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Gene: PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B) Homo sapiens
Symbol: PPM1B
Name: protein phosphatase, Mg2+/Mn2+ dependent 1B
Description: Exhibits protein serine/threonine phosphatase activity. Involved in several processes, including negative regulation of defense response to virus; negative regulation of intracellular signal transduction; and peptidyl-threonine dephosphorylation. Localizes to cytosol and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC21657; PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; protein phosphatase 1b, magnesium dependent, beta isoform; protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; Ser/Thr protein phosphatase type 2C beta 2 isoform
Mus musculus (house mouse) : Ppm1b (protein phosphatase 1B, magnesium dependent, beta isoform)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)
Canis lupus familiaris (dog) : PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent 1B)
Sus scrofa (pig) : PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)
Chlorocebus sabaeus (African green monkey) : PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)
Heterocephalus glaber (naked mole-rat) : Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent 1B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl244,167,969 - 44,244,384 (+)EnsemblGRCh38hg38GRCh38
GRCh38244,168,803 - 44,247,330 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37244,395,984 - 44,471,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,249,504 - 44,315,246 (+)NCBINCBI36hg18NCBI36
Build 34244,307,666 - 44,370,261NCBI
Celera244,234,958 - 44,300,689 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef244,132,461 - 44,198,020 (+)NCBIHuRef
CHM1_1244,325,361 - 44,391,185 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPM1B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733846
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.