID:36221902) UniProt PMID:36221902 NCBI chr 5:150,846,521...150,902,402
Ensembl chr 5:150,846,521...150,900,736 		JBrowse link
G LILRB4 leukocyte immunoglobulin like receptor B4 involved_in IMP (PMID:19380766) ARUK-UCL PMID:19380766 NCBI chr19:54,662,985...54,668,718
Ensembl chr19:54,643,889...54,670,359 		JBrowse link
G MAPKBP1 mitogen-activated protein kinase binding protein 1 involved_in IMP
IEA
IBA		 (PMID:22700971) UniProt
TreeGrafter
GO_Central		 PMID:22700971 GO_REF:0000033 GO_REF:0000118 NCBI chr15:41,774,484...41,827,855
Ensembl chr15:41,774,434...41,827,855 		JBrowse link
G MIR138-1 microRNA 138-1 involved_in IDA (PMID:23319823) ARUK-UCL PMID:23319823 NCBI chr 3:44,114,212...44,114,310
Ensembl chr 3:44,114,212...44,114,310 		JBrowse link
G MIR138-2 microRNA 138-2 involved_in IDA (PMID:23319823) ARUK-UCL PMID:23319823 NCBI chr16:56,858,518...56,858,601
Ensembl chr16:56,858,518...56,858,601 		JBrowse link
G MIR146A microRNA 146a involved_in IDA (PMID:25515214) ARUK-UCL PMID:25515214 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
G MIR15A microRNA 15a involved_in IDA (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr13:50,049,119...50,049,201
Ensembl chr13:50,049,119...50,049,201 		JBrowse link
G MIR15B microRNA 15b involved_in IDA (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr 3:160,404,588...160,404,685
Ensembl chr 3:160,404,588...160,404,685 		JBrowse link
G MIR16-1 microRNA 16-1 involved_in IDA (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr13:50,048,973...50,049,061
Ensembl chr13:50,048,973...50,049,061 		JBrowse link
G MIR16-2 microRNA 16-2 involved_in IDA (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr 3:160,404,745...160,404,825
Ensembl chr 3:160,404,745...160,404,825 		JBrowse link
G MIR195 microRNA 195 involved_in IDA (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr17:7,017,615...7,017,701
Ensembl chr17:7,017,615...7,017,701 		JBrowse link
G MIR30C2 microRNA 30c-2 involved_in IDA (PMID:25732226) ARUK-UCL PMID:25732226 NCBI chr 6:71,376,960...71,377,031
Ensembl chr 6:71,376,960...71,377,031 		JBrowse link
G MIR365A microRNA 365a involved_in IDA (PMID:30910589) ARUK-UCL PMID:30910589 NCBI chr16:14,309,285...14,309,371
Ensembl chr16:14,309,285...14,309,371 		JBrowse link
G MIR365B microRNA 365b involved_in IDA (PMID:30910589) ARUK-UCL PMID:30910589 NCBI chr17:31,575,411...31,575,521
Ensembl chr17:31,575,411...31,575,521 		JBrowse link
G MIR497 microRNA 497 involved_in IDA (PMID:23487264) ARUK-UCL PMID:23487264 NCBI chr17:7,017,911...7,018,022
Ensembl chr17:7,017,911...7,018,022 		JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in IEA
IDA		 (PMID:1493333), (PMID:25038658) Ensembl
UniProt		 PMID:1493333 PMID:25038658 GO_REF:0000107 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NFKBID NFKB inhibitor delta acts_upstream_of_or_within ISO (PMID:11931770) MGI PMID:11931770 NCBI chr19:35,887,952...35,902,303
Ensembl chr19:35,887,630...35,902,303 		JBrowse link
G NFKBIL1 NFKB inhibitor like 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:31,546,851...31,558,829
Ensembl chr 6:31,546,870...31,558,829 		JBrowse link
G NKIRAS1 NFKB inhibitor interacting Ras like 1 involved_in NAS
IEA		 (PMID:10657303) UniProt
InterPro		 PMID:10657303 GO_REF:0000002 NCBI chr 3:23,889,951...23,946,562
Ensembl chr 3:23,889,951...23,946,591 		JBrowse link
G NKIRAS2 NFKB inhibitor interacting Ras like 2 involved_in NAS
IEA		 (PMID:10657303) UniProt
InterPro		 PMID:10657303 GO_REF:0000002 NCBI chr17:42,017,576...42,025,641
Ensembl chr17:42,011,382...42,025,644 		JBrowse link
G NLRC3 NLR family CARD domain containing 3 acts_upstream_of_or_within
involved_in		 IMP
IEA
IBA		 (PMID:22863753) MGI
TreeGrafter
GO_Central		 PMID:22863753 GO_REF:0000033 GO_REF:0000118 NCBI chr16:3,539,033...3,577,403
Ensembl chr16:3,539,033...3,577,403 		JBrowse link
G NLRP12 NLR family pyrin domain containing 12 involved_in IDA
IBA
IEA		 (PMID:16203735) HGNC-UCL
GO_Central
TreeGrafter		 PMID:16203735 GO_REF:0000033 GO_REF:0000118 NCBI chr19:53,793,584...53,824,403
Ensembl chr19:53,793,741...53,824,403 		JBrowse link
G NLRP6 NLR family pyrin domain containing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22763455) Ensembl
MGI		 PMID:22763455 GO_REF:0000107 NCBI chr11:278,407...285,388
Ensembl chr11:278,407...285,388 		JBrowse link
G NLRX1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:21703540) Ensembl
MGI
GO_Central		 PMID:21703540 GO_REF:0000033 GO_REF:0000107 NCBI chr11:119,168,334...119,184,016
Ensembl chr11:119,166,568...119,184,016 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA
IDA		 (PMID:21242261) Ensembl
UniProt		 PMID:21242261 GO_REF:0000107 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G OLFM4 olfactomedin 4 acts_upstream_of_or_within ISO (PMID:20534456) MGI PMID:20534456 NCBI chr13:53,028,813...53,052,057
Ensembl chr13:53,028,813...53,052,057 		JBrowse link
G OPTN optineurin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17702576) Ensembl
MGI		 PMID:17702576 GO_REF:0000107 NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308 		JBrowse link
G OTUD7B OTU deubiquitinase 7B involved_in IEA
IDA		 (PMID:11463333) Ensembl
HGNC-UCL		 PMID:11463333 GO_REF:0000107 NCBI chr 1:149,937,812...150,067,653
Ensembl chr 1:149,937,812...150,010,726 		JBrowse link
G PER1 period circadian regulator 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:8,140,472...8,152,404
Ensembl chr17:8,140,472...8,156,506 		JBrowse link
G PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A involved_in IMP
IBA
IEA		 (PMID:18930133) UniProt
GO_Central
TreeGrafter		 PMID:18930133 GO_REF:0000033 GO_REF:0000118 NCBI chr14:60,245,750...60,299,087
Ensembl chr14:60,245,752...60,299,087 		JBrowse link
G PPM1B protein phosphatase, Mg2+/Mn2+ dependent 1B involved_in IMP
IEA
IBA		 (PMID:18930133) UniProt
TreeGrafter
GO_Central		 PMID:18930133 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:44,168,875...44,246,928
Ensembl chr 2:44,167,969...44,244,384 		JBrowse link
G PPM1N protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:45,498,443...45,502,513
Ensembl chr19:45,488,777...45,502,513 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IDA (PMID:12486103) UniProt PMID:12486103 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G PYDC1 pyrin domain containing 1 involved_in IDA (PMID:12656673) HGNC-UCL PMID:12656673 NCBI chr16:31,215,962...31,217,135
Ensembl chr16:31,215,962...31,217,135 		JBrowse link
G RHOA ras homolog family member A ISO RGD PMID:17615156 RGD:1642824 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G RHOH ras homolog family member H involved_in IDA (PMID:11809807) UniProt PMID:11809807 NCBI chr 4:40,191,080...40,246,967
Ensembl chr 4:40,191,011...40,246,967 		JBrowse link
G RIOK3 RIO kinase 3 involved_in IDA (PMID:19557502) UniProt PMID:19557502 NCBI chr18:23,453,287...23,483,140
Ensembl chr18:23,453,287...23,486,603 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IMP (PMID:17047155) UniProt PMID:17047155 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187 		JBrowse link
G RORA RAR related orphan receptor A involved_in IMP (PMID:11252722) UniProt PMID:11252722 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G SIRT1 sirtuin 1 involved_in IDA (PMID:17680780) UniProt PMID:17680780 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC39A8 solute carrier family 39 member 8 acts_upstream_of_negative_effect IMP (PMID:23403290) UniProt PMID:23403290 NCBI chr 4:102,251,041...102,345,482
