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Gene: TICAM2 (toll like receptor adaptor molecule 2) Homo sapiens
Symbol: TICAM2
Name: toll like receptor adaptor molecule 2
Description: Involved in several processes, including positive regulation of interleukin-18-mediated signaling pathway; regulation of chemokine (C-C motif) ligand 5 production; and regulation of innate immune response. Localizes to the endoplasmic reticulum; endosome; and phagocytic cup.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytoplasmic adaptor; MGC129876; MGC129877; MyD88-4; NF-kappa-B-activating protein 502; putative NF-kappa-B-activating protein 502; TICAM-2; TIR domain-containing adapter molecule 2; TIR-containing adapter molecule-2; TIRAP3; TIRP; toll-like receptor adaptor molecule 2; toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule; TRIF-related adaptor molecule
Mus musculus (house mouse) : Ticam2 (toll-like receptor adaptor molecule 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ticam2 (toll-like receptor adaptor molecule 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ticam2 (toll like receptor adaptor molecule 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TICAM2 (toll like receptor adaptor molecule 2)
Canis lupus familiaris (dog) : TICAM2 (toll like receptor adaptor molecule 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ticam2 (toll like receptor adaptor molecule 2)
Sus scrofa (pig) : TICAM2 (toll like receptor adaptor molecule 2)
Chlorocebus sabaeus (African green monkey) : TICAM2 (toll like receptor adaptor molecule 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5115,578,650 - 115,602,479 (-)Ensembl
GRCh385115,578,496 - 115,602,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375114,914,339 - 114,952,142 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365114,942,247 - 114,989,610 (-)NCBINCBI36hg18NCBI36
Build 345114,942,246 - 114,989,610NCBI
Celera5110,863,614 - 110,887,385 (-)NCBI
Cytogenetic Map5q22.3NCBI
HuRef5110,095,959 - 110,119,799 (-)NCBIHuRef
CHM1_15114,346,838 - 114,370,822 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TICAM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317929
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.