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ONTOLOGY REPORT - ANNOTATIONS


Term:I-kappaB phosphorylation
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Accession:GO:0007252 term browser browse the term
Definition:The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms:exact_synonym: IKB phosphorylation;   IkappaB phosphorylation;   inhibitor of NF-kappaB phosphorylation;   inhibitor of kappaB phosphorylation
 never_in_taxon: NCBITaxon:4751 ! Fungi



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I-kappaB phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chuk component of inhibitor of nuclear factor kappa B kinase complex involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
GO_REF:0000024
(MGI:4453088|PMID:19948740)
UniProt
RGD
PMID:19948740 GO_REF:0000024 MGI:4453088 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Elp1 elongator acetyltransferase complex subunit 1 IDA RGD PMID:12133632 RGD:1626124 NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 involved_in ISO
IEA
(PMID:15218148)
GO_REF:0000107
RGD
Ensembl
PMID:15218148 GO_REF:0000107 NCBI chr 4:152,763,664...153,055,706
Ensembl chr 4:152,767,419...153,055,639
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000108
(MGI:3836513|PMID:18981174)
GOC
RGD
PMID:18981174 GO_REF:0000108 MGI:3836513 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon acts_upstream_of_or_within ISO (MGI:1928258|PMID:10421793) RGD PMID:10421793 MGI:1928258 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in
acts_upstream_of_or_within
ISO
IEA
ISS
(PMID:11460167)
GO_REF:0000104
MGI:104798|MGI:96536 (MGI:3607973|PMID:16260493)
GO_REF:0000024
RGD
UniProt
PMID:11460167 PMID:16260493 GO_REF:0000024 GO_REF:0000104 MGI:3607973 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO (PMID:19740627) RGD PMID:19740627 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:19740627) RGD PMID:19740627 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:19740627)
MGI:1860885 (MGI:3835701|PMID:18820689)
GO_REF:0000107
RGD
Ensembl
PMID:18820689 PMID:19740627 GO_REF:0000107 MGI:3835701 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr7 toll-like receptor 7 involved_in ISO (PMID:19740627) RGD PMID:19740627 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:19740627) RGD PMID:19740627 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Usp25 ubiquitin specific peptidase 25 involved_in ISO MGI:4332130 (MGI:5441108|PMID:23042150) RGD PMID:23042150 MGI:5441108 NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348
JBrowse link
negative regulation of I-kappaB phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir27b microRNA 27b acts_upstream_of_or_within ISO UniProtKB:P01375 (PMID:31124343) RGD PMID:31124343 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
JBrowse link
G Sirpa signal-regulatory protein alpha involved_in ISO (MGI:3760575|PMID:17954568) RGD PMID:17954568 MGI:3760575 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098
JBrowse link
positive regulation of I-kappaB phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in ISO
IEA
UniProtKB:P35411 (PMID:10869418)
GO_REF:0000107
RGD
Ensembl
PMID:10869418 GO_REF:0000107 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in IGI PMID:10869418 ARUK-UCL PMID:10869418 RGD:4892026 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:23675531) RGD PMID:23675531 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680
JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in ISO
IEA
(MGI:5300086|PMID:22041900)
GO_REF:0000107
RGD
Ensembl
PMID:22041900 GO_REF:0000107 MGI:5300086 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO (PMID:31124343) RGD PMID:31124343 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Traf2 Tnf receptor-associated factor 2 involved_in ISO (MGI:5616328|PMID:11374864) RGD PMID:11374864 MGI:5616328 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    signaling 7708
      signal transduction 7133
        intracellular signal transduction 2748
          I-kappaB kinase/NF-kappaB signaling 297
            I-kappaB phosphorylation 22
              negative regulation of I-kappaB phosphorylation 2
              positive regulation of I-kappaB phosphorylation 7
              regulation of I-kappaB phosphorylation + 9
Path 2
Term Annotations click to browse term
  biological_process 20091
    biological regulation 13996
      regulation of biological process 13218
        regulation of cellular process 12482
          signal transduction 7133
            intracellular signal transduction 2748
              I-kappaB kinase/NF-kappaB signaling 297
                I-kappaB phosphorylation 22
                  negative regulation of I-kappaB phosphorylation 2
                  positive regulation of I-kappaB phosphorylation 7
                  regulation of I-kappaB phosphorylation + 9
paths to the root