Ensembl chr 4:102,251,080...102,431,258 		JBrowse link
G SNIP1 Smad nuclear interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:37,534,449...37,554,293
Ensembl chr 1:37,534,449...37,554,293 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 involved_in IMP (PMID:10848577) UniProt PMID:10848577 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IMP
IEA		 (PMID:25861989) UniProt
InterPro		 PMID:25861989 GO_REF:0000002 NCBI chr 2:161,136,963...161,236,230
Ensembl chr 2:161,136,908...161,236,230 		JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 involved_in IDA (PMID:29130787) BHF-UCL PMID:29130787 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335 		JBrowse link
G TLE1 TLE family member 1, transcriptional corepressor involved_in IDA (PMID:17680780) UniProt PMID:17680780 NCBI chr 9:81,583,683...81,689,547
Ensembl chr 9:81,583,683...81,689,547 		JBrowse link
G TMSB4X thymosin beta 4 X-linked acts_upstream_of_or_within_positive_effect IMP (PMID:21343177) CAFA PMID:21343177 NCBI chr  X:12,975,110...12,977,223
Ensembl chr  X:12,975,110...12,977,227 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IDA
IEA		 (PMID:11463333), (PMID:15258597), (PMID:21127049) BHF-UCL
Ensembl		 PMID:11463333 PMID:15258597 PMID:21127049 GO_REF:0000107 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TNIP1 TNFAIP3 interacting protein 1 involved_in IDA
IBA
IEA		 (PMID:16684768) UniProt
GO_Central
TreeGrafter		 PMID:16684768 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:151,029,943...151,087,685
Ensembl chr 5:151,029,945...151,093,577 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 acts_upstream_of_or_within ISO (PMID:11390377) MGI PMID:11390377 NCBI chr 4:2,741,648...2,756,336
Ensembl chr 4:2,741,648...2,756,342 		JBrowse link
G TNIP3 TNFAIP3 interacting protein 3 involved_in IDA (PMID:17088249) UniProt PMID:17088249 NCBI chr 4:121,131,408...121,227,483
Ensembl chr 4:121,131,408...121,227,466 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
G TRIM39 tripartite motif containing 39 involved_in IMP (PMID:26363554) UniProt PMID:26363554 NCBI chr 6:30,326,469...30,343,729
Ensembl chr 6:30,326,479...30,343,729 		JBrowse link
G TRIM59 tripartite motif containing 59 acts_upstream_of_or_within
involved_in		 IMP
IBA
IEA		 (PMID:22588174) MGI
GO_Central
Ensembl		 PMID:22588174 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:160,435,503...160,449,786
Ensembl chr 3:160,432,445...160,485,773 		JBrowse link
G TSPAN6 tetraspanin 6 involved_in IDA (PMID:22908223) UniProt PMID:22908223 NCBI chr  X:100,627,108...100,637,104
Ensembl chr  X:100,627,108...100,639,991 		JBrowse link
G UACA uveal autoantigen with coiled-coil domains and ankyrin repeats involved_in ISO (PMID:14961764) MGI PMID:14961764 NCBI chr15:70,654,554...70,778,903
Ensembl chr15:70,654,554...70,763,558 		JBrowse link
G USP10 ubiquitin specific peptidase 10 involved_in IMP (PMID:25861989) UniProt PMID:25861989 NCBI chr16:84,700,000...84,779,922
Ensembl chr16:84,699,986...84,779,922 		JBrowse link
G USP20 ubiquitin specific peptidase 20 involved_in IDA (PMID:26839314) UniProt PMID:26839314 NCBI chr 9:129,835,458...129,881,828
Ensembl chr 9:129,834,698...129,881,828 		JBrowse link
G WDR62 WD repeat domain 62 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:36,054,897...36,111,145
Ensembl chr19:36,054,649...36,105,108 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA
ISS
IMP		 (PMID:25861989) Ensembl
UniProt		 PMID:25861989 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:37,474,580...37,484,377
Ensembl chr 1:37,474,580...37,484,377 		JBrowse link
G ZMYND11 zinc finger MYND-type containing 11 involved_in IMP (PMID:20732415) UniProt PMID:20732415 NCBI chr10:130,088...254,637
Ensembl chr10:130,088...254,637 		JBrowse link
G ZNF675 zinc finger protein 675 involved_in IDA (PMID:11751921) UniProt PMID:11751921 NCBI chr19:23,652,801...23,687,212
Ensembl chr19:23,525,631...23,687,220 		JBrowse link
negative regulation of I-kappaB phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR27B microRNA 27b acts_upstream_of_or_within IGI (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr 9:95,085,445...95,085,541
Ensembl chr 9:95,085,445...95,085,541 		JBrowse link
G SIRPA signal regulatory protein alpha involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr20:1,894,167...1,940,592
Ensembl chr20:1,894,167...1,940,592 		JBrowse link
positive regulation of canonical NF-kappaB signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18025176) Ensembl
MGI		 PMID:18025176 GO_REF:0000107 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675 		JBrowse link
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:18025176) MGI PMID:18025176 NCBI chr 1:179,099,330...179,229,677
Ensembl chr 1:179,099,330...179,229,684 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:12087086), (PMID:14522956) UniProt
MGI
Ensembl		 PMID:12087086 PMID:14522956 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AGT angiotensinogen acts_upstream_of_or_within ISO (PMID:19404405) MGI PMID:19404405 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AJUBA ajuba LIM protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:22,971,177...22,982,551
Ensembl chr14:22,971,177...22,982,551 		JBrowse link
G AKAP13 A-kinase anchoring protein 13 involved_in IMP
IBA
IEA		 (PMID:23090968) UniProt
GO_Central
TreeGrafter		 PMID:23090968 GO_REF:0000033 GO_REF:0000118 NCBI chr15:85,380,603...85,749,358
Ensembl chr15:85,380,571...85,749,358 		JBrowse link
G ALPK1 alpha kinase 1 involved_in IDA (PMID:28222186), (PMID:28877472), (PMID:30111836) UniProt PMID:28222186 PMID:28877472 PMID:30111836 NCBI chr 4:112,297,369...112,442,621
Ensembl chr 4:112,285,509...112,442,621 		JBrowse link
G ANKRD17 ankyrin repeat domain 17 involved_in IDA (PMID:22328336) UniProt PMID:22328336 NCBI chr 4:73,073,376...73,258,798
Ensembl chr 4:73,073,376...73,258,798 		JBrowse link
G APOL3 apolipoprotein L3 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr22:36,140,323...36,166,177
Ensembl chr22:36,140,329...36,166,177 		JBrowse link
G ATP2C1 ATPase secretory pathway Ca2+ transporting 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 3:130,850,595...131,016,712
Ensembl chr 3:130,850,595...131,016,712 		JBrowse link
G BCL10 BCL10 immune signaling adaptor involved_in IDA
IEP		 (PMID:18287044), (PMID:27777308)
(PMID:12761501)		 UniProt PMID:12761501 PMID:18287044 PMID:27777308 NCBI chr 1:85,265,776...85,276,632
Ensembl chr 1:85,265,776...85,276,632 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 involved_in IEP
IEA		 (PMID:12761501) UniProt
Ensembl		 PMID:12761501 GO_REF:0000107 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 involved_in TAS (PMID:20651737) UniProt PMID:20651737 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BRD4 bromodomain containing 4 involved_in IDA (PMID:19103749) UniProt PMID:19103749 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545 		JBrowse link
G BST2 bone marrow stromal cell antigen 2 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630 		JBrowse link
G C18orf32 chromosome 18 open reading frame 32 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr18:49,477,243...49,487,234
Ensembl chr18:49,477,243...49,487,252 		JBrowse link
G CANT1 calcium activated nucleotidase 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr17:78,991,716...79,009,764
Ensembl chr17:78,991,716...79,009,867 		JBrowse link
G CARD11 caspase recruitment domain family member 11 involved_in IEA
