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Gene: ILK (integrin linked kinase) Homo sapiens
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Symbol: ILK
Name: integrin linked kinase
Description: Exhibits protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Localizes to cytosol; focal adhesion; and nucleoplasm. Predicted to colocalize with stress fiber. Implicated in pancreatic cancer. Biomarker of ovarian cancer; prostate adenocarcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 59 kDa serine/threonine-protein kinase; DKFZp686F1765; epididymis secretory protein Li 28; HEL-S-28; ILK-1; ILK-2; integrin-linked kinase; integrin-linked kinase-2; integrin-linked protein kinase; P59; p59ILK
Orthologs:
Mus musculus (house mouse) : Ilk (integrin linked kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ilk (integrin-linked kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ilk (integrin linked kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ILK (integrin linked kinase)
Canis lupus familiaris (dog) : ILK (integrin linked kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ilk (integrin linked kinase)
Sus scrofa (pig) : ILK (integrin linked kinase)
Chlorocebus sabaeus (African green monkey) : ILK (integrin linked kinase)
Heterocephalus glaber (naked mole-rat) : Ilk (integrin linked kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl116,603,708 - 6,610,874 (+)EnsemblGRCh38hg38GRCh38
GRCh38116,603,708 - 6,610,874 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,624,938 - 6,632,105 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,581,540 - 6,588,677 (+)NCBINCBI36hg18NCBI36
Build 34116,581,587 - 6,588,673NCBI
Celera116,744,031 - 6,751,167 (+)NCBI
Cytogenetic Map11p15.4NCBI
HuRef116,283,875 - 6,291,037 (+)NCBIHuRef
CHM1_1116,623,840 - 6,631,006 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ILK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732855
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.