TIFA (TRAF interacting protein with forkhead associated domain) - Rat Genome Database

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Gene: TIFA (TRAF interacting protein with forkhead associated domain) Homo sapiens
Analyze
Symbol: TIFA
Name: TRAF interacting protein with forkhead associated domain
RGD ID: 1606192
HGNC Page HGNC:19075
Description: Involved in several processes, including cytoplasmic pattern recognition receptor signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and protein homooligomerization. Located in cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC20791; putative MAPK-activating protein PM14; putative NF-kappa-B-activating protein 20; T2BP; T6BP; TIFAA; TRAF-interacting protein with a forkhead-associated domain; TRAF-interacting protein with FHA domain-containing protein A; TRAF-interacting protein with forkhead-associated domain; TRAF2 binding protein; TRAF2-binding protein; TRAF6 binding protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384112,274,537 - 112,285,904 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4112,272,968 - 112,285,955 (-)EnsemblGRCh38hg38GRCh38
GRCh374113,195,693 - 113,207,060 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364113,416,231 - 113,426,508 (-)NCBINCBI36Build 36hg18NCBI36
Celera4110,490,861 - 110,501,136 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4108,928,327 - 108,938,602 (-)NCBIHuRef
CHM1_14113,173,595 - 113,183,871 (-)NCBICHM1_1
T2T-CHM13v2.04115,582,899 - 115,594,247 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
cisplatin  (EXP)
clothianidin  (EXP)
cobalt dichloride  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
dimethylarsinic acid  (ISO)
dorsomorphin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hypochlorous acid  (ISO)
ketamine  (ISO)
lipopolysaccharide  (EXP,ISO)
methylarsonic acid  (ISO)
orphenadrine  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
protein kinase inhibitor  (EXP)
quercetin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
succimer  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
urethane  (EXP)
valproic acid  (EXP)
vanadyl sulfate  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA)
cytosol  (TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:11798190   PMID:12477932   PMID:12566447   PMID:12761501   PMID:15047173   PMID:15492226   PMID:16189514   PMID:16643855   PMID:19322201   PMID:20332099   PMID:21516116  
PMID:21873635   PMID:22566686   PMID:25416956   PMID:26068852   PMID:26389808   PMID:26501855   PMID:27107012   PMID:27107014   PMID:27217568   PMID:27965388   PMID:28069801   PMID:28222186  
PMID:28514442   PMID:28514661   PMID:28715499   PMID:28811347   PMID:28877472   PMID:29263897   PMID:29337150   PMID:29581234   PMID:29975933   PMID:30111836   PMID:30378729   PMID:31123889  
PMID:31515488   PMID:32101751   PMID:32296183   PMID:32393512   PMID:32910997   PMID:33037203   PMID:33961781   PMID:34238983   PMID:34328245   PMID:35089437   PMID:35635239   PMID:36098982  
PMID:36586274   PMID:36965415  