IBA
ISS
IMP		 (PMID:12154360) Ensembl
GO_Central
TreeGrafter
UniProt		 PMID:12154360 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:2,906,142...3,043,867
Ensembl chr 7:2,906,142...3,044,228 		JBrowse link
G CARD16 caspase recruitment domain family member 16 involved_in IDA (PMID:15383541) UniProt PMID:15383541 NCBI chr11:105,041,563...105,045,335
Ensembl chr11:105,041,326...105,101,431 		JBrowse link
G CARD9 caspase recruitment domain family member 9 involved_in IEP
IDA
IBA		 (PMID:11053425) UniProt
GO_Central		 PMID:11053425 GO_REF:0000033 NCBI chr 9:136,363,956...136,373,669
Ensembl chr 9:136,363,956...136,373,681 		JBrowse link
G CASP1 caspase 1 involved_in IEP
IMP		 (PMID:12761501)
(PMID:15383541)		 UniProt PMID:12761501 PMID:15383541 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP10 caspase 10 involved_in IMP (PMID:12884866) UniProt PMID:12884866 NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428 		JBrowse link
G CASP8 caspase 8 involved_in IEP
IMP		 (PMID:12761501)
(PMID:12884866)		 UniProt PMID:12761501 PMID:12884866 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CAV1 caveolin 1 involved_in IMP (PMID:23319823) ARUK-UCL PMID:23319823 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CC2D1A coiled-coil and C2 domain containing 1A involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr19:13,906,201...13,930,879
Ensembl chr19:13,906,201...13,930,879 		JBrowse link
G CCDC22 coiled-coil domain containing 22 involved_in IMP (PMID:23563313) UniProt PMID:23563313 NCBI chr  X:49,235,470...49,250,520
Ensembl chr  X:49,235,470...49,250,520 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in IDA (PMID:15059845) BHF-UCL PMID:15059845 NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276 		JBrowse link
G CCL21 C-C motif chemokine ligand 21 involved_in IDA (PMID:15059845) BHF-UCL PMID:15059845 NCBI chr 9:34,709,005...34,710,136
Ensembl chr 9:34,709,005...34,710,136 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 involved_in IC (PMID:15059845) BHF-UCL PMID:15059845 NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,553,769...40,565,472 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in
acts_upstream_of_or_within		 IEA
ISO
IGI		 (PMID:16061696)
(PMID:20037584)		 Ensembl
MGI
ARUK-UCL		 PMID:16061696 PMID:20037584 GO_REF:0000107 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G CD4 CD4 molecule involved_in IDA (PMID:24942581) CAFA PMID:24942581 NCBI chr12:6,789,528...6,820,799
Ensembl chr12:6,786,858...6,820,799 		JBrowse link
G CD40 CD40 molecule involved_in IEP
IEA		 (PMID:12761501) UniProt
TreeGrafter		 PMID:12761501 GO_REF:0000118 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CD74 CD74 molecule involved_in IDA (PMID:24942581) CAFA PMID:24942581 NCBI chr 5:150,401,639...150,412,910
Ensembl chr 5:150,401,637...150,412,969 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in IMP
IDA		 (PMID:23487264)
(PMID:12656673)		 ARUK-UCL PMID:12656673 PMID:23487264 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CLEC4D C-type lectin domain family 4 member D involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:8,513,503...8,531,696
Ensembl chr12:8,509,475...8,522,366 		JBrowse link
G CLEC6A C-type lectin domain containing 6A involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:8,455,962...8,478,330
Ensembl chr12:8,455,962...8,478,330 		JBrowse link
G CLEC7A C-type lectin domain containing 7A involved_in ISS UniProt GO_REF:0000024 NCBI chr12:10,116,777...10,130,304
Ensembl chr12:10,116,777...10,130,258 		JBrowse link
G CTH cystathionine gamma-lyase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851 		JBrowse link
G CUL1 cullin 1 involved_in IDA (PMID:10644755) UniProt PMID:10644755 NCBI chr 7:148,697,756...148,801,110
Ensembl chr 7:148,697,914...148,801,110 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 involved_in ISS
IGI		 (PMID:10869418) ARUK-UCL PMID:10869418 GO_REF:0000024 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735 		JBrowse link
G CXXC5 CXXC finger protein 5 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 5:139,647,299...139,683,882
Ensembl chr 5:139,647,299...139,683,882 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:121,567,074...121,785,530
Ensembl chr 9:121,567,057...121,785,530 		JBrowse link
G DDX1 DEAD-box helicase 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:15,591,868...15,631,101
Ensembl chr 2:15,591,178...15,634,346 		JBrowse link
G DDX21 DExD-box helicase 21 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:68,956,170...68,985,068
Ensembl chr10:68,956,135...68,985,068 		JBrowse link
G DHX15 DEAH-box helicase 15 involved_in IDA (PMID:24990078) UniProt PMID:24990078 NCBI chr 4:24,527,475...24,584,554
Ensembl chr 4:24,517,441...24,584,554 		JBrowse link
G DHX36 DEAH-box helicase 36 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:154,272,546...154,324,487
Ensembl chr 3:154,272,546...154,324,487 		JBrowse link
G ECM1 extracellular matrix protein 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:150,508,109...150,513,789
Ensembl chr 1:150,508,062...150,513,789 		JBrowse link
G ECT2 epithelial cell transforming 2 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 3:172,750,726...172,829,265
Ensembl chr 3:172,750,682...172,821,474 		JBrowse link
G EDA ectodysplasin A involved_in
acts_upstream_of_or_within		 IEA
IDA
ISO		 (PMID:11039935)
(PMID:18689798)		 Ensembl
HGNC-UCL
MGI		 PMID:11039935 PMID:18689798 GO_REF:0000107 NCBI chr  X:69,616,113...70,039,472
Ensembl chr  X:69,616,067...70,039,472 		JBrowse link
G EDA2R ectodysplasin A2 receptor involved_in IEA
IDA
IBA		 (PMID:11039935) InterPro
HGNC-UCL
GO_Central
TreeGrafter		 PMID:11039935 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:66,595,637...66,639,269
Ensembl chr  X:66,595,637...66,639,298 		JBrowse link
G EDAR ectodysplasin A receptor involved_in IEA
IBA		 InterPro
TreeGrafter
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:108,894,471...108,989,220
Ensembl chr 2:108,894,471...108,989,372 		JBrowse link
G EDN1 endothelin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDNRA endothelin receptor type A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954 		JBrowse link
G EDNRB endothelin receptor type B involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529 		JBrowse link
G F2R coagulation factor II thrombin receptor involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IDA (PMID:11413129) UniProt PMID:11413129 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315 		JBrowse link
G FADD Fas associated via death domain involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FAIM Fas apoptotic inhibitory molecule ISO RGD PMID:15520226 RGD:1357927 NCBI chr 3:138,608,771...138,633,376
Ensembl chr 3:138,608,606...138,633,376 		JBrowse link
G FASLG Fas ligand involved_in IEP
IEA
IBA		 (PMID:12761501) UniProt
TreeGrafter
GO_Central		 PMID:12761501 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FBXW11 F-box and WD repeat domain containing 11 involved_in IDA (PMID:10644755) UniProt PMID:10644755 NCBI chr 5:171,861,549...172,006,638
Ensembl chr 5:171,861,549...172,006,873 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164 		JBrowse link
G FLNA filamin A involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr  X:154,348,531...154,374,634
Ensembl chr  X:154,348,524...154,374,634 		JBrowse link
G FLOT1 flotillin 1 involved_in IMP (PMID:23319823) ARUK-UCL PMID:23319823 NCBI chr 6:30,727,709...30,742,687
