TREM2 (triggering receptor expressed on myeloid cells 2) - Rat Genome Database

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Gene: TREM2 (triggering receptor expressed on myeloid cells 2) Homo sapiens
Analyze
Symbol: TREM2
Name: triggering receptor expressed on myeloid cells 2
RGD ID: 1320401
HGNC Page HGNC
Description: Enables several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of signal transduction; and regulation of neuroinflammatory response. Acts upstream of with a positive effect on memory and social behavior. Acts upstream of or within with a positive effect on CXCL12-activated CXCR4 signaling pathway. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; osteoclast differentiation; and positive regulation of macromolecule metabolic process. Located in plasma membrane. Is integral component of membrane and intrinsic component of plasma membrane. Part of plasma membrane raft. Biomarker of syphilis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl641,158,506 - 41,163,186 (-)EnsemblGRCh38hg38GRCh38
GRCh38641,158,508 - 41,163,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,126,246 - 41,130,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,234,230 - 41,238,892 (-)NCBINCBI36hg18NCBI36
Build 34641,234,230 - 41,238,892NCBI
Celera642,678,948 - 42,683,624 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,844,044 - 40,848,724 (-)NCBIHuRef
CHM1_1641,129,139 - 41,133,819 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
amyloid-beta clearance by cellular catabolic process  (IMP,ISS)
apoptotic cell clearance  (ISS)
astrocyte activation  (ISS)
cellular response to amyloid-beta  (ISS)
cellular response to glucose stimulus  (IEA)
cellular response to hypoxia  (IEA)
cellular response to lipid  (IMP)
cellular response to lipoteichoic acid  (IEA)
cellular response to oxidised low-density lipoprotein particle stimulus  (IDA)
cellular response to peptidoglycan  (IEA)
complement-mediated synapse pruning  (ISS)
CXCL12-activated CXCR4 signaling pathway  (IMP)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISS)
dendritic cell differentiation  (IDA)
dendritic spine maintenance  (ISS)
detection of lipopolysaccharide  (IEA)
detection of lipoteichoic acid  (IEA)
detection of peptidoglycan  (IEA)
excitatory synapse pruning  (ISS)
humoral immune response  (TAS)
import into cell  (ISS)
lipid homeostasis  (ISS)
memory  (IDA,IMP)
microglial cell activation  (ISS)
microglial cell activation involved in immune response  (ISS)
microglial cell proliferation  (ISS)
negative regulation of amyloid fibril formation  (ISS)
negative regulation of apoptotic process  (ISO)
negative regulation of astrocyte activation  (ISS)
negative regulation of autophagic cell death  (ISS)
negative regulation of autophagy  (ISS)
negative regulation of cell activation  (ISS)
negative regulation of cholesterol storage  (ISS)
negative regulation of cytokine production involved in inflammatory response  (ISS)
negative regulation of fat cell proliferation  (ISS)
negative regulation of glial cell apoptotic process  (ISS)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISS)
negative regulation of inflammatory response to antigenic stimulus  (ISS)
negative regulation of interleukin-1 beta production  (IEA)
negative regulation of macrophage colony-stimulating factor signaling pathway  (IMP)
negative regulation of neuroinflammatory response  (IMP,ISS)
negative regulation of NLRP3 inflammasome complex assembly  (IMP,ISS)
negative regulation of p38MAPK cascade  (ISS)
negative regulation of phosphatidylinositol 3-kinase signaling  (ISS)
negative regulation of sequestering of triglyceride  (ISS)
negative regulation of toll-like receptor 2 signaling pathway  (ISS)
negative regulation of toll-like receptor 4 signaling pathway  (ISS)
negative regulation of tumor necrosis factor production  (IEA)
neuroinflammatory response  (IEA)
osteoclast differentiation  (IMP)
phagocytosis, engulfment  (IEA,ISO)
phagocytosis, recognition  (IMP)
