Sirpa (signal-regulatory protein alpha) - Rat Genome Database

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Gene: Sirpa (signal-regulatory protein alpha) Rattus norvegicus
Analyze
Symbol: Sirpa
Name: signal-regulatory protein alpha
RGD ID: 3449
Description: Enables GTPase regulator activity; enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; monocyte extravasation; and regulation of cytokine production. Located in cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; CD172 antigen-like family member A; inhibitory receptor SHPS-1; macrophage fusion receptor; macrophage membrane protein MFP150; protein tyrosine phosphatase non-receptor type substrate 1; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHPS-1; signal-regulatory protein alpha-1; sirp-alpha-1; tyrosine-protein phosphatase non-receptor type substrate 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23116,819,730 - 116,858,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,819,726 - 116,858,098 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,717,512 - 120,755,285 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03129,313,130 - 129,350,902 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03126,973,615 - 127,011,386 (+)NCBIRnor_WKY
Rnor_6.03122,113,735 - 122,152,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,114,108 - 122,152,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03127,864,145 - 127,902,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,210,116 - 117,247,840 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13117,115,688 - 117,153,412 (+)NCBI
Celera3115,635,887 - 115,673,609 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-gluconic acid  (EXP)
deoxycholic acid  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
NSC 23766  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
cell migration  (IDA)
cell-matrix adhesion  (ISO)
cellular response to hydrogen peroxide  (IMP)
cellular response to interleukin-1  (IMP)
cellular response to interleukin-12  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to type II interferon  (IMP)
cytoskeleton organization  (ISO)
granulocyte migration  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
heterotypic cell-cell adhesion  (IEA)
monocyte extravasation  (IMP)
negative regulation of chemokine (C-C motif) ligand 5 production  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of I-kappaB phosphorylation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interferon-beta production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of JNK cascade  (ISO)
negative regulation of macrophage inflammatory protein 1 alpha production  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of phagocytosis  (IMP,ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
obsolete movement of cell or subcellular component  (ISO)
phagocytosis, engulfment  (ISO)
phagocytosis, recognition  (ISO)
positive regulation of phagocytosis  (IBA,ISO)
positive regulation of T cell activation  (IBA)
regulation of gene expression  (ISO)
regulation of interleukin-1 beta production  (IMP)
regulation of interleukin-6 production  (IMP)
regulation of nitric oxide biosynthetic process  (IMP)
regulation of tumor necrosis factor production  (IMP,ISO)
regulation of type II interferon production  (ISO)

Cellular Component
cell surface  (IDA,ISO)
membrane  (IEA)
plasma membrane  (IBA,ISO,TAS)

References

References - curated
# Reference Title Reference Citation
1. Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. Adams S, etal., J Immunol 1998 Aug 15;161(4):1853-9.
2. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
3. Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium. de Vries HE, etal., J Immunol 2002 Jun 1;168(11):5832-9.
4. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Fujioka Y, etal., Mol Cell Biol 1996 Dec;16(12):6887-99.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPa (signal regulatory protein-a) on phagocytes. Gitik M, etal., J Neuroinflammation. 2011 Mar 15;8:24. doi: 10.1186/1742-2094-8-24.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. SIRPalpha interacts with nephrin at the podocyte slit diaphragm. Kajiho Y, etal., FEBS J. 2012 Sep;279(17):3010-21. doi: 10.1111/j.1742-4658.2012.08682.x. Epub 2012 Jul 23.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. BIT (Bit) maps to mouse chromosome 2. Ohnishi H, etal., Genomics 1997 Mar 15;40(3):504-6.
12. Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. Ohnishi H, etal., J Biol Chem 1996 Oct 11;271(41):25569-74.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. MFR, a putative receptor mediating the fusion of macrophages. Saginario C, etal., Mol Cell Biol 1998 Nov;18(11):6213-23.
16. BIT, an immune antigen receptor-like molecule in the brain. Sano S, etal., FEBS Lett 1997 Jul 14;411(2-3):327-34.
17. Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. Takada T, etal., J Biol Chem. 1998 Apr 10;273(15):9234-42.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9344856   PMID:10082587   PMID:11118207   PMID:11509594   PMID:12393607   PMID:12477932   PMID:12763253   PMID:12807424   PMID:14634079   PMID:14741368   PMID:15047126   PMID:15158458  
PMID:15858173   PMID:16159885   PMID:16371655   PMID:16511298   PMID:16920950   PMID:17954568   PMID:17999719   PMID:19056867   PMID:20207740   PMID:20554646   PMID:21553247   PMID:22193512  
PMID:22871113   PMID:23562609   PMID:24026300   PMID:24029230  