Ensembl chr 6:30,727,709...30,742,732 		JBrowse link
G FLOT2 flotillin 2 involved_in IMP (PMID:23319823) ARUK-UCL PMID:23319823 NCBI chr17:28,879,339...28,897,733
Ensembl chr17:28,879,335...28,897,733 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase involved_in IDA (PMID:23332158) UniProt PMID:23332158 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GOLT1B golgi transport 1B involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr12:21,501,789...21,518,408
Ensembl chr12:21,501,781...21,518,408 		JBrowse link
G GPR89A G protein-coupled receptor 89A involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:145,607,988...145,670,650
Ensembl chr 1:145,607,988...145,670,650
Ensembl chr 1:145,607,988...145,670,650 		JBrowse link
G GPR89B G protein-coupled receptor 89B involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:147,928,420...148,025,934
Ensembl chr 1:147,928,393...147,993,592
Ensembl chr 1:147,928,393...147,993,592 		JBrowse link
G GPRC5B G protein-coupled receptor class C group 5 member B involved_in ISS CAFA GO_REF:0000024 NCBI chr16:19,856,691...19,885,634
Ensembl chr16:19,856,691...19,886,167 		JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 involved_in IDA (PMID:24942581) CAFA PMID:24942581 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr 2:231,108,230...231,125,042
Ensembl chr 2:231,108,230...231,125,042 		JBrowse link
G IFIT5 interferon induced protein with tetratricopeptide repeats 5 involved_in IMP (PMID:26334375) UniProt PMID:26334375 NCBI chr10:89,414,568...89,420,997
Ensembl chr10:89,414,568...89,421,605 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta involved_in IMP
IDA		 (PMID:30337470)
(PMID:12656673), (PMID:9346484)		 UniProt PMID:9346484 PMID:12656673 PMID:30337470 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in IEP
IDA		 (PMID:12761501)
(PMID:10882136)		 UniProt
GO_Central		 PMID:10882136 PMID:12761501 NCBI chr 1:206,470,476...206,496,889
Ensembl chr 1:206,470,476...206,496,889 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:17702576)
(PMID:18287044), (PMID:27777308)		 MGI
GO_Central
UniProt		 PMID:17702576 PMID:18287044 PMID:27777308 GO_REF:0000033 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046 		JBrowse link
G IL1A interleukin 1 alpha involved_in ISO
IEA		 RGD
Ensembl		 PMID:15671867 GO_REF:0000107 RGD:1358666 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta involved_in
acts_upstream_of		 ISO
IMP
IDA
IEA		 (PMID:18201371)
(PMID:26020802)		 RGD
AgBase
ARUK-UCL
Ensembl		 PMID:15671867 PMID:18201371 PMID:26020802 GO_REF:0000107 RGD:1358666 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G ILK integrin linked kinase involved_in IMP (PMID:21343177) CAFA PMID:21343177 NCBI chr11:6,603,774...6,610,870
Ensembl chr11:6,603,708...6,610,874 		JBrowse link
G INAVA innate immunity activator involved_in IMP (PMID:28436939) UniProt PMID:28436939 NCBI chr 1:200,891,531...200,915,742
Ensembl chr 1:200,891,048...200,915,742 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in
acts_upstream_of_or_within		 TAS
IBA
IMP		 (PMID:22158417) Reactome
GO_Central
MGI		 PMID:22158417 GO_REF:0000033 Reactome:R-HSA-937039 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902 		JBrowse link
G IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:78,867,551...78,979,411
Ensembl chr 6:78,867,551...78,946,440 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 NOT|acts_upstream_of_or_within ISO (PMID:12220507) MGI PMID:12220507 NCBI chr 3:10,164,919...10,243,745
Ensembl chr 3:10,164,919...10,243,745 		JBrowse link
G IRAK4 interleukin 1 receptor associated kinase 4 acts_upstream_of_or_within
involved_in		 IMP
IBA
IEA		 (PMID:22158417) MGI
GO_Central
UniProt		 PMID:22158417 GO_REF:0000033 GO_REF:0000117 NCBI chr12:43,758,951...43,789,541
Ensembl chr12:43,758,944...43,798,307 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:20670634 GO_REF:0000107 RGD:5128809 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G JMJD8 jumonji domain containing 8 involved_in IMP (PMID:27671354) UniProt PMID:27671354 NCBI chr16:681,670...684,334
Ensembl chr16:681,670...684,528 		JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 involved_in IDA (PMID:21343296) ARUK-UCL PMID:21343296 NCBI chr 1:110,401,253...110,407,924
Ensembl chr 1:110,401,249...110,407,942 		JBrowse link
G LGALS1 galectin 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802 		JBrowse link
G LGALS9 galectin 9 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560 		JBrowse link
G LIMS1 LIM zinc finger domain containing 1 involved_in IMP (PMID:21343177) CAFA PMID:21343177 NCBI chr 2:108,533,671...108,687,246
Ensembl chr 2:108,533,671...108,687,246 		JBrowse link
G LITAF lipopolysaccharide induced TNF factor involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr16:11,547,722...11,640,317
Ensembl chr16:11,547,722...11,636,381 		JBrowse link
G LPAR1 lysophosphatidic acid receptor 1 involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr 9:110,873,263...111,038,998
Ensembl chr 9:110,873,263...111,038,470 		JBrowse link
G LRRC19 leucine rich repeat containing 19 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:26,993,136...27,005,672
Ensembl chr 9:26,993,136...27,005,672 		JBrowse link
G LTB lymphotoxin beta involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522 		JBrowse link
G LTBR lymphotoxin beta receptor involved_in IEP
IBA
IEA		 (PMID:12761501) UniProt
GO_Central
InterPro		 PMID:12761501 GO_REF:0000002 GO_REF:0000033 NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571 		JBrowse link
G LTF lactotransferrin involved_in IDA (PMID:20345905) UniProt PMID:20345905 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234 		JBrowse link
G LURAP1 leucine rich adaptor protein 1 involved_in IDA
IBA
IEA		 (PMID:21048106) UniProt
GO_Central
InterPro		 PMID:21048106 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:46,203,334...46,221,256
Ensembl chr 1:46,203,334...46,221,256 		JBrowse link
G LURAP1L leucine rich adaptor protein 1 like involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:12,775,020...12,823,060
Ensembl chr 9:12,775,020...12,823,060 		JBrowse link
G MALT1 MALT1 paracaspase involved_in HMP
IDA
IEA		 (PMID:12761501)
(PMID:18223652)		 UniProt
TreeGrafter		 PMID:12761501 PMID:18223652 GO_REF:0000118 NCBI chr18:58,671,465...58,754,477
Ensembl chr18:58,671,465...58,754,477 		JBrowse link
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr17:63,622,417...63,696,305
Ensembl chr17:63,622,415...63,696,305 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO
IEA
IDA
IMP		 (PMID:11460167)
(PMID:14982987)		 RGD
TreeGrafter
UniProt
Ensembl		 PMID:11460167 PMID:14982987 PMID:17947700 GO_REF:0000107 GO_REF:0000118 RGD:5508194 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19404405) Ensembl
MGI		 PMID:19404405 GO_REF:0000107 NCBI chr 6:159,888,787...159,917,447
Ensembl chr 6:159,890,988...159,917,447 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr20:3,846,834...3,876,118
Ensembl chr20:3,846,799...3,876,123 		JBrowse link
G MIB2 MIB E3 ubiquitin protein ligase 2 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:1,613,731...1,630,605
Ensembl chr 1:1,615,454...1,630,605 		JBrowse link
G MID2 midline 2 involved_in IDA (PMID:23077300) UniProt PMID:23077300 NCBI chr  X:107,825,735...107,931,637
Ensembl chr  X:107,825,755...107,931,637 		JBrowse link
G MIER1 MIER1 transcriptional regulator involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:66,924,990...66,988,619
