CUL1 (cullin 1) - Rat Genome Database

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Gene: CUL1 (cullin 1) Homo sapiens
Analyze
Symbol: CUL1
Name: cullin 1
RGD ID: 1317768
HGNC Page HGNC
Description: Predicted to have ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Localizes to Parkin-FBXW7-Cul1 ubiquitin ligase complex; SCF ubiquitin ligase complex; and plasma membrane; PARTICIPATES IN neddylation pathway; Notch signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; aflatoxin B1; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CUL-1; cullin-1; MGC149834; MGC149835
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CUL1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7148,697,914 - 148,801,110 (+)EnsemblGRCh38hg38GRCh38
GRCh387148,697,756 - 148,801,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377148,394,848 - 148,498,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,026,866 - 148,129,135 (+)NCBINCBI36hg18NCBI36
Build 347147,833,580 - 147,935,849NCBI
Celera7143,066,358 - 143,168,625 (+)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7142,474,925 - 142,577,198 (+)NCBIHuRef
CHM1_17148,404,339 - 148,506,599 (+)NCBICHM1_1
CRA_TCAGchr7v27147,733,888 - 147,836,155 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8681378   PMID:8889548   PMID:9430629   PMID:9636170   PMID:9663463   PMID:9736735   PMID:9827542   PMID:9990852   PMID:10023660   PMID:10066435   PMID:10230406   PMID:10230407  
PMID:10321728   PMID:10531035   PMID:10559858   PMID:10559916   PMID:10597293   PMID:10644755   PMID:10648623   PMID:10713156   PMID:10748083   PMID:10790373   PMID:10851089   PMID:11027288  
PMID:11032804   PMID:11076863   PMID:11158290   PMID:11230166   PMID:11231585   PMID:11245432   PMID:11337588   PMID:11359933   PMID:11384984   PMID:11445862   PMID:11483504   PMID:11506706  
PMID:11565034   PMID:11585921   PMID:11689688   PMID:11717410   PMID:11850407   PMID:11861641   PMID:11956208   PMID:11961546   PMID:11967155   PMID:12140560   PMID:12234927   PMID:12417738  
PMID:12477932   PMID:12481031   PMID:12504025   PMID:12504026   PMID:12565873   PMID:12609982   PMID:12628165   PMID:12628923   PMID:12679038   PMID:12684064   PMID:12690205   PMID:12706828  
PMID:12717421   PMID:12759363   PMID:12769844   PMID:12791267   PMID:12820959   PMID:12840033   PMID:12853948   PMID:12861003   PMID:12904573   PMID:14508008   PMID:14603323   PMID:14673179  
PMID:14681206   PMID:14685242   PMID:14702039   PMID:14743216   PMID:14752276   PMID:15103331   PMID:15118074   PMID:15145941   PMID:15361859   PMID:15448697   PMID:15452136   PMID:15456869  
PMID:15469984   PMID:15489334   PMID:15489336   PMID:15536641   PMID:15537541   PMID:15604093   PMID:15640526   PMID:15759013   PMID:15798217   PMID:15966899   PMID:16009132   PMID:16036220  
PMID:16045761   PMID:16051867   PMID:16103149   PMID:16123585   PMID:16123592   PMID:16137618   PMID:16196087   PMID:16275325   PMID:16278047   PMID:16357137   PMID:16381901   PMID:16410731  
PMID:16503656   PMID:16620772   PMID:16714087   PMID:16759355   PMID:16774918   PMID:16797541   PMID:16861300   PMID:16880511   PMID:17015689   PMID:17028207   PMID:17079684   PMID:17081987  
PMID:17098746   PMID:17148452   PMID:17205132   PMID:17215248   PMID:17254749   PMID:17274640   PMID:17290223   PMID:17318178   PMID:17353931   PMID:17389604   PMID:17429597   PMID:17438373  
PMID:17439941   PMID:17452440   PMID:17463251   PMID:17494702   PMID:17550899   PMID:17569795   PMID:17704768   PMID:17914462   PMID:18056411   PMID:18071316   PMID:18094045   PMID:18173839  
PMID:18203720   PMID:18239684   PMID:18264111   PMID:18274552   PMID:18354482   PMID:18378770   PMID:18495667   PMID:18606781   PMID:18644861   PMID:18650423   PMID:18660753   PMID:18667692  
PMID:18723677   PMID:18765672   PMID:18775313   PMID:18784078   PMID:18805092   PMID:18809579   PMID:18818696   PMID:18826954   PMID:18851830   PMID:18929646   PMID:19028597   PMID:19037258  
PMID:19066453   PMID:19141280   PMID:19150432   PMID:19193609   PMID:19245792   PMID:19250909   PMID:19256485   PMID:19270694   PMID:19295130   PMID:19349673   PMID:19398581   PMID:19509332  
PMID:19581926   PMID:19596235   PMID:19615732   PMID:19617556   PMID:19656241   PMID:19679553   PMID:19713960   PMID:19738611   PMID:19762596   PMID:19762597   PMID:19779646   PMID:19786724  
PMID:19808933   PMID:19933270   PMID:19935701   PMID:19942853   PMID:19945379   PMID:19966869   PMID:20068069   PMID:20160477   PMID:20190741   PMID:20198633   PMID:20379614   PMID:20399188  
