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Gene: TMED4 (transmembrane p24 trafficking protein 4) Homo sapiens
Symbol: TMED4
Name: transmembrane p24 trafficking protein 4
Description: Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to localize to several cellular components, including the COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; benzo[a]pyrene diol epoxide I; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endoplasmic reticulum stress-response protein 25 kDa; ERS25; GMP25iso; HNLF; p24 family protein alpha-3; p24a3; p24alpha3; putative NF-kappa-B-activating protein 156; putative NFkB activating protein HNLF; transmembrane emp24 domain-containing protein 4; transmembrane emp24 protein transport domain containing 4
Mus musculus (house mouse) : Tmed4 (transmembrane p24 trafficking protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tmed4 (transmembrane p24 trafficking protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmed4 (transmembrane p24 trafficking protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TMED4 (transmembrane p24 trafficking protein 4)
Canis lupus familiaris (dog) : TMED4 (transmembrane p24 trafficking protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmed4 (transmembrane p24 trafficking protein 4)
Sus scrofa (pig) : TMED4 (transmembrane p24 trafficking protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl744,577,894 - 44,582,287 (-)Ensembl
GRCh38744,577,894 - 44,582,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37744,617,493 - 44,621,881 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,585,287 - 44,588,352 (-)NCBINCBI36hg18NCBI36
Build 34744,392,002 - 44,395,067NCBI
Celera744,717,606 - 44,720,671 (-)NCBI
Cytogenetic Map7p13NCBI
HuRef744,503,138 - 44,506,203 (-)NCBIHuRef
CHM1_1744,621,889 - 44,626,290 (-)NCBICHM1_1
CRA_TCAGchr7v2744,658,279 - 44,661,344 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TMED4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352955
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.