SIRPA (signal regulatory protein alpha) - Rat Genome Database
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Gene: SIRPA (signal regulatory protein alpha) Homo sapiens
Analyze
Symbol: SIRPA
Name: signal regulatory protein alpha
RGD ID: 736759
HGNC Page HGNC
Description: Exhibits cell-cell adhesion mediator activity and protein antigen binding activity. Involved in cellular response to interleukin-12; negative regulation of inflammatory response; and regulation of cytokine production. Localizes to cell surface and integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BIT; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; CD172A; inhibitory receptor SHPS-1; macrophage fusion receptor; MFR; MYD-1; myd-1 antigen; P84; protein tyrosine phosphatase, non-receptor type substrate 1; PTPNS1; SHPS-1; SHPS1; signal-regulatory protein alpha; SIRP; SIRP-ALPHA-1; SIRPalpha; SIRPalpha2; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: SIRPAP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl201,894,167 - 1,940,592 (+)EnsemblGRCh38hg38GRCh38
GRCh38201,894,167 - 1,940,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37201,874,813 - 1,921,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,822,813 - 1,868,540 (+)NCBINCBI36hg18NCBI36
Build 34201,823,424 - 1,868,535NCBI
Celera201,938,791 - 1,984,521 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef201,824,406 - 1,870,408 (+)NCBIHuRef
CHM1_1201,875,015 - 1,920,758 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
copper(II) sulfate  (EXP)
cycloheximide  (EXP)
cyproconazole  (ISO)
D-gluconic acid  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (EXP)
glafenine  (ISO)
isotretinoin  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
LY294002  (EXP)
menadione  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nitrofen  (ISO)
NSC 23766  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
selenium atom  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
terbufos  (EXP)
Tesaglitazar  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vorinostat  (EXP)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
cell adhesion  (TAS)
cell migration  (ISO,ISS)
cell-matrix adhesion  (ISO)
cellular response to hydrogen peroxide  (ISS)
cellular response to interferon-gamma  (ISS)
cellular response to interleukin-1  (ISS)
cellular response to interleukin-12  (IMP)
cellular response to lipopolysaccharide  (ISS)
cytoskeleton organization  (ISO)
granulocyte migration  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
heterotypic cell-cell adhesion  (IEA)
leukocyte migration  (TAS)
monocyte extravasation  (ISS)
negative regulation of chemokine (C-C motif) ligand 5 production  (ISS)
negative regulation of cytokine production involved in inflammatory response  (ISS)
negative regulation of ERK1 and ERK2 cascade  (ISS)
negative regulation of I-kappaB phosphorylation  (ISS)
negative regulation of inflammatory response  (IMP)
negative regulation of interferon-beta production  (ISS)
negative regulation of interleukin-6 production  (ISS)
negative regulation of JNK cascade  (ISS)
negative regulation of macrophage inflammatory protein 1 alpha production  (ISS)
negative regulation of nitric oxide biosynthetic process  (ISS)
negative regulation of phagocytosis  (ISS)
negative regulation of protein phosphorylation  (ISS)
negative regulation of tumor necrosis factor production  (ISS)
neutrophil degranulation  (TAS)
phagocytosis, engulfment  (ISO)
phagocytosis, recognition  (ISO)
positive regulation of phagocytosis  (IBA,ISO)
positive regulation of T cell activation  (IBA)
regulation of catalytic activity  (IEA)
regulation of gene expression  (IMP)
regulation of interferon-gamma production  (IMP)
regulation of interleukin-1 beta production  (ISS)
regulation of interleukin-6 production  (ISS)
regulation of nitric oxide biosynthetic process  (ISS)
regulation of tumor necrosis factor production  (IGI,ISS)

Cellular Component