PMID:20467437   PMID:20473970   PMID:20518860   PMID:20596027   PMID:20638939   PMID:20708156   PMID:20832730   PMID:20847044   PMID:20878082   PMID:21102408   PMID:21119685   PMID:21130766  
PMID:21135578   PMID:21145461   PMID:21169563   PMID:21190721   PMID:21205095   PMID:21247897   PMID:21249194   PMID:21572392   PMID:21572988   PMID:21640084   PMID:21725316   PMID:21738080  
PMID:21757720   PMID:21765416   PMID:21778237   PMID:21813641   PMID:21873635   PMID:21903097   PMID:21946088   PMID:21988832   PMID:22013077   PMID:22017875   PMID:22113614   PMID:22190034  
PMID:22190037   PMID:22268729   PMID:22310285   PMID:22388891   PMID:22399757   PMID:22405651   PMID:22450327   PMID:22464731   PMID:22466964   PMID:22474075   PMID:22479149   PMID:22524983  
PMID:22590978   PMID:22632967   PMID:22660580   PMID:22674379   PMID:22711876   PMID:22730322   PMID:22748924   PMID:22767593   PMID:22822056   PMID:22851693   PMID:22863883   PMID:22939624  
PMID:22939629   PMID:22956996   PMID:22959436   PMID:22972877   PMID:22975506   PMID:23019411   PMID:23027877   PMID:23108047   PMID:23109433   PMID:23201271   PMID:23213463   PMID:23263282  
PMID:23297342   PMID:23319600   PMID:23322298   PMID:23324393   PMID:23408908   PMID:23429288   PMID:23452855   PMID:23452856   PMID:23453757   PMID:23469015   PMID:23554956   PMID:23563313  
PMID:23589227   PMID:23592700   PMID:23624913   PMID:23658844   PMID:23770852   PMID:23776465   PMID:23868976   PMID:23951410   PMID:23972993   PMID:24035498   PMID:24076655   PMID:24082123  
PMID:24085301   PMID:24157836   PMID:24192928   PMID:24211582   PMID:24269809   PMID:24318128   PMID:24332808   PMID:24349473   PMID:24390425   PMID:24457600   PMID:24469040   PMID:24500709  
PMID:24657926   PMID:24700029   PMID:24767980   PMID:24778179   PMID:24785407   PMID:24793136   PMID:24794231   PMID:24804778   PMID:24811749   PMID:24819753   PMID:24912918   PMID:24949976  
PMID:24973710   PMID:25143387   PMID:25144743   PMID:25201578   PMID:25241761   PMID:25249620   PMID:25332235   PMID:25349211   PMID:25411243   PMID:25425648   PMID:25435324   PMID:25488749  
PMID:25505247   PMID:25515538   PMID:25582197   PMID:25585578   PMID:25593308   PMID:25609649   PMID:25652886   PMID:25654763   PMID:25670854   PMID:25720964   PMID:25756610   PMID:25900982  
PMID:25921289   PMID:25970626   PMID:25973042   PMID:26085330   PMID:26087183   PMID:26097587   PMID:26112410   PMID:26124079   PMID:26124108   PMID:26186194   PMID:26265931   PMID:26344197  
PMID:26400522   PMID:26474281   PMID:26496610   PMID:26511642   PMID:26540345   PMID:26631746   PMID:26632597   PMID:26638075   PMID:26666832   PMID:26717892   PMID:26725323   PMID:26753747  
PMID:26774286   PMID:26790640   PMID:26885983   PMID:26906416   PMID:26972000   PMID:26976582   PMID:26976604   PMID:27001857   PMID:27029215   PMID:27234298   PMID:27312089   PMID:27348078  
PMID:27365398   PMID:27383304   PMID:27432908   PMID:27449035   PMID:27462432   PMID:27497298   PMID:27503909   PMID:27542266   PMID:27565346   PMID:27568981   PMID:27591266   PMID:27609421  
PMID:27677741   PMID:27684187   PMID:27697867   PMID:27705803   PMID:27716508   PMID:27754753   PMID:27773672   PMID:27774986   PMID:27780719   PMID:27833851   PMID:27910872   PMID:28007894  
PMID:28049764   PMID:28090088   PMID:28152074   PMID:28180282   PMID:28229514   PMID:28269751   PMID:28315506   PMID:28443643   PMID:28475037   PMID:28514442   PMID:28522751   PMID:28560438  
PMID:28581483   PMID:28599312   PMID:28614300   PMID:28715492   PMID:28776569   PMID:28805820   PMID:28883095   PMID:28923850   PMID:28954236   PMID:28977802   PMID:29053956   PMID:29070679  
PMID:29103612   PMID:29137415   PMID:29142209   PMID:29149593   PMID:29160310   PMID:29229926   PMID:29331416   PMID:29370161   PMID:29395067   PMID:29408378   PMID:29420262   PMID:29435596  
PMID:29467282   PMID:29497989   PMID:29499133   PMID:29507620   PMID:29507755   PMID:29564676   PMID:29695787   PMID:29863914   PMID:29871923   PMID:29884807   PMID:29945959   PMID:29958295  
PMID:30018425   PMID:30177679   PMID:30190310   PMID:30240640   PMID:30258100   PMID:30349055   PMID:30428154   PMID:30526252   PMID:30575818   PMID:30578411   PMID:30587576   PMID:30653357  
PMID:30655559   PMID:30659753   PMID:30685895   PMID:30714168   PMID:30804394   PMID:30804502   PMID:30833792   PMID:30940648   PMID:30948266   PMID:31043584   PMID:31091453   PMID:31130363  
PMID:31160578   PMID:31175550   PMID:31217475   PMID:31269066   PMID:31285543   PMID:31289136   PMID:31296559   PMID:31319543   PMID:31406304   PMID:31549767   PMID:31560077   PMID:31577344  
