NFKBIL1 (NFKB inhibitor like 1) - Rat Genome Database

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Gene: NFKBIL1 (NFKB inhibitor like 1) Homo sapiens
Analyze
Symbol: NFKBIL1
Name: NFKB inhibitor like 1
RGD ID: 1351897
HGNC Page HGNC:7800
Description: Predicted to enable transcription regulator inhibitor activity. Involved in cellular response to lipopolysaccharide; negative regulation of signal transduction; and negative regulation of tumor necrosis factor production. Located in nucleoplasm. Implicated in rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: I-kappa-B-like protein; ikappaBL; IKBL; inhibitor of kappa B-like protein; inhibitor of kappa light chain gene enhancer in B cells-like; LST1; NF-kappa-B inhibitor-like protein 1; NFKBIL; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,546,851 - 31,558,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,546,870 - 31,558,829 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,514,628 - 31,526,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,623,351 - 31,634,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,623,350 - 31,634,584NCBI
Celera633,112,858 - 33,124,825 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,301,366 - 31,313,342 (+)NCBIHuRef
CHM1_1631,516,762 - 31,528,738 (+)NCBICHM1_1
T2T-CHM13v2.0631,399,939 - 31,411,908 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Okamoto K, etal., Am J Hum Genet 2003 Feb;72(2):303-12. Epub 2002 Dec 31.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8081366   PMID:8499947   PMID:9480751   PMID:10202016   PMID:10369924   PMID:11113070   PMID:12477932   PMID:12618859   PMID:14574404   PMID:14989711   PMID:15018649   PMID:15843211  
PMID:15969671   PMID:16101831   PMID:16634865   PMID:16644022   PMID:16720219   PMID:16804398   PMID:17119950   PMID:17353931   PMID:17485095   PMID:17517687   PMID:17544510   PMID:17847930  
PMID:17855452   PMID:18029348   PMID:18295675   PMID:18987644   PMID:19143814   PMID:19158815   PMID:19165231   PMID:19242354   PMID:19578685   PMID:19773279   PMID:19851445   PMID:19886988  
PMID:19913121   PMID:20379614   PMID:20568399   PMID:20587610   PMID:20628086   PMID:20662065   PMID:20829348   PMID:20854863   PMID:20933106   PMID:21873635   PMID:21988832   PMID:22210660  
PMID:23128233   PMID:23953137   PMID:25809685   PMID:26186194   PMID:26496610   PMID:27173435   PMID:28031328   PMID:28514442   PMID:30804502   PMID:31162003   PMID:31753913   PMID:32296183  
PMID:32513696   PMID:33961781   PMID:35044719   PMID:35944360   PMID:36398662  


Genomics

Comparative Map Data
NFKBIL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,546,851 - 31,558,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,546,870 - 31,558,829 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,514,628 - 31,526,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,623,351 - 31,634,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,623,350 - 31,634,584NCBI
Celera633,112,858 - 33,124,825 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,301,366 - 31,313,342 (+)NCBIHuRef
CHM1_1631,516,762 - 31,528,738 (+)NCBICHM1_1
T2T-CHM13v2.0631,399,939 - 31,411,908 (+)NCBIT2T-CHM13v2.0
Nfkbil1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,439,151 - 35,455,457 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,439,151 - 35,454,768 (-)EnsemblGRCm39 Ensembl
GRCm381735,220,175 - 35,236,481 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,220,175 - 35,235,792 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,357,120 - 35,372,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,828,227 - 34,843,867 (-)NCBIMGSCv36mm8
Celera1738,316,892 - 38,337,965 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.6NCBI
Nfkbil1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,595,319 - 3,610,295 (+)NCBIGRCr8
