S100a1 (S100 calcium binding protein A1) - Rat Genome Database

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Gene: S100a1 (S100 calcium binding protein A1) Rattus norvegicus
Analyze
Symbol: S100a1
Name: S100 calcium binding protein A1
RGD ID: 3614
Description: Enables calcium ion binding activity; calcium-dependent protein binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of voltage-gated calcium channel activity. Located in M band and Z disc. Orthologous to human S100A1 (S100 calcium binding protein A1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,291,503 - 178,296,346 (-)NCBIGRCr8
mRatBN7.22175,993,922 - 175,998,765 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,993,922 - 175,999,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2183,134,036 - 183,138,882 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,156,299 - 181,161,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,756,640 - 175,761,484 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,900,505 - 189,905,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,900,667 - 189,903,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,330,969 - 209,336,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,784,818 - 182,787,370 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12182,734,773 - 182,737,446 (-)NCBI
Celera2169,929,425 - 169,934,268 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlormequat chloride  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
heparin  (EXP)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
jaspamide  (ISO)
Licochalcone B  (ISO)
malathion  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methomyl  (EXP)
Muraglitazar  (EXP)
nickel atom  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
phenobarbital  (EXP)
PhIP  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
A band  (IDA)
cytoplasm  (IBA)
cytosol  (ISO)
Golgi apparatus  (ISO)
I band  (IDA)
M band  (IDA)
mitochondrion  (IEA)
nucleoplasm  (ISO)
nucleus  (ISO)
sarcoplasmic reticulum  (IBA,IEA,ISO)
Z disc  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Synapsins as major neuronal Ca2+/S100A1-interacting proteins. Heierhorst J, etal., Biochem J. 1999 Dec 1;344 Pt 2:577-83.
3. Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons. Hernandez-Ochoa EO, etal., Am J Physiol Cell Physiol. 2009 Oct;297(4):C955-70. doi: 10.1152/ajpcell.00140.2009. Epub 2009 Aug 5.
4. S100A1, a new marker for acute myocardial ischemia. Kiewitz R, etal., Biochem Biophys Res Commun. 2000 Aug 11;274(3):865-71.
5. Distribution of the Ca2+-binding S100A1 protein at different sarcomere lengths of slow and fast rat skeletal muscles. Maco B, etal., Gen Physiol Biophys. 2000 Jun;19(2):237-44.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
9. S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex. Okada M, etal., J Biol Chem. 2004 Feb 6;279(6):4221-33. Epub 2003 Nov 24.
10. S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes. Reppel M, etal., J Biol Chem. 2005 Oct 28;280(43):36019-28. Epub 2005 Aug 28.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Calcium, troponin, calmodulin, S100 proteins: from myocardial basics to new therapeutic strategies. Schaub MC and Heizmann CW, Biochem Biophys Res Commun. 2008 Apr 25;369(1):247-64. Epub 2007 Oct 25.
14. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. Shimamoto S, etal., FEBS Lett. 2010 Mar 19;584(6):1119-25. doi: 10.1016/j.febslet.2010.02.055. Epub 2010 Feb 24.
15. S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction. Tsoporis JN, etal., Circ Res. 2010 Jan 8;106(1):93-101. Epub 2009 Nov 12.
16. The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart. Tsoporis JN, etal., Mol Cell Biochem 2003 Jan;242(1-2):27-33.
17. The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy. Wright NT, etal., J Mol Biol. 2005 Oct 21;353(2):410-26.
18. Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues. Zimmer DB, etal., Brain Res Bull 1991 Aug;27(2):157-62.
Additional References at PubMed
PMID:8793102   PMID:10913138   PMID:12042313   PMID:12118070   PMID:12804600   PMID:15171681   PMID:16189514   PMID:18650434   PMID:21296671   PMID:22926577   PMID:23683996   PMID:24244340  
PMID:25416956   PMID:27107012   PMID:31505169  