PMID:31586073   PMID:31678254   PMID:31754404   PMID:31787846   PMID:31843895   PMID:31950832   PMID:32015321   PMID:32047038   PMID:32086376   PMID:32126207   PMID:32129710   PMID:32145688  
PMID:32249768   PMID:32416067   PMID:32811853   PMID:32871949   PMID:32877691   PMID:33144569  


Genomics

Comparative Map Data
CUL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7148,697,914 - 148,801,110 (+)EnsemblGRCh38hg38GRCh38
GRCh387148,697,756 - 148,801,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377148,394,848 - 148,498,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,026,866 - 148,129,135 (+)NCBINCBI36hg18NCBI36
Build 347147,833,580 - 147,935,849NCBI
Celera7143,066,358 - 143,168,625 (+)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7142,474,925 - 142,577,198 (+)NCBIHuRef
CHM1_17148,404,339 - 148,506,599 (+)NCBICHM1_1
CRA_TCAGchr7v27147,733,888 - 147,836,155 (+)NCBI
Cul1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39647,430,666 - 47,503,078 (+)NCBIGRCm39mm39
GRCm39 Ensembl647,430,332 - 47,503,073 (+)Ensembl
GRCm38647,453,732 - 47,526,144 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl647,453,398 - 47,526,139 (+)EnsemblGRCm38mm10GRCm38
MGSCv37647,404,323 - 47,476,138 (+)NCBIGRCm37mm9NCBIm37
MGSCv36647,383,910 - 47,455,725 (+)NCBImm8
Celera647,309,280 - 47,381,243 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
Cul1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2476,551,952 - 76,625,830 (+)NCBI
Rnor_6.0 Ensembl477,211,692 - 77,280,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0477,211,814 - 77,283,369 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04141,883,675 - 141,954,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4475,636,914 - 75,705,724 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1475,913,432 - 75,981,935 (+)NCBI
Celera471,356,492 - 71,424,907 (+)NCBICelera
Cytogenetic Map4q24NCBI
Cul1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554914,165,561 - 4,212,054 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554914,165,400 - 4,212,483 (+)NCBIChiLan1.0ChiLan1.0
CUL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17152,907,803 - 153,011,254 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7152,908,303 - 153,011,254 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07140,428,442 - 140,531,136 (+)NCBIMhudiblu_PPA_v0panPan3
CUL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,995,637 - 2,086,853 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,995,960 - 2,052,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha163,094,500 - 3,190,996 (-)NCBI
ROS_Cfam_1.0161,800,318 - 1,893,359 (-)NCBI
UMICH_Zoey_3.1161,786,922 - 1,879,856 (-)NCBI
UNSW_CanFamBas_1.0161,646,255 - 1,739,205 (-)NCBI
UU_Cfam_GSD_1.0161,650,453 - 1,743,455 (-)NCBI
Cul1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051187,883,967 - 7,967,988 (-)NCBI
SpeTri2.0NW_0049365274,971,002 - 5,019,465 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9109,454,534 - 109,557,649 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19109,454,523 - 109,559,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29120,392,339 - 120,495,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121117,271,477 - 117,373,983 (+)NCBI
ChlSab1.1 Ensembl21117,271,548 - 117,374,379 (+)Ensembl
Cul1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248006,877,986 - 6,978,587 (-)NCBI

Position Markers
D7S2419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,422,194 - 148,422,373UniSTSGRCh37
GRCh377148,422,059 - 148,422,230UniSTSGRCh37
Build 367148,053,127 - 148,053,306RGDNCBI36
Celera7143,092,484 - 143,092,655UniSTS
Celera7143,092,619 - 143,092,798RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,501,186 - 142,501,365UniSTS
HuRef7142,501,051 - 142,501,222UniSTS
CRA_TCAGchr7v27147,760,149 - 147,760,328UniSTS
CRA_TCAGchr7v27147,760,014 - 147,760,185UniSTS
Marshfield Genetic Map7159.53RGD
Genethon Genetic Map7163.4UniSTS
BCD3347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,498,014 - 148,498,134UniSTSGRCh37
Build 367148,128,947 - 148,129,067RGDNCBI36
Celera7143,168,437 - 143,168,557RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,577,010 - 142,577,130UniSTS
CRA_TCAGchr7v27147,835,967 - 147,836,087UniSTS
GeneMap99-GB4 RH Map7697.14UniSTS
RH44316  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,497,942 - 148,498,131UniSTSGRCh37
Build 367148,128,875 - 148,129,064RGDNCBI36
Celera7143,168,365 - 143,168,554RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,576,938 - 142,577,127UniSTS
CRA_TCAGchr7v27147,835,895 - 147,836,084UniSTS
SHGC-79521  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,450,087 - 148,450,420UniSTSGRCh37