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8525433   PMID:8810330   PMID:8943344   PMID:9062191   PMID:9070220   PMID:9271230   PMID:9485180   PMID:9632768   PMID:9712903   PMID:9872987   PMID:10098842   PMID:10469599  
PMID:10572074   PMID:10585853   PMID:10660565   PMID:10660620   PMID:10842184   PMID:10962556   PMID:11509594   PMID:11780052   PMID:11792697   PMID:11907074   PMID:12477932   PMID:12483539  
PMID:12805067   PMID:14662855   PMID:14729615   PMID:15359629   PMID:15374953   PMID:15489334   PMID:15842360   PMID:15888547   PMID:16189514   PMID:16291597   PMID:16335952   PMID:16339511  
PMID:16344560   PMID:16691243   PMID:16697668   PMID:16825188   PMID:17070842   PMID:17098740   PMID:17142753   PMID:17178844   PMID:17360380   PMID:17500595   PMID:17632076   PMID:17954568  
PMID:17999719   PMID:18051954   PMID:18647419   PMID:18820737   PMID:18855618   PMID:18954403   PMID:19056867   PMID:19165527   PMID:19299420   PMID:19628875   PMID:19748659   PMID:19820697  
PMID:19874234   PMID:20207740   PMID:20299253   PMID:20473329   PMID:20643654   PMID:20705613   PMID:20826546   PMID:20826801   PMID:21169408   PMID:21223598   PMID:21225905   PMID:21369691  
PMID:21706016   PMID:21788504   PMID:21788509   PMID:21799000   PMID:21873635   PMID:22139419   PMID:22409853   PMID:22451913   PMID:22490440   PMID:22511785   PMID:22738830   PMID:22747997  
PMID:22815949   PMID:23271705   PMID:23314616   PMID:23320069   PMID:23504854   PMID:23669395   PMID:24026300   PMID:24101669   PMID:24124411   PMID:24143245   PMID:24162948   PMID:24511121  
PMID:24516072   PMID:24550402   PMID:24968096   PMID:25416956   PMID:25468996   PMID:25795378   PMID:25837251   PMID:26085683   PMID:26116271   PMID:26186194   PMID:26492885   PMID:26534964  
PMID:26573233   PMID:27728760   PMID:27793032   PMID:27856600   PMID:27900675   PMID:28514442   PMID:28669759   PMID:29084248   PMID:29158380   PMID:29180619   PMID:30194290   PMID:30639242  
PMID:30833751   PMID:30863997   PMID:30888336   PMID:30910815   PMID:31089204   PMID:31507080   PMID:31611550   PMID:32240171   PMID:32296183   PMID:32433947  


Genomics

Comparative Map Data
SIRPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl201,894,167 - 1,940,592 (+)EnsemblGRCh38hg38GRCh38
GRCh38201,894,167 - 1,940,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37201,874,813 - 1,921,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,822,813 - 1,868,540 (+)NCBINCBI36hg18NCBI36
Build 34201,823,424 - 1,868,535NCBI
Celera201,938,791 - 1,984,521 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef201,824,406 - 1,870,408 (+)NCBIHuRef
CHM1_1201,875,015 - 1,920,758 (+)NCBICHM1_1
Sirpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,432,962 - 129,474,148 (+)NCBIGRCm39mm39
GRCm39 Ensembl2129,434,755 - 129,474,148 (+)Ensembl
GRCm382129,591,042 - 129,632,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,592,835 - 129,632,228 (+)EnsemblGRCm38mm10GRCm38
MGSCv372129,418,575 - 129,457,964 (+)NCBIGRCm37mm9NCBIm37
MGSCv362129,284,759 - 129,322,373 (+)NCBImm8
Celera2130,820,643 - 130,860,425 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.19NCBI
Sirpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23116,819,730 - 116,858,099 (+)NCBI
Rnor_6.0 Ensembl3122,114,108 - 122,152,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03122,113,735 - 122,152,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03127,864,145 - 127,902,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,210,116 - 117,247,840 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13117,115,688 - 117,153,412 (+)NCBI
Celera3115,635,887 - 115,673,609 (+)NCBICelera
Cytogenetic Map3q36NCBI
Sirpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541513,030,752 - 13,072,735 (+)NCBIChiLan1.0ChiLan1.0
SIRPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1201,773,271 - 1,818,106 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl201,773,271 - 1,818,106 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0202,006,994 - 2,052,894 (+)NCBIMhudiblu_PPA_v0panPan3
SIRPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,094,930 - 19,136,655 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,923,276 - 18,964,758 (-)NCBI
ROS_Cfam_1.02419,551,905 - 19,593,551 (-)NCBI
UMICH_Zoey_3.12419,108,428 - 19,149,479 (-)NCBI
UNSW_CanFamBas_1.02419,218,798 - 19,260,377 (-)NCBI
UU_Cfam_GSD_1.02419,547,368 - 19,588,981 (-)NCBI
Sirpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640168,176,954 - 168,219,753 (-)NCBI
SpeTri2.0NW_00493648516,608,317 - 16,654,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11733,566,270 - 33,611,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21737,961,460 - 37,968,581 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRPA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1254,590,151 - 54,636,381 (-)NCBI
Sirpa
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247413,157,734 - 3,202,018 (+)NCBI

Position Markers
RH68309  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,918,424 - 1,918,551UniSTSGRCh37
Build 36201,866,424 - 1,866,551RGDNCBI36
Celera201,982,402 - 1,982,529RGD
Cytogenetic Map20p13UniSTS
HuRef201,868,286 - 1,868,413UniSTS
D20S793  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,898,591 - 1,898,692UniSTSGRCh37
Build 36201,846,591 - 1,846,692RGDNCBI36
Celera201,962,569 - 1,962,670RGD
Cytogenetic Map20p13UniSTS
HuRef201,848,463 - 1,848,564UniSTS
TNG Radiation Hybrid Map201178.0UniSTS
Stanford-G3 RH Map20113.0UniSTS
NCBI RH Map2019.4UniSTS
PTPNS1_1575  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,919,811 - 1,920,707UniSTSGRCh37
Build 36201,867,811 - 1,868,707RGDNCBI36
Celera201,983,792 - 1,984,688RGD
HuRef201,869,679 - 1,870,575UniSTS
D20S203E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,920,280 - 1,920,457UniSTSGRCh37
Build 36201,868,280 - 1,868,457RGDNCBI36
Celera201,984,261 - 1,984,438RGD
Cytogenetic Map20p13UniSTS
HuRef201,870,148 - 1,870,325UniSTS
SHGC-31938  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,918,959 - 1,919,108UniSTSGRCh37
Build 36201,866,959 - 1,867,108RGDNCBI36
Celera201,982,940 - 1,983,089RGD
Cytogenetic Map20p13UniSTS
HuRef201,868,827 - 1,868,976UniSTS
GeneMap99-GB4 RH Map2011.04UniSTS
GeneMap99-GB4 RH Map2013.18UniSTS
Whitehead-RH Map2019.9UniSTS
NCBI RH Map209.8UniSTS
GeneMap99-G3 RH Map20118.0UniSTS
G18068  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,898,208 - 1,898,394UniSTSGRCh37
Build 36201,846,208 - 1,846,394RGDNCBI36
Celera201,962,186 - 1,962,372RGD
Cytogenetic Map20p13UniSTS
HuRef201,848,080 - 1,848,266UniSTS
BCD2069  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,920,330 - 1,920,429UniSTSGRCh37
Build 36201,868,330 - 1,868,429RGDNCBI36
Celera201,984,311 - 1,984,410RGD
Cytogenetic Map20p13UniSTS
HuRef201,870,198 - 1,870,297UniSTS
GeneMap99-GB4 RH Map2011.04UniSTS
WI-14028  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,903,263 - 1,903,362UniSTSGRCh37
Build 36201,851,263 - 1,851,362RGDNCBI36
Celera201,967,241 - 1,967,340RGD
Cytogenetic Map20p13UniSTS
HuRef201,853,133 - 1,853,232UniSTS
GeneMap99-GB4 RH Map2010.26UniSTS
GeneMap99-GB4 RH Map2011.14UniSTS
Whitehead-RH Map2019.9UniSTS
NCBI RH Map2028.2UniSTS
STS-M78966  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,919,114 - 1,919,215UniSTSGRCh37
Build 36201,867,114 - 1,867,215RGDNCBI36
Celera201,983,095 - 1,983,196RGD
Cytogenetic Map20p13UniSTS
HuRef201,868,982 - 1,869,083UniSTS
GeneMap99-GB4 RH Map2012.19UniSTS
D20S1066  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,920,287 - 1,920,519UniSTSGRCh37
Build 36201,868,287 - 1,868,519RGDNCBI36
Celera201,984,268 - 1,984,500RGD
Cytogenetic Map20p13UniSTS
HuRef201,870,155 - 1,870,387UniSTS
GeneMap99-GB4 RH Map209.78UniSTS
GeneMap99-GB4 RH Map2010.26UniSTS
Whitehead-RH Map2015.1UniSTS
Whitehead-YAC Contig Map20 UniSTS
RH11752  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,920,287 - 1,920,428UniSTSGRCh37
Build 36201,868,287 - 1,868,428RGDNCBI36
Celera201,984,268 - 1,984,409RGD
