RGD Reference Report - ILK, PINCH and parvin: the tIPP of integrin signalling. - Rat Genome Database

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ILK, PINCH and parvin: the tIPP of integrin signalling.

Authors: Legate, KR  Montanez, E  Kudlacek, O  Fassler, R 
Citation: Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
RGD ID: 2300344
Pubmed: (View Article at PubMed) PMID:16493410
DOI: Full-text: DOI:10.1038/nrm1789

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways. All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion.

Annotation

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Ilk  (integrin-linked kinase)
Ilkap  (ILK associated serine/threonine phosphatase)
Lims1  (LIM zinc finger domain containing 1)
Lims2  (LIM zinc finger domain containing 2)
Nck2  (NCK adaptor protein 2)
Parva  (parvin, alpha)
Parvb  (parvin, beta)
Parvg  (parvin, gamma)
Pxn  (paxillin)
test  (test1)

Genes (Mus musculus)
Ilk  (integrin linked kinase)
Ilkap  (integrin-linked kinase-associated serine/threonine phosphatase 2C)
Lims1  (LIM and senