ILK (integrin linked kinase) - Rat Genome Database

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Pathways
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Gene: ILK (integrin linked kinase) Chlorocebus sabaeus
Analyze
Symbol: ILK
Name: integrin linked kinase
RGD ID: 18768722
Description: ENCODES a protein that exhibits integrin binding (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell morphogenesis (ortholog); cell population proliferation (ortholog); PARTICIPATES IN altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); costamere (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin-linked protein kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,214,630 - 58,221,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,213,310 - 58,221,217 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,040,403 - 156,047,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell projection organization  (IEA,ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (IEA,ISO)
fibroblast migration  (IEA,ISO)
integrin-mediated signaling pathway  (IEA,ISO)
myelin assembly  (ISO)
myelination in peripheral nervous system  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of neural precursor cell proliferation  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
nerve development  (IEA,ISO)
neural precursor cell proliferation  (IEA,ISO)
neuron projection morphogenesis  (ISO)
outflow tract morphogenesis  (IEA)
peptidyl-serine phosphorylation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
platelet aggregation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of BMP signaling pathway  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of signal transduction  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell growth  (ISO)
Schwann cell development  (IEA,ISO)
signal transduction  (IEA)
substrate adhesion-dependent cell spreading  (IEA,ISO)
supramolecular fiber organization  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ILK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,214,630 - 58,221,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,213,310 - 58,221,217 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,040,403 - 156,047,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ILK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,603,774 - 6,610,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,603,708 - 6,610,874 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,625,004 - 6,632,101 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,581,540 - 6,588,677 (+)NCBINCBI36Build 36hg18NCBI36
Build 34116,581,587 - 6,588,673NCBI
Celera116,744,031 - 6,751,167 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef116,283,875 - 6,291,037 (+)NCBIHuRef
CHM1_1116,623,840 - 6,631,006 (+)NCBICHM1_1
T2T-CHM13v2.0116,662,246 - 6,669,338 (+)NCBIT2T-CHM13v2.0
Ilk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,385,797 - 105,392,132 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,385,799 - 105,392,132 (+)EnsemblGRCm39 Ensembl
GRCm387105,736,590 - 105,742,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,736,592 - 105,742,925 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,885,104 - 112,891,439 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,610,569 - 105,616,743 (+)NCBIMGSCv36mm8
Celera7106,007,890 - 106,014,225 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.97NCBI
Ilk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,500,716 - 169,506,972 (+)NCBIGRCr8
mRatBN7.21160,088,839 - 160,095,140 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1160,088,897 - 160,095,140 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1168,111,452 - 168,117,707 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,297,450 - 175,303,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,199,208 - 168,205,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,578,941 - 170,585,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,578,889 - 170,585,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,584,793 - 177,591,044 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,481,299 - 163,487,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,576,775 - 163,583,027 (+)NCBI
Celera1158,020,986 - 158,027,237 (+)NCBICelera
Cytogenetic Map1q32NCBI
Ilk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,316,047 - 22,322,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,316,243 - 22,322,979 (+)NCBIChiLan1.0ChiLan1.0
ILK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v299,041,409 - 9,048,059 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1119,005,236 - 9,011,879 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,735,735 - 6,742,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,418,717 - 6,425,788 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,418,717 - 6,425,788 (+)Ensemblpanpan1.1panPan2
ILK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,911,326 - 29,917,972 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,911,364 - 29,917,974 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,613,150 - 29,619,814 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,737,472 - 30,744,133 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,737,533 - 30,744,128 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12130,058,249 - 30,064,907 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02130,223,907 - 30,230,574 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,419,226 - 30,425,893 (+)NCBIUU_Cfam_GSD_1.0
Ilk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,007,496 - 56,013,566 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842661,996 - 667,993 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936842661,961 - 667,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ILK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,145,608 - 3,159,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,145,647 - 3,152,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,803,434 - 3,810,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ilk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248178,096,898 - 8,106,683 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248178,096,539 - 8,103,096 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002379   ⟹   ENSCSAP00000000695
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl158,213,310 - 58,221,217 (-)Ensembl
RefSeq Acc Id: XM_008008451   ⟹   XP_008006642
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1158,214,630 - 58,221,770 (-)NCBI
Vero_WHO_p1.0NW_023666038156,040,406 - 156,047,520 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008008452   ⟹   XP_008006643
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1158,214,631 - 58,221,644 (-)NCBI
Vero_WHO_p1.0NW_023666038156,040,406 - 156,047,478 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008008453   ⟹   XP_008006644
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1158,214,630 - 58,221,770 (-)NCBI
Vero_WHO_p1.0NW_023666038156,040,403 - 156,047,519 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037999782   ⟹   XP_037855710
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038156,040,403 - 156,047,520 (-)NCBI
RefSeq Acc Id: XM_037999784   ⟹   XP_037855712
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038156,040,403 - 156,047,441 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008006644   ⟸   XM_008008453
- Peptide Label: isoform X4
RefSeq Acc Id: XP_008006642   ⟸   XM_008008451
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QWF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008006643   ⟸   XM_008008452
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QWF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000695   ⟸   ENSCSAT00000002379
RefSeq Acc Id: XP_037855710   ⟸   XM_037999782
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037855712   ⟸   XM_037999784
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004353 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002379.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PK_ILK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report csab:103241301 UniProtKB/TrEMBL
NCBI Gene ILK ENTREZGENE
PANTHER INTEGRIN-LINKED PROTEIN KINASE UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QWF6 ENTREZGENE, UniProtKB/TrEMBL