Ensembl chr 1:66,924,895...66,988,619 		JBrowse link
G MTDH metadherin involved_in IEA
IDA		 (PMID:16452207), (PMID:18316612) InterPro
UniProt		 PMID:16452207 PMID:18316612 GO_REF:0000002 NCBI chr 8:97,644,184...97,730,260
Ensembl chr 8:97,644,184...97,730,260 		JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:20,499,448...20,508,151
Ensembl chr 1:20,499,448...20,508,151 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA
IEP		 (PMID:12761501) Ensembl
UniProt
InterPro		 PMID:12761501 GO_REF:0000002 GO_REF:0000107 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 5:142,108,779...142,154,440
Ensembl chr 5:142,108,779...142,154,440 		JBrowse link
G NDFIP2 Nedd4 family interacting protein 2 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr13:79,481,155...79,556,077
Ensembl chr13:79,481,155...79,556,077 		JBrowse link
G NEK6 NIMA related kinase 6 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 9:124,257,606...124,353,307
Ensembl chr 9:124,257,606...124,353,307 		JBrowse link
G NFAT5 nuclear factor of activated T cells 5 involved_in IMP (PMID:25515214) ARUK-UCL PMID:25515214 NCBI chr16:69,565,966...69,704,654
Ensembl chr16:69,565,094...69,704,666 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
IDA		 (PMID:12791997)
(PMID:10329646)		 Ensembl
UniProt
MGI		 PMID:10329646 PMID:12791997 GO_REF:0000107 NCBI chr 7:30,424,527...30,478,784
Ensembl chr 7:30,424,527...30,478,784 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 IDA
IBA
IMP
IEA		 (PMID:12527755)
(PMID:11087742), (PMID:12514169), (PMID:12626759), (PMID:15044951), (PMID:17355968)
(PMID:15998797)		 MGI
GO_Central
UniProt
Ensembl		 PMID:11087742 PMID:12514169 PMID:12527755 PMID:12626759 PMID:15044951 More... GO_REF:0000033 GO_REF:0000107 NCBI chr16:50,693,606...50,733,075
Ensembl chr16:50,693,588...50,733,077 		JBrowse link
G NUP62 nucleoporin 62 involved_in IDA (PMID:10356400) UniProt PMID:10356400 NCBI chr19:49,906,825...49,929,504
Ensembl chr19:49,906,825...49,929,764 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in IDA (PMID:22464733) UniProt PMID:22464733 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PEDS1-UBE2V1 PEDS1-UBE2V1 readthrough involved_in IMP (PMID:16129784) HGNC-UCL PMID:16129784 NCBI chr20:50,081,124...50,153,723
Ensembl chr20:50,081,124...50,153,637 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
TAS		 (PMID:19734906) Ensembl
MGI
Reactome		 PMID:19734906 GO_REF:0000107 Reactome:R-HSA-937039 NCBI chr 2:64,092,652...64,144,420
Ensembl chr 2:64,092,652...64,144,420 		JBrowse link
G PELI2 pellino E3 ubiquitin protein ligase family member 2 involved_in TAS Reactome Reactome:R-HSA-937039 NCBI chr14:56,118,411...56,301,524
Ensembl chr14:56,117,814...56,301,524 		JBrowse link
G PIM2 Pim-2 proto-oncogene, serine/threonine kinase involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:48,913,182...48,919,024
Ensembl chr  X:48,913,182...48,919,024 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IDA (PMID:19880420) BHF-UCL PMID:19880420 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PLEKHG5 pleckstrin homology and RhoGEF domain containing G5 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:6,467,122...6,520,092
Ensembl chr 1:6,467,122...6,520,074 		JBrowse link
G PLK2 polo like kinase 2 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 5:58,453,982...58,460,086
Ensembl chr 5:58,453,982...58,460,139 		JBrowse link
G PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A involved_in HMP
IEA		 (PMID:12761501) UniProt
TreeGrafter		 PMID:12761501 GO_REF:0000118 NCBI chr14:60,245,750...60,299,087
Ensembl chr14:60,245,752...60,299,087 		JBrowse link
G PPM1B protein phosphatase, Mg2+/Mn2+ dependent 1B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:44,168,875...44,246,928
Ensembl chr 2:44,167,969...44,244,384 		JBrowse link
G PPP5C protein phosphatase 5 catalytic subunit involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr19:46,347,087...46,390,975
Ensembl chr19:46,347,087...46,392,981 		JBrowse link
G PRKCB protein kinase C beta involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611 		JBrowse link
G PRKCE protein kinase C epsilon involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11696589) Ensembl
MGI		 PMID:11696589 GO_REF:0000107 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990 		JBrowse link
G PRKD1 protein kinase D1 involved_in IMP (PMID:12505989) UniProt PMID:12505989 NCBI chr14:29,576,479...29,927,847
Ensembl chr14:29,576,479...30,191,898 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IMP
IDA		 (PMID:23453807)
(PMID:17314283), (PMID:19880420)		 ParkinsonsUK-UCL PMID:17314283 PMID:19880420 PMID:23453807 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G PRL prolactin involved_in IDA (PMID:23619365) BHF-UCL PMID:23619365 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IDA (PMID:12656673) HGNC-UCL PMID:12656673 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in IEA
IBA
IDA		 (PMID:19136968), (PMID:21455173) Ensembl
GO_Central
UniProt		 PMID:19136968 PMID:21455173 GO_REF:0000033 GO_REF:0000107 NCBI chr20:408,299...432,139
Ensembl chr20:407,498...432,139 		JBrowse link
G RBX1 ring-box 1 involved_in IDA (PMID:10644755) UniProt PMID:10644755 NCBI chr22:40,951,378...40,973,309
Ensembl chr22:40,951,347...40,973,309 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEP
IEA		 (PMID:12761501) UniProt
Ensembl		 PMID:12761501 GO_REF:0000107 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RFPL1 ret finger protein like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr22:29,387,909...29,442,455
Ensembl chr22:29,438,583...29,442,455 		JBrowse link
G RFPL2 ret finger protein like 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr22:32,190,438...32,205,073
Ensembl chr22:32,190,435...32,205,073 		JBrowse link
G RFPL3 ret finger protein like 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr22:32,354,885...32,361,161
Ensembl chr22:32,354,885...32,361,161 		JBrowse link
G RFPL4A ret finger protein like 4A involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:55,757,294...55,763,421
Ensembl chr19:55,759,097...55,763,421 		JBrowse link
G RFPL4AL1 ret finger protein like 4A like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:55,769,118...55,773,420
Ensembl chr19:55,769,118...55,773,420 		JBrowse link
G RHOA ras homolog family member A involved_in IEP
IMP		 (PMID:12761501)
(PMID:25515214)		 UniProt
ARUK-UCL		 PMID:12761501 PMID:25515214 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G RHOC ras homolog family member C involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 1:112,701,131...112,707,408
Ensembl chr 1:112,701,127...112,707,434 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IDA
IEP		 (PMID:22089168)
(PMID:17389591)
(PMID:12761501)		 Ensembl
MGI
UniProt		 PMID:12761501 PMID:17389591 PMID:22089168 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
IBA
IDA		 (PMID:10329646) Ensembl
GO_Central
UniProt
MGI		 PMID:10329646 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 8:89,757,816...89,791,064
Ensembl chr 8:89,757,806...89,791,064 		JBrowse link
G RNF31 ring finger protein 31 involved_in IEA
IDA		 (PMID:19136968), (PMID:21455173), (PMID:23806334), (PMID:28481331) Ensembl
UniProt		 PMID:19136968 PMID:21455173 PMID:23806334 PMID:28481331 GO_REF:0000107 NCBI chr14:24,146,875...24,160,655
Ensembl chr14:24,146,683...24,160,660 		JBrowse link
G ROR1 receptor tyrosine kinase like orphan receptor 1 involved_in IMP
IBA
IEA		 (PMID:27162350) UniProt
