MIR15B (microRNA 15b) - Rat Genome Database

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Gene: MIR15B (microRNA 15b) Homo sapiens
Analyze
Symbol: MIR15B
Name: microRNA 15b
RGD ID: 1343014
HGNC Page HGNC:31544
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including negative regulation of cell migration; negative regulation of endothelial cell proliferation; and regulation of translation. Located in extracellular space. Part of extracellular vesicle.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-15b; miR-15b; MIRN15B
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383160,404,588 - 160,404,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3160,404,588 - 160,404,685 (+)EnsemblGRCh38hg38GRCh38
GRCh373160,122,376 - 160,122,473 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,605,069 - 161,605,166 (+)NCBINCBI36hg18NCBI36
Celera3158,543,743 - 158,543,840 (+)NCBI
Cytogenetic Map3q25.33NCBI
HuRef3157,520,958 - 157,521,055 (+)NCBIHuRef
CHM1_13160,085,265 - 160,085,362 (+)NCBICHM1_1
T2T-CHM13v2.03163,179,200 - 163,179,297 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in blood vessel morphogenesis  (IMP)
cardiac muscle hypertrophy  (ISS)
cellular response to amino acid stimulus  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular senescence  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
miRNA-mediated gene silencing  (HDA,IDA,IEA)
miRNA-mediated gene silencing by inhibition of translation  (IDA,IGI)
negative regulation of amyloid precursor protein catabolic process  (IDA)
negative regulation of amyloid-beta formation  (IDA)
negative regulation of angiogenesis  (IDA,ISS)
negative regulation of blood vessel endothelial cell migration  (IDA,IMP)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA)
negative regulation of cell population proliferation  (IGI)
negative regulation of cellular response to insulin stimulus  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (IDA)
negative regulation of glycogen biosynthetic process  (IMP)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
negative regulation of inflammatory response  (IGI)
negative regulation of insulin receptor signaling pathway  (IMP)
negative regulation of mitotic cell cycle  (ISS)
negative regulation of neuron apoptotic process  (IGI)
negative regulation of NIK/NF-kappaB signaling  (IGI)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISS)
negative regulation of trophoblast cell migration  (IDA)
negative regulation of vascular associated smooth muscle cell differentiation  (IMP)
negative regulation of vascular endothelial cell proliferation  (IDA)
negative regulation of vascular endothelial growth factor production  (HMP)
negative regulation of wound healing  (IMP)
positive regulation of apoptotic process  (IDA)
positive regulation of connective tissue replacement  (ISS)
positive regulation of translation  (IGI)
response to bacterium  (ISO)
response to oxygen levels  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation. Ito N, etal., Br J Pharmacol. 2017 Mar;174(5):386-395. doi: 10.1111/bph.13698. Epub 2017 Jan 23.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
Additional References at PubMed
PMID:12007417   PMID:12554860   PMID:14573789   PMID:16381832   PMID:17604727   PMID:17616659   PMID:18320040   PMID:18449891   PMID:18548003   PMID:19135980   PMID:19956871   PMID:21037258  
PMID:21454377   PMID:21725369   PMID:22045185   PMID:22139073   PMID:22613985   PMID:23287814   PMID:23487264   PMID:23688497   PMID:23907579   PMID:24122375   PMID:24152911   PMID:24435757  
PMID:24995320   PMID:25092292   PMID:25103110   PMID:25155861   PMID:25261849   PMID:25329674   PMID:25403480   PMID:25594541   PMID:25708817   PMID:25721211   PMID:25783158   PMID:25888955  
PMID:25901555   PMID:26007664   PMID:26023735   PMID:26087886   PMID:26119771   PMID:26144250   PMID:26166038   PMID:26179126   PMID:26191187   PMID:26202983   PMID:26324892   PMID:26440600  
PMID:26586400   PMID:26646931   PMID:26676972   PMID:26743779   PMID:26884837   PMID:26931521   PMID:26959556   PMID:27027998   PMID:27082313   PMID:27195958   PMID:27208409   PMID:27380148  
