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Gene: WDR83 (WD repeat domain 83) Homo sapiens
Symbol: WDR83
Name: WD repeat domain 83
Description: This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MAPK organizer 1; MGC4238; mitogen-activated protein kinase organizer 1; MORG1; WD repeat domain-containing protein 83
Mus musculus (house mouse) : Wdr83 (WD repeat domain containing 83)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wdr83 (WD repeat domain 83)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wdr83 (WD repeat domain 83)
Pan paniscus (bonobo/pygmy chimpanzee) : WDR83 (WD repeat domain 83)
Canis lupus familiaris (dog) : WDR83 (WD repeat domain 83)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wdr83 (WD repeat domain 83)
Sus scrofa (pig) : WDR83 (WD repeat domain 83)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381912,666,804 - 12,675,832 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,777,618 - 12,786,646 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,638,628 - 12,647,646 (+)NCBINCBI36hg18NCBI36
Celera1912,667,332 - 12,676,360 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,350,706 - 12,359,681 (+)NCBIHuRef
CHM1_11912,778,123 - 12,787,151 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on WDR83
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1601942
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.