S100A1 (S100 calcium binding protein A1) - Rat Genome Database

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Gene: S100A1 (S100 calcium binding protein A1) Homo sapiens
Analyze
Symbol: S100A1
Name: S100 calcium binding protein A1
RGD ID: 1349517
HGNC Page HGNC:10486
Description: Enables ATPase binding activity; S100 protein binding activity; and protein homodimerization activity. Involved in positive regulation of nitric-oxide synthase activity and positive regulation of sprouting angiogenesis. Located in several cellular components, including Golgi apparatus; nucleoplasm; and sarcoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100; S100 alpha; S100 calcium-binding protein A1; S100 protein, alpha polypeptide; S100-alpha; S100A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BW57_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,628,434 - 153,632,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,627,926 - 153,632,039 (+)EnsemblGRCh38hg38GRCh38
GRCh371153,600,910 - 153,604,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,867,497 - 151,871,137 (+)NCBINCBI36Build 36hg18NCBI36
Build 341150,413,945 - 150,417,586NCBI
Celera1126,671,908 - 126,675,547 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,964,378 - 124,968,018 (+)NCBIHuRef
CHM1_11154,996,850 - 155,000,490 (+)NCBICHM1_1
T2T-CHM13v2.01152,765,698 - 152,769,303 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
S100A1HumanCardiomegaly  ISOS100a1 (Rattus norvegicus)9068941 RGDPMID:12619862 and REF_RGD_ID:735233
S100A1HumanMyocardial Ischemia  IEP 1579977protein:increased expression:serum (human)RGD 
S100A1Humannephrotoxicity treatmentISOS100a1 (Rattus norvegicus)329853759 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
S100A1Humangastrointestinal stromal tumor  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
S100A1Humanimmunodeficiency 42  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiencyClinVarPMID:28492532
S100A1HumanMHC class II deficiency  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: MHC class II deficiencyClinVarPMID:28492532
S100A1Humanparathyroid carcinoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
S100A1Humansevere congenital neutropenia 3  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Kostmann syndromeClinVarPMID:28492532
S100A1Humansevere congenital neutropenia 5  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital neutropenia-myelofibrosis-nephromegaly syndromeClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
S100A1Humanintracranial vasospasm  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12186470

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Object Symbol
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Term
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Reference
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Original Reference(s)
S100A1Human1,2-dimethylhydrazine multiple interactionsISOS100a1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of S100A1 mRNACTDPMID:22206623
S100A1Human1,3,5-trinitro-1,3,5-triazinane decreases expressionISOS100a1 (Rattus norvegicus)6480464cyclonite results in decreased expression of S100A1 mRNACTDPMID:25559034
S100A1Human17alpha-ethynylestradiol affects expressionISOS100a1 (Rattus norvegicus)6480464Ethinyl Estradiol affects the expression of S100A1 mRNACTDPMID:20170705
S100A1Human17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of S100A1 mRNACTDPMID:23019147
S100A1Human17beta-estradiol increases expressionISOS100a1 (Mus musculus)6480464Estradiol results in increased expression of S100A1 mRNACTDPMID:39298647
S100A1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOS100a1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of S100A1 mRNACTDPMID:21570461 and PMID:24680724
S100A1Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOS100a1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of S100A1 mRNACTDPMID:33387578
S100A1Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOS100a1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of S100A1 mRNACTDPMID:32109520
S100A1Human3,3',4,4',5-pentachlorobiphenyl decreases expressionISOS100a1 (Rattus norvegicus)64804643 more ...CTDPMID:23196670
S100A1Human4,4'-diaminodiphenylmethane affects expressionISOS100a1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane affects the expression of S100A1 mRNACTDPMID:18648102
S100A1Human4,4'-sulfonyldiphenol increases expressionISOS100a1 (Mus musculus)6480464bisphenol S results in increased expression of S100A1 mRNACTDPMID:39298647
S100A1Human4,4'-sulfonyldiphenol multiple interactionsISOS100a1 (Rattus norvegicus)6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of S100A1 mRNACTDPMID:36041667
S100A1Human4-hydroxyphenyl retinamide decreases expressionISOS100a1 (Mus musculus)6480464Fenretinide results in decreased expression of S100A1 mRNACTDPMID:28973697
S100A1Human6-propyl-2-thiouracil decreases expressionISOS100a1 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of S100A1 mRNACTDPMID:24780913
S100A1Human9-cis-retinoic acid decreases expressionEXP 6480464Alitretinoin results in decreased expression of S100A1 mRNACTDPMID:15982314
S100A1Humanall-trans-4-oxoretinoic acid decreases expressionEXP 64804644-oxoretinoic acid results in decreased expression of S100A1 mRNACTDPMID:15982314
S100A1Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin metabolite results in decreased expression of S100A1 mRNACTDPMID:15982314
S100A1Humanamitrole decreases expressionISOS100a1 (Rattus norvegicus)6480464Amitrole results in decreased expression of S100A1 mRNACTDPMID:30047161
S100A1Humanammonium chloride affects expressionISOS100a1 (Rattus norvegicus)6480464Ammonium Chloride affects the expression of S100A1 mRNACTDPMID:16483693
S100A1Humanaristolochic acid A increases expressionEXP 6480464aristolochic acid I results in increased expression of S100A1 mRNACTDPMID:33212167

