Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CARD11 (caspase recruitment domain family member 11) Homo sapiens
Symbol: CARD11
Name: caspase recruitment domain family member 11
Description: Exhibits CARD domain binding activity. Involved in several processes, including T cell costimulation; intracellular signal transduction; and positive regulation of NF-kappaB transcription factor activity. Localizes to the CBM complex; membrane raft; and plasma membrane. Implicated in diffuse large B-cell lymphoma and primary immunodeficiency disease. Biomarker of precursor T-lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bcl10-interacting maguk protein 3; BENTA; BIMP3; CARD-containing MAGUK protein 1; card-maguk protein 1; carma 1; CARMA1; caspase recruitment domain family, member 11; caspase recruitment domain-containing protein 11; IMD11; IMD11A; MGC133069; PPBL
Mus musculus (house mouse) : Card11 (caspase recruitment domain family, member 11)  MGI  Alliance
Rattus norvegicus (Norway rat) : Card11 (caspase recruitment domain family, member 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Card11 (caspase recruitment domain family member 11)
Pan paniscus (bonobo/pygmy chimpanzee) : CARD11 (caspase recruitment domain family member 11)
Canis lupus familiaris (dog) : CARD11 (caspase recruitment domain family member 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Card11 (caspase recruitment domain family member 11)
Sus scrofa (pig) : CARD11 (caspase recruitment domain family member 11)
Chlorocebus sabaeus (green monkey) : CARD11 (caspase recruitment domain family member 11)
Heterocephalus glaber (naked mole-rat) : Card11 (caspase recruitment domain family member 11)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl72,906,141 - 3,043,945 (-)Ensembl
GRCh3872,906,075 - 3,043,867 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3772,945,709 - 3,083,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3672,912,295 - 3,050,105 (-)NCBINCBI36hg18NCBI36
Build 3472,719,023 - 2,856,711NCBI
Celera72,914,379 - 3,052,190 (-)NCBI
Cytogenetic Map7p22.2NCBI
HuRef72,863,784 - 3,002,087 (-)NCBIHuRef
CHM1_172,945,368 - 3,083,787 (-)NCBICHM1_1
CRA_TCAGchr7v272,993,579 - 3,131,390 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CARD11
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319685
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.