FLOT2 (flotillin 2) - Rat Genome Database

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Gene: FLOT2 (flotillin 2) Homo sapiens
Analyze
Symbol: FLOT2
Name: flotillin 2
RGD ID: 735666
HGNC Page HGNC
Description: Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of NF-kappaB transcription factor activity; and protein localization to cell periphery. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and uropod. Part of flotillin complex. Colocalizes with cortical actin cytoskeleton.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ECS-1; ECS1; epidermal surface antigen; ESA; ESA1; Flotillin 2 (epidermal surface antigen 1); flotillin-2; M17S1; membrane component chromosome 17 surface marker 1; membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1728,879,335 - 28,897,733 (-)EnsemblGRCh38hg38GRCh38
GRCh381728,879,339 - 28,897,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371727,206,357 - 27,224,751 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,230,483 - 24,248,841 (-)NCBINCBI36hg18NCBI36
Build 341724,230,483 - 24,248,696NCBI
Celera1724,065,775 - 24,084,131 (-)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1723,414,667 - 23,432,931 (-)NCBIHuRef
CHM1_11727,268,892 - 27,287,277 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1769667   PMID:8051082   PMID:8125298   PMID:10212252   PMID:10462713   PMID:11159550   PMID:11598189   PMID:11999340   PMID:12107410   PMID:12202484   PMID:12477932   PMID:12493773  
PMID:14667819   PMID:15489334   PMID:15492257   PMID:15569306   PMID:16521037   PMID:17013097   PMID:17110338   PMID:17113085   PMID:17307333   PMID:17342744   PMID:17600709   PMID:17854803  
PMID:18237819   PMID:18296650   PMID:18337418   PMID:19056867   PMID:19318123   PMID:19404397   PMID:19542222   PMID:19605558   PMID:19738201   PMID:19946888   PMID:20027317   PMID:20360068  
PMID:20458337   PMID:20515742   PMID:20682791   PMID:21119006   PMID:21187433   PMID:21423176   PMID:21674799   PMID:21696602   PMID:21701559   PMID:21832049   PMID:21873635   PMID:21988832  
PMID:22081607   PMID:22261722   PMID:22438585   PMID:22669515   PMID:22869152   PMID:22939629   PMID:23012365   PMID:23064789   PMID:23146906   PMID:23314748   PMID:23319823   PMID:23376485  
PMID:23533145   PMID:23658725   PMID:23825023   PMID:23945257   PMID:23983584   PMID:24013648   PMID:24046456   PMID:24167781   PMID:24391950   PMID:24457600   PMID:24612608   PMID:24711643  
PMID:24747692   PMID:24797263   PMID:24809731   PMID:24854103   PMID:25014228   PMID:25053596   PMID:25105415   PMID:25204797   PMID:25229320   PMID:25403318   PMID:25437307   PMID:25659154  
PMID:25738752   PMID:25755751   PMID:25755754   PMID:25893612   PMID:25909165   PMID:26161893   PMID:26186194   PMID:26206082   PMID:26339392   PMID:26496610   PMID:26556629   PMID:26576674  
PMID:26638075   PMID:26641092   PMID:26760575   PMID:26949739   PMID:27221048   PMID:27262438   PMID:27342126   PMID:27609421   PMID:27664330   PMID:27684187   PMID:27981826   PMID:28031328  
PMID:28188157   PMID:28503944   PMID:28514442   PMID:28581508   PMID:28718761   PMID:28739689   PMID:28986522   PMID:29115528   PMID:29121065   PMID:29128334   PMID:29180619   PMID:29467281  
PMID:29509190   PMID:29568061   PMID:29715546   PMID:29961565   PMID:30021884   PMID:30111578   PMID:30425250   PMID:30452906   PMID:30471916   PMID:30639242   PMID:30663389   PMID:30820716  
PMID:30833792   PMID:30836864   PMID:30914515   PMID:30948266   PMID:31091453   PMID:31138766   PMID:31180492   PMID:31182584   PMID:31446795   PMID:31501420   PMID:31586073   PMID:31678930  
PMID:31753913   PMID:31950832   PMID:31995728   PMID:32196611   PMID:32203420   PMID:32296183   PMID:32780723   PMID:32814769   PMID:32877691   PMID:33024031   PMID:33144569   PMID:33403043  
PMID:33631676   PMID:33744853   PMID:33916271   PMID:33957083   PMID:33961781   PMID:34079125  


Genomics

Comparative Map Data
FLOT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1728,879,335 - 28,897,733 (-)EnsemblGRCh38hg38GRCh38
GRCh381728,879,339 - 28,897,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371727,206,357 - 27,224,751 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,230,483 - 24,248,841 (-)NCBINCBI36hg18NCBI36
Build 341724,230,483 - 24,248,696NCBI
