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Gene: Sirpa (signal-regulatory protein alpha) Rattus norvegicus
Symbol: Sirpa
Name: signal-regulatory protein alpha
RGD ID: 3449
Description: Exhibits GTPase regulator activity; enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; monocyte extravasation; and regulation of cytokine production. Localizes to cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
Also known as: Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; CD172 antigen-like family member A; inhibitory receptor SHPS-1; macrophage fusion receptor; macrophage membrane protein MFP150; protein tyrosine phosphatase non-receptor type substrate 1; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHPS-1; signal-regulatory protein alpha-1; sirp-alpha-1; tyrosine-protein phosphatase non-receptor type substrate 1
Homo sapiens (human) : SIRPA (signal regulatory protein alpha)  HGNC  Alliance
Mus musculus (house mouse) : Sirpa (signal-regulatory protein alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirpa (signal regulatory protein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRPA (signal regulatory protein alpha)
Canis lupus familiaris (dog) : SIRPA (signal regulatory protein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirpa (signal regulatory protein alpha)
Sus scrofa (pig) : SIRPA (signal regulatory protein alpha)
Chlorocebus sabaeus (African green monkey) : SIRPA (signal regulatory protein alpha)
Heterocephalus glaber (naked mole-rat) : Sirpa (signal regulatory protein alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03122,113,735 - 122,152,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,114,108 - 122,152,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03127,864,145 - 127,902,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,210,116 - 117,247,840 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13117,115,688 - 117,153,412 (+)NCBI
Celera3115,635,887 - 115,673,609 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Sirpa
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3449
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.