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ONTOLOGY REPORT - ANNOTATIONS


Term:I-kappaB phosphorylation
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Accession:GO:0007252 term browser browse the term
Definition:The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms:exact_synonym: IKB phosphorylation;   IkappaB phosphorylation;   inhibitor of NF-kappaB phosphorylation;   inhibitor of kappaB phosphorylation


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I-kappaB phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:1600115
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Elp1 elongator complex protein 1 JBrowse link 5 73,503,406 73,552,798 RGD:1626124
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:1624291
RGD:1600115
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:1600115
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:1600115
G LOC100910771 mitogen-activated protein kinase kinase kinase 7-like JBrowse link 9 114,022,058 114,077,887 RGD:1600115
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
RGD:1600115
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
negative regulation of I-kappaB phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sirpa signal-regulatory protein alpha JBrowse link 3 122,113,735 122,152,478 RGD:1624291
RGD:1600115
positive regulation of I-kappaB phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:1600115
RGD:1624291
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:4892026
G Ddrgk1 DDRGK domain containing 1 JBrowse link 3 123,195,580 123,206,828 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    signaling 7531
      signal transduction 6946
        intracellular signal transduction 2594
          I-kappaB kinase/NF-kappaB signaling 272
            I-kappaB phosphorylation 20
              negative regulation of I-kappaB phosphorylation 1
              positive regulation of I-kappaB phosphorylation 6
              regulation of I-kappaB phosphorylation + 7
Path 2
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11953
      organic substance metabolic process 11358
        organonitrogen compound metabolic process 6980
          protein metabolic process 6076
            cellular protein metabolic process 5413
              cellular protein modification process 3896
                protein phosphorylation 1963
                  I-kappaB phosphorylation 20
                    negative regulation of I-kappaB phosphorylation 1
                    positive regulation of I-kappaB phosphorylation 6
                    regulation of I-kappaB phosphorylation + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.