RGD Reference Report - The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart. - Rat Genome Database

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The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart.

Authors: Tsoporis, JN  Marks, A  Zimmer, DB  McMahon, C  Parker, TG 
Citation: Tsoporis JN, etal., Mol Cell Biochem 2003 Jan;242(1-2):27-33.
RGD ID: 735233
Pubmed: PMID:12619862   (View Abstract at PubMed)

S100A1 and S100B are members of a family of 20 kDa Ca2+-binding homodimers that play a role in signal transduction in mammalian cells. S100A1 is the major isoform in normal heart and S100B, normally a brain protein, is induced in hypertrophic myocardium and functions as an intrinsic negative modulator of the hypertrophic response. In order to examine the function of S100A1, we first showed that, in contrast to S100B, S100A1 was downregulated in rat experimental models of myocardial hypertrophy following myocardial infarction or pressure overload. Second, in co-transfection experiments in cultured neonatal rat cardiac myocytes, S100A1 inhibited the alpha1-adrenergic activation of promoters of genes induced during the hypertrophic response including the fetal genes skeletal alpha actin (skACT), and beta-myosin heavy chain (MHC) and S100B, but not the triiodothyronine (T3) activation of the promoter of the alpha-MHC gene, that is normally expressed in adult myocardium. These results suggest that S100A1 is involved in the maintenance of the genetic program that defines normal myocardial function and that its downregulation is permissive for the induction of genes that underlie myocardial hypertrophy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
S100a1RatCardiomegaly  IDA  RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
S100a1Ratnegative regulation of transcription by RNA polymerase II  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
S100a1  (S100 calcium binding protein A1)


Additional Information