mRatBN7.2203,589,974 - 3,608,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,590,642 - 3,605,616 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,290,621 - 4,305,605 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,652,685 - 3,667,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,190,181 - 4,205,242 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,823,590 - 4,839,202 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,822,935 - 4,839,202 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,903,968 - 6,919,602 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,629,246 - 3,644,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,629,467 - 3,644,449 (+)NCBI
Celera204,419,824 - 4,434,802 (-)NCBICelera
Cytogenetic Map20p12NCBI
Nfkbil1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543790,577 - 100,918 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543790,623 - 100,918 (+)NCBIChiLan1.0ChiLan1.0
NFKBIL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,023,790 - 46,041,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,985,346 - 41,997,336 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,207,927 - 31,219,916 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,097,824 - 32,109,944 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,098,554 - 32,109,944 (+)Ensemblpanpan1.1panPan2
NFKBIL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,048,393 - 1,057,458 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,049,109 - 1,057,237 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,185,620 - 1,193,682 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,193,625 - 1,202,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,194,366 - 1,202,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,053,212 - 1,061,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,121,119 - 1,129,138 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,187,867 - 1,195,929 (+)NCBIUU_Cfam_GSD_1.0
Nfkbil1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,597,631 - 35,611,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,950,057 - 1,963,245 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,950,356 - 1,963,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,669,595 - 23,685,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,673,002 - 23,685,089 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,566,956 - 27,578,752 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFKBIL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,428,001 - 40,440,386 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,428,222 - 40,439,433 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,447,986 - 31,460,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbil1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,639,860 - 24,649,968 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,639,757 - 24,652,059 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NFKBIL1
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001144962.2(NFKBIL1):c.-13+590T>A single nucleotide variant Rheumatoid arthritis [RCV000008996] Chr6:31547563 [GRCh38]
Chr6:31515340 [GRCh37]
Chr6:6p21.33		 risk factor
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32		 uncertain significance
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
Chr6:6p21.33-21.31		 likely pathogenic
NC_000006.11:g.(?_30695893)_(31937492_?)dup duplication not provided [RCV003107453] Chr6:30695893..31937492 [GRCh37]
Chr6:6p21.33		 uncertain significance
NC_000006.11:g.28005012_31683185del deletion Megacolon [RCV001290055] Chr6:28005012..31683185 [GRCh37]
Chr6:6p22.1-21.33		 likely pathogenic
GRCh37/hg19 6p21.33(chr6:31384577-31902308) copy number gain not specified [RCV002053564] Chr6:31384577..31902308 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_005007.4(NFKBIL1):c.731G>A (p.Arg244Gln) single nucleotide variant Inborn genetic diseases [RCV002998008] Chr6:31558196 [GRCh38]
