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Gene: LITAF (lipopolysaccharide induced TNF factor) Homo sapiens
Symbol: LITAF
Name: lipopolysaccharide induced TNF factor
Description: Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity; WW domain binding activity; and zinc ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. Localizes to several cellular components, including the cytoplasmic side of endosome membrane; cytoplasmic side of lysosomal membrane; and cytoplasmic side of plasma membrane. Implicated in Charcot-Marie-Tooth disease type 1C.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; lipopolysaccharide-induced tumor necrosis factor-alpha factor; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; p53-induced gene 7 protein; PIG7; SIMPLE; small integral membrane protein of lysosome/late endosome; TP53I7; tumor protein p53 inducible protein 7
Mus musculus (house mouse) : Litaf (LPS-induced TN factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Litaf (lipopolysaccharide-induced TNF factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Litaf (lipopolysaccharide induced TNF factor)
Pan paniscus (bonobo/pygmy chimpanzee) : LITAF (lipopolysaccharide induced TNF factor)
Canis lupus familiaris (dog) : LITAF (lipopolysaccharide induced TNF factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Litaf (lipopolysaccharide induced TNF factor)
Sus scrofa (pig) : LITAF (lipopolysaccharide induced TNF factor)
Chlorocebus sabaeus (African green monkey) : LITAF (lipopolysaccharide induced TNF factor)
Heterocephalus glaber (naked mole-rat) : Litaf (lipopolysaccharide induced TNF factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1611,547,722 - 11,636,381 (-)Ensembl
GRCh381611,547,722 - 11,636,377 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371611,641,578 - 11,681,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,549,357 - 11,587,730 (-)NCBINCBI36hg18NCBI36
Build 341611,549,957 - 11,587,730NCBI
Celera1611,813,516 - 11,854,903 (-)NCBI
Cytogenetic Map16p13.13NCBI
HuRef1611,558,982 - 11,598,664 (-)NCBIHuRef
CHM1_11611,641,642 - 11,681,379 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LITAF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735583
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.