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Gene: TRIM8 (tripartite motif containing 8) Homo sapiens
Symbol: TRIM8
Name: tripartite motif containing 8
Description: Exhibits protein homodimerization activity. Involved in several processes, including negative regulation of viral release from host cell; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of NF-kappaB transcription factor activity. Localizes to the PML body.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase TRIM8; GERP; glioblastoma expressed ring finger protein; glioblastoma-expressed RING finger protein; probable E3 ubiquitin-protein ligase TRIM8; ring finger protein 27; RING-type E3 ubiquitin transferase TRIM8; RNF27; tripartite motif protein TRIM8; tripartite motif-containing 8; tripartite motif-containing protein 8
Mus musculus (house mouse) : Trim8 (tripartite motif-containing 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trim8 (tripartite motif-containing 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trim8 (tripartite motif containing 8)
Pan paniscus (bonobo/pygmy chimpanzee) : TRIM8 (tripartite motif containing 8)
Canis lupus familiaris (dog) : TRIM8 (tripartite motif containing 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trim8 (tripartite motif containing 8)
Sus scrofa (pig) : TRIM8 (tripartite motif containing 8)
Chlorocebus sabaeus (African green monkey) : TRIM8 (tripartite motif containing 8)
Heterocephalus glaber (naked mole-rat) : Trim8 (tripartite motif containing 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10102,642,310 - 102,660,680 (+)Ensembl
GRCh3810102,644,495 - 102,658,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710104,403,326 - 104,418,076 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,394,242 - 104,408,066 (+)NCBINCBI36hg18NCBI36
Build 3410104,394,355 - 104,408,064NCBI
Celera1098,145,270 - 98,159,115 (+)NCBI
Cytogenetic Map10q24.32NCBI
HuRef1098,038,827 - 98,052,661 (+)NCBIHuRef
CHM1_110104,688,022 - 104,701,849 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRIM8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319835
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.