Cytogenetic Map20p13UniSTS
HuRef201,870,155 - 1,870,296UniSTS
GeneMap99-GB4 RH Map2015.0UniSTS
NCBI RH Map2028.8UniSTS
STS-D29515  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37201,918,748 - 1,918,997UniSTSGRCh37
Build 36201,866,748 - 1,866,997RGDNCBI36
Celera201,982,729 - 1,982,978RGD
Cytogenetic Map20p13UniSTS
HuRef201,868,616 - 1,868,865UniSTS
GeneMap99-GB4 RH Map2011.04UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR20Ahsa-miR-20a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23562609
MIR17hsa-miR-17-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23562609
MIR106Ahsa-miR-106a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23562609

Predicted Target Of
Summary Value
Count of predictions:3468
Count of miRNA genes:705
Interacting mature miRNAs:782
Transcripts:ENST00000356025, ENST00000358771, ENST00000400068
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1987 2632 1579 585 1359 426 3793 1483 3632 370 1194 1421 170 1204 2313 2
Low 408 345 139 36 474 35 562 709 84 46 250 144 2 475 1 1
Below cutoff 16 2 2 2 50 3 2 13 2 10 26 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001040022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001040023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005260670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006723545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011529173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB023430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL034562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D86043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA471662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN989886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000356025   ⟹   ENSP00000348307
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl201,894,783 - 1,939,897 (+)Ensembl
RefSeq Acc Id: ENST00000358771   ⟹   ENSP00000351621
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl201,895,296 - 1,939,897 (+)Ensembl
RefSeq Acc Id: ENST00000400068   ⟹   ENSP00000382941
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl201,894,167 - 1,939,894 (+)Ensembl
RefSeq Acc Id: ENST00000622179   ⟹   ENSP00000478763
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl201,894,508 - 1,940,592 (+)Ensembl
RefSeq Acc Id: NM_001040022   ⟹   NP_001035111
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,167 - 1,939,894 (+)NCBI
GRCh37201,874,763 - 1,920,540 (+)NCBI
Build 36201,822,813 - 1,868,540 (+)NCBI Archive
HuRef201,824,406 - 1,870,408 (+)ENTREZGENE
CHM1_1201,875,015 - 1,920,758 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001040023   ⟹   NP_001035112
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,895,407 - 1,940,592 (+)NCBI
GRCh37201,874,763 - 1,920,540 (+)NCBI
Build 36201,823,826 - 1,868,540 (+)NCBI Archive
HuRef201,824,406 - 1,870,408 (+)ENTREZGENE
CHM1_1201,876,028 - 1,920,758 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001330728   ⟹   NP_001317657
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,167 - 1,939,894 (+)NCBI
Sequence:
RefSeq Acc Id: NM_080792   ⟹   NP_542970
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,742 - 1,940,592 (+)NCBI
GRCh37201,874,763 - 1,920,540 (+)NCBI
Build 36201,823,425 - 1,868,540 (+)NCBI Archive
HuRef201,824,406 - 1,870,408 (+)ENTREZGENE
CHM1_1201,875,627 - 1,920,758 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005260670   ⟹   XP_005260727
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,780 - 1,939,895 (+)NCBI
GRCh37201,874,763 - 1,920,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006723545   ⟹   XP_006723608
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,895,184 - 1,939,895 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011529173   ⟹   XP_011527475
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,914,308 - 1,939,895 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024451836   ⟹   XP_024307604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,946 - 1,939,895 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001035111   ⟸   NM_001040022