Build 367148,081,020 - 148,081,353RGDNCBI36
Celera7143,120,513 - 143,120,846RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,529,080 - 142,529,413UniSTS
CRA_TCAGchr7v27147,788,043 - 147,788,376UniSTS
TNG Radiation Hybrid Map766586.0UniSTS
G54220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375127,121,589 - 127,121,797UniSTSGRCh37
Build 365127,149,488 - 127,149,696RGDNCBI36
Celera5123,252,320 - 123,252,528RGD
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map7q36.1UniSTS
HuRef5122,313,044 - 122,313,252UniSTS
SHGC-151181  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,422,095 - 148,422,387UniSTSGRCh37
Build 367148,053,028 - 148,053,320RGDNCBI36
Celera7143,092,520 - 143,092,812RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,501,087 - 142,501,379UniSTS
CRA_TCAGchr7v27147,760,050 - 147,760,342UniSTS
TNG Radiation Hybrid Map766594.0UniSTS
TNG Radiation Hybrid Map1522910.0UniSTS
SHGC-152293  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,422,056 - 148,422,337UniSTSGRCh37
Build 367148,052,989 - 148,053,270RGDNCBI36
Celera7143,092,481 - 143,092,762RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,501,048 - 142,501,329UniSTS
CRA_TCAGchr7v27147,760,011 - 147,760,292UniSTS
TNG Radiation Hybrid Map138119.0UniSTS
SHGC-30511  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,494,360 - 148,494,486UniSTSGRCh37
Build 367148,125,293 - 148,125,419RGDNCBI36
Celera7143,164,782 - 143,164,908RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,573,356 - 142,573,482UniSTS
CRA_TCAGchr7v27147,832,312 - 147,832,438UniSTS
TNG Radiation Hybrid Map766511.0UniSTS
GeneMap99-GB4 RH Map7675.32UniSTS
Whitehead-RH Map7645.8UniSTS
GeneMap99-G3 RH Map78185.0UniSTS
STS-AA028139  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,472,802 - 148,472,933UniSTSGRCh37
Build 367148,103,735 - 148,103,866RGDNCBI36
Celera7143,143,224 - 143,143,355RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,551,789 - 142,551,920UniSTS
CRA_TCAGchr7v27147,810,754 - 147,810,885UniSTS
GeneMap99-GB4 RH Map7673.9UniSTS
NCBI RH Map71509.5UniSTS
RH45747  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,497,891 - 148,498,044UniSTSGRCh37
Build 367148,128,824 - 148,128,977RGDNCBI36
Celera7143,168,314 - 143,168,467RGD
Cytogenetic Map7q36.1UniSTS
HuRef7142,576,887 - 142,577,040UniSTS
CRA_TCAGchr7v27147,835,844 - 147,835,997UniSTS
GeneMap99-GB4 RH Map7675.32UniSTS
CUL1_3035  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377148,497,645 - 148,498,257UniSTSGRCh37
Build 367148,128,578 - 148,129,190RGDNCBI36
Celera7143,168,068 - 143,168,680RGD
HuRef7142,576,641 - 142,577,253UniSTS
CRA_TCAGchr7v27147,835,598 - 147,836,210UniSTS
D7S2419  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q36.1UniSTS
Marshfield Genetic Map7159.53UniSTS
Genethon Genetic Map7163.4UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:479
Count of miRNA genes:242
Interacting mature miRNAs:245
Transcripts:ENST00000325222, ENST00000409469, ENST00000602748
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2432 2507 1715 616 1568 458 4355 2100 3541 407 1448 1607 171 1204 2788 4
Low 4 481 10 6 381 6 1 94 185 11 6 5 3 1 1
Below cutoff 2 1 1 1 1 1 8 1 4 1 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_065171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AACC02000041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF062536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG391038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA945052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000325222   ⟹   ENSP00000326804
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,903 - 148,801,110 (+)Ensembl
RefSeq Acc Id: ENST00000409469   ⟹   ENSP00000387160
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,697,914 - 148,800,582 (+)Ensembl
RefSeq Acc Id: ENST00000602748   ⟹   ENSP00000473318
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,645 - 148,801,025 (+)Ensembl
RefSeq Acc Id: ENST00000617797   ⟹   ENSP00000482123
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,729,999 - 148,800,707 (+)Ensembl
RefSeq Acc Id: ENST00000655324   ⟹   ENSP00000499675
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,866 - 148,800,981 (+)Ensembl
RefSeq Acc Id: ENST00000656001   ⟹   ENSP00000499287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,903 - 148,801,086 (+)Ensembl
RefSeq Acc Id: ENST00000660013   ⟹   ENSP00000499325
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,730,179 - 148,783,984 (+)Ensembl
RefSeq Acc Id: ENST00000660240   ⟹   ENSP00000499358
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,965 - 148,800,969 (+)Ensembl
RefSeq Acc Id: ENST00000662132   ⟹   ENSP00000499276
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,897 - 148,801,088 (+)Ensembl
RefSeq Acc Id: ENST00000662670   ⟹   ENSP00000499321
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,923 - 148,801,024 (+)Ensembl
RefSeq Acc Id: ENST00000662716   ⟹   ENSP00000499277
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,072 - 148,800,988 (+)Ensembl
RefSeq Acc Id: ENST00000662975
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,700,007 - 148,760,484 (+)Ensembl
RefSeq Acc Id: ENST00000663044   ⟹   ENSP00000499398
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,593 - 148,801,024 (+)Ensembl
RefSeq Acc Id: ENST00000663835   ⟹   ENSP00000499525
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,857 - 148,801,087 (+)Ensembl
RefSeq Acc Id: ENST00000665936   ⟹   ENSP00000499255
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,517 - 148,801,004 (+)Ensembl
RefSeq Acc Id: ENST00000666124   ⟹   ENSP00000499244
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,903 - 148,801,013 (+)Ensembl
RefSeq Acc Id: ENST00000671397   ⟹   ENSP00000499516
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,907 - 148,801,019 (+)Ensembl
RefSeq Acc Id: ENST00000671421   ⟹   ENSP00000499303
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7148,698,903 - 148,800,974 (+)Ensembl
RefSeq Acc Id: NM_001370660   ⟹   NP_001357589
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,697,756 - 148,801,110 (+)NCBI
RefSeq Acc Id: NM_001370661   ⟹   NP_001357590
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,698,363 - 148,801,110 (+)NCBI
RefSeq Acc Id: NM_001370662   ⟹   NP_001357591
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,698,645 - 148,801,110 (+)NCBI
RefSeq Acc Id: NM_001370663   ⟹   NP_001357592
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,698,645 - 148,801,110 (+)NCBI
RefSeq Acc Id: NM_001370664   ⟹   NP_001357593
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,699,710 - 148,801,110 (+)NCBI
RefSeq Acc Id: NM_003592   ⟹   NP_003583
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,698,903 - 148,801,110 (+)NCBI
GRCh377148,395,631 - 148,498,202 (+)NCBI
Build 367148,026,866 - 148,129,135 (+)NCBI Archive
HuRef7142,474,925 - 142,577,198 (+)ENTREZGENE
CHM1_17148,404,339 - 148,506,599 (+)NCBI
CRA_TCAGchr7v27147,733,888 - 147,836,155 (+)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003583   ⟸   NM_003592
- UniProtKB: Q13616 (UniProtKB/Swiss-Prot),   A0A090N7U0 (UniProtKB/TrEMBL),   B3KTW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001357589   ⟸   NM_001370660
RefSeq Acc Id: NP_001357590   ⟸   NM_001370661
RefSeq Acc Id: NP_001357591   ⟸   NM_001370662
RefSeq Acc Id: NP_001357592   ⟸   NM_001370663
RefSeq Acc Id: NP_001357593   ⟸   NM_001370664
RefSeq Acc Id: ENSP00000499358   ⟸   ENST00000660240
RefSeq Acc Id: ENSP00000499325   ⟸   ENST00000660013
RefSeq Acc Id: ENSP00000499276   ⟸   ENST00000662132
RefSeq Acc Id: ENSP00000499277   ⟸   ENST00000662716
RefSeq Acc Id: ENSP00000499321   ⟸   ENST00000662670
RefSeq Acc Id: ENSP00000499525   ⟸   ENST00000663835
RefSeq Acc Id: ENSP00000499398   ⟸   ENST00000663044
RefSeq Acc Id: ENSP00000499255   ⟸   ENST00000665936
RefSeq Acc Id: ENSP00000499244   ⟸   ENST00000666124
RefSeq Acc Id: ENSP00000326804   ⟸   ENST00000325222
RefSeq Acc Id: ENSP00000499675   ⟸   ENST00000655324
RefSeq Acc Id: ENSP00000473318   ⟸   ENST00000602748
RefSeq Acc Id: ENSP00000499287   ⟸   ENST00000656001
RefSeq Acc Id: ENSP00000482123   ⟸   ENST00000617797
RefSeq Acc Id: ENSP00000387160   ⟸   ENST00000409469
RefSeq Acc Id: ENSP00000499303   ⟸   ENST00000671421
RefSeq Acc Id: ENSP00000499516   ⟸   ENST00000671397
Protein Domains
Cullin   CULLIN_2

Promoters
RGD ID:6805417
Promoter ID:HG_KWN:60188
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:NM_003592
Position:
Human AssemblyChrPosition (strand)Source
Build 367148,026,679 - 148,027,179 (+)MPROMDB
RGD ID:6852326
Promoter ID:EP73970
Type:single initiation site
Name:HS_CUL1
Description:Cullin 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 367148,057,986 - 148,058,046EPD
RGD ID:6805418
Promoter ID:HG_KWN:60190
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC003WFA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367148,110,851 - 148,111,351 (+)MPROMDB
RGD ID:7212207
Promoter ID:EPDNEW_H11849
Type:initiation region
Name:CUL1_1
Description:cullin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11850  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,698,903 - 148,698,963EPDNEW
