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Gene: AKAP13 (A-kinase anchoring protein 13) Homo sapiens
Symbol: AKAP13
Name: A-kinase anchoring protein 13
Description: Exhibits MAP-kinase scaffold activity; Rho guanyl-nucleotide exchange factor activity; and protein kinase A binding activity. Involved in adrenergic receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of Rho protein signal transduction. Localizes to cell cortex and cytosol. Colocalizes with cortical actin cytoskeleton.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; A-kinase anchoring protein; AKAP-13; AKAP-Lbc; ARHGEF13; breast cancer nuclear receptor-binding auxiliary protein; BRX; c-lbc; FLJ11952; FLJ43341; guanine nucleotide exchange factor Lbc; HA-3; Ht31; human thyroid-anchoring protein 31; LBC; LBC oncogene; lymphoid blast crisis oncogene; non-oncogenic Rho GTPase-specific GTP exchange factor; p47; PRKA13; protein kinase A-anchoring protein 13; PROTO-LB; PROTO-LBC
Mus musculus (house mouse) : Akap13 (A kinase (PRKA) anchor protein 13)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akap13 (A-kinase anchoring protein 13)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akap13 (A-kinase anchoring protein 13)
Pan paniscus (bonobo/pygmy chimpanzee) : AKAP13 (A-kinase anchoring protein 13)
Canis lupus familiaris (dog) : AKAP13 (A-kinase anchoring protein 13)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akap13 (A-kinase anchoring protein 13)
Sus scrofa (pig) : AKAP13 (A-kinase anchoring protein 13)
Chlorocebus sabaeus (African green monkey) : AKAP13 (A-kinase anchoring protein 13)
Heterocephalus glaber (naked mole-rat) : Akap13 (A-kinase anchoring protein 13)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1585,380,571 - 85,749,358 (+)EnsemblGRCh38hg38GRCh38
GRCh381585,380,603 - 85,749,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371585,923,818 - 86,292,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361583,724,875 - 84,093,590 (+)NCBINCBI36hg18NCBI36
Build 341584,021,271 - 84,093,590NCBI
Celera1562,323,846 - 62,692,414 (+)NCBI
Cytogenetic Map15q25.3NCBI
HuRef1561,986,401 - 62,354,887 (+)NCBIHuRef
CHM1_11585,765,298 - 86,134,016 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AKAP13
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736118
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.