Genomics

Comparative Map Data
Sirpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23116,819,730 - 116,858,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3116,819,726 - 116,858,098 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3120,717,512 - 120,755,285 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03129,313,130 - 129,350,902 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03126,973,615 - 127,011,386 (+)NCBIRnor_WKY
Rnor_6.03122,113,735 - 122,152,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,114,108 - 122,152,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03127,864,145 - 127,902,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,210,116 - 117,247,840 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13117,115,688 - 117,153,412 (+)NCBI
Celera3115,635,887 - 115,673,609 (+)NCBICelera
Cytogenetic Map3q36NCBI
SIRPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38201,894,167 - 1,940,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl201,894,167 - 1,940,592 (+)EnsemblGRCh38hg38GRCh38
GRCh37201,874,813 - 1,921,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,822,813 - 1,868,540 (+)NCBINCBI36Build 36hg18NCBI36
Build 34201,823,424 - 1,868,535NCBI
Celera201,938,791 - 1,984,521 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef201,824,406 - 1,870,408 (+)NCBIHuRef
CHM1_1201,875,015 - 1,920,758 (+)NCBICHM1_1
T2T-CHM13v2.0201,924,358 - 1,970,769 (+)NCBIT2T-CHM13v2.0
Sirpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392129,432,962 - 129,474,148 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2129,434,755 - 129,474,148 (+)EnsemblGRCm39 Ensembl
GRCm382129,591,042 - 129,632,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2129,592,835 - 129,632,228 (+)EnsemblGRCm38mm10GRCm38
MGSCv372129,418,575 - 129,457,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362129,284,759 - 129,322,373 (+)NCBIMGSCv36mm8
Celera2130,820,643 - 130,860,425 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.19NCBI
Sirpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541513,030,752 - 13,072,735 (+)NCBIChiLan1.0ChiLan1.0
SIRPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1201,773,271 - 1,818,106 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl201,773,271 - 1,818,106 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0202,006,994 - 2,052,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SIRPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,094,930 - 19,136,655 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,923,276 - 18,964,758 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02419,551,905 - 19,593,551 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12419,108,428 - 19,149,479 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02419,218,798 - 19,260,377 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02419,547,368 - 19,588,981 (-)NCBIUU_Cfam_GSD_1.0
Sirpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640168,176,954 - 168,219,753 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648516,608,317 - 16,654,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11733,566,270 - 33,611,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21737,961,460 - 37,968,581 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1254,590,151 - 54,636,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660871,006,396 - 1,052,664 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247413,157,734 - 3,202,018 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirpa
440 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:313
Count of miRNA genes:185
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000006408
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 33 40 32 15 32 74 29 33 11
Low 1 10 17 9 4 9 8 11 6 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF055065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000006408   ⟹   ENSRNOP00000006408
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,820,372 - 116,858,098 (+)Ensembl
Rnor_6.0 Ensembl3122,114,754 - 122,152,477 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091935   ⟹   ENSRNOP00000069024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,819,726 - 116,856,803 (+)Ensembl
Rnor_6.0 Ensembl3122,114,108 - 122,151,182 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095684   ⟹   ENSRNOP00000092321
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,823,799 - 116,858,098 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103247   ⟹   ENSRNOP00000082474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,820,605 - 116,858,098 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109073   ⟹   ENSRNOP00000087384
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,836,048 - 116,858,098 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117905   ⟹   ENSRNOP00000083855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3116,820,372 - 116,858,098 (+)Ensembl
RefSeq Acc Id: NM_013016   ⟹   NP_037148
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,820,372 - 116,858,099 (+)NCBI
Rnor_6.03122,114,754 - 122,152,478 (+)NCBI
Rnor_5.03127,864,145 - 127,902,598 (-)NCBI
RGSC_v3.43117,210,116 - 117,247,840 (+)RGD
Celera3115,635,887 - 115,673,609 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234951   ⟹   XP_006235013