GO_Central
TreeGrafter		 PMID:27162350 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:63,774,017...64,181,498
Ensembl chr 1:63,774,017...64,181,498 		JBrowse link
G S100A1 S100 calcium binding protein A1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:153,628,434...153,632,039
Ensembl chr 1:153,627,926...153,632,039 		JBrowse link
G S100A12 S100 calcium binding protein A12 involved_in IDA
IBA		 (PMID:15033494) UniProt
GO_Central		 PMID:15033494 GO_REF:0000033 NCBI chr 1:153,373,711...153,375,621
Ensembl chr 1:153,373,711...153,375,621 		JBrowse link
G S100A13 S100 calcium binding protein A13 involved_in IDA
IBA		 (PMID:15033494) UniProt
GO_Central		 PMID:15033494 GO_REF:0000033 NCBI chr 1:153,618,799...153,634,361
Ensembl chr 1:153,618,787...153,631,360 		JBrowse link
G S100A4 S100 calcium binding protein A4 involved_in IDA
IEA
IBA		 (PMID:15033494) UniProt
TreeGrafter
GO_Central		 PMID:15033494 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136 		JBrowse link
G S100B S100 calcium binding protein B involved_in IDA
IBA
IEA		 (PMID:15033494) UniProt
GO_Central
TreeGrafter		 PMID:15033494 GO_REF:0000033 GO_REF:0000118 NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208 		JBrowse link
G SECTM1 secreted and transmembrane 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr17:82,321,024...82,333,959
Ensembl chr17:82,321,024...82,334,074 		JBrowse link
G SHARPIN SHANK associated RH domain interactor involved_in IDA
IBA
IEA		 (PMID:21455173) UniProt
GO_Central
TreeGrafter
Ensembl		 PMID:21455173 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:144,098,637...144,103,773
Ensembl chr 8:144,098,633...144,108,124 		JBrowse link
G SHISA5 shisa family member 5 involved_in HMP
IEA		 (PMID:12761501) UniProt
TreeGrafter		 PMID:12761501 GO_REF:0000118 NCBI chr 3:48,467,876...48,504,810
Ensembl chr 3:48,467,798...48,504,826 		JBrowse link
G SLC20A1 solute carrier family 20 member 1 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 2:112,645,939...112,663,825
Ensembl chr 2:112,645,939...112,663,825 		JBrowse link
G SLC35B2 solute carrier family 35 member B2 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 6:44,254,101...44,257,890
Ensembl chr 6:44,254,096...44,257,890 		JBrowse link
G SLC44A2 solute carrier family 44 member 2 (CTL2 blood group) involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr19:10,602,455...10,644,557
Ensembl chr19:10,602,457...10,644,557 		JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 involved_in IEP
IBA
IEA
IDA		 (PMID:12761501)
(PMID:15327770), (PMID:18079694), (PMID:22158122)		 UniProt
GO_Central
TreeGrafter		 PMID:12761501 PMID:15327770 PMID:18079694 PMID:22158122 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:149,217,926...149,411,607
Ensembl chr 6:149,218,641...149,411,613 		JBrowse link
G TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 involved_in IMP
IBA
IEA
IDA		 (PMID:23487264)
(PMID:15327770), (PMID:18079694), (PMID:22158122)		 ARUK-UCL
GO_Central
TreeGrafter
UniProt		 PMID:15327770 PMID:18079694 PMID:22158122 PMID:23487264 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:30,827,442...30,889,254
Ensembl chr  X:30,827,442...30,975,084 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114 		JBrowse link
G TERF2IP TERF2 interacting protein involved_in ISO (MGI:4821187|PMID:20622870) UniProt PMID:20622870 MGI:4821187 NCBI chr16:75,760,050...75,914,672
Ensembl chr16:75,647,773...75,761,872 		JBrowse link
G TERF2IP TERF2 interacting protein involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:75,647,773...75,657,432
Ensembl chr16:75,647,773...75,761,872 		JBrowse link
G TFG trafficking from ER to golgi regulator involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 3:100,709,290...100,748,967
Ensembl chr 3:100,709,295...100,748,964 		JBrowse link
G TFRC transferrin receptor involved_in IMP (PMID:23016877) ARUK-UCL PMID:23016877 NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in IMP (PMID:25196641) BHF-UCL PMID:25196641 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGM2 transglutaminase 2 ISO RGD PMID:15471861 RGD:1579987 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 involved_in ISS
IBA
HMP
IMP
IEA		 (PMID:12761501)
(PMID:14982987)		 UniProt
GO_Central
Ensembl		 PMID:12761501 PMID:14982987 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712 		JBrowse link
G TICAM2 TIR domain containing adaptor molecule 2 involved_in HMP
IBA		 (PMID:12761501) UniProt
GO_Central		 PMID:12761501 GO_REF:0000033 NCBI chr 5:115,578,496...115,602,479
Ensembl chr 5:115,578,496...115,602,479 		JBrowse link
G TIFA TRAF interacting protein with forkhead associated domain involved_in IDA
IEA
IBA		 (PMID:26068852), (PMID:28222186), (PMID:28877472), (PMID:30111836) UniProt
InterPro
TreeGrafter
GO_Central
Ensembl		 PMID:26068852 PMID:28222186 PMID:28877472 PMID:30111836 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:112,274,537...112,285,904
Ensembl chr 4:112,272,968...112,285,955 		JBrowse link
G TIFAB TIFA inhibitor involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:135,444,226...135,452,351
Ensembl chr 5:135,444,226...135,452,351 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IMP
IBA		 (PMID:19509286), (PMID:24275656) AgBase
GO_Central		 PMID:19509286 PMID:24275656 GO_REF:0000033 NCBI chr11:126,283,093...126,294,933
Ensembl chr11:126,282,497...126,298,845 		JBrowse link
G TLR3 toll like receptor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO
IGI		 (PMID:19734906)
(PMID:20037584)		 Ensembl
MGI
ARUK-UCL		 PMID:19734906 PMID:20037584 GO_REF:0000107 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TLR6 toll like receptor 6 acts_upstream_of_or_within
involved_in		 IDA
IGI		 (PMID:10231569)
(PMID:20037584)		 MGI
ARUK-UCL		 PMID:10231569 PMID:20037584 NCBI chr 4:38,822,897...38,868,390
Ensembl chr 4:38,822,897...38,856,817 		JBrowse link
G TLR7 toll like receptor 7 involved_in IDA (PMID:12032557) GO_Central PMID:12032557 NCBI chr  X:12,867,072...12,890,361
Ensembl chr  X:12,867,072...12,890,361 		JBrowse link
G TLR8 toll like receptor 8 involved_in IDA (PMID:12032557) UniProt PMID:12032557 NCBI chr  X:12,906,620...12,923,169
Ensembl chr  X:12,906,620...12,923,169 		JBrowse link
G TLR9 toll like receptor 9 involved_in IDA (PMID:17128265), (PMID:19740627) BHF-UCL PMID:17128265 PMID:19740627 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645 		JBrowse link
G TMED4 transmembrane p24 trafficking protein 4 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr 7:44,577,894...44,582,231
Ensembl chr 7:44,577,894...44,582,287 		JBrowse link
G TMED7-TICAM2 TMED7-TICAM2 readthrough involved_in HMP
IBA		 (PMID:12761501) UniProt
GO_Central		 PMID:12761501 GO_REF:0000033 NCBI chr 5:115,578,496...115,626,036
Ensembl chr 5:115,578,642...115,626,161 		JBrowse link
G TMEM101 transmembrane protein 101 involved_in HMP
IEA		 (PMID:12761501) UniProt
TreeGrafter		 PMID:12761501 GO_REF:0000118 NCBI chr17:44,011,188...44,023,215
Ensembl chr17:44,011,188...44,023,946 		JBrowse link
G TMEM106A transmembrane protein 106A involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:43,211,875...43,220,041
Ensembl chr17:43,211,835...43,220,041 		JBrowse link
G TMEM9B TMEM9 domain family member B involved_in HMP
IEA		 (PMID:12761501) UniProt
TreeGrafter		 PMID:12761501 GO_REF:0000118 NCBI chr11:8,947,202...8,964,947
Ensembl chr11:8,947,202...8,965,011 		JBrowse link
G TNF tumor necrosis factor involved_in ISO
IBA
NAS
IMP
IDA
ISS
IEA
TAS		 (PMID:23878390)
