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Gene: Sirpa (signal-regulatory protein alpha) Mus musculus
Symbol: Sirpa
Name: signal-regulatory protein alpha
Description: Exhibits protein phosphatase binding activity and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of protein phosphorylation; and regulation of phagocytosis. Localizes to the integral component of plasma membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human SIRPA (signal regulatory protein alpha); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; brain immunological-like with tyrosine-based motifs; CD172 antigen-like family member A; CD172a; inhibitory receptor SHPS-1; mSIRP-alpha1; myD-1 antigen; P84; protein tyrosine phosphatase, non-receptor type substrate 1; Ptpns1; SHP substrate 1; SHP-1; SHPS-1; signal-regulatory protein alpha-1; SIRP; sirp-alpha-1; tyrosine-protein phosphatase non-receptor type substrate 1
Homo sapiens (human) : SIRPA (signal regulatory protein alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sirpa (signal-regulatory protein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirpa (signal regulatory protein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRPA (signal regulatory protein alpha)
Canis lupus familiaris (dog) : SIRPA (signal regulatory protein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirpa (signal regulatory protein alpha)
Sus scrofa (pig) : SIRPA (signal regulatory protein alpha)
Chlorocebus sabaeus (African green monkey) : SIRPA (signal regulatory protein alpha)
Heterocephalus glaber (naked mole-rat) : Sirpa (signal regulatory protein alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2129,592,835 - 129,632,228 (+)EnsemblGRCm38mm10GRCm38
GRCm382129,591,042 - 129,632,228 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372129,418,575 - 129,457,964 (+)NCBIGRCm37mm9NCBIm37
MGSCv362129,284,759 - 129,322,373 (+)NCBImm8
Celera2130,820,643 - 130,860,425 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sirpa
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10243
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.