- Peptide Label: isoform 1 precursor
- UniProtKB: P78324 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001035112   ⟸   NM_001040023
- Peptide Label: isoform 1 precursor
- UniProtKB: P78324 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_542970   ⟸   NM_080792
- Peptide Label: isoform 1 precursor
- UniProtKB: P78324 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005260727   ⟸   XM_005260670
- Peptide Label: isoform X1
- UniProtKB: P78324 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006723608   ⟸   XM_006723545
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011527475   ⟸   XM_011529173
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001317657   ⟸   NM_001330728
- Peptide Label: isoform 2 precursor
- UniProtKB: P78324 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024307604   ⟸   XM_024451836
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000478763   ⟸   ENST00000622179
RefSeq Acc Id: ENSP00000382941   ⟸   ENST00000400068
RefSeq Acc Id: ENSP00000348307   ⟸   ENST00000356025
RefSeq Acc Id: ENSP00000351621   ⟸   ENST00000358771
Protein Domains
Ig-like C1-type   Ig-like V-type

Promoters
RGD ID:6799053
Promoter ID:HG_KWN:38357
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid,   NB4
Transcripts:ENST00000358771,   NM_001040022,   OTTHUMT00000251762,   OTTHUMT00000251763,   UC002WFT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36201,823,274 - 1,823,774 (+)MPROMDB
RGD ID:13206149
Promoter ID:EPDNEW_H26655
Type:initiation region
Name:SIRPA_2
Description:signal regulatory protein alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26656  EPDNEW_H26657  EPDNEW_H26658  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,117 - 1,894,177EPDNEW
RGD ID:13206151
Promoter ID:EPDNEW_H26656
Type:initiation region
Name:SIRPA_1
Description:signal regulatory protein alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26655  EPDNEW_H26657  EPDNEW_H26658  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,488 - 1,894,548EPDNEW
RGD ID:13206153
Promoter ID:EPDNEW_H26657
Type:initiation region
Name:SIRPA_4
Description:signal regulatory protein alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26655  EPDNEW_H26656  EPDNEW_H26658  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,894,708 - 1,894,768EPDNEW
RGD ID:13206155
Promoter ID:EPDNEW_H26658
Type:initiation region
Name:SIRPA_3
Description:signal regulatory protein alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26655  EPDNEW_H26656  EPDNEW_H26657  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38201,895,379 - 1,895,439EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20p13-11.21(chr20:89939-25697564)x3 copy number gain See cases [RCV000051227] Chr20:89939..25697564 [GRCh38]
Chr20:70580..25678200 [GRCh37]
Chr20:18580..25626200 [NCBI36]
Chr20:20p13-11.21
pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19146279)x3 copy number gain See cases [RCV000051041] Chr20:89939..19146279 [GRCh38]
Chr20:70580..19126923 [GRCh37]
Chr20:18580..19074923 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p13(chr20:89939-1939218)x1 copy number loss See cases [RCV000052735] Chr20:89939..1939218 [GRCh38]
Chr20:70580..1919864 [GRCh37]
Chr20:18580..1867864 [NCBI36]
Chr20:20p13
pathogenic
GRCh38/hg38 20p13(chr20:121781-2290194)x1 copy number loss See cases [RCV000052738] Chr20:121781..2290194 [GRCh38]
Chr20:102422..2270840 [GRCh37]
Chr20:50422..2218840 [NCBI36]
Chr20:20p13
pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19071495)x3 copy number gain See cases [RCV000052995] Chr20:89939..19071495 [GRCh38]
Chr20:70580..19052139 [GRCh37]
Chr20:18580..19000139 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p13-11.22(chr20:89939-21787252)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|See cases [RCV000052996] Chr20:89939..21787252 [GRCh38]
Chr20:70580..21767890 [GRCh37]