Chr6:31525973 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_005007.4(NFKBIL1):c.746G>A (p.Arg249Gln) single nucleotide variant Inborn genetic diseases [RCV002931307] Chr6:31558211 [GRCh38]
Chr6:31525988 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_005007.4(NFKBIL1):c.836C>G (p.Ala279Gly) single nucleotide variant Inborn genetic diseases [RCV003195706] Chr6:31558301 [GRCh38]
Chr6:31526078 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_005007.4(NFKBIL1):c.343G>A (p.Asp115Asn) single nucleotide variant Inborn genetic diseases [RCV003178417] Chr6:31557636 [GRCh38]
Chr6:31525413 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_005007.4(NFKBIL1):c.390A>G (p.Ile130Met) single nucleotide variant Inborn genetic diseases [RCV003384876] Chr6:31557683 [GRCh38]
Chr6:31525460 [GRCh37]
Chr6:6p21.33		 uncertain significance
NM_005007.4(NFKBIL1):c.670C>T (p.Arg224Cys) single nucleotide variant NFKBIL1-related condition [RCV003982120] Chr6:31558135 [GRCh38]
Chr6:31525912 [GRCh37]
Chr6:6p21.33		 benign
NM_005007.4(NFKBIL1):c.752G>A (p.Arg251Gln) single nucleotide variant NFKBIL1-related condition [RCV003904049] Chr6:31558217 [GRCh38]
Chr6:31525994 [GRCh37]
Chr6:6p21.33		 benign
NM_005007.4(NFKBIL1):c.814C>G (p.Arg272Gly) single nucleotide variant NFKBIL1-related condition [RCV003979435] Chr6:31558279 [GRCh38]
Chr6:31526056 [GRCh37]
Chr6:6p21.33		 likely benign
NM_005007.4(NFKBIL1):c.378C>T (p.Ser126=) single nucleotide variant NFKBIL1-related condition [RCV003977248] Chr6:31557671 [GRCh38]
Chr6:31525448 [GRCh37]
Chr6:6p21.33		 benign
NC_000006.11:g.(?_30695893)_(36953949_?)dup duplication Proteasome-associated autoinflammatory syndrome 1 [RCV003113679] Chr6:30695893..36953949 [GRCh37]
Chr6:6p21.33-21.2		 uncertain significance
GRCh37/hg19 6p21.33(chr6:31384577-31902308)x3 copy number gain See cases [RCV000448679] Chr6:31384577..31902308 [GRCh37]
Chr6:6p21.33		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_005007.4(NFKBIL1):c.725A>G (p.Glu242Gly) single nucleotide variant Inborn genetic diseases [RCV003249301] Chr6:31558190 [GRCh38]
Chr6:31525967 [GRCh37]
Chr6:6p21.33		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1375
Count of miRNA genes:561
Interacting mature miRNAs:639
Transcripts:ENST00000376145, ENST00000376146, ENST00000376148, ENST00000473655, ENST00000496233
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH46868  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,526,427 - 31,526,580UniSTSGRCh37
Build 36631,634,406 - 31,634,559RGDNCBI36
Celera633,124,646 - 33,124,799RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,313,163 - 31,313,316UniSTS
GeneMap99-GB4 RH Map6120.15UniSTS
STS-X77909  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,526,360 - 31,526,595UniSTSGRCh37
Build 36631,634,339 - 31,634,574RGDNCBI36
Celera633,124,579 - 33,124,814RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,313,096 - 31,313,331UniSTS
GeneMap99-GB4 RH Map6119.82UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2423 2367 1612 518 1718 359 4256 1808 3304 397 1456 1610 175 1 1193 2688 5 2
Low 16 624 114 106 231 106 101 389 430 22 4 3 11 100 1