Celera1724,065,775 - 24,084,131 (-)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1723,414,667 - 23,432,931 (-)NCBIHuRef
CHM1_11727,268,892 - 27,287,277 (-)NCBICHM1_1
Flot2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,928,757 - 77,951,260 (+)NCBIGRCm39mm39
GRCm39 Ensembl1177,928,757 - 77,951,260 (+)Ensembl
GRCm381178,037,931 - 78,060,434 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,037,931 - 78,060,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,851,443 - 77,873,934 (+)NCBIGRCm37mm9NCBIm37
MGSCv361177,856,499 - 77,876,627 (+)NCBImm8
Celera1185,537,567 - 85,560,033 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Flot2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21062,926,047 - 62,947,759 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1062,920,665 - 62,947,756 (+)Ensembl
Rnor_6.01065,304,901 - 65,329,332 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,304,902 - 65,329,312 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,303,072 - 66,327,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,081,463 - 64,104,166 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11064,095,085 - 64,117,788 (+)NCBI
Celera1061,904,365 - 61,926,029 (+)NCBICelera
Cytogenetic Map10q25NCBI
Flot2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,276,860 - 4,298,523 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,276,847 - 4,298,523 (+)NCBIChiLan1.0ChiLan1.0
FLOT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11728,385,192 - 28,403,523 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,385,191 - 28,405,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01727,876,424 - 27,894,836 (+)NCBIMhudiblu_PPA_v0panPan3
DHRS13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1943,050,929 - 43,066,886 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl943,052,114 - 43,071,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha942,206,071 - 42,222,098 (-)NCBI
ROS_Cfam_1.0943,868,682 - 43,884,709 (-)NCBI
UMICH_Zoey_3.1942,652,184 - 42,668,203 (-)NCBI
UNSW_CanFamBas_1.0942,944,151 - 42,960,172 (-)NCBI
UU_Cfam_GSD_1.0943,022,851 - 43,038,879 (-)NCBI
Flot2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560242,193,601 - 42,212,358 (-)NCBI
SpeTri2.0NW_0049365385,071,546 - 5,090,287 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLOT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,101,514 - 45,120,463 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11245,102,205 - 45,120,503 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,153,539 - 47,163,743 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLOT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,639,403 - 22,658,311 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,639,381 - 22,658,194 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660757,449,441 - 7,468,230 (+)NCBIVero_WHO_p1.0
Flot2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247861,449,001 - 1,465,208 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH17712  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,206,496 - 27,206,644UniSTSGRCh37
Build 361724,230,622 - 24,230,770RGDNCBI36
Celera1724,065,914 - 24,066,062RGD
Cytogenetic Map17q11-q12UniSTS
HuRef1723,414,806 - 23,414,954UniSTS
RH78255  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,224,911 - 27,225,031UniSTSGRCh37
Build 361724,249,037 - 24,249,157RGDNCBI36
Celera1724,084,327 - 24,084,447RGD
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map17q11-q12UniSTS
HuRef1723,433,127 - 23,433,247UniSTS
RH12224  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,217,928 - 27,218,032UniSTSGRCh37
Build 361724,242,054 - 24,242,158RGDNCBI36
Celera1724,077,344 - 24,077,448RGD
Cytogenetic Map17q11-q12UniSTS
HuRef1723,426,236 - 23,426,340UniSTS
RH17814  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,224,832 - 27,225,062UniSTSGRCh37
Build 361724,248,958 - 24,249,188RGDNCBI36
Celera1724,084,248 - 24,084,478RGD
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map17q11-q12UniSTS
HuRef1723,433,048 - 23,433,278UniSTS
D17S963  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,206,887 - 27,207,113UniSTSGRCh37
Build 361724,231,013 - 24,231,239RGDNCBI36
Celera1724,066,305 - 24,066,531RGD
Cytogenetic Map17q11-q12UniSTS
HuRef1723,415,197 - 23,415,423UniSTS
FLOT2__6735  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,206,366 - 27,207,267UniSTSGRCh37
Build 361724,230,492 - 24,231,393RGDNCBI36
Celera1724,065,784 - 24,066,685RGD
HuRef1723,414,676 - 23,415,577UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6047
Count of miRNA genes:1021
Interacting mature miRNAs:1278
Transcripts:ENST00000394906, ENST00000394908, ENST00000465427, ENST00000577789, ENST00000580313, ENST00000580805, ENST00000581509, ENST00000582174, ENST00000584569, ENST00000585169, ENST00000586827, ENST00000593158
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 237 237 1
Medium 2438 2725 1721 620 1714 461 4356 2169 3717 417 1458 1613 175 1 1204 2788 6 2
Low 1 29 5 4 4 1 28 17 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001330170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005257953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC024267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ019299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA390100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000394906   ⟹   ENSP00000378366
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,879,335 - 28,897,652 (-)Ensembl
RefSeq Acc Id: ENST00000394908   ⟹   ENSP00000378368
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,879,339 - 28,897,733 (-)Ensembl
RefSeq Acc Id: ENST00000465427   ⟹   ENSP00000465819
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,881,344 - 28,885,947 (-)Ensembl
RefSeq Acc Id: ENST00000577789
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,879,341 - 28,897,652 (-)Ensembl
RefSeq Acc Id: ENST00000580313
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,882,633 - 28,886,011 (-)Ensembl
RefSeq Acc Id: ENST00000580805   ⟹   ENSP00000463304
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,879,339 - 28,897,653 (-)Ensembl
RefSeq Acc Id: ENST00000581509
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,882,979 - 28,889,026 (-)Ensembl
RefSeq Acc Id: ENST00000582174
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,882,740 - 28,897,654 (-)Ensembl
RefSeq Acc Id: ENST00000584569
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,879,341 - 28,882,659 (-)Ensembl
RefSeq Acc Id: ENST00000585169   ⟹   ENSP00000463503
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,879,341 - 28,897,652 (-)Ensembl
RefSeq Acc Id: ENST00000586827   ⟹   ENSP00000465022
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,880,578 - 28,897,588 (-)Ensembl
RefSeq Acc Id: ENST00000593158
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,881,775 - 28,897,588 (-)Ensembl
RefSeq Acc Id: NM_001330170   ⟹   NP_001317099
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,733 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004475   ⟹   NP_004466
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,733 (-)NCBI
GRCh371727,206,356 - 27,224,715 (-)NCBI
Build 361724,230,483 - 24,248,841 (-)NCBI Archive
HuRef1723,414,667 - 23,432,931 (-)ENTREZGENE
CHM1_11727,268,892 - 27,287,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005257953   ⟹   XP_005258010
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,723 (-)NCBI
GRCh371727,206,356 - 27,224,715 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017024394   ⟹   XP_016879883
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017024395   ⟹   XP_016879884
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,703 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017024396   ⟹   XP_016879885
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,083 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024450666   ⟹   XP_024306434
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,690 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024450667   ⟹   XP_024306435
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,879,339 - 28,897,077 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004466   ⟸   NM_004475
- Peptide Label: isoform 1
- UniProtKB: Q14254 (UniProtKB/Swiss-Prot),   A0A024QZ62 (UniProtKB/TrEMBL),   Q9BTI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005258010   ⟸   XM_005257953
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016879884   ⟸   XM_017024395
- Peptide Label: isoform X2
- UniProtKB: Q14254 (UniProtKB/Swiss-Prot),   Q6FG43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016879885   ⟸   XM_017024396
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016879883   ⟸   XM_017024394
- Peptide Label: isoform X2
- UniProtKB: Q14254 (UniProtKB/Swiss-Prot),   Q6FG43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001317099   ⟸   NM_001330170
- Peptide Label: isoform 2
- UniProtKB: J3QLD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024306434   ⟸   XM_024450666
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024306435   ⟸   XM_024450667
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000463304   ⟸   ENST00000580805
RefSeq Acc Id: ENSP00000465819   ⟸   ENST00000465427
RefSeq Acc Id: ENSP00000463503   ⟸   ENST00000585169
RefSeq Acc Id: ENSP00000465022   ⟸   ENST00000586827
RefSeq Acc Id: ENSP00000378368   ⟸   ENST00000394908
RefSeq Acc Id: ENSP00000378366   ⟸   ENST00000394906
Protein Domains
PHB

Promoters
RGD ID:7234453
Promoter ID:EPDNEW_H22971
Type:initiation region
Name:FLOT2_1
Description:flotillin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,897,708 - 28,897,768EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q11.2(chr17:28283125-28904397)x3 copy number gain See cases [RCV000136494] Chr17:28283125..28904397 [GRCh38]
Chr17:26610151..27231415 [GRCh37]
Chr17:23634278..24255541 [NCBI36]
Chr17:17q11.2
benign
GRCh38/hg38 17q11.2(chr17:28757283-29216419)x3 copy number gain See cases [RCV000142450] Chr17:28757283..29216419 [GRCh38]
Chr17:27084301..27543437 [GRCh37]
Chr17:24108428..24567563 [NCBI36]
Chr17:17q11.2
uncertain significance
GRCh37/hg19 17q11.1-11.2(chr17:25403446-31685464)x3 copy number gain not provided [RCV000762776] Chr17:25403446..31685464 [GRCh37]
Chr17:17q11.1-11.2
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q11.1-11.2(chr17:25248166-30645676)x1 copy number loss Mitogen-activated protein kinase kinase inhibitor response [RCV000626439] Chr17:25248166..30645676 [GRCh37]
Chr17:17q11.1-11.2
drug response
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p11.2-q11.2(chr17:21279289-27474974)x2 copy number gain not provided [RCV000739439] Chr17:21279289..27474974 [GRCh37]
Chr17:17p11.2-q11.2
likely pathogenic
NM_004475.3(FLOT2):c.510G>A (p.Thr170=) single nucleotide variant not provided [RCV000903805] Chr17:28882406 [GRCh38]
Chr17:27209424 [GRCh37]
Chr17:17q11.2
benign
NM_004475.3(FLOT2):c.1003A>G (p.Lys335Glu) single nucleotide variant not provided [RCV000881621] Chr17:28881287 [GRCh38]
Chr17:27208305 [GRCh37]
Chr17:17q11.2
benign
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
GRCh37/hg19 17q11.1-11.2(chr17:25274363-28450707)x3 copy number gain not provided [RCV001006886] Chr17:25274363..28450707 [GRCh37]
Chr17:17q11.1-11.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3758 AgrOrtholog
COSMIC FLOT2 COSMIC
Ensembl Genes ENSG00000132589 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000378366 UniProtKB/TrEMBL
  ENSP00000378368 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000463304 UniProtKB/TrEMBL
  ENSP00000463503 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000465022 UniProtKB/TrEMBL
  ENSP00000465819 UniProtKB/TrEMBL
Ensembl Transcript ENST00000394906 UniProtKB/TrEMBL
  ENST00000394908 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000465427 UniProtKB/TrEMBL
  ENST00000580805 UniProtKB/TrEMBL
  ENST00000585169 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000586827 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000132589 GTEx
HGNC ID HGNC:3758 ENTREZGENE
Human Proteome Map FLOT2 Human Proteome Map
InterPro Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flotillin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flotillin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2319 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2319 ENTREZGENE
OMIM 131560 OMIM
PANTHER PTHR13806 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28176 PharmGKB
SMART PHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024QZ62 ENTREZGENE, UniProtKB/TrEMBL
  E7EMK3_HUMAN UniProtKB/TrEMBL
  FLOT2_HUMAN UniProtKB/Swiss-Prot
  J3QKZ4_HUMAN UniProtKB/TrEMBL
  J3QLD9 ENTREZGENE, UniProtKB/TrEMBL
  K7EJ47_HUMAN UniProtKB/TrEMBL
  K7EKW9_HUMAN UniProtKB/TrEMBL
  Q14254 ENTREZGENE
  Q6FG43 ENTREZGENE, UniProtKB/TrEMBL
  Q9BTI6 ENTREZGENE, UniProtKB/TrEMBL