Genomics

Comparative Map Data
S100a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,291,503 - 178,296,346 (-)NCBIGRCr8
mRatBN7.22175,993,922 - 175,998,765 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,993,922 - 175,999,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2183,134,036 - 183,138,882 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,156,299 - 181,161,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,756,640 - 175,761,484 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,900,505 - 189,905,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,900,667 - 189,903,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,330,969 - 209,336,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,784,818 - 182,787,370 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12182,734,773 - 182,737,446 (-)NCBI
Celera2169,929,425 - 169,934,268 (-)NCBICelera
Cytogenetic Map2q34NCBI
S100A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,628,434 - 153,632,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,627,926 - 153,632,039 (+)EnsemblGRCh38hg38GRCh38
GRCh371153,600,910 - 153,604,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,867,497 - 151,871,137 (+)NCBINCBI36Build 36hg18NCBI36
Build 341150,413,945 - 150,417,586NCBI
Celera1126,671,908 - 126,675,547 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,964,378 - 124,968,018 (+)NCBIHuRef
CHM1_11154,996,850 - 155,000,490 (+)NCBICHM1_1
T2T-CHM13v2.01152,765,698 - 152,769,303 (+)NCBIT2T-CHM13v2.0
S100a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39390,418,341 - 90,421,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl390,418,341 - 90,421,699 (-)EnsemblGRCm39 Ensembl
GRCm38390,511,034 - 90,514,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl390,511,034 - 90,514,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37390,314,956 - 90,318,252 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36390,596,964 - 90,600,318 (-)NCBIMGSCv36mm8
Celera390,548,873 - 90,552,169 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.24NCBI
S100a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955545276,868 - 281,015 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955545276,868 - 281,015 (+)NCBIChiLan1.0ChiLan1.0
S100A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,201,116 - 96,204,797 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,936,306 - 95,939,987 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01128,984,296 - 128,987,979 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,612,533 - 132,616,194 (+)NCBIpanpan1.1PanPan1.1panPan2
S100A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,428,819 - 43,432,637 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,428,820 - 43,433,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,921,842 - 42,925,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,378,532 - 43,382,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,378,533 - 43,383,154 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,080,591 - 43,084,382 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,134,307 - 43,138,106 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,417,962 - 43,421,754 (-)NCBIUU_Cfam_GSD_1.0
S100a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505824,399,294 - 24,403,185 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365803,427,212 - 3,434,577 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365803,429,697 - 3,433,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S100A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,007,028 - 96,012,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1496,007,026 - 96,012,305 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,900,208 - 104,900,536 (-)NCBISscrofa10.2Sscrofa10.2susScr3
S100A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,172,916 - 10,176,905 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660389,550,156 - 9,554,176 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S100a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248853,512,288 - 3,516,850 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248853,512,288 - 3,516,845 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in S100a1
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000017000
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
AI266795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22175,994,110 - 175,994,223 (+)MAPPERmRatBN7.2
Rnor_6.02189,900,694 - 189,900,806NCBIRnor6.0
Rnor_5.02209,331,158 - 209,331,270UniSTSRnor5.0
RGSC_v3.42182,784,845 - 182,784,957UniSTSRGSC3.4
Celera2169,929,614 - 169,929,726UniSTS
Cytogenetic Map2q34UniSTS
RH131783  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22175,994,008 - 175,994,209 (+)MAPPERmRatBN7.2
Rnor_6.02189,900,592 - 189,900,792NCBIRnor6.0
Rnor_5.02209,331,056 - 209,331,256UniSTSRnor5.0
RGSC_v3.42182,784,743 - 182,784,943UniSTSRGSC3.4
Celera2169,929,512 - 169,929,712UniSTS
RH 3.4 Map21162.5UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017000   ⟹   ENSRNOP00000017000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2175,993,922 - 175,999,544 (-)Ensembl
Rnor_6.0 Ensembl2189,900,667 - 189,903,219 (-)Ensembl
RefSeq Acc Id: NM_001007636   ⟹   NP_001007637
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82178,291,503 - 178,296,346 (-)NCBI
mRatBN7.22175,993,922 - 175,998,765 (-)NCBI
Rnor_6.02189,900,505 - 189,905,348 (-)NCBI
Rnor_5.02209,330,969 - 209,336,331 (-)NCBI
RGSC_v3.42182,784,818 - 182,787,370 (-)RGD
Celera2169,929,425 - 169,934,268 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001007637 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB20539 (Get FASTA)   NCBI Sequence Viewer  
  AAB53657 (Get FASTA)   NCBI Sequence Viewer  
  EDM00555 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017000.4
GenBank Protein P35467 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007637   ⟸   NM_001007636
- UniProtKB: P35467 (UniProtKB/Swiss-Prot),   A6J6N4 (UniProtKB/TrEMBL),   A6J6N5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017000   ⟸   ENSRNOT00000017000
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35467-F1-model_v2 AlphaFold P35467 1-94 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3614 AgrOrtholog
BioCyc Gene G2FUF-52338 BioCyc
Ensembl Genes ENSRNOG00000012410 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017000.5 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100-A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100/CaBP-9k_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100_Ca-bd_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295214 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene S100a1 ENTREZGENE
PANTHER PROTEIN S100-A1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100 CALCIUM-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen S100a1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100_CABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012410 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q8M0_RAT UniProtKB/TrEMBL
  A6J6N4 ENTREZGENE, UniProtKB/TrEMBL
  A6J6N5 ENTREZGENE, UniProtKB/TrEMBL
  P35467 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 S100a1  S100 calcium binding protein A1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA expression decreases in experimental models of myocardial hypertrophy 735233
gene_mutations_overexpression overexpression inhibits alpha1-adrenergic activation of transcription from the skeletal alpha actin (skACT), beta-myosin heavy chain (MHC) and S100B promoters 735233