(PMID:18201371)
(PMID:11374864), (PMID:15310755), (PMID:17922812)
(PMID:29702085)		 RGD
GO_Central
BHF-UCL
AgBase
ARUK-UCL
Ensembl		 PMID:11374864 PMID:12631113 PMID:15310755 PMID:17922812 PMID:18201371 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:1580306 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b involved_in IEP (PMID:12761501) UniProt PMID:12761501 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TNFRSF19 TNF receptor superfamily member 19 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:10764796) Ensembl
MGI
GO_Central
InterPro		 PMID:10764796 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr13:23,570,412...23,676,093
Ensembl chr13:23,570,370...23,676,104 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A involved_in IEP
IEA		 (PMID:12761501) UniProt
Ensembl		 PMID:12761501 GO_REF:0000107 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TNFSF10 TNF superfamily member 10 involved_in IEP
IBA		 (PMID:12761501) UniProt
GO_Central		 PMID:12761501 GO_REF:0000033 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in IDA
IBA		 (PMID:21784860) UniProt
GO_Central		 PMID:21784860 GO_REF:0000033 NCBI chr 4:2,741,648...2,756,336
Ensembl chr 4:2,741,648...2,756,342 		JBrowse link
G TRADD TNFRSF1A associated via death domain involved_in IEP
IEA		 (PMID:12761501) UniProt
Ensembl
InterPro		 PMID:12761501 GO_REF:0000002 GO_REF:0000107 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909 		JBrowse link
G TRAF2 TNF receptor associated factor 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607 		JBrowse link
G TRAF3IP2 TRAF3 interacting protein 2 involved_in IEP
IBA		 (PMID:12761501) UniProt
GO_Central		 PMID:12761501 GO_REF:0000033 NCBI chr 6:111,555,381...111,605,878
Ensembl chr 6:111,555,381...111,606,906 		JBrowse link
G TRAF5 TNF receptor associated factor 5 involved_in IEP
IEA		 (PMID:12761501) UniProt
InterPro		 PMID:12761501 GO_REF:0000002 NCBI chr 1:211,326,635...211,374,946
Ensembl chr 1:211,326,615...211,374,946 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IDA
IEA		 (PMID:17135271) UniProt
Ensembl		 PMID:17135271 GO_REF:0000107 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G TRIM13 tripartite motif containing 13 involved_in HMP
IEA
IBA
IDA		 (PMID:12761501)
(PMID:23077300)		 UniProt
TreeGrafter
GO_Central		 PMID:12761501 PMID:23077300 GO_REF:0000033 GO_REF:0000118 NCBI chr13:49,997,042...50,018,467
Ensembl chr13:49,995,888...50,020,481 		JBrowse link
G TRIM21 tripartite motif containing 21 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:4,384,897...4,393,702
Ensembl chr11:4,384,897...4,393,702 		JBrowse link
G TRIM22 tripartite motif containing 22 involved_in IDA
IBA
IEA		 (PMID:23077300) UniProt
GO_Central
TreeGrafter		 PMID:23077300 GO_REF:0000033 GO_REF:0000118 NCBI chr11:5,689,790...5,710,863
Ensembl chr11:5,689,610...5,737,089 		JBrowse link
G TRIM25 tripartite motif containing 25 involved_in IDA (PMID:23077300) UniProt PMID:23077300 NCBI chr17:56,887,909...56,914,049
Ensembl chr17:56,836,387...56,914,080 		JBrowse link
G TRIM32 tripartite motif containing 32 involved_in IDA (PMID:23077300) UniProt PMID:23077300 NCBI chr 9:116,687,305...116,701,299
Ensembl chr 9:116,687,305...116,701,300 		JBrowse link
G TRIM34 tripartite motif containing 34 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:5,619,944...5,644,398
Ensembl chr11:5,619,764...5,644,398 		JBrowse link
G TRIM38 tripartite motif containing 38 involved_in HMP
IBA
IDA		 (PMID:12761501)
(PMID:23077300)		 UniProt
GO_Central		 PMID:12761501 PMID:23077300 GO_REF:0000033 NCBI chr 6:25,962,802...25,991,231
Ensembl chr 6:25,962,802...25,991,231 		JBrowse link
G TRIM5 tripartite motif containing 5 involved_in IDA
IEA
IBA
IMP		 (PMID:23077300)
(PMID:21512573)		 UniProt
TreeGrafter
GO_Central		 PMID:21512573 PMID:23077300 GO_REF:0000033 GO_REF:0000118 NCBI chr11:5,588,635...5,685,074
Ensembl chr11:5,663,195...5,938,619 		JBrowse link
G TRIM52 tripartite motif containing 52 involved_in IDA (PMID:27667714), (PMID:28073078) UniProt PMID:27667714 PMID:28073078 NCBI chr 5:181,249,062...181,261,143
Ensembl chr 5:181,254,077...181,261,150 		JBrowse link
G TRIM58 tripartite motif containing 58 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:247,857,187...247,880,138
Ensembl chr 1:247,857,187...247,880,138 		JBrowse link
G TRIM6 tripartite motif containing 6 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr11:5,596,111...5,612,952
Ensembl chr11:5,596,109...5,612,958 		JBrowse link
G TRIM62 tripartite motif containing 62 involved_in IDA
IBA		 (PMID:23077300) UniProt
GO_Central		 PMID:23077300 GO_REF:0000033 NCBI chr 1:33,145,399...33,182,043
Ensembl chr 1:33,145,399...33,182,059 		JBrowse link
G TRIM68 tripartite motif containing 68 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:4,598,672...4,608,231
Ensembl chr11:4,598,672...4,608,231 		JBrowse link
G TRIM8 tripartite motif containing 8 involved_in IDA (PMID:23077300) UniProt PMID:23077300 NCBI chr10:102,644,479...102,658,319
Ensembl chr10:102,642,503...102,658,318 		JBrowse link
G TSPAN6 tetraspanin 6 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr  X:100,627,108...100,637,104
Ensembl chr  X:100,627,108...100,639,991 		JBrowse link
G UBD ubiquitin D involved_in IMP
IEA
IBA		 (PMID:19959714) UniProt
TreeGrafter
GO_Central
Ensembl		 PMID:19959714 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732 		JBrowse link
G UBE2I ubiquitin conjugating enzyme E2 I acts_upstream_of_or_within ISO (PMID:9223278) MGI PMID:9223278 NCBI chr16:1,309,152...1,327,017
Ensembl chr16:1,291,444...1,327,018 		JBrowse link
G UBE2N ubiquitin conjugating enzyme E2 N involved_in IMP (PMID:16129784) HGNC-UCL PMID:16129784 NCBI chr12:93,405,684...93,441,947
Ensembl chr12:93,405,673...93,441,947 		JBrowse link
G UBE2V1 ubiquitin conjugating enzyme E2 V1 involved_in IMP (PMID:16129784) HGNC-UCL PMID:16129784 NCBI chr20:50,081,124...50,115,957
Ensembl chr20:50,081,124...50,115,959 		JBrowse link
G UNC5CL unc-5 family C-terminal like acts_upstream_of_or_within
involved_in		 IDA
IEA
IBA		 (PMID:22158417) MGI
TreeGrafter
GO_Central		 PMID:22158417 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:41,026,895...41,039,221
Ensembl chr 6:41,026,895...41,039,221 		JBrowse link
G VAPA VAMP associated protein A involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr18:9,914,016...9,960,021
Ensembl chr18:9,914,016...9,960,021 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in NAS (PMID:23878390) BHF-UCL PMID:23878390 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G WLS Wnt ligand secretion mediator involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:68,098,459...68,232,546
Ensembl chr 1:68,098,473...68,233,120 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in IDA (PMID:19667203), (PMID:22607974) UniProt PMID:19667203 PMID:22607974 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 involved_in IMP (PMID:21102435) UniProt PMID:21102435 NCBI chr 7:139,043,515...139,109,720
Ensembl chr 7:139,043,515...139,132,122 		JBrowse link
G ZDHHC13 zinc finger DHHC-type palmitoyltransferase 13 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr11:19,117,104...19,176,415
Ensembl chr11:19,117,099...19,176,422 		JBrowse link
G ZDHHC17 zinc finger DHHC-type palmitoyltransferase 17 involved_in HMP (PMID:12761501) UniProt PMID:12761501 NCBI chr12:76,764,115...76,853,701
Ensembl chr12:76,764,103...76,853,696 		JBrowse link
