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Gene: TRAF3 (TNF receptor associated factor 3) Homo sapiens
Symbol: TRAF3
Name: TNF receptor associated factor 3
Description: Exhibits enzyme binding activity and tumor necrosis factor receptor binding activity. Involved in negative regulation of NF-kappaB transcription factor activity; regulation of proteolysis; and tumor necrosis factor-mediated signaling pathway. Predicted to localize to the CD40 receptor complex and cytoplasmic side of plasma membrane. Implicated in brain disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAP-1; CAP1; CD40 associated protein 1; CD40 binding protein; CD40 receptor associated factor 1; CD40 receptor-associated factor 1; CD40-binding protein; CD40bp; CRAF1; IIAE5; LAP1; LMP1 associated protein; LMP1-associated protein 1; RING-type E3 ubiquitin transferase TRAF3; RNF118; TNF receptor-associated factor 3
Mus musculus (house mouse) : Traf3 (TNF receptor-associated factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Traf3 (Tnf receptor-associated factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Traf3 (TNF receptor associated factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TRAF3 (TNF receptor associated factor 3)
Canis lupus familiaris (dog) : TRAF3 (TNF receptor associated factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Traf3 (TNF receptor associated factor 3)
Sus scrofa (pig) : TRAF3 (TNF receptor associated factor 3)
Chlorocebus sabaeus (green monkey) : TRAF3 (TNF receptor associated factor 3)
Heterocephalus glaber (naked mole-rat) : Traf3 (TNF receptor associated factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl14102,777,449 - 102,911,500 (+)Ensembl
GRCh38 Ensembl14102,777,476 - 102,911,500 (+)Ensembl
GRCh3814102,777,449 - 102,911,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714103,243,816 - 103,377,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614102,313,569 - 102,442,381 (+)NCBINCBI36hg18NCBI36
Celera1483,297,948 - 83,426,752 (+)NCBI
Cytogenetic Map14q32.32NCBI
HuRef1483,420,470 - 83,553,138 (+)NCBIHuRef
CHM1_114103,181,586 - 103,315,592 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRAF3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312182
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.