positive regulation of amyloid-beta clearance  (IMP,ISS)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (IDA)
positive regulation of ATP biosynthetic process  (ISS)
positive regulation of C-C chemokine receptor CCR7 signaling pathway  (IDA)
positive regulation of calcium-mediated signaling  (IBA,IDA)
positive regulation of CAMKK-AMPK signaling cascade  (ISS)
positive regulation of CD40 signaling pathway  (IDA)
positive regulation of chemotaxis  (ISS)
positive regulation of cholesterol efflux  (ISS)
positive regulation of complement activation, classical pathway  (ISS)
positive regulation of engulfment of apoptotic cell  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IBA,IDA,IMP)
positive regulation of establishment of protein localization  (ISS)
positive regulation of gene expression  (IMP,ISS)
positive regulation of high-density lipoprotein particle clearance  (ISS)
positive regulation of interleukin-10 production  (IEA)
positive regulation of inward rectifier potassium channel activity  (ISS)
positive regulation of kinase activity  (IDA)
positive regulation of low-density lipoprotein particle clearance  (ISS)
positive regulation of macrophage fusion  (ISS)
positive regulation of microglial cell activation  (IBA,IMP,ISS)
positive regulation of microglial cell migration  (IMP,ISS)
positive regulation of mitochondrion organization  (ISS)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phagocytosis  (IMP,ISS)
positive regulation of phagocytosis, engulfment  (IBA,IMP,ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISS)
positive regulation of proteasomal protein catabolic process  (ISS)
positive regulation of protein localization to plasma membrane  (IDA)
positive regulation of protein phosphorylation  (ISS)
positive regulation of protein secretion  (IMP)
positive regulation of synapse pruning  (IMP)
positive regulation of TOR signaling  (ISS)
pyroptosis  (ISS)
regulation of cytokine production involved in inflammatory response  (ISS)
regulation of gene expression  (ISO,ISS)
regulation of hippocampal neuron apoptotic process  (ISS)
regulation of innate immune response  (ISS)
regulation of interleukin-6 production  (ISS)
regulation of intracellular signal transduction  (ISS)
regulation of lipid metabolic process  (IMP)
regulation of macrophage inflammatory protein 1 alpha production  (ISS)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISS)
regulation of peptidyl-tyrosine phosphorylation  (IBA,ISS)
regulation of plasma membrane bounded cell projection organization  (IBA,IGI,ISS)
regulation of resting membrane potential  (ISS)
regulation of toll-like receptor 6 signaling pathway  (ISS)
regulation of TOR signaling  (ISS)
respiratory burst after phagocytosis  (ISS)
response to axon injury  (IMP,ISS)
response to ischemia  (IEA)
social behavior  (IMP,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal adipose tissue morphology  (IAGP)
Abnormal brain FDG positron emission tomography  (IAGP)
Abnormal cerebral white matter morphology  (IAGP)
Abnormal lower motor neuron morphology  (IAGP)
Abnormal social behavior  (IAGP)
Abnormality of epiphysis morphology  (IAGP)
Abnormality of extrapyramidal motor function  (IAGP)
Abnormality of vision  (IAGP)
Abulia  (IAGP)
Acute leukemia  (IAGP)
Aggressive behavior  (IAGP)
Agitation  (IAGP)
Agnosia  (IAGP)
Alexia  (IAGP)
Amyotrophic lateral sclerosis  (IAGP)
Anomic aphasia  (IAGP)
Anxiety  (IAGP)
Apathy  (IAGP)
Aphasia  (IAGP)
Apraxia  (IAGP)
Arthralgia  (IAGP)
Astrocytosis  (IAGP)
Ataxia  (IAGP)
Autosomal recessive inheritance  (IAGP)
Babinski sign  (IAGP)
Basal ganglia calcification  (IAGP)
Bilateral tonic-clonic seizure  (IAGP)
Bone cyst  (IAGP)
Bone pain  (IAGP)
Brain atrophy  (IAGP)
Caudate atrophy  (IAGP)
Cerebral calcification  (IAGP)
Cerebral cortical atrophy  (IAGP)
Chorea  (IAGP)
CNS demyelination  (IAGP)
Collectionism  (IAGP)
Confusion  (IAGP)
Dementia  (IAGP)
Deposits immunoreactive to beta-amyloid protein  (IAGP)
Depression  (IAGP)
