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Gene: TRAF4 (TNF receptor associated factor 4) Homo sapiens
Symbol: TRAF4
Name: TNF receptor associated factor 4
Description: Exhibits several functions, including WW domain binding activity; enzyme binding activity; and tumor necrosis factor receptor binding activity. Involved in positive regulation of JNK cascade and positive regulation of protein kinase activity. Localizes to cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CART1; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; RING finger protein 83; RNF83; TNF receptor-associated factor 4; TRAF4 variant 6; tumor necrosis receptor-associated factor 4A
Mus musculus (house mouse) : Traf4 (TNF receptor associated factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Traf4 (Tnf receptor associated factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Traf4 (TNF receptor associated factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TRAF4 (TNF receptor associated factor 4)
Canis lupus familiaris (dog) : TRAF4 (TNF receptor associated factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Traf4 (TNF receptor associated factor 4)
Sus scrofa (pig) : TRAF4 (TNF receptor associated factor 4)
Chlorocebus sabaeus (African green monkey) : TRAF4 (TNF receptor associated factor 4)
Heterocephalus glaber (naked mole-rat) : Traf4 (TNF receptor associated factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1728,744,005 - 28,750,956 (+)EnsemblGRCh38hg38GRCh38
GRCh381728,744,004 - 28,750,956 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371727,071,023 - 27,077,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,095,150 - 24,102,103 (+)NCBINCBI36hg18NCBI36
Build 341724,095,172 - 24,101,223NCBI
Celera1723,930,211 - 23,937,232 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1723,279,873 - 23,286,815 (+)NCBIHuRef
CHM1_11727,133,507 - 27,140,459 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRAF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315478
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.