RGD ID:7212209
Promoter ID:EPDNEW_H11850
Type:initiation region
Name:CUL1_2
Description:cullin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11849  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387148,729,961 - 148,730,021EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q35-36.1(chr7:147345844-150426340)x1 copy number loss See cases [RCV000050838] Chr7:147345844..150426340 [GRCh38]
Chr7:147042936..150123428 [GRCh37]
Chr7:146673869..149754361 [NCBI36]
Chr7:7q35-36.1
pathogenic
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q35-36.1(chr7:143884559-152674271)x1 copy number loss See cases [RCV000050750] Chr7:143884559..152674271 [GRCh38]
Chr7:143581652..152371356 [GRCh37]
Chr7:143212585..152002289 [NCBI36]
Chr7:7q35-36.1
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 copy number gain See cases [RCV000051101] Chr7:132850196..159325876 [GRCh38]
Chr7:132534956..159118566 [GRCh37]
Chr7:132185496..158811327 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:147250465-159325876)x1 copy number loss See cases [RCV000051108] Chr7:147250465..159325876 [GRCh38]
Chr7:146947557..159118566 [GRCh37]
Chr7:146578490..158811327 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 copy number gain See cases [RCV000053576] Chr7:136309982..159307523 [GRCh38]
Chr7:135994730..159100212 [GRCh37]
Chr7:135645270..158792973 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:142021716-159325876)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|See cases [RCV000053577] Chr7:142021716..159325876 [GRCh38]
Chr7:142528609..159118566 [GRCh37]
Chr7:141367985..158811327 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:143884559-159282390)x1 copy number loss See cases [RCV000054178] Chr7:143884559..159282390 [GRCh38]
Chr7:143581652..159075079 [GRCh37]
Chr7:143212585..158767840 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:145699944-159296617)x1 copy number loss See cases [RCV000054188] Chr7:145699944..159296617 [GRCh38]
Chr7:145397037..159089306 [GRCh37]
Chr7:145027970..158782067 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q36.1(chr7:148256584-152332535)x1 copy number loss See cases [RCV000054189] Chr7:148256584..152332535 [GRCh38]
Chr7:147953676..152029620 [GRCh37]
Chr7:147584609..151660553 [NCBI36]
Chr7:7q36.1
pathogenic
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] Chr7:132023155..149309794 [GRCh38]
Chr7:131707914..149006885 [GRCh37]
Chr7:131358454..148637818 [NCBI36]
Chr7:7q32.3-36.1
pathogenic
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] Chr7:139365967..159282531 [GRCh38]
Chr7:139050713..159075220 [GRCh37]
Chr7:138701253..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:140754198-159307523)x1 copy number loss See cases [RCV000054176] Chr7:140754198..159307523 [GRCh38]
Chr7:140453998..159100212 [GRCh37]
Chr7:140100467..158792973 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:142358524-159282531)x1 copy number loss See cases [RCV000054177] Chr7:142358524..159282531 [GRCh38]
Chr7:142528609..159075220 [GRCh37]
Chr7:141726947..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q35-36.2(chr7:147345844-153833351)x3 copy number gain See cases [RCV000135825] Chr7:147345844..153833351 [GRCh38]
Chr7:147042936..153530436 [GRCh37]
Chr7:146673869..153161369 [NCBI36]
Chr7:7q35-36.2
pathogenic
GRCh38/hg38 7q33-36.2(chr7:137751200-154815582)x3 copy number gain See cases [RCV000136592] Chr7:137751200..154815582 [GRCh38]
Chr7:137435946..154607292 [GRCh37]
Chr7:137086486..154238225 [NCBI36]
Chr7:7q33-36.2
pathogenic
GRCh38/hg38 7q35-36.1(chr7:145999194-148860586)x1 copy number loss See cases [RCV000135939] Chr7:145999194..148860586 [GRCh38]
Chr7:145696287..148557678 [GRCh37]
Chr7:145327220..148188611 [NCBI36]
Chr7:7q35-36.1
likely pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:141960861-159335866)x1 copy number loss See cases [RCV000137256] Chr7:141960861..159335866 [GRCh38]
Chr7:142528609..159128556 [GRCh37]
Chr7:141307130..158821317 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:145436544-159331441)x1 copy number loss See cases [RCV000137338] Chr7:145436544..159331441 [GRCh38]
Chr7:145133637..159124131 [GRCh37]
Chr7:144764570..158816892 [NCBI36]
Chr7:7q35-36.3
pathogenic|likely pathogenic
GRCh38/hg38 7q35-36.3(chr7:145250254-159335866)x1 copy number loss See cases [RCV000138005] Chr7:145250254..159335866 [GRCh38]
Chr7:144947347..159128556 [GRCh37]
Chr7:144578280..158821317 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 copy number loss See cases [RCV000138120] Chr7:134666829..158591882 [GRCh38]
Chr7:134351581..158384574 [GRCh37]