Developmental regression  (IAGP)
Disinhibition  (IAGP)
Dyscalculia  (IAGP)
Dysgraphia  (IAGP)
Dyslexia  (IAGP)
Dysphasia  (IAGP)
Dyspnea  (IAGP)
Echolalia  (IAGP)
EEG abnormality  (IAGP)
EEG with continuous slow activity  (IAGP)
Emotional blunting  (IAGP)
Emotional lability  (IAGP)
Expressive aphasia  (IAGP)
Fasciculations  (IAGP)
Fatigable weakness of respiratory muscles  (IAGP)
Fatigable weakness of swallowing muscles  (IAGP)
Fatigue  (IAGP)
Finger agnosia  (IAGP)
Frontal lobe dementia  (IAGP)
Frontotemporal cerebral atrophy  (IAGP)
Frontotemporal dementia  (IAGP)
Functional abnormality of the gastrointestinal tract  (IAGP)
Gait disturbance  (IAGP)
Generalized muscle weakness  (IAGP)
Grammar-specific speech disorder  (IAGP)
Hallucinations  (IAGP)
Hydrocephalus  (IAGP)
Hyperorality  (IAGP)
Hyperreflexia  (IAGP)
Hypertonia  (IAGP)
Hypoplasia of the corpus callosum  (IAGP)
Inappropriate behavior  (IAGP)
Intellectual disability  (IAGP)
Irritability  (IAGP)
Lack of insight  (IAGP)
Language impairment  (IAGP)
Laryngospasm  (IAGP)
Leukoencephalopathy  (IAGP)
Limitation of joint mobility  (IAGP)
Loss of speech  (IAGP)
Memory impairment  (IAGP)
Muscle spasm  (IAGP)
Mutism  (IAGP)
Myoclonus  (IAGP)
Nausea and vomiting  (IAGP)
Neurodegeneration  (IAGP)
Neurofibrillary tangles  (IAGP)
Neurological speech impairment  (IAGP)
Oculomotor apraxia  (IAGP)
Osteopenia  (IAGP)
Pain  (IAGP)
Paralysis  (IAGP)
Parkinsonism  (IAGP)
Pathologic fracture  (IAGP)
Perseveration  (IAGP)
Personality changes  (IAGP)
Poor speech  (IAGP)
Primitive reflex  (IAGP)
Psychosis  (IAGP)
Reduced bone mineral density  (IAGP)
Respiratory failure  (IAGP)
Restlessness  (IAGP)
Restrictive behavior  (IAGP)
Seizure  (IAGP)
Semantic dementia  (IAGP)
Senile plaques  (IAGP)
Skeletal dysplasia  (IAGP)
Skeletal muscle atrophy  (IAGP)
Spasticity  (IAGP)
Spoken word recognition deficit  (IAGP)
Stereotypy  (IAGP)
T2 hypointense thalamus  (IAGP)
Temporal cortical atrophy  (IAGP)
Thickened nuchal skin fold  (IAGP)
Upper motor neuron dysfunction  (IAGP)
Ventriculomegaly  (IAGP)
Visual agnosia  (IAGP)
Xerostomia  (IAGP)
References

Additional References at PubMed
PMID:11602640   PMID:12080485   PMID:12477932   PMID:12645956   PMID:12754369   PMID:12913093   PMID:12925681   PMID:15489334   PMID:15966270   PMID:16505336   PMID:16715077   PMID:17530208  
PMID:18546367   PMID:18551625   PMID:19019460   PMID:19079182   PMID:19230638   PMID:19457124   PMID:19913121   PMID:20301376   PMID:20421649   PMID:20628086   PMID:20640189   PMID:21834902  
PMID:21841309   PMID:21873635   PMID:22939635   PMID:23150908   PMID:23150934   PMID:23380991   PMID:23383108   PMID:23391427   PMID:23407992   PMID:23533697   PMID:23582655   PMID:23721075  
PMID:23759145   PMID:23800361   PMID:23855982   PMID:23855984   PMID:23870839   PMID:24002183   PMID:24078628   PMID:24119542   PMID:24131187   PMID:24139279   PMID:24184202   PMID:24355566  
PMID:24378087   PMID:24535663   PMID:24602511   PMID:24663666   PMID:24725293   PMID:24762945   PMID:24866402   PMID:24899047   PMID:24910390   PMID:24990881   PMID:25027412   PMID:25042114  
PMID:25160042   PMID:25186855   PMID:25186950   PMID:25260849   PMID:25281879   PMID:25499537   PMID:25585992   PMID:25596843   PMID:25615530   PMID:25732305   PMID:25852195   PMID:25886450  
PMID:25936935   PMID:26001891   PMID:26021840   PMID:26026943   PMID:26037549   PMID:26058841   PMID:26058955   PMID:26079507   PMID:26184544   PMID:26332043   PMID:26337043   PMID:26365049  
PMID:26374897   PMID:26374899   PMID:26384438   PMID:26414614   PMID:26506595   PMID:26651418   PMID:26694609   PMID:26704436   PMID:26754172   PMID:26754641   PMID:26758262   PMID:26911435  
PMID:26941262   PMID:26949937   PMID:27044754   PMID:27051467   PMID:27067662   PMID:27084067   PMID:27102437   PMID:27130565   PMID:27196974   PMID:27477018   PMID:27501831   PMID:27520774  
PMID:27522519   PMID:27589997   PMID:27662313   PMID:27769848   PMID:27779645   PMID:27887626   PMID:27934908   PMID:27974666   PMID:27995897   PMID:28005267   PMID:28214109   PMID:28365005  
PMID:28376694   PMID:28412600   PMID:28442216   PMID:28453482   PMID:28483841   PMID:28490631   PMID:28714976   PMID:28768830   PMID:28774784   PMID:28789839   PMID:28802038   PMID:28855300  
PMID:28855301   PMID:28869414   PMID:28923481   PMID:28930663   PMID:28978423   PMID:28987033   PMID:29037207   PMID:29104108   PMID:29256968   PMID:29278889   PMID:29321225   PMID:29322490  
PMID:29333781   PMID:29377401   PMID:29480181   PMID:29518356   PMID:29518357   PMID:29557178   PMID:29587871   PMID:29606617   PMID:29611543   PMID:29655369   PMID:29740051   PMID:29748150  
PMID:29752066   PMID:29794134   PMID:29842899   PMID:29887864   PMID:29889572   PMID:30033062   PMID:30053297   PMID:30076618   PMID:30097493   PMID:30106757   PMID:30152135   PMID:30157425  
PMID:30185230   PMID:30222607   PMID:30341064   PMID:30442540   PMID:30458365   PMID:30482868   PMID:30485483   PMID:30568991   PMID:30630532   PMID:30705288   PMID:30883352   PMID:30978656  
PMID:31028072   PMID:31068200   PMID:31101881   PMID:31235932   PMID:31350575   PMID:31362167   PMID:31413141   PMID:31462511   PMID:31464095   PMID:31481003   PMID:31513029   PMID:31724242  
PMID:31779670   PMID:31812991   PMID:31833018   PMID:31847649   PMID:31902528   PMID:31907987   PMID:31915256   PMID:31932797   PMID:31958095   PMID:31959733   PMID:32000403   PMID:32031293  
PMID:32065223   PMID:32067825   PMID:32107424   PMID:32267026   PMID:32276587   PMID:32508528   PMID:32514138   PMID:32544086   PMID:32630447   PMID:32635934   PMID:32681391   PMID:32684831  
PMID:32772264   PMID:32840654   PMID:32842621   PMID:32977944   PMID:33097708   PMID:33101276   PMID:33198789   PMID:33297569   PMID:33446504   PMID:33461764   PMID:33486152   PMID:33506893  
PMID:33826063   PMID:33839686   PMID:33969597   PMID:34002612  


Genomics

Comparative Map Data
TREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl641,158,506 - 41,163,186 (-)EnsemblGRCh38hg38GRCh38
GRCh38641,158,508 - 41,163,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,126,246 - 41,130,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,234,230 - 41,238,892 (-)NCBINCBI36hg18NCBI36
Build 34641,234,230 - 41,238,892NCBI
Celera642,678,948 - 42,683,624 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,844,044 - 40,848,724 (-)NCBIHuRef
CHM1_1641,129,139 - 41,133,819 (-)NCBICHM1_1
Trem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,653,429 - 48,659,304 (+)NCBIGRCm39mm39
GRCm39 Ensembl1748,653,429 - 48,661,175 (+)Ensembl
GRCm381748,346,401 - 48,352,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,346,401 - 48,354,147 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,485,726 - 48,491,598 (+)NCBIGRCm37mm9NCBIm37
MGSCv361747,811,968 - 47,817,840 (+)NCBImm8
Celera1751,775,275 - 51,781,147 (+)NCBICelera
Cytogenetic Map17CNCBI
Trem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2912,647,605 - 12,654,190 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl912,647,259 - 12,654,170 (-)Ensembl
Rnor_6.0914,611,541 - 14,618,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,532,905 - 13,539,382 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,059,023 - 8,065,585 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.198,059,020 - 8,065,484 (-)NCBI
Celera910,419,918 - 10,426,480 (-)NCBICelera
Cytogenetic Map9q12NCBI
Trem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,780,679 - 7,785,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554377,780,886 - 7,785,597 (-)NCBIChiLan1.0ChiLan1.0
TREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1642,043,887 - 42,048,578 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,043,900 - 42,048,578 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0640,735,483 - 40,740,208 (-)NCBIMhudiblu_PPA_v0panPan3
TREM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,915,692 - 9,928,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,915,677 - 9,928,174 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha129,945,665 - 9,950,515 (-)NCBI
ROS_Cfam_1.01210,395,282 - 10,400,132 (-)NCBI
UMICH_Zoey_3.1129,927,392 - 9,932,242 (-)NCBI
UNSW_CanFamBas_1.01210,009,135 - 10,013,985 (-)NCBI
UU_Cfam_GSD_1.01210,104,147 - 10,108,997 (-)NCBI
Trem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,295,126 - 45,300,504 (-)NCBI
SpeTri2.0NW_00493647618,659,725 - 18,665,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,464,034 - 36,471,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,465,921 - 36,471,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,763,412 - 41,767,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,965,091 - 30,999,073 (+)NCBI
ChlSab1.1 Ensembl1730,994,357 - 30,999,087 (+)Ensembl
Vero_WHO_p1.0NW_02366604441,158,611 - 41,163,469 (-)NCBI
Trem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475417,643,397 - 17,649,255 (+)NCBI

Position Markers
RH94034  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37641,126,438 - 41,126,673UniSTSGRCh37
Build 36641,234,416 - 41,234,651RGDNCBI36
Celera642,679,140 - 42,679,375RGD
Cytogenetic Map6p21.1UniSTS
HuRef640,844,238 - 40,844,473UniSTS
GeneMap99-GB4 RH Map6156.31UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:542
Count of miRNA genes:288
Interacting mature miRNAs:306
Transcripts:ENST00000338469, ENST00000373113, ENST00000373122
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 51 314 274 107 33 66 725 6 1309 142 150 521 42 306 477 2
Low 1626 1813 1113 299 689 188 1794 807 2254 177 825 783 117 1 829 1062 1
Below cutoff 629 803 270 171 668 161 1387 1056 102 60 376 138 12 66 938 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000338469   ⟹   ENSP00000342651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,158,507 - 41,163,186 (-)Ensembl
RefSeq Acc Id: ENST00000373113   ⟹   ENSP00000362205
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,158,508 - 41,163,116 (-)Ensembl
RefSeq Acc Id: ENST00000373122   ⟹   ENSP00000362214
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,158,506 - 41,163,103 (-)Ensembl
RefSeq Acc Id: NM_001271821   ⟹   NP_001258750
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,158,508 - 41,163,116 (-)NCBI
HuRef640,844,044 - 40,848,724 (-)NCBI
CHM1_1641,129,139 - 41,133,819 (-)NCBI
Sequence:
RefSeq Acc Id: NM_018965   ⟹   NP_061838
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,158,508 - 41,163,116 (-)NCBI
GRCh37641,126,244 - 41,130,924 (-)NCBI
Build 36641,234,230 - 41,238,892 (-)NCBI Archive
HuRef640,844,044 - 40,848,724 (-)NCBI
CHM1_1641,129,139 - 41,133,819 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061838   ⟸   NM_018965
- Peptide Label: precursor isoform 1 precursor
- UniProtKB: Q9NZC2 (UniProtKB/Swiss-Prot),   Q5TCX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258750   ⟸   NM_001271821
- Peptide Label: precursor isoform 2 precursor
- UniProtKB: Q9NZC2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000362205   ⟸   ENST00000373113
RefSeq Acc Id: ENSP00000362214   ⟸   ENST00000373122
RefSeq Acc Id: ENSP00000342651   ⟸   ENST00000338469
Protein Domains
Ig-like V-type   IGv

Promoters
RGD ID:7207983
Promoter ID:EPDNEW_H9736
Type:initiation region
Name:TREM2_1
Description:triggering receptor expressed on myeloid cells 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9737  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,163,116 - 41,163,176EPDNEW
RGD ID:7207981
Promoter ID:EPDNEW_H9737
Type:initiation region
Name:TREM2_2
Description:triggering receptor expressed on myeloid cells 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9736  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,163,195 - 41,163,255EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_018965.3(TREM2):c.233G>A (p.Trp78Ter) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000005523]|Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000721925] Chr6:41161421 [GRCh38]
Chr6:41129159 [GRCh37]
Chr6:6p21.1
pathogenic|likely pathogenic
NM_018965.3(TREM2):c.558G>T (p.Lys186Asn) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000005524] Chr6:41158991 [GRCh38]
Chr6:41126729 [GRCh37]
Chr6:6p21.1
pathogenic|uncertain significance
NM_018965.3(TREM2):c.401A>G (p.Asp134Gly) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000005525] Chr6:41159873 [GRCh38]
Chr6:41127611 [GRCh37]
Chr6:6p21.1
pathogenic|uncertain significance
TREM2, IVS3DS, T-C, +2 single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000005526] Chr6:6p21.2 pathogenic
NM_018965.3(TREM2):c.132G>A (p.Trp44Ter) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000005527] Chr6:41161522 [GRCh38]
Chr6:41129260 [GRCh37]
Chr6:6p21.1
pathogenic|likely pathogenic
NM_018965.3(TREM2):c.377T>G (p.Val126Gly) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000005528]|Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000721926] Chr6:41161277 [GRCh38]
Chr6:41129015 [GRCh37]
Chr6:6p21.1
pathogenic|likely pathogenic
NM_018965.3(TREM2):c.97C>T (p.Gln33Ter) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000005529]|Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000721927] Chr6:41161557 [GRCh38]
Chr6:41129295 [GRCh37]
Chr6:6p21.1
pathogenic
NM_018965.3(TREM2):c.431C>G (p.Pro144Arg) single nucleotide variant not provided [RCV000728256] Chr6:41159843 [GRCh38]
Chr6:41127581 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.269del (p.Gly90fs) deletion Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000050134] Chr6:41161385 [GRCh38]
Chr6:41129123 [GRCh37]
Chr6:6p21.1
likely pathogenic
NM_018965.3(TREM2):c.313del (p.Ala105fs) deletion Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000050135] Chr6:41161341 [GRCh38]
Chr6:41129079 [GRCh37]
Chr6:6p21.1
likely pathogenic
NM_018965.4(TREM2):c.40+4_40+6del deletion Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000050136] Chr6:41163037..41163039 [GRCh38]
Chr6:41130775..41130777 [GRCh37]
Chr6:6p21.1
pathogenic|likely pathogenic|conflicting interpretations of pathogenicity
NM_018965.3(TREM2):c.40G>T (p.Glu14Ter) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000050137]|Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000993682] Chr6:41163043 [GRCh38]
Chr6:41130781 [GRCh37]
Chr6:6p21.1
pathogenic|likely pathogenic
NM_018965.3(TREM2):c.482+2T>C single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000050138] Chr6:41159790 [GRCh38]
Chr6:41127528 [GRCh37]
Chr6:6p21.1
likely pathogenic
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1
pathogenic
NM_018965.3(TREM2):c.496G>A (p.Gly166Arg) single nucleotide variant Malignant melanoma [RCV000067362] Chr6:41159053 [GRCh38]
Chr6:41126791 [GRCh37]
Chr6:41234769 [NCBI36]
Chr6:6p21.1
not provided
NM_018965.3(TREM2):c.140G>A (p.Arg47His) single nucleotide variant not provided [RCV000514799]|not specified [RCV000175913] Chr6:41161514 [GRCh38]
Chr6:41129252 [GRCh37]
Chr6:6p21.1
likely benign
NM_018965.3(TREM2):c.469C>T (p.His157Tyr) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000352563]|not provided [RCV000513757]|not specified [RCV000177312] Chr6:41159805 [GRCh38]
Chr6:41127543 [GRCh37]
Chr6:6p21.1
benign|likely benign
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
NM_018965.3(TREM2):c.113A>G (p.Tyr38Cys) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000192212] Chr6:41161541 [GRCh38]
Chr6:41129279 [GRCh37]
Chr6:6p21.1
pathogenic
NM_018965.3(TREM2):c.197C>T (p.Thr66Met) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000192213] Chr6:41161457 [GRCh38]
Chr6:41129195 [GRCh37]
Chr6:6p21.1
pathogenic
NM_018965.3(TREM2):c.*73G>A single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000291327]|not provided [RCV000224373]|not specified [RCV000733767] Chr6:41158691 [GRCh38]
Chr6:41126429 [GRCh37]
Chr6:6p21.1
benign|likely benign
NM_018965.3(TREM2):c.259G>A (p.Asp87Asn) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001154720]|not provided [RCV000725660]|not specified [RCV000243611] Chr6:41161395 [GRCh38]
Chr6:41129133 [GRCh37]
Chr6:6p21.1
benign|conflicting interpretations of pathogenicity|uncertain significance
NM_018965.3(TREM2):c.115G>A (p.Asp39Asn) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000397547] Chr6:41161539 [GRCh38]
Chr6:41129277 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.393C>T (p.Asp131=) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000397560] Chr6:41159881 [GRCh38]
Chr6:41127619 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.-51G>A single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000355027] Chr6:41163133 [GRCh38]
Chr6:41130871 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.*111A>G single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000376374] Chr6:41158653 [GRCh38]
Chr6:41126391 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.632T>C (p.Leu211Pro) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000288246]|not provided [RCV001516643]|not specified [RCV000593161] Chr6:41158917 [GRCh38]
Chr6:41126655 [GRCh37]
Chr6:6p21.1
benign|likely benign
NM_018965.3(TREM2):c.690G>A (p.Thr230=) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000405068] Chr6:41158767 [GRCh38]
Chr6:41126505 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.*30G>A single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000346653]|not provided [RCV001572928] Chr6:41158734 [GRCh38]
Chr6:41126472 [GRCh37]
Chr6:6p21.1
benign|likely benign
NM_018965.3(TREM2):c.254C>T (p.Thr85Ile) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000367540] Chr6:41161400 [GRCh38]
Chr6:41129138 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.287C>A (p.Thr96Lys) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000312921]|not provided [RCV000444438]|not specified [RCV000591330] Chr6:41161367 [GRCh38]
Chr6:41129105 [GRCh37]
Chr6:6p21.1
benign|likely benign
NM_018965.3(TREM2):c.40+13C>T single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV000300134] Chr6:41163030 [GRCh38]
Chr6:41130768 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.314C>T (p.Ala105Val) single nucleotide variant not provided [RCV000271251] Chr6:41161340 [GRCh38]
Chr6:41129078 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.399G>T (p.Leu133=) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000625433]|Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001151686]|not provided [RCV000284005] Chr6:41159875 [GRCh38]
Chr6:41127613 [GRCh37]
Chr6:6p21.1
likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_018965.3(TREM2):c.173G>A (p.Gly58Asp) single nucleotide variant not provided [RCV000369103] Chr6:41161481 [GRCh38]
Chr6:41129219 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.204C>G (p.Asn68Lys) single nucleotide variant not provided [RCV000595282] Chr6:41161450 [GRCh38]
Chr6:41129188 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.407G>A (p.Arg136Gln) single nucleotide variant not provided [RCV000593199] Chr6:41159867 [GRCh38]
Chr6:41127605 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.292C>T (p.Arg98Trp) single nucleotide variant not provided [RCV000598110] Chr6:41161362 [GRCh38]
Chr6:41129100 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.3(TREM2):c.677-6T>C single nucleotide variant not provided [RCV000593813] Chr6:41158786 [GRCh38]
Chr6:41126524 [GRCh37]
Chr6:6p21.1
conflicting interpretations of pathogenicity|uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_018965.3(TREM2):c.185G>A (p.Arg62His) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000625434]|not provided [RCV000513870]|not specified [RCV000591525] Chr6:41161469 [GRCh38]
Chr6:41129207 [GRCh37]
Chr6:6p21.1
benign|likely benign|conflicting interpretations of pathogenicity
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_018965.3(TREM2):c.514C>T (p.Pro172Ser) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 [RCV000625432] Chr6:41159035 [GRCh38]
Chr6:41126773 [GRCh37]
Chr6:6p21.1
likely benign
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_018965.4(TREM2):c.258C>T (p.Asp86=) single nucleotide variant not provided [RCV000942320] Chr6:41161396 [GRCh38]