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001144961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001144962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001144963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB088115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB103621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB202112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF098268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF236169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM044744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX001040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX927320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR753892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR942185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC370256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF477889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF477890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF477891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF477892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF477893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y14768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000376145   ⟹   ENSP00000365315
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,547,613 - 31,558,829 (+)Ensembl
RefSeq Acc Id: ENST00000376146   ⟹   ENSP00000365316
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,546,870 - 31,558,829 (+)Ensembl
RefSeq Acc Id: ENST00000376148   ⟹   ENSP00000365318
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,547,608 - 31,558,829 (+)Ensembl
RefSeq Acc Id: ENST00000473655
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,547,661 - 31,557,959 (+)Ensembl
RefSeq Acc Id: ENST00000496233   ⟹   ENSP00000437148
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl631,547,640 - 31,557,705 (+)Ensembl
RefSeq Acc Id: NM_001144961   ⟹   NP_001138433
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,547,608 - 31,558,829 (+)NCBI
GRCh37631,514,628 - 31,526,606 (+)ENTREZGENE
HuRef631,301,366 - 31,313,342 (+)ENTREZGENE
CHM1_1631,517,486 - 31,528,738 (+)NCBI
T2T-CHM13v2.0631,400,695 - 31,411,908 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001144962   ⟹   NP_001138434
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,546,851 - 31,558,829 (+)NCBI
GRCh37631,514,628 - 31,526,606 (+)ENTREZGENE
HuRef631,301,366 - 31,313,342 (+)ENTREZGENE
CHM1_1631,516,762 - 31,528,738 (+)NCBI
T2T-CHM13v2.0631,399,939 - 31,411,908 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001144963   ⟹   NP_001138435
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,546,851 - 31,558,829 (+)NCBI
GRCh37631,514,628 - 31,526,606 (+)ENTREZGENE
HuRef631,301,366 - 31,313,342 (+)ENTREZGENE
CHM1_1631,516,762 - 31,528,738 (+)NCBI
T2T-CHM13v2.0631,399,939 - 31,411,908 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005007   ⟹   NP_004998
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,547,608 - 31,558,829 (+)NCBI
GRCh37631,514,628 - 31,526,606 (+)ENTREZGENE
Build 36631,623,351 - 31,634,585 (+)NCBI Archive
HuRef631,301,366 - 31,313,342 (+)ENTREZGENE
CHM1_1631,517,486 - 31,528,738 (+)NCBI
T2T-CHM13v2.0631,400,695 - 31,411,908 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001138433 (Get FASTA)   NCBI Sequence Viewer  
  NP_001138434 (Get FASTA)   NCBI Sequence Viewer  
  NP_001138435 (Get FASTA)   NCBI Sequence Viewer  
  NP_004998 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD38108 (Get FASTA)   NCBI Sequence Viewer  
  AAD38109 (Get FASTA)   NCBI Sequence Viewer  
  AAD38110 (Get FASTA)   NCBI Sequence Viewer  
  AAD38111 (Get FASTA)   NCBI Sequence Viewer  
  AAD38112 (Get FASTA)   NCBI Sequence Viewer  
  AAD38113 (Get FASTA)   NCBI Sequence Viewer  
  AAD38114 (Get FASTA)   NCBI Sequence Viewer  
  AAD38115 (Get FASTA)   NCBI Sequence Viewer  
  AAD38116 (Get FASTA)   NCBI Sequence Viewer  
  AAD38117 (Get FASTA)   NCBI Sequence Viewer  
  AAD38118 (Get FASTA)   NCBI Sequence Viewer  
  AAI05065 (Get FASTA)   NCBI Sequence Viewer  
  AAI05069 (Get FASTA)   NCBI Sequence Viewer  
  AAI43672 (Get FASTA)   NCBI Sequence Viewer  
  AQY76956 (Get FASTA)   NCBI Sequence Viewer  
  AQY76957 (Get FASTA)   NCBI Sequence Viewer  
  AQY76958 (Get FASTA)   NCBI Sequence Viewer  
  AQY76959 (Get FASTA)   NCBI Sequence Viewer  