PMID:27499071   PMID:27530410   PMID:27663089   PMID:27896672   PMID:28145098   PMID:28184024   PMID:28228555   PMID:28254819   PMID:28289072   PMID:28350138   PMID:28431233   PMID:28498424  
PMID:28523344   PMID:28560431   PMID:28646148   PMID:28798470   PMID:28835435   PMID:28923398   PMID:29207665   PMID:29217406   PMID:29323737   PMID:29363862   PMID:29528396   PMID:29930741  
PMID:29961672   PMID:30093112   PMID:30423818   PMID:30442369   PMID:30449704   PMID:30521861   PMID:30543848   PMID:30684575   PMID:30701698   PMID:30753902   PMID:30796205   PMID:30850365  
PMID:30965092   PMID:31330194   PMID:31637848   PMID:31638225   PMID:31737898   PMID:31799643   PMID:31858826   PMID:32016977   PMID:32049388   PMID:32220063   PMID:32341409   PMID:32635759  
PMID:32713026   PMID:32797181   PMID:32945458   PMID:33080309   PMID:33105440   PMID:33112434   PMID:33198785   PMID:33208053   PMID:33277569   PMID:33462141   PMID:33506036   PMID:33545201  
PMID:33760109   PMID:33836616   PMID:34224334   PMID:34263708   PMID:34752173   PMID:34791478   PMID:34955516   PMID:35137664   PMID:35156506   PMID:35452205  


Genomics

Comparative Map Data
MIR15B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383160,404,588 - 160,404,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3160,404,588 - 160,404,685 (+)EnsemblGRCh38hg38GRCh38
GRCh373160,122,376 - 160,122,473 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,605,069 - 161,605,166 (+)NCBINCBI36hg18NCBI36
Celera3158,543,743 - 158,543,840 (+)NCBI
Cytogenetic Map3q25.33NCBI
HuRef3157,520,958 - 157,521,055 (+)NCBIHuRef
CHM1_13160,085,265 - 160,085,362 (+)NCBICHM1_1
T2T-CHM13v2.03163,179,200 - 163,179,297 (+)NCBI
Mir15b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39368,917,105 - 68,917,168 (+)NCBIGRCm39mm39
GRCm39 Ensembl368,917,105 - 68,917,168 (+)Ensembl
GRCm38369,009,772 - 69,009,835 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,009,772 - 69,009,835 (+)EnsemblGRCm38mm10GRCm38
MGSCv37368,813,694 - 68,813,757 (+)NCBIGRCm37mm9NCBIm37
Celera369,117,586 - 69,117,649 (+)NCBICelera
Cytogenetic Map3E1NCBI
Mir15b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22153,245,200 - 153,245,297 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2153,245,200 - 153,245,297 (+)Ensembl
Rnor_6.02165,605,923 - 165,606,020 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,605,923 - 165,606,020 (+)EnsemblRnor6.0rn6Rnor6.0
Celera2147,596,000 - 147,596,097 (+)NCBICelera
Cytogenetic Map2q32NCBI
MIR15B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,460,663 - 26,460,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,460,645 - 26,460,741 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,502,808 - 30,502,867 (+)NCBI
ROS_Cfam_1.03426,517,327 - 26,517,386 (+)NCBI
ROS_Cfam_1.0 Ensembl3426,517,309 - 26,517,405 (+)Ensembl
UMICH_Zoey_3.13426,447,008 - 26,447,067 (+)NCBI
UNSW_CanFamBas_1.03426,407,665 - 26,407,724 (+)NCBI
UU_Cfam_GSD_1.03426,647,752 - 26,647,811 (+)NCBI
MIR15B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13100,083,172 - 100,083,269 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113100,083,172 - 100,083,269 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,388,133 - 108,388,230 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
RND2hsa-miR-15b-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CCNE1hsa-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19135980
CCNE1hsa-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18794849
RECKhsa-miR-15b-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assayFunctional MTI20154725
BCL2hsa-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI18449891
CCND1hsa-miR-15b-5pMirtarbaseexternal_infoqRT-PCR//Western blotNon-Functional MTI19135980
VEGFAhsa-miR-15b-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayFunctional MTI18320040
EIF4A1hsa-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI16609010
IFNGhsa-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22379033
PURAhsa-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22835829