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Cellular Component
1 to 20 of 23 rows

  
Object Symbol
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Original Reference(s)
S100A1HumanA band  ISOS100a1 (Rattus norvegicus)9068941 RGDPMID:11156445 and REF_RGD_ID:7205634
S100A1HumanA band located_inIEAUniProtKB:P35467 and ensembl:ENSRNOP00000017000150520179 EnsemblGO_REF:0000107
S100A1Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
S100A1Humancytoplasm is_active_inIBAMGI:1338917 more ...150520179 GO_CentralGO_REF:0000033
S100A1Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
S100A1Humancytosol located_inIDA 150520179 HPAGO_REF:0000052
S100A1Humanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-166072 more ...
S100A1HumanGolgi apparatus located_inIDA 150520179 HPAGO_REF:0000052
S100A1HumanI band  ISOS100a1 (Rattus norvegicus)9068941 RGDPMID:11156445 and REF_RGD_ID:7205634
S100A1HumanI band located_inIEAUniProtKB:P35467 and ensembl:ENSRNOP00000017000150520179 EnsemblGO_REF:0000107
S100A1HumanM band  ISOS100a1 (Rattus norvegicus)9068941 RGDPMID:11156445 and REF_RGD_ID:7205634
S100A1HumanM band located_inIEAUniProtKB:P35467 and ensembl:ENSRNOP00000017000150520179 EnsemblGO_REF:0000107
S100A1Humanmitochondrion located_inIEAUniProtKB-SubCell:SL-0173150520179 UniProtGO_REF:0000044
S100A1Humanmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
S100A1Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
S100A1Humannucleus located_inIDA 150520179 PMID:12118070UniProtPMID:12118070
S100A1Humanprotein-containing complex part_ofNAS 150520179 PMID:14638689UniProtPMID:14638689
S100A1Humansarcoplasmic reticulum located_inIDA 150520179 PMID:12804600UniProtPMID:12804600
S100A1Humansarcoplasmic reticulum is_active_inIBAMGI:1338917 more ...150520179 GO_CentralGO_REF:0000033
S100A1Humansarcoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-0239150520179 UniProtGO_REF:0000044
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Molecular Function
1 to 20 of 30 rows

  
Object Symbol
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Reference
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Original Reference(s)
S100A1HumanATPase binding enablesIPIUniProtKB:P16615150520179 PMID:12804600UniProtPMID:12804600
S100A1Humancalcium ion binding enablesIBAMGI:1330282 more ...150520179 GO_CentralGO_REF:0000033
S100A1Humancalcium ion binding enablesIEAUniProtKB:P35467 and ensembl:ENSRNOP00000017000150520179 EnsemblGO_REF:0000107
S100A1Humancalcium ion binding enablesIEAInterPro:IPR002048 and InterPro:IPR028486150520179 InterProGO_REF:0000002
S100A1Humancalcium ion binding enablesTAS 150520179 PMID:1998503PINCPMID:1998503
S100A1Humancalcium ion binding  ISOS100a1 (Rattus norvegicus)9068941 RGDPMID:16169012 and REF_RGD_ID:7205632
S100A1Humancalcium-dependent protein binding  ISOSyn1 (Rattus norvegicus)9068941 RGDPMID:10567243 and REF_RGD_ID:7205635
S100A1Humancalcium-dependent protein binding enablesIEAUniProtKB:P35467 and ensembl:ENSRNOP00000017000150520179 EnsemblGO_REF:0000107
S100A1Humancalcium-dependent protein binding enablesIBAPANTHER:PTN007521306 more ...150520179 GO_CentralGO_REF:0000033
S100A1Humancalcium-dependent protein binding  ISOSyn2 (Rattus norvegicus)9068941 RGDPMID:10567243 and REF_RGD_ID:7205635
S100A1Humanidentical protein binding enablesIEAUniProtKB:P35467 and ensembl:ENSRNOP00000017000150520179 EnsemblGO_REF:0000107
S100A1Humanidentical protein binding enablesIPIUniProtKB:Q5T7Y6150520179 PMID:27107012IntActPMID:27107012
S100A1Humanidentical protein binding enablesIPIUniProtKB:P23297150520179 PMID:10913138 more ...IntActPMID:10913138 more ...
S100A1Humanidentical protein binding  ISOS100a1 (Rattus norvegicus)9068941homodimerizationRGDPMID:16169012 and REF_RGD_ID:7205632
S100A1Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
S100A1Humanprotein binding enablesIPIUniProtKB:P04271 more ...150520179 PMID:16189514IntActPMID:16189514
S100A1Humanprotein binding enablesIPIUniProtKB:P04271 and UniProtKB:P25815150520179 PMID:27107012IntActPMID:27107012
S100A1Humanprotein binding enablesIPIUniProtKB:O15151 more ...150520179 PMID:31837246IntActPMID:31837246
S100A1Humanprotein binding enablesIPIUniProtKB:P04271 and UniProtKB:Q04864-2150520179 PMID:26871637IntActPMID:26871637
S100A1Humanprotein binding enablesIPIUniProtKB:P04271 and UniProtKB:Q96CV9150520179 PMID:32814053IntActPMID:32814053
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RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
S100A1Humancalcium/calcium-mediated signaling pathway   ISOTNNC1 (Homo sapiens)7204682 RGD 
S100A1Humancalcium/calcium-mediated signaling pathway   TAS 7204682 RGD 
S100A1Humancalcium/calcium-mediated signaling pathway   IMP 1579960 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
S100A1HumanGastrointestinal stroma tumor  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
S100A1HumanParathyroid carcinoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. S100A1, a new marker for acute myocardial ischemia. Kiewitz R, etal., Biochem Biophys Res Commun. 2000 Aug 11;274(3):865-71.
3. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
4. S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes. Reppel M, etal., J Biol Chem. 2005 Oct 28;280(43):36019-28. Epub 2005 Aug 28.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Calcium, troponin, calmodulin, S100 proteins: from myocardial basics to new therapeutic strategies. Schaub MC and Heizmann CW, Biochem Biophys Res Commun. 2008 Apr 25;369(1):247-64. Epub 2007 Oct 25.
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PMID:1384693   PMID:1998503   PMID:3722149   PMID:4052452   PMID:7620916   PMID:7759097   PMID:8341667   PMID:8641565   PMID:8701470   PMID:8894274   PMID:8898862   PMID:9298970  
PMID:9468301   PMID:9645951   PMID:9803314   PMID:9883272   PMID:9920416   PMID:9925766   PMID:9926943   PMID:10510252   PMID:10753920   PMID:10869553   PMID:10913138   PMID:11007787  
PMID:11829317   PMID:11909974   PMID:12042313   PMID:12118070   PMID:12477932   PMID:12721284   PMID:12804600   PMID:12960148   PMID:14638689   PMID:15147519   PMID:15171681   PMID:15489334  
PMID:15578088   PMID:15608682   PMID:15654019   PMID:15780567   PMID:16169012   PMID:16189514   PMID:16710414   PMID:16760135   PMID:16969478   PMID:17210106   PMID:17396138   PMID:17483815  
PMID:17512776   PMID:18029348   PMID:18193148   PMID:18360353   PMID:18845991   PMID:18976975   PMID:19011512   PMID:19037854   PMID:19297317   PMID:19302533   PMID:19384190   PMID:19482672  
PMID:19538970   PMID:19601998   PMID:19680475   PMID:19926575   PMID:20042890   PMID:20188096   PMID:20347987   PMID:20429377   PMID:20591429   PMID:20864512   PMID:21090249   PMID:21296671  
PMID:21516116   PMID:21873635   PMID:22399290   PMID:22451665   PMID:22647434   PMID:22926577   PMID:22989881   PMID:23048072   PMID:23351007   PMID:23595519   PMID:23662436   PMID:23671622  
PMID:23683996   PMID:23824909   PMID:24244340   PMID:24402969   PMID:24501865   PMID:24833748   PMID:25157660   PMID:25269953   PMID:25416956   PMID:25611268   PMID:26264872   PMID:26871637  
PMID:26943607   PMID:26958883   PMID:27107012   PMID:27226555   PMID:27356898   PMID:27435061   PMID:27644758   PMID:27861869   PMID:28368280   PMID:28408431   PMID:28595036   PMID:28765046  
PMID:28819010   PMID:28825380   PMID:29240297   PMID:29248577   PMID:29444082   PMID:29997244   PMID:31515488   PMID:31523180   PMID:31837246   PMID:32296183   PMID:32497081   PMID:32814053  
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S100A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,628,434 - 153,632,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,627,926 - 153,632,039 (+)EnsemblGRCh38hg38GRCh38
GRCh371153,600,910 - 153,604,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,867,497 - 151,871,137 (+)NCBINCBI36Build 36hg18NCBI36
Build 341150,413,945 - 150,417,586NCBI
Celera1126,671,908 - 126,675,547 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,964,378 - 124,968,018 (+)NCBIHuRef
CHM1_11154,996,850 - 155,000,490 (+)NCBICHM1_1
T2T-CHM13v2.01152,765,698 - 152,769,303 (+)NCBIT2T-CHM13v2.0
S100a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39390,418,341 - 90,421,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl390,418,341 - 90,421,699 (-)EnsemblGRCm39 Ensembl
GRCm38390,511,034 - 90,514,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl390,511,034 - 90,514,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37390,314,956 - 90,318,252 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36390,596,964 - 90,600,318 (-)NCBIMGSCv36mm8
Celera390,548,873 - 90,552,169 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.24NCBI
S100a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,291,503 - 178,296,346 (-)NCBIGRCr8
mRatBN7.22175,993,922 - 175,998,765 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,993,922 - 175,999,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2183,134,036 - 183,138,882 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,156,299 - 181,161,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,756,640 - 175,761,484 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,900,505 - 189,905,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,900,667 - 189,903,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,330,969 - 209,336,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,784,818 - 182,787,370 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12182,734,773 - 182,737,446 (-)NCBI
Celera2169,929,425 - 169,934,268 (-)NCBICelera
Cytogenetic Map2q34NCBI
S100a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955545276,868 - 281,015 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955545276,868 - 281,015 (+)NCBIChiLan1.0ChiLan1.0
S100A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,201,116 - 96,204,797 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,936,306 - 95,939,987 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01128,984,296 - 128,987,979 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,612,533 - 132,616,194 (+)NCBIpanpan1.1PanPan1.1panPan2
S100A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,428,819 - 43,432,637 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,428,820 - 43,433,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,921,842 - 42,925,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,378,532 - 43,382,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,378,533 - 43,383,154 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,080,591 - 43,084,382 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,134,307 - 43,138,106 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,417,962 - 43,421,754 (-)NCBIUU_Cfam_GSD_1.0
S100a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505824,399,294 - 24,403,185 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365803,427,212 - 3,434,577 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365803,429,697 - 3,433,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S100A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,007,028 - 96,012,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1496,007,026 - 96,012,305 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,900,208 - 104,900,536 (-)NCBISscrofa10.2Sscrofa10.2susScr3
S100A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,172,916 - 10,176,905 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660389,550,156 - 9,554,176 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S100a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248853,512,288 - 3,516,850 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248853,512,288 - 3,516,845 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in S100A1
8 total Variants

1 to 10 of 26 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1q21.3(chr1:153412418-153604246)x3 copy number gain Breast ductal adenocarcinoma [RCV000207267] Chr1:153412418..153604246 [GRCh37]
Chr1:1q21.3		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_006271.2(S100A1):c.119C>T (p.Thr40Met) single nucleotide variant not specified [RCV004289539] Chr1:153630640 [GRCh38]
Chr1:153603116 [GRCh37]
Chr1:1q21.3		 uncertain significance
GRCh37/hg19 1q21.3(chr1:150853044-154647786)x3 copy number gain not provided [RCV000684655] Chr1:150853044..154647786 [GRCh37]
Chr1:1q21.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q21.3(chr1:153488723-153750339)x3 copy number gain not provided [RCV000749192] Chr1:153488723..153750339 [GRCh37]
Chr1:1q21.3		 benign
NM_006271.2(S100A1):c.60G>A (p.Ser20=) single nucleotide variant not provided [RCV000899559] Chr1:153630581 [GRCh38]
Chr1:153603057 [GRCh37]
Chr1:1q21.3		 benign
1 to 10 of 26 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR132hsa-miR-132-3pTarbaseexternal_infoMicroarrayPOSITIVE

Predicted Target Of
Summary Value
Count of predictions:1283
Count of miRNA genes:571
Interacting mature miRNAs:628
Transcripts:ENST00000292169, ENST00000368696, ENST00000368698, ENST00000436839, ENST00000469893
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human

STS-X58079  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371153,604,305 - 153,604,487UniSTSGRCh37
Build 361151,870,929 - 151,871,111RGDNCBI36
Celera1126,675,340 - 126,675,522RGD
Cytogenetic Map1q21UniSTS
HuRef1124,967,810 - 124,967,992UniSTS
GeneMap99-GB4 RH Map1558.0UniSTS
NCBI RH Map11196.1UniSTS
S100A1_2878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371153,604,127 - 153,604,612UniSTSGRCh37
Build 361151,870,751 - 151,871,236RGDNCBI36
Celera1126,675,162 - 126,675,647RGD
HuRef1124,967,632 - 124,968,117UniSTS
S100A1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371153,604,195 - 153,604,294UniSTSGRCh37
Celera1126,675,230 - 126,675,329UniSTS
HuRef1124,967,700 - 124,967,799UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2438 2788 2253 4972 1721 2339 6 623 1888 464 2269 7241 6409 51 3727 1 852 1743 1606 174 1


1 to 18 of 18 rows
RefSeq Transcripts NM_006271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK126904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL162258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN341830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENST00000292169   ⟹   ENSP00000292169
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1153,628,434 - 153,632,039 (+)Ensembl
Ensembl Acc Id: ENST00000368696   ⟹   ENSP00000357685
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1153,628,422 - 153,631,804 (+)Ensembl
Ensembl Acc Id: ENST00000368698   ⟹   ENSP00000357687
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1153,627,926 - 153,632,034 (+)Ensembl
Ensembl Acc Id: ENST00000436839   ⟹   ENSP00000389708
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1153,628,464 - 153,630,625 (+)Ensembl
Ensembl Acc Id: ENST00000469893
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1153,628,384 - 153,632,039 (+)Ensembl
RefSeq Acc Id: NM_006271   ⟹   NP_006262
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381153,628,434 - 153,632,039 (+)NCBI
GRCh371153,600,873 - 153,604,513 (+)NCBI
Build 361151,867,497 - 151,871,137 (+)NCBI Archive
HuRef1124,964,378 - 124,968,018 (+)NCBI
CHM1_11154,996,850 - 155,000,490 (+)NCBI
T2T-CHM13v2.01152,765,698 - 152,769,303 (+)NCBI
Sequence:
RefSeq Acc Id: NP_006262   ⟸   NM_006271
- UniProtKB: B2R5D9 (UniProtKB/Swiss-Prot),   Q5T7Y3 (UniProtKB/Swiss-Prot),   P23297 (UniProtKB/Swiss-Prot),   A0A0S2Z4H2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000292169   ⟸   ENST00000292169
Ensembl Acc Id: ENSP00000357685   ⟸   ENST00000368696
Ensembl Acc Id: ENSP00000357687   ⟸   ENST00000368698
Ensembl Acc Id: ENSP00000389708   ⟸   ENST00000436839
EF-hand   S100/CaBP-9k-type calcium binding subdomain

Name Modeler Protein Id AA Range Protein Structure
AF-P23297-F1-model_v2 AlphaFold P23297 1-94 view protein structure

RGD ID:6786770
Promoter ID:HG_KWN:5201
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   NB4
Transcripts:NM_006271,   OTTHUMT00000089934,   OTTHUMT00000089935,   OTTHUMT00000089936,   UC001FCL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361151,867,344 - 151,867,844 (+)MPROMDB
RGD ID:6852866
Promoter ID:EP74250
Type:initiation region
Name:HS_S100A1
Description:S100 calcium binding protein A1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361151,867,562 - 151,867,622EPD
RGD ID:6857246
Promoter ID:EPDNEW_H1788
Type:initiation region
Name:S100A1_3
Description:S100 calcium binding protein A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1790  EPDNEW_H1792  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381153,627,423 - 153,627,483EPDNEW
RGD ID:6857250
Promoter ID:EPDNEW_H1790
Type:initiation region
Name:S100A1_2
Description:S100 calcium binding protein A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1788  EPDNEW_H1792  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381153,627,893 - 153,627,953EPDNEW
RGD ID:6857254
Promoter ID:EPDNEW_H1792
Type:initiation region
Name:S100A1_1
Description:S100 calcium binding protein A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1788  EPDNEW_H1790  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381153,628,438 - 153,628,498EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
COSMIC S100A1 COSMIC
Ensembl Genes ENSG00000160678 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000292169 ENTREZGENE
  ENST00000292169.6 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
GTEx ENSG00000160678 GTEx
HGNC ID HGNC:10486 ENTREZGENE
Human Proteome Map S100A1 Human Proteome Map
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  S100-A1 UniProtKB/Swiss-Prot
  S100/CaBP-9k_CS UniProtKB/Swiss-Prot
  S100_Ca-bd_sub UniProtKB/Swiss-Prot
KEGG Report hsa:6271 UniProtKB/Swiss-Prot
NCBI Gene 6271 ENTREZGENE
OMIM 176940 OMIM
PANTHER PROTEIN S100-A1-RELATED UniProtKB/Swiss-Prot
  S100 CALCIUM-BINDING PROTEIN UniProtKB/Swiss-Prot
Pfam EF-hand_1 UniProtKB/Swiss-Prot
  S_100 UniProtKB/Swiss-Prot
PharmGKB PA34898 PharmGKB
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  S100_CABP UniProtKB/Swiss-Prot
SMART EFh UniProtKB/Swiss-Prot
  S_100 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A0S2Z4H2 ENTREZGENE, UniProtKB/TrEMBL
  B2R5D9 ENTREZGENE
  P23297 ENTREZGENE
  Q5T7Y3 ENTREZGENE
  Q5T7Y4_HUMAN UniProtKB/TrEMBL
  Q5T7Y5_HUMAN UniProtKB/TrEMBL
  Q5T7Y6_HUMAN UniProtKB/TrEMBL
  S10A1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2R5D9 UniProtKB/Swiss-Prot
  Q5T7Y3 UniProtKB/Swiss-Prot
1 to 38 of 38 rows