  ASZ70076 (Get FASTA)   NCBI Sequence Viewer  
  ASZ70077 (Get FASTA)   NCBI Sequence Viewer  
  ASZ70078 (Get FASTA)   NCBI Sequence Viewer  
  ASZ70079 (Get FASTA)   NCBI Sequence Viewer  
  ASZ70080 (Get FASTA)   NCBI Sequence Viewer  
  BAB63398 (Get FASTA)   NCBI Sequence Viewer  
  BAC54951 (Get FASTA)   NCBI Sequence Viewer  
  BAE78635 (Get FASTA)   NCBI Sequence Viewer  
  BAF31285 (Get FASTA)   NCBI Sequence Viewer  
  BAF84582 (Get FASTA)   NCBI Sequence Viewer  
  BAG62473 (Get FASTA)   NCBI Sequence Viewer  
  CAA54867 (Get FASTA)   NCBI Sequence Viewer  
  CAA75072 (Get FASTA)   NCBI Sequence Viewer  
  EAX03417 (Get FASTA)   NCBI Sequence Viewer  
  EAX03418 (Get FASTA)   NCBI Sequence Viewer  
  EAX03419 (Get FASTA)   NCBI Sequence Viewer  
  EAX03420 (Get FASTA)   NCBI Sequence Viewer  
  EAX03421 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000365315
  ENSP00000365315.4
  ENSP00000365316
  ENSP00000365316.4
  ENSP00000365318
  ENSP00000365318.4
  ENSP00000372992.4
  ENSP00000383137.3
  ENSP00000383142.3
  ENSP00000394486.2
  ENSP00000395544.2
  ENSP00000395977.2
  ENSP00000396656.2
  ENSP00000399871.2
  ENSP00000401830.2
  ENSP00000404901.2
  ENSP00000407809.2
  ENSP00000408426.2
  ENSP00000411174.2
  ENSP00000411611.2
  ENSP00000413643.2
  ENSP00000413952.2
  ENSP00000414084.2
  ENSP00000414206.2
  ENSP00000433434.1
  ENSP00000435404.1
  ENSP00000437148.1
GenBank Protein Q9UBC1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001138434   ⟸   NM_001144962
- Peptide Label: isoform 3
- UniProtKB: Q5STV6 (UniProtKB/TrEMBL),   Q5ST97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138435   ⟸   NM_001144963
- Peptide Label: isoform 4
- UniProtKB: A0A1U9X847 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_004998   ⟸   NM_005007
- Peptide Label: isoform 1
- UniProtKB: Q5STV5 (UniProtKB/Swiss-Prot),   Q5STV4 (UniProtKB/Swiss-Prot),   Q5ST96 (UniProtKB/Swiss-Prot),   Q5RJ72 (UniProtKB/Swiss-Prot),   Q5HYU4 (UniProtKB/Swiss-Prot),   Q14625 (UniProtKB/Swiss-Prot),   B4DUW1 (UniProtKB/Swiss-Prot),   A6NL91 (UniProtKB/Swiss-Prot),   Q9UBX4 (UniProtKB/Swiss-Prot),   Q9UBC1 (UniProtKB/Swiss-Prot),   Q5ST97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138433   ⟸   NM_001144961
- Peptide Label: isoform 2
- UniProtKB: A0A0A0MRT5 (UniProtKB/TrEMBL),   A0A1U9X847 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000365316   ⟸   ENST00000376146
RefSeq Acc Id: ENSP00000365315   ⟸   ENST00000376145
RefSeq Acc Id: ENSP00000365318   ⟸   ENST00000376148
RefSeq Acc Id: ENSP00000437148   ⟸   ENST00000496233

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UBC1-F1-model_v2 AlphaFold Q9UBC1 1-381 view protein structure

Promoters
RGD ID:6872508
Promoter ID:EPDNEW_H9419
Type:initiation region
Name:NFKBIL1_2
Description:NFKB inhibitor like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9420  EPDNEW_H9421  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,546,949 - 31,547,009EPDNEW
RGD ID:6872510
Promoter ID:EPDNEW_H9420
Type:initiation region
Name:NFKBIL1_1
Description:NFKB inhibitor like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9419  EPDNEW_H9421  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,547,609 - 31,547,669EPDNEW
RGD ID:6872512
Promoter ID:EPDNEW_H9421
Type:initiation region
Name:NFKBIL1_3
Description:NFKB inhibitor like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9419  EPDNEW_H9420  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,548,109 - 31,548,169EPDNEW
RGD ID:6804190
Promoter ID:HG_KWN:52933
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000303892,   ENST00000376146,   ENST00000376151,   NM_001144963,   NM_138282,   OTTHUMT00000259096,   UC003NTV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,622,211 - 31,622,711 (-)MPROMDB
RGD ID:6804497
Promoter ID:HG_KWN:52934
