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Gene: FLNA (filamin A) Homo sapiens
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Symbol: FLNA
Name: filamin A
Description: Exhibits several functions, including enzyme binding activity; ion channel binding activity; and signaling receptor binding activity. Involved in several processes, including actin cytoskeleton organization; protein localization to membrane; and regulation of transcription, DNA-templated. Localizes to several cellular components, including the Myb complex; actin cytoskeleton; and nucleolus. Implicated in FG syndrome; craniosynostosis; mitral valve prolapse; osteochondrodysplasia; and periventricular nodular heterotopia. Biomarker of epilepsy and tuberous sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABP-280; ABPX; actin binding protein 280; alpha filamin; alpha-filamin; CSBS; CVD1; DKFZp434P031; endothelial actin-binding protein; FG syndrome 2; FGS2; filamin 1; filamin A, alpha; filamin-1; filamin-A; FLJ43642; FLN; FLN-A; FLN1; FMD; MNS; NHBP; non-muscle filamin; OPD; OPD1; OPD2; XLVD; XMVD
Orthologs:
Mus musculus (house mouse) : Flna (filamin, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Flna (filamin A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flna (filamin A)
Pan paniscus (bonobo/pygmy chimpanzee) : FLNA (filamin A)
Canis lupus familiaris (dog) : FLNA (filamin A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flna (filamin A)
Sus scrofa (pig) : FLNA (filamin A)
Chlorocebus sabaeus (green monkey) : FLNA (filamin A)
Heterocephalus glaber (naked mole-rat) : Flna (filamin A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX154,348,524 - 154,374,638 (-)Ensembl
GRCh38X154,348,531 - 154,374,638 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,576,900 - 153,603,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,230,091 - 153,252,845 (-)NCBINCBI36hg18NCBI36
Build 34X153,097,811 - 153,123,776NCBI
CeleraX153,737,962 - 153,764,068 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,154,186 - 142,180,218 (-)NCBIHuRef
CHM1_1X153,488,516 - 153,514,622 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Molecular Pathway Annotations
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