Chr20:18580..21715890 [NCBI36]
Chr20:20p13-11.22
pathogenic
GRCh38/hg38 20p13-12.1(chr20:89939-14818511)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|See cases [RCV000052997] Chr20:89939..14818511 [GRCh38]
Chr20:70580..14799157 [GRCh37]
Chr20:18580..14747157 [NCBI36]
Chr20:20p13-12.1
pathogenic
GRCh37/hg19 20p13(chr20:71023-2129746)x1 copy number loss See cases [RCV000184090] Chr20:71023..2129746 [GRCh37]
Chr20:20p13
pathogenic
GRCh38/hg38 20p13-q11.1(chr20:80106-30227427)x3 copy number gain See cases [RCV000133996] Chr20:80106..30227427 [GRCh38]
Chr20:60747..29462103 [GRCh37]
Chr20:8747..28075764 [NCBI36]
Chr20:20p13-q11.1
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20p13-12.1(chr20:80106-13029401)x3 copy number gain See cases [RCV000138677] Chr20:80106..13029401 [GRCh38]
Chr20:60747..13010049 [GRCh37]
Chr20:8747..12958049 [NCBI36]
Chr20:20p13-12.1
pathogenic
GRCh38/hg38 20p13-12.3(chr20:80093-6386012)x3 copy number gain See cases [RCV000139597] Chr20:80093..6386012 [GRCh38]
Chr20:60734..6366659 [GRCh37]
Chr20:8734..6314659 [NCBI36]
Chr20:20p13-12.3
pathogenic
GRCh38/hg38 20p13-12.3(chr20:84402-6159078)x3 copy number gain See cases [RCV000141348] Chr20:84402..6159078 [GRCh38]
Chr20:65043..6139725 [GRCh37]
Chr20:13043..6087725 [NCBI36]
Chr20:20p13-12.3
pathogenic
GRCh38/hg38 20p13-11.1(chr20:80927-26324843)x3 copy number gain See cases [RCV000142017] Chr20:80927..26324843 [GRCh38]
Chr20:61568..26305479 [GRCh37]
Chr20:9568..26253479 [NCBI36]
Chr20:20p13-11.1
pathogenic
GRCh38/hg38 20p13-12.3(chr20:80927-5447679)x3 copy number gain See cases [RCV000142285] Chr20:80927..5447679 [GRCh38]
Chr20:61568..5428325 [GRCh37]
Chr20:9568..5376325 [NCBI36]
Chr20:20p13-12.3
uncertain significance
GRCh38/hg38 20p13-12.3(chr20:1269303-8626911)x3 copy number gain See cases [RCV000142917] Chr20:1269303..8626911 [GRCh38]
Chr20:1249947..8607558 [GRCh37]
Chr20:1197947..8555558 [NCBI36]
Chr20:20p13-12.3
pathogenic
GRCh38/hg38 20p13-11.23(chr20:80928-18688031)x3 copy number gain See cases [RCV000143426] Chr20:80928..18688031 [GRCh38]
Chr20:61569..18668675 [GRCh37]
Chr20:9569..18616675 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh37/hg19 20p13-12.3(chr20:121521-5564937)x3 copy number gain See cases [RCV000239772] Chr20:121521..5564937 [GRCh37]
Chr20:20p13-12.3
pathogenic
GRCh37/hg19 20p13-11.1(chr20:80198-26075841)x3 copy number gain See cases [RCV000239954] Chr20:80198..26075841 [GRCh37]
Chr20:20p13-11.1
pathogenic
GRCh37/hg19 20p13(chr20:61568-4914872)x3 copy number gain See cases [RCV000446883] Chr20:61568..4914872 [GRCh37]
Chr20:20p13
pathogenic
GRCh37/hg19 20p13(chr20:121521-2073612)x1 copy number loss See cases [RCV000446640] Chr20:121521..2073612 [GRCh37]
Chr20:20p13
pathogenic
GRCh37/hg19 20p13(chr20:61568-4904599)x3 copy number gain See cases [RCV000448397] Chr20:61568..4904599 [GRCh37]
Chr20:20p13
pathogenic
GRCh37/hg19 20p13-q11.21(chr20:80198-26208081)x3 copy number gain not provided [RCV000487461] Chr20:80198..26208081 [GRCh37]
Chr20:20p13-q11.21
pathogenic
GRCh37/hg19 20p13-12.3(chr20:213423-5483406)x3 copy number gain See cases [RCV000510531] Chr20:213423..5483406 [GRCh37]
Chr20:20p13-12.3
uncertain significance
GRCh37/hg19 20p13(chr20:61568-2824960)x3 copy number gain See cases [RCV000511991] Chr20:61568..2824960 [GRCh37]
Chr20:20p13
uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-12.2(chr20:61568-10486106)x3 copy number gain See cases [RCV000512556] Chr20:61568..10486106 [GRCh37]
Chr20:20p13-12.2
likely pathogenic
GRCh37/hg19 20p13(chr20:61568-2010334)x1 copy number loss not provided [RCV000684132] Chr20:61568..2010334 [GRCh37]
Chr20:20p13
likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13(chr20:1895079-1895490)x0 copy number loss not provided [RCV000741069] Chr20:1895079..1895490 [GRCh37]
Chr20:20p13
benign
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_001040023.2(SIRPA):c.1389G>A (p.Ala463=) single nucleotide variant not provided [RCV000923960] Chr20:1937442 [GRCh38]