MAP2K4hsa-miR-15b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
BCL2hsa-miR-15b-5pTarbaseexternal_infoReporter GenePOSITIVE
BCL2hsa-miR-15b-5pMirecordsexternal_info{unchanged}NA18449891
RECKhsa-miR-15b-5pMirecordsexternal_info{unchanged}NA20154725
MAP2K4hsa-miR-15b-5pMirecordsexternal_info{unchanged}NA19861690
BMI1hsa-miR-15b-5pMirecordsexternal_infoNANA21725369
SUZ12hsa-miR-15b-5pOncomiRDBexternal_infoNANA22908280
BMI1hsa-miR-15b-5pOncomiRDBexternal_infoNANA21725369
CCND1hsa-miR-15b-5pOncomiRDBexternal_infoNANA21629246
CCNE1hsa-miR-15b-5pOncomiRDBexternal_infoNANA19135980
BCL2hsa-miR-15b-5pOncomiRDBexternal_infoNANA18449891
BCL2hsa-miR-15b-5pOncomiRDBexternal_infoNANA16166262

Predicted Targets
Summary Value
Count of predictions:42523
Count of gene targets:14591
Count of transcripts:31755
Interacting mature miRNAs:hsa-miR-15b-3p, hsa-miR-15b-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 3 3
Low 4 19 3 2 36 2 12 2 5 2 9 8 6 1
Below cutoff 15 12 4 38 1 18 16 19 6 20 12 2 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385045
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3160,404,588 - 160,404,685 (+)Ensembl
RefSeq Acc Id: NR_029663
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383160,404,588 - 160,404,685 (+)NCBI
GRCh373160,122,376 - 160,122,473 (+)RGD
Celera3158,543,743 - 158,543,840 (+)RGD
HuRef3157,520,958 - 157,521,055 (+)ENTREZGENE
CHM1_13160,085,265 - 160,085,362 (+)NCBI
T2T-CHM13v2.03163,179,200 - 163,179,297 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q25.1-29(chr3:152100512-198118383)x3 copy number gain See cases [RCV000139435] Chr3:152100512..198118383 [GRCh38]
Chr3:151818301..197845254 [GRCh37]
Chr3:153300991..199329651 [NCBI36]
Chr3:3q25.1-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156321878-198113452)x3 copy number gain See cases [RCV000140849] Chr3:156321878..198113452 [GRCh38]
Chr3:156039667..197840323 [GRCh37]
Chr3:157522361..199324720 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156118441-198125115)x3 copy number gain See cases [RCV000142310] Chr3:156118441..198125115 [GRCh38]
Chr3:155836230..197851986 [GRCh37]
Chr3:157318924..199336383 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.32-26.31(chr3:158141556-172788324)x3 copy number gain See cases [RCV000051735] Chr3:158141556..172788324 [GRCh38]
Chr3:157859345..172506114 [GRCh37]
Chr3:159342039..173988808 [NCBI36]
Chr3:3q25.32-26.31
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
GRCh38/hg38 3q25.33-26.1(chr3:159748682-161533654)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051538]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051538]|See cases [RCV000051538] Chr3:159748682..161533654 [GRCh38]
Chr3:159466471..161251442 [GRCh37]
Chr3:160949165..162734136 [NCBI36]
Chr3:3q25.33-26.1
uncertain significance
GRCh38/hg38 3q24-26.32(chr3:147442566-178522531)x3 copy number gain See cases [RCV000051724] Chr3:147442566..178522531 [GRCh38]
Chr3:147160353..178240319 [GRCh37]
Chr3:148643043..179723013 [NCBI36]
Chr3:3q24-26.32
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:157293378-198134727)x3 copy number gain See cases [RCV000051726] Chr3:157293378..198134727 [GRCh38]
Chr3:157011167..197861598 [GRCh37]
Chr3:158493861..199345995 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.33(chr3:160060060-160985414)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053998]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053998]|See cases [RCV000053998] Chr3:160060060..160985414 [GRCh38]
Chr3:159777847..160703202 [GRCh37]
Chr3:161260541..162185896 [NCBI36]
Chr3:3q25.33
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31544 AgrOrtholog
COSMIC MIR15B COSMIC
Ensembl Genes ENSG00000207779 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385045 ENTREZGENE
GTEx ENSG00000207779 GTEx
HGNC ID HGNC:31544 ENTREZGENE
Human Proteome Map MIR15B Human Proteome Map
miRBase MI0000438 ENTREZGENE
NCBI Gene 406949 ENTREZGENE
OMIM 619572 OMIM
PharmGKB PA164722517 PharmGKB
RNAcentral URS000041CB9C RNACentral
  URS000045A9D7 RNACentral
  URS00004AD914 RNACentral