positive regulation of I-kappaB phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in IMP (PMID:26514923) CAFA PMID:26514923 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 involved_in IGI (PMID:10869418) ARUK-UCL PMID:10869418 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735 		JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IMP (PMID:23675531) UniProt PMID:23675531 NCBI chr20:3,190,350...3,204,682
Ensembl chr20:3,190,350...3,204,685 		JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:81,779,291...81,962,685
Ensembl chr16:81,779,279...81,962,685 		JBrowse link
G TNF tumor necrosis factor acts_upstream_of_or_within IDA (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
regulation of canonical NF-kappaB signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT1 angiopoietin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20060382) Ensembl
MGI		 PMID:20060382 GO_REF:0000107 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055 		JBrowse link
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12843402) Ensembl
MGI		 PMID:12843402 GO_REF:0000107 NCBI chr10:101,354,048...101,557,313
Ensembl chr10:101,354,033...101,557,321 		JBrowse link
G CAPN3 calpain 3 involved_in IMP
IEA		 (PMID:18073330) UniProt
Ensembl		 PMID:18073330 GO_REF:0000107 NCBI chr15:42,359,501...42,412,317
Ensembl chr15:42,359,498...42,412,949 		JBrowse link
G CARD8 caspase recruitment domain family member 8 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr19:48,179,825...48,255,946
Ensembl chr19:48,180,770...48,255,946 		JBrowse link
G CLEC7A C-type lectin domain containing 7A involved_in ISS
IBA		 ARUK-UCL
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr12:10,116,777...10,130,304
Ensembl chr12:10,116,777...10,130,258 		JBrowse link
G CPNE1 copine 1 involved_in IMP
IBA		 (PMID:14674885) UniProt
GO_Central		 PMID:14674885 GO_REF:0000033 NCBI chr20:35,626,044...35,664,900
Ensembl chr20:35,626,031...35,664,956 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:121,567,074...121,785,530
Ensembl chr 9:121,567,057...121,785,530 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IDA (PMID:18453611) UniProt PMID:18453611 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315 		JBrowse link
G GBP7 guanylate binding protein 7 involved_in IMP (PMID:33408175) UniProt PMID:33408175 NCBI chr 1:89,131,742...89,176,003
Ensembl chr 1:89,131,742...89,176,009 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295 		JBrowse link
G IL1B interleukin 1 beta involved_in IDA (PMID:10748004) BHF-UCL PMID:10748004 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G LIME1 Lck interacting transmembrane adaptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16249387) Ensembl
MGI		 PMID:16249387 GO_REF:0000107 NCBI chr20:63,735,701...63,739,103
Ensembl chr20:63,736,283...63,739,103 		JBrowse link
G NFKBIB NFKB inhibitor beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893 		JBrowse link
G NKIRAS2 NFKB inhibitor interacting Ras like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr17:42,017,576...42,025,641
Ensembl chr17:42,011,382...42,025,644 		JBrowse link
G NLRP12 NLR family pyrin domain containing 12 acts_upstream_of_or_within IDA (PMID:12019269) MGI PMID:12019269 NCBI chr19:53,793,584...53,824,403
Ensembl chr19:53,793,741...53,824,403 		JBrowse link
G OPTN optineurin involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in IMP (PMID:16207722) UniProt PMID:16207722 NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188 		JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in IMP (PMID:17159900) UniProt PMID:17159900 NCBI chr11:799,184...809,501
Ensembl chr11:799,179...809,753 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 NOT|involved_in ISO (MGI:5305504|PMID:22187458) UniProt PMID:22187458 MGI:5305504 NCBI chr10:96,593,315...96,720,514
Ensembl chr10:96,593,315...96,720,514 		JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:81,779,291...81,962,685
Ensembl chr16:81,779,279...81,962,685 		JBrowse link
G SPHK2 sphingosine kinase 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717 		JBrowse link
G SQSTM1 sequestosome 1 involved_in IMP (PMID:12857745) UniProt PMID:12857745 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SUMO4 small ubiquitin like modifier 4 involved_in IDA (PMID:15247916), (PMID:18708028) UniProt PMID:15247916 PMID:18708028 NCBI chr 6:149,400,262...149,401,278
Ensembl chr 6:149,400,262...149,401,278 		JBrowse link
G TNF tumor necrosis factor involved_in IDA (PMID:10748004) BHF-UCL PMID:10748004 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNIP1 TNFAIP3 interacting protein 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr 5:151,029,943...151,087,685
Ensembl chr 5:151,029,945...151,093,577 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in IEA UniProt GO_REF:0000117 NCBI chr 4:2,741,648...2,756,336
Ensembl chr 4:2,741,648...2,756,342 		JBrowse link
G TNIP3 TNFAIP3 interacting protein 3 involved_in IEA UniProt GO_REF:0000117 NCBI chr 4:121,131,408...121,227,483
Ensembl chr 4:121,131,408...121,227,466 		JBrowse link
G TRAF1 TNF receptor associated factor 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173 		JBrowse link
G TRAF3 TNF receptor associated factor 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:102,777,449...102,911,500
Ensembl chr14:102,777,449...102,911,500 		JBrowse link
G TRAF4 TNF receptor associated factor 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:28,744,011...28,750,956
Ensembl chr17:28,744,011...28,750,956 		JBrowse link
G TRAF5 TNF receptor associated factor 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:211,326,635...211,374,946
Ensembl chr 1:211,326,615...211,374,946 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 6:96,521,806...96,555,276
Ensembl chr 6:96,521,595...96,555,276 		JBrowse link
G WDR83 WD repeat domain 83 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29402223) Ensembl
MGI		 PMID:29402223 GO_REF:0000107 NCBI chr19:12,666,807...12,675,832
Ensembl chr19:12,666,802...12,675,832 		JBrowse link
G WNT5A Wnt family member 5A involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539 		JBrowse link
G ZFAND6 zinc finger AN1-type containing 6 involved_in IMP (PMID:21810480) UniProt PMID:21810480 NCBI chr15:80,058,951...80,138,393
Ensembl chr15:80,059,568...80,138,393 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    cellular process 18244
      signal transduction 6571
        intracellular signal transduction 2993
          intracellular signaling cassette 2123
            canonical NF-kappaB signal transduction 336
              I-kappaB phosphorylation + 9
              negative regulation of canonical NF-kappaB signal transduction 77
              positive regulation of canonical NF-kappaB signal transduction 226
              regulation of canonical NF-kappaB signal transduction + 314
Path 2
Term Annotations click to browse term
  biological_process 19612
    biological regulation 13365
      regulation of biological process 12981
        signaling 7175
          signal transduction 6571
            intracellular signal transduction 2993
              intracellular signaling cassette 2123
                canonical NF-kappaB signal transduction 336
                  I-kappaB phosphorylation + 9
                  negative regulation of canonical NF-kappaB signal transduction 77
                  positive regulation of canonical NF-kappaB signal transduction 226
                  regulation of canonical NF-kappaB signal transduction + 314
paths to the root