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Gene: NOD2 (nucleotide binding oligomerization domain containing 2) Homo sapiens
Symbol: NOD2
Name: nucleotide binding oligomerization domain containing 2
Description: Exhibits several functions, including CARD domain binding activity; heat shock protein binding activity; and muramyl dipeptide binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and response to bacterium. Localizes to several cellular components, including the Golgi apparatus; basolateral plasma membrane; and cell surface. Implicated in several diseases, including Behcet's disease; Blau syndrome; autoimmune hypersensitivity disease (multiple); intestinal disease (multiple); and lung disease (multiple). Biomarker of allergic rhinitis and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACUG; BLAU; BLAUS; CARD15; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; CD; CLR16.3; IBD1; inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NLRC2; NOD-like receptor C2; NOD2B; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; nucleotide-binding oligomerization domain-containing protein 2; PSORAS1; YAOS
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381650,693,587 - 50,733,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,727,507 - 50,766,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,514 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NOD2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314945
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.