Chr6:41129134 [GRCh37]
Chr6:6p21.1
likely benign
NM_018965.4(TREM2):c.288G>A (p.Thr96=) single nucleotide variant not provided [RCV000899924] Chr6:41161366 [GRCh38]
Chr6:41129104 [GRCh37]
Chr6:6p21.1
likely benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_018965.4(TREM2):c.396C>G (p.Pro132=) single nucleotide variant not provided [RCV000898373] Chr6:41159878 [GRCh38]
Chr6:41127616 [GRCh37]
Chr6:6p21.1
likely benign
NM_018965.4(TREM2):c.574G>A (p.Ala192Thr) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001151684] Chr6:41158975 [GRCh38]
Chr6:41126713 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.4(TREM2):c.117C>G (p.Asp39Glu) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001154721] Chr6:41161537 [GRCh38]
Chr6:41129275 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.4(TREM2):c.40+88T>C single nucleotide variant not provided [RCV001539676] Chr6:41162955 [GRCh38]
Chr6:41130693 [GRCh37]
Chr6:6p21.1
benign
NM_018965.4(TREM2):c.668C>T (p.Thr223Ile) single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001157135]|not provided [RCV000886696] Chr6:41158881 [GRCh38]
Chr6:41126619 [GRCh37]
Chr6:6p21.1
benign|likely benign
NM_018965.4(TREM2):c.*107G>T single nucleotide variant not provided [RCV000891054] Chr6:41158657 [GRCh38]
Chr6:41126395 [GRCh37]
Chr6:6p21.1
benign|conflicting interpretations of pathogenicity
NM_018965.4(TREM2):c.*148C>T single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001157133] Chr6:41158616 [GRCh38]
Chr6:41126354 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.4(TREM2):c.*48A>T single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001157134] Chr6:41158716 [GRCh38]
Chr6:41126454 [GRCh37]
Chr6:6p21.1
likely benign
NM_018965.4(TREM2):c.*156G>T single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001157132]|not provided [RCV001307366] Chr6:41158608 [GRCh38]
Chr6:41126346 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.4(TREM2):c.482+7C>T single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001151685] Chr6:41159785 [GRCh38]
Chr6:41127523 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.4(TREM2):c.*157G>A single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001155458] Chr6:41158607 [GRCh38]
Chr6:41126345 [GRCh37]
Chr6:6p21.1
uncertain significance
NC_000006.12:g.41163180G>A single nucleotide variant Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 [RCV001155556] Chr6:41163180 [GRCh38]
Chr6:41130918 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.4(TREM2):c.674C>T (p.Pro225Leu) single nucleotide variant not provided [RCV001310916] Chr6:41158875 [GRCh38]
Chr6:41126613 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_018965.4(TREM2):c.483-106G>A single nucleotide variant not provided [RCV001538833] Chr6:41159172 [GRCh38]
Chr6:41126910 [GRCh37]
Chr6:6p21.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17761 AgrOrtholog
COSMIC TREM2 COSMIC
Ensembl Genes ENSG00000095970 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000342651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000362205 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000362214 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000338469 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000373113 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000373122 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000095970 GTEx
HGNC ID HGNC:17761 ENTREZGENE
Human Proteome Map TREM2 Human Proteome Map
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54209 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54209 ENTREZGENE
OMIM 605086 OMIM
  618193 OMIM
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38468 PharmGKB
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E3WHI5_HUMAN UniProtKB/TrEMBL
  Q5TCX1 ENTREZGENE, UniProtKB/TrEMBL
  Q9NZC2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A6NDG2 UniProtKB/TrEMBL
  Q8N5H8 UniProtKB/Swiss-Prot
  Q8WYN6 UniProtKB/Swiss-Prot