Chr20:1918088 [GRCh37]
Chr20:20p13
likely benign
NM_001040023.2(SIRPA):c.637G>A (p.Ala213Thr) single nucleotide variant not provided [RCV000882878] Chr20:1921595 [GRCh38]
Chr20:1902241 [GRCh37]
Chr20:20p13
benign
NM_001040023.2(SIRPA):c.754+6A>G single nucleotide variant not provided [RCV000950287] Chr20:1921718 [GRCh38]
Chr20:1902364 [GRCh37]
Chr20:20p13
benign
NM_001040023.2(SIRPA):c.1059G>A (p.Pro353=) single nucleotide variant not provided [RCV000894471] Chr20:1922617 [GRCh38]
Chr20:1903263 [GRCh37]
Chr20:20p13
likely benign
GRCh37/hg19 20p13(chr20:61568-2269777)x1 copy number loss not provided [RCV001007065] Chr20:61568..2269777 [GRCh37]
Chr20:20p13
pathogenic
NM_001040023.2(SIRPA):c.1071C>T (p.Gly357=) single nucleotide variant not provided [RCV000893170] Chr20:1922629 [GRCh38]
Chr20:1903275 [GRCh37]
Chr20:20p13
benign
GRCh37/hg19 20p13(chr20:1886492-2028451)x3 copy number gain not provided [RCV000846348] Chr20:1886492..2028451 [GRCh37]
Chr20:20p13
uncertain significance
NM_001040023.2(SIRPA):c.1025G>C (p.Ser342Thr) single nucleotide variant not provided [RCV000883105] Chr20:1922583 [GRCh38]
Chr20:1903229 [GRCh37]
Chr20:20p13
likely benign
NM_001040023.2(SIRPA):c.601G>A (p.Val201Ile) single nucleotide variant not provided [RCV000887181] Chr20:1921559 [GRCh38]
Chr20:1902205 [GRCh37]
Chr20:20p13
benign
NM_001040023.2(SIRPA):c.1392G>A (p.Ser464=) single nucleotide variant not provided [RCV000897226] Chr20:1937445 [GRCh38]
Chr20:1918091 [GRCh37]
Chr20:20p13
likely benign
NM_001040023.2(SIRPA):c.1380G>A (p.Pro460=) single nucleotide variant not provided [RCV000892755] Chr20:1937433 [GRCh38]
Chr20:1918079 [GRCh37]
Chr20:20p13
benign
NM_001040023.2(SIRPA):c.1444C>T (p.Pro482Ser) single nucleotide variant not provided [RCV000958240] Chr20:1937497 [GRCh38]
Chr20:1918143 [GRCh37]
Chr20:20p13
likely benign
GRCh37/hg19 20p13-11.1(chr20:61568-26305479)x3 copy number gain not provided [RCV001007068] Chr20:61568..26305479 [GRCh37]
Chr20:20p13-11.1
pathogenic
GRCh37/hg19 20p13(chr20:1886492-2028451)x4 copy number gain not provided [RCV001258902] Chr20:1886492..2028451 [GRCh37]
Chr20:20p13
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9662 AgrOrtholog
COSMIC SIRPA COSMIC
Ensembl Genes ENSG00000198053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000348307 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000351621 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000382941 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000478763 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000356025 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000358771 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000400068 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000622179 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000198053 GTEx
HGNC ID HGNC:9662 ENTREZGENE
Human Proteome Map SIRPA Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_C1-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
KEGG Report hsa:140885 UniProtKB/Swiss-Prot
NCBI Gene 140885 ENTREZGENE
OMIM 602461 OMIM
Pfam C1-set UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PharmGKB PA34006 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART IGc1 UniProtKB/Swiss-Prot
  IGv UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt P78324 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2A2E1 UniProtKB/Swiss-Prot
  A8K411 UniProtKB/Swiss-Prot
  B2R6C3 UniProtKB/Swiss-Prot
  O00683 UniProtKB/Swiss-Prot
  O43799 UniProtKB/Swiss-Prot
  Q8N517 UniProtKB/Swiss-Prot
  Q8TAL8 UniProtKB/Swiss-Prot
  Q9H0Z2 UniProtKB/Swiss-Prot
  Q9UDX2 UniProtKB/Swiss-Prot
  Q9UIJ6 UniProtKB/Swiss-Prot
  Q9Y4U9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 SIRPA  signal regulatory protein alpha    signal-regulatory protein alpha  Symbol and/or name change 5135510 APPROVED
2011-08-16 SIRPA  signal-regulatory protein alpha  SIRPA  signal-regulatory protein alpha  Symbol and/or name change 5135510 APPROVED