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,820,074 - 116,858,099 (+)NCBI
Rnor_6.03122,114,556 - 122,152,478 (+)NCBI
Rnor_5.03127,864,145 - 127,902,598 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234952   ⟹   XP_006235014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,819,730 - 116,858,099 (+)NCBI
Rnor_6.03122,113,910 - 122,152,478 (+)NCBI
Rnor_5.03127,864,145 - 127,902,598 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234953   ⟹   XP_006235015
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,819,928 - 116,858,099 (+)NCBI
Rnor_6.03122,113,910 - 122,152,478 (+)NCBI
Rnor_5.03127,864,145 - 127,902,598 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591496   ⟹   XP_017446985
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,819,859 - 116,858,099 (+)NCBI
Rnor_6.03122,113,910 - 122,152,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591497   ⟹   XP_017446986
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,819,928 - 116,858,099 (+)NCBI
Rnor_6.03122,113,911 - 122,152,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104380   ⟹   XP_038960308
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,819,928 - 116,858,099 (+)NCBI
RefSeq Acc Id: XM_039104381   ⟹   XP_038960309
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23116,819,928 - 116,858,099 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037148   ⟸   NM_013016
- Peptide Label: precursor
- UniProtKB: Q9QWI5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006235014   ⟸   XM_006234952
- Peptide Label: isoform X1
- UniProtKB: Q499T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235015   ⟸   XM_006234953
- Peptide Label: isoform X1
- UniProtKB: Q499T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235013   ⟸   XM_006234951
- Peptide Label: isoform X1
- UniProtKB: Q499T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446985   ⟸   XM_017591496
- Peptide Label: isoform X1
- UniProtKB: Q499T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446986   ⟸   XM_017591497
- Peptide Label: isoform X2
- UniProtKB: Q9QWI5 (UniProtKB/Swiss-Prot),   P97710 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006408   ⟸   ENSRNOT00000006408
RefSeq Acc Id: ENSRNOP00000069024   ⟸   ENSRNOT00000091935
RefSeq Acc Id: XP_038960308   ⟸   XM_039104380
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960309   ⟸   XM_039104381
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A0T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083855   ⟸   ENSRNOT00000117905
RefSeq Acc Id: ENSRNOP00000092321   ⟸   ENSRNOT00000095684
RefSeq Acc Id: ENSRNOP00000087384   ⟸   ENSRNOT00000109073
RefSeq Acc Id: ENSRNOP00000082474   ⟸   ENSRNOT00000103247
Protein Domains
Ig-like   Ig-like C1-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97710-F1-model_v2 AlphaFold P97710 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692430
Promoter ID:EPDNEW_R2949
Type:initiation region
Name:Sirpa_1
Description:signal-regulatory protein alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03122,114,200 - 122,114,260EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3449 AgrOrtholog
BioCyc Gene G2FUF-47901 BioCyc
Ensembl Genes ENSRNOG00000004763 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006408 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069024 ENTREZGENE
  ENSRNOP00000069024.1 UniProtKB/TrEMBL
  ENSRNOP00000082474.1 UniProtKB/TrEMBL
  ENSRNOP00000083855 ENTREZGENE
  ENSRNOP00000083855.1 UniProtKB/TrEMBL
  ENSRNOP00000087384.1 UniProtKB/TrEMBL
  ENSRNOP00000092321.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006408 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000091935 ENTREZGENE
  ENSRNOT00000091935.2 UniProtKB/TrEMBL
  ENSRNOT00000095684.1 UniProtKB/TrEMBL
  ENSRNOT00000103247.1 UniProtKB/TrEMBL
  ENSRNOT00000109073.1 UniProtKB/TrEMBL
  ENSRNOT00000117905 ENTREZGENE
  ENSRNOT00000117905.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25528 UniProtKB/Swiss-Prot
NCBI Gene 25528 ENTREZGENE
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirpa PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228492
UniProt A0A8I5ZU69_RAT UniProtKB/TrEMBL
  A0A8I6A0T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7V6_RAT UniProtKB/TrEMBL
  A0A8I6ADR4_RAT UniProtKB/TrEMBL
  P97710 ENTREZGENE
  Q499T3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QWI5 ENTREZGENE
  SHPS1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O08951 UniProtKB/Swiss-Prot
  O70426 UniProtKB/Swiss-Prot
  Q9QWI5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Sirpa  signal-regulatory protein alpha  Ptpns1  protein tyrosine phosphatase, non-receptor type substrate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ptpns1  protein tyrosine phosphatase, non-receptor type substrate 1      Symbol and Name updated 629477 APPROVED
2003-03-06 Ptpns1  protein tyrosine phosphatase, non-receptor type substrate 1  Bit  Brain immunoglobulin like protein with tyrosine - based activation motifs  Data Merged 628472 PROVISIONAL
2002-06-10 Ptpns1  Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Bit  Brain immunoglobulin like protein with tyrosine - based activation motifs      Symbol and Name status set to approved 70586 APPROVED