Chr7:134002121..158077335 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:146047157-157522158)x1 copy number loss See cases [RCV000137781] Chr7:146047157..157522158 [GRCh38]
Chr7:145744250..157314852 [GRCh37]
Chr7:145375183..157007613 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q35-36.1(chr7:143596735-150089125)x4 copy number gain See cases [RCV000138555] Chr7:143596735..150089125 [GRCh38]
Chr7:143293828..149786214 [GRCh37]
Chr7:143003950..149417147 [NCBI36]
Chr7:7q35-36.1
likely pathogenic
GRCh38/hg38 7q33-36.1(chr7:135017687-148807400)x1 copy number loss See cases [RCV000138903] Chr7:135017687..148807400 [GRCh38]
Chr7:134702438..148504492 [GRCh37]
Chr7:134352978..148135425 [NCBI36]
Chr7:7q33-36.1
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 copy number gain See cases [RCV000139654] Chr7:132444095..159335866 [GRCh38]
Chr7:132128854..159128556 [GRCh37]
Chr7:131779394..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 copy number gain See cases [RCV000142802] Chr7:131228764..159335866 [GRCh38]
Chr7:130913523..159128556 [GRCh37]
Chr7:130564063..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 copy number gain See cases [RCV000143754] Chr7:131171478..159327017 [GRCh38]
Chr7:130856237..159119707 [GRCh37]
Chr7:130506777..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 copy number gain See cases [RCV000143707] Chr7:132438072..159327017 [GRCh38]
Chr7:132122831..159119707 [GRCh37]
Chr7:131773371..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:147144002-159327017)x1 copy number loss See cases [RCV000143503] Chr7:147144002..159327017 [GRCh38]
Chr7:146841094..159119707 [GRCh37]
Chr7:146472027..158812468 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137589621-159119707)x3 copy number gain See cases [RCV000449264] Chr7:137589621..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q35-36.3(chr7:143839360-159138663) copy number loss Abnormality of esophagus morphology [RCV000416719] Chr7:143839360..159138663 [GRCh37]
Chr7:7q35-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:133799185-159119707)x1 copy number loss See cases [RCV000448836] Chr7:133799185..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:140636858-159119707)x1 copy number loss See cases [RCV000510250] Chr7:140636858..159119707 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:136758593-159119707)x3 copy number gain See cases [RCV000510490] Chr7:136758593..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137917376-159119707)x1 copy number loss See cases [RCV000511889] Chr7:137917376..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q36.1(chr7:148189771-150867270)x4 copy number gain See cases [RCV000511618] Chr7:148189771..150867270 [GRCh37]
Chr7:7q36.1
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:140133025-158982771)x1 copy number loss not provided [RCV000682910] Chr7:140133025..158982771 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:139623170-158329903)x3 copy number gain not provided [RCV000747070] Chr7:139623170..158329903 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:141938235-159126310)x1 copy number loss not provided [RCV000747083] Chr7:141938235..159126310 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q35-36.1(chr7:143711059-152573935)x3 copy number gain not provided [RCV000747094] Chr7:143711059..152573935 [GRCh37]
Chr7:7q35-36.1
benign
GRCh37/hg19 7q36.1-36.3(chr7:148238976-159126310)x1 copy number loss not provided [RCV000747115] Chr7:148238976..159126310 [GRCh37]
Chr7:7q36.1-36.3
pathogenic
GRCh37/hg19 7q36.1(chr7:148394595-148395978)x3 copy number gain not provided [RCV000747116] Chr7:148394595..148395978 [GRCh37]
Chr7:7q36.1
benign
GRCh37/hg19 7q36.1(chr7:148395124-148395948)x4 copy number gain not provided [RCV000747117] Chr7:148395124..148395948 [GRCh37]
Chr7:7q36.1
benign
GRCh37/hg19 7q36.1(chr7:148395124-148395978)x4 copy number gain not provided [RCV000747118] Chr7:148395124..148395978 [GRCh37]
Chr7:7q36.1
benign
GRCh37/hg19 7q36.1(chr7:148395124-148396168)x4 copy number gain not provided [RCV000747119] Chr7:148395124..148396168 [GRCh37]
Chr7:7q36.1
benign
GRCh37/hg19 7q36.1(chr7:148395124-148396278)x3 copy number gain not provided [RCV000747120] Chr7:148395124..148396278 [GRCh37]
Chr7:7q36.1
benign
GRCh37/hg19 7q36.1(chr7:148395838-148396655)x1 copy number loss not provided [RCV000747121] Chr7:148395838..148396655 [GRCh37]
Chr7:7q36.1
benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
Single allele duplication not provided [RCV000844986] Chr7:147897705..149874566 [GRCh37]
Chr7:7q35-36.1
not provided
