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Gene: SIRPA (signal regulatory protein alpha) Homo sapiens
Symbol: SIRPA
Name: signal regulatory protein alpha
Description: Exhibits cell-cell adhesion mediator activity and protein antigen binding activity. Involved in several processes, including cellular response to interleukin-12; regulation of interferon-gamma production; and regulation of tumor necrosis factor production. Localizes to the cell surface and integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BIT; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; CD172A; inhibitory receptor SHPS-1; macrophage fusion receptor; MFR; MYD-1; myd-1 antigen; P84; protein tyrosine phosphatase, non-receptor type substrate 1; PTPNS1; SHPS-1; SHPS1; signal-regulatory protein alpha; SIRP; SIRP-ALPHA-1; SIRPalpha; SIRPalpha2; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Mus musculus (house mouse) : Sirpa (signal-regulatory protein alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sirpa (signal-regulatory protein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirpa (signal regulatory protein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRPA (signal regulatory protein alpha)
Canis lupus familiaris (dog) : SIRPA (signal regulatory protein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirpa (signal regulatory protein alpha)
Sus scrofa (pig) : SIRPA (signal regulatory protein alpha)
Chlorocebus sabaeus (green monkey) : SIRPA (signal regulatory protein alpha)
Heterocephalus glaber (naked mole-rat) : Sirpa (signal regulatory protein alpha)
more info ...
Related Pseudogenes: SIRPAP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl201,894,167 - 1,940,592 (+)Ensembl
GRCh38201,894,167 - 1,940,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37201,874,763 - 1,920,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,822,813 - 1,868,540 (+)NCBINCBI36hg18NCBI36
Build 34201,823,424 - 1,868,535NCBI
Celera201,938,791 - 1,984,521 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef201,824,406 - 1,870,408 (+)NCBIHuRef
CHM1_1201,875,015 - 1,920,758 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIRPA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736759
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.