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000376145,   ENST00000376147,   OTTHUMT00000076036,   OTTHUMT00000076038,   OTTHUMT00000259082
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,622,741 - 31,623,417 (+)MPROMDB
RGD ID:6852786
Promoter ID:EP74208
Type:initiation region
Name:HS_NFKBIL1
Description:Nuclear factor of kappa light polypeptide gene enhancer in B-cellsinhibitor-like 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,623,865 - 31,623,925EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7800 AgrOrtholog
COSMIC NFKBIL1 COSMIC
Ensembl Genes ENSG00000204498 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000206440 UniProtKB/Swiss-Prot
  ENSG00000227565 UniProtKB/Swiss-Prot
  ENSG00000234530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000235125 UniProtKB/Swiss-Prot
  ENSG00000236196 UniProtKB/Swiss-Prot
  ENSG00000236346 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000376145 ENTREZGENE
  ENST00000376145.8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000376146 ENTREZGENE
  ENST00000376146.8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000376148 ENTREZGENE
  ENST00000376148.9 UniProtKB/Swiss-Prot
  ENST00000383500.4 UniProtKB/Swiss-Prot
  ENST00000400279.7 UniProtKB/Swiss-Prot
  ENST00000400285.7 UniProtKB/Swiss-Prot
  ENST00000414391.6 UniProtKB/Swiss-Prot
  ENST00000419122.6 UniProtKB/Swiss-Prot
  ENST00000419623.6 UniProtKB/Swiss-Prot
  ENST00000421396.2 UniProtKB/Swiss-Prot
  ENST00000424652.6 UniProtKB/Swiss-Prot
  ENST00000428467.6 UniProtKB/Swiss-Prot
  ENST00000430501.2 UniProtKB/Swiss-Prot
  ENST00000430961.6 UniProtKB/Swiss-Prot
  ENST00000432160.6 UniProtKB/Swiss-Prot
  ENST00000434332.6 UniProtKB/Swiss-Prot
  ENST00000442947.6 UniProtKB/Swiss-Prot
  ENST00000451911.2 UniProtKB/Swiss-Prot
  ENST00000453377.6 UniProtKB/Swiss-Prot
  ENST00000455376.6 UniProtKB/Swiss-Prot
  ENST00000456607.6 UniProtKB/Swiss-Prot
  ENST00000460131.1 UniProtKB/TrEMBL
  ENST00000468464.1 UniProtKB/TrEMBL
  ENST00000496233.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204498 GTEx
  ENSG00000206440 GTEx
  ENSG00000227565 GTEx
  ENSG00000234530 GTEx
  ENSG00000235125 GTEx
  ENSG00000236196 GTEx
  ENSG00000236346 GTEx
HGNC ID HGNC:7800 ENTREZGENE
Human Proteome Map NFKBIL1 Human Proteome Map
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NFKBIL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4795 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4795 ENTREZGENE
OMIM 601022 OMIM
PANTHER NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15263 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31604 PharmGKB
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MRT5 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TA04_HUMAN UniProtKB/TrEMBL
  A0A1U9X847 ENTREZGENE, UniProtKB/TrEMBL
  A0A286SD72_HUMAN UniProtKB/TrEMBL
  A0A286SD75_HUMAN UniProtKB/TrEMBL
  A0A286SD76_HUMAN UniProtKB/TrEMBL
  A0A286SD77_HUMAN UniProtKB/TrEMBL
  A0A286SD81_HUMAN UniProtKB/TrEMBL
  A6NL91 ENTREZGENE
  A8K778_HUMAN UniProtKB/TrEMBL
  B4DUW1 ENTREZGENE
  F2Z390_HUMAN UniProtKB/TrEMBL
  IKBL1_HUMAN UniProtKB/Swiss-Prot
  Q14625 ENTREZGENE
  Q5HYU4 ENTREZGENE
  Q5RJ72 ENTREZGENE
  Q5ST96 ENTREZGENE
  Q5ST97 ENTREZGENE, UniProtKB/TrEMBL
  Q5STV4 ENTREZGENE
  Q5STV5 ENTREZGENE
  Q5STV6 ENTREZGENE, UniProtKB/TrEMBL
  Q9UBC1 ENTREZGENE
  Q9UBX4 ENTREZGENE
UniProt Secondary A6NL91 UniProtKB/Swiss-Prot
  B4DUW1 UniProtKB/Swiss-Prot
  Q14625 UniProtKB/Swiss-Prot
  Q5HYU4 UniProtKB/Swiss-Prot
  Q5RJ72 UniProtKB/Swiss-Prot
  Q5ST96 UniProtKB/Swiss-Prot
  Q5STV4 UniProtKB/Swiss-Prot
  Q5STV5 UniProtKB/Swiss-Prot
  Q9UBX4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 NFKBIL1  NFKB inhibitor like 1  NFKBIL1  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1  Symbol and/or name change 5135510 APPROVED