GRCh37/hg19 7q32.3-36.3(chr7:131414604-159126310)x1 copy number loss See cases [RCV001007432] Chr7:131414604..159126310 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q32.3-36.3(chr7:130592554-159119707)x3 copy number gain not provided [RCV000849569] Chr7:130592554..159119707 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3
pathogenic
GRCh37/hg19 7q35-36.3(chr7:145962558-159119707)x1 copy number loss not provided [RCV001006022] Chr7:145962558..159119707 [GRCh37]
Chr7:7q35-36.3
pathogenic
NC_000007.14:g.(?_146116001)_(148847318_?)del deletion Pitt-Hopkins-like syndrome 1 [RCV001033573] Chr7:145813093..148544410 [GRCh37]
Chr7:7q35-36.1
pathogenic
NC_000007.14:g.(?_146116001)_(148847318_?)dup duplication Pitt-Hopkins-like syndrome 1 [RCV001032388] Chr7:145813093..148544410 [GRCh37]
Chr7:7q35-36.1
uncertain significance
NC_000007.14:g.(?_147395589)_(148847318_?)del deletion Pitt-Hopkins-like syndrome 1 [RCV001033596] Chr7:147092681..148544410 [GRCh37]
Chr7:7q35-36.1
pathogenic
GRCh37/hg19 7q35-36.1(chr7:147897705-149874566)x3 copy number loss not provided [RCV001249216] Chr7:147897705..149874566 [GRCh37]
Chr7:7q35-36.1
not provided
GRCh37/hg19 7q35-36.3(chr7:143107740-156886246)x3 copy number gain not provided [RCV001249383] Chr7:143107740..156886246 [GRCh37]
Chr7:7q35-36.3
not provided
GRCh37/hg19 7q36.1(chr7:148370799-148659745)x3 copy number gain not provided [RCV001258983] Chr7:148370799..148659745 [GRCh37]
Chr7:7q36.1
uncertain significance
NC_000007.13:g.(?_145813093)_(148544390_?)dup duplication Pitt-Hopkins-like syndrome 1 [RCV001314626] Chr7:145813093..148544390 [GRCh37]
Chr7:7q35-36.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2551 AgrOrtholog
COSMIC CUL1 COSMIC
Ensembl Genes ENSG00000055130 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000326804 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387160 UniProtKB/Swiss-Prot
  ENSP00000473318 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000482123 UniProtKB/TrEMBL
  ENSP00000499244 UniProtKB/TrEMBL
  ENSP00000499255 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000499276 UniProtKB/TrEMBL
  ENSP00000499277 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000499287 UniProtKB/TrEMBL
  ENSP00000499303 UniProtKB/TrEMBL
  ENSP00000499321 UniProtKB/TrEMBL
  ENSP00000499325 UniProtKB/TrEMBL
  ENSP00000499358 UniProtKB/TrEMBL
  ENSP00000499398 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000499516 UniProtKB/TrEMBL
  ENSP00000499525 UniProtKB/TrEMBL
  ENSP00000499675 UniProtKB/TrEMBL
Ensembl Transcript ENST00000325222 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409469 UniProtKB/Swiss-Prot
  ENST00000602748 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000617797 UniProtKB/TrEMBL
  ENST00000655324 UniProtKB/TrEMBL
  ENST00000656001 UniProtKB/TrEMBL
  ENST00000660013 UniProtKB/TrEMBL
  ENST00000660240 UniProtKB/TrEMBL
  ENST00000662132 UniProtKB/TrEMBL
  ENST00000662670 UniProtKB/TrEMBL
  ENST00000662716 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000663044 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000663835 UniProtKB/TrEMBL
  ENST00000665936 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000666124 UniProtKB/TrEMBL
  ENST00000671397 UniProtKB/TrEMBL
  ENST00000671421 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000055130 GTEx
HGNC ID HGNC:2551 ENTREZGENE
Human Proteome Map CUL1 Human Proteome Map
InterPro Cullin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_homology UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8454 ENTREZGENE
OMIM 603134 OMIM
Pfam Cullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27047 PharmGKB
PROSITE CULLIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CULLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF74788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF75632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A090N7U0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0C4DGX4_HUMAN UniProtKB/TrEMBL
  A0A590UJ21_HUMAN UniProtKB/TrEMBL
  A0A590UJ50_HUMAN UniProtKB/TrEMBL
  A0A590UJ56_HUMAN UniProtKB/TrEMBL
  A0A590UJ59_HUMAN UniProtKB/TrEMBL
  A0A590UJ97_HUMAN UniProtKB/TrEMBL
  A0A590UJA0_HUMAN UniProtKB/TrEMBL
  A0A590UJC4_HUMAN UniProtKB/TrEMBL
  A0A590UJM8_HUMAN UniProtKB/TrEMBL
  A0A590UJR3_HUMAN UniProtKB/TrEMBL
  A0A590UK34_HUMAN UniProtKB/TrEMBL
  B3KTW0 ENTREZGENE, UniProtKB/TrEMBL
  CUL1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q75MQ1_HUMAN UniProtKB/TrEMBL
UniProt Secondary D3DWG3 UniProtKB/Swiss-Prot
  O60719 UniProtKB/Swiss-Prot
  Q08AL6 UniProtKB/Swiss-Prot
  Q8IYW1 UniProtKB/Swiss-Prot