Genomics

Comparative Map Data
TIFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384112,274,537 - 112,285,904 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4112,272,968 - 112,285,955 (-)EnsemblGRCh38hg38GRCh38
GRCh374113,195,693 - 113,207,060 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364113,416,231 - 113,426,508 (-)NCBINCBI36Build 36hg18NCBI36
Celera4110,490,861 - 110,501,136 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4108,928,327 - 108,938,602 (-)NCBIHuRef
CHM1_14113,173,595 - 113,183,871 (-)NCBICHM1_1
T2T-CHM13v2.04115,582,899 - 115,594,247 (-)NCBIT2T-CHM13v2.0
Tifa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393127,582,524 - 127,592,043 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3127,583,454 - 127,625,813 (+)EnsemblGRCm39 Ensembl
GRCm383127,788,875 - 127,798,394 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3127,789,805 - 127,832,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv373127,492,831 - 127,501,307 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363127,781,941 - 127,800,104 (+)NCBIMGSCv36mm8
MGSCv363128,273,227 - 128,291,450 (+)NCBIMGSCv36mm8
Celera3134,292,137 - 134,300,604 (+)NCBICelera
Cytogenetic Map3G2NCBI
cM Map356.54NCBI
Tifa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82218,927,724 - 218,942,111 (+)NCBIGRCr8
mRatBN7.22216,257,926 - 216,267,635 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2216,234,774 - 216,267,841 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2223,922,080 - 223,931,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02221,821,777 - 221,831,000 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02216,675,867 - 216,685,087 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02232,104,394 - 232,137,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2232,104,809 - 232,137,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02251,423,679 - 251,482,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42225,067,695 - 225,076,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12225,054,374 - 225,063,575 (+)NCBI
Celera2208,569,719 - 208,578,933 (+)NCBICelera
Cytogenetic Map2q42NCBI
Tifa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545714,444,814 - 14,450,767 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545714,444,811 - 14,460,168 (+)NCBIChiLan1.0ChiLan1.0
TIFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23110,350,189 - 110,362,391 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14110,637,766 - 110,655,760 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04104,765,007 - 104,776,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14115,328,436 - 115,338,732 (-)NCBIpanpan1.1PanPan1.1panPan2
TIFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13232,125,870 - 32,135,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3232,126,634 - 32,127,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha329,896,747 - 9,907,233 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03232,349,595 - 32,360,055 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3232,349,597 - 32,359,545 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13232,332,694 - 32,343,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03232,093,596 - 32,104,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,757,210 - 7,767,777 (+)NCBIUU_Cfam_GSD_1.0
Tifa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053018,750,214 - 8,757,559 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365633,152,049 - 3,158,999 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365633,151,515 - 3,159,071 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8110,377,892 - 110,389,604 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18110,377,817 - 110,394,190 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28118,358,074 - 118,366,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1760,074,764 - 60,085,029 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl760,076,999 - 60,077,556 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603738,834,354 - 38,846,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tifa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248386,160,712 - 6,167,408 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TIFA
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3		 pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3		 pathogenic
GRCh38/hg38 4q25-26(chr4:111069785-116691879)x1 copy number loss See cases [RCV000134955] Chr4:111069785..116691879 [GRCh38]
Chr4:111990941..117613035 [GRCh37]
Chr4:112210390..117832483 [NCBI36]
Chr4:4q25-26		 likely pathogenic
NC_000004.10:g.111994000_115504000del3510001 deletion Congenital aniridia [RCV000257787] Chr4:110853395..114363395 [GRCh38]
Chr4:111774551..115284551 [GRCh37]
Chr4:111994000..115504000 [NCBI36]
Chr4:4q25-26		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25-26(chr4:112857598-115434654)x1 copy number loss See cases [RCV000448547] Chr4:112857598..115434654 [GRCh37]
Chr4:4q25-26		 likely pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2		 pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25(chr4:112901280-113403129)x1 copy number loss not provided [RCV000682445] Chr4:112901280..113403129 [GRCh37]
Chr4:4q25		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25(chr4:113175966-113835185)x1 copy number loss not provided [RCV000743921] Chr4:113175966..113835185 [GRCh37]
Chr4:4q25		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25(chr4:113116277-113602286)x3 copy number gain not provided [RCV000847514] Chr4:113116277..113602286 [GRCh37]
Chr4:4q25		 uncertain significance
GRCh37/hg19 4q25(chr4:111334313-113223858)x1 copy number loss not provided [RCV001259302] Chr4:111334313..113223858 [GRCh37]
Chr4:4q25		 pathogenic
GRCh37/hg19 4q24-31.21(chr4:104715235-145252595) copy number gain not specified [RCV002053446] Chr4:104715235..145252595 [GRCh37]
Chr4:4q24-31.21		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q25-26(chr4:112849108-115434557) copy number loss not specified [RCV002053449] Chr4:112849108..115434557 [GRCh37]
Chr4:4q25-26		 likely pathogenic
NM_052864.3(TIFA):c.82T>G (p.Cys28Gly) single nucleotide variant not specified [RCV004085406] Chr4:112278335 [GRCh38]
Chr4:113199491 [GRCh37]
Chr4:4q25		 uncertain significance
NM_052864.3(TIFA):c.248T>A (p.Leu83His) single nucleotide variant not specified [RCV004238919] Chr4:112278169 [GRCh38]
Chr4:113199325 [GRCh37]
Chr4:4q25		 uncertain significance
NM_052864.3(TIFA):c.292G>A (p.Val98Met) single nucleotide variant not specified [RCV004176029] Chr4:112278125 [GRCh38]
Chr4:113199281 [GRCh37]
Chr4:4q25		 uncertain significance
NC_000004.12:g.110650730_112833790del deletion Axenfeld-Rieger syndrome type 1 [RCV003225703] Chr4:110650730..112833790 [GRCh38]
Chr4:4q25		 likely pathogenic
NM_052864.3(TIFA):c.331C>A (p.Leu111Met) single nucleotide variant not specified [RCV004346680] Chr4:112278086 [GRCh38]
Chr4:113199242 [GRCh37]
Chr4:4q25		 uncertain significance
GRCh37/hg19 4q24-35.2(chr4:101203509-190957473)x3 copy number gain not specified [RCV003986496] Chr4:101203509..190957473 [GRCh37]
Chr4:4q24-35.2		 pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_052864.3(TIFA):c.182A>G (p.Gln61Arg) single nucleotide variant not specified [RCV004686812] Chr4:112278235 [GRCh38]
Chr4:113199391 [GRCh37]
Chr4:4q25		 uncertain significance
NM_052864.3(TIFA):c.184G>A (p.Asp62Asn) single nucleotide variant not specified [RCV004676914] Chr4:112278233 [GRCh38]
Chr4:113199389 [GRCh37]
Chr4:4q25		 uncertain significance
GRCh37/hg19 4q25(chr4:112481911-113756889) copy number gain Neurodevelopmental delay [RCV002280697] Chr4:112481911..113756889 [GRCh37]
Chr4:4q25		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:964
Count of miRNA genes:622
Interacting mature miRNAs:677
Transcripts:ENST00000361717, ENST00000500655
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1643256BW127_HBody Weight QTL 127 (human)1.310.007Body weightbody mass index4106319694132319694Human

Markers in Region
D4S2756  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374113,198,272 - 113,198,392UniSTSGRCh37
Build 364113,417,721 - 113,417,841RGDNCBI36
Celera4110,492,351 - 110,492,471RGD
Cytogenetic Map4q25UniSTS
HuRef4108,929,817 - 108,929,937UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2252 4972 1726 2351 6 624 1951 465 2269 7305 6471 53 3732 1 852 1744 1617 174 1

Sequence


Ensembl Acc Id: ENST00000361717   ⟹   ENSP00000354911
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4112,274,537 - 112,285,904 (-)Ensembl
Ensembl Acc Id: ENST00000500655   ⟹   ENSP00000424231
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4112,277,759 - 112,281,773 (-)Ensembl
Ensembl Acc Id: ENST00000610220   ⟹   ENSP00000516322
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4112,272,968 - 112,285,955 (-)Ensembl
RefSeq Acc Id: NM_052864   ⟹   NP_443096
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384112,274,537 - 112,285,904 (-)NCBI
GRCh374113,196,782 - 113,207,059 (-)RGD
Build 364113,416,231 - 113,426,508 (-)NCBI Archive
Celera4110,490,861 - 110,501,136 (-)RGD
HuRef4108,928,327 - 108,938,602 (-)RGD
CHM1_14113,173,595 - 113,183,871 (-)NCBI
T2T-CHM13v2.04115,582,899 - 115,594,247 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054351250   ⟹   XP_054207225
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04115,582,899 - 115,590,056 (-)NCBI
RefSeq Acc Id: NP_443096   ⟸   NM_052864
- UniProtKB: Q96CG3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000354911   ⟸   ENST00000361717
Ensembl Acc Id: ENSP00000424231   ⟸   ENST00000500655
Ensembl Acc Id: ENSP00000516322   ⟸   ENST00000610220
RefSeq Acc Id: XP_054207225   ⟸   XM_054351250
- Peptide Label: isoform X1
- UniProtKB: Q96CG3 (UniProtKB/Swiss-Prot)
Protein Domains
FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96CG3-F1-model_v2 AlphaFold Q96CG3 1-184 view protein structure

Promoters
RGD ID:6868292
Promoter ID:EPDNEW_H7311
Type:initiation region
Name:TIFA_1
Description:TRAF interacting protein with forkhead associated domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384112,285,904 - 112,285,964EPDNEW
RGD ID:6802662
Promoter ID:HG_KWN:48929
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC010IMN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364113,418,501 - 113,419,962 (-)MPROMDB
RGD ID:6802660
Promoter ID:HG_KWN:48930
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_052864
Position:
Human AssemblyChrPosition (strand)Source
Build 364113,426,286 - 113,426,786 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19075 AgrOrtholog
COSMIC TIFA COSMIC
Ensembl Genes ENSG00000145365 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000361717 ENTREZGENE
  ENST00000361717.4 UniProtKB/Swiss-Prot
  ENST00000500655.2 UniProtKB/Swiss-Prot
  ENST00000610220.2 UniProtKB/Swiss-Prot
GTEx ENSG00000145365 GTEx
HGNC ID HGNC:19075 ENTREZGENE
Human Proteome Map TIFA Human Proteome Map
InterPro FHA_dom UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:92610 UniProtKB/Swiss-Prot
NCBI Gene 92610 ENTREZGENE
OMIM 609028 OMIM
PANTHER PTHR31266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FHA UniProtKB/Swiss-Prot
PharmGKB PA162405777 PharmGKB
PROSITE FHA_DOMAIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt I6L962_HUMAN UniProtKB/TrEMBL
  Q96CG3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 TIFA  TRAF interacting protein with forkhead associated domain    TRAF-interacting protein with forkhead-associated domain  Symbol and/or name change 5135510 APPROVED