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Gene: ECT2 (epithelial cell transforming 2) Homo sapiens
Symbol: ECT2
Name: epithelial cell transforming 2
Description: Exhibits GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; and protein homodimerization activity. Involved in several processes, including activation of GTPase activity; bicellular tight junction assembly; and regulation of cell cycle process. Localizes to several cellular components, including the bicellular tight junction; centralspindlin complex; and midbody.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARHGEF31; epithelial cell transforming sequence 2 oncogene; epithelial cell-transforming sequence 2 oncogene; FLJ10461; MGC138291
Mus musculus (house mouse) : Ect2 (ect2 oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ect2 (epithelial cell transforming 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ect2 (epithelial cell transforming 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ECT2 (epithelial cell transforming 2)
Canis lupus familiaris (dog) : ECT2 (epithelial cell transforming 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ect2 (epithelial cell transforming 2)
Sus scrofa (pig) : ECT2 (epithelial cell transforming 2)
Chlorocebus sabaeus (African green monkey) : ECT2 (epithelial cell transforming 2)
Heterocephalus glaber (naked mole-rat) : Ect2 (epithelial cell transforming 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3172,750,682 - 172,821,474 (+)EnsemblGRCh38hg38GRCh38
GRCh383172,750,685 - 172,829,273 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373172,468,425 - 172,539,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,951,336 - 174,021,957 (+)NCBINCBI36hg18NCBI36
Build 343173,954,999 - 174,021,965NCBI
Celera3170,871,530 - 170,938,230 (+)NCBI
Cytogenetic Map3q26.31NCBI
HuRef3169,839,394 - 169,910,198 (+)NCBIHuRef
CHM1_13172,431,384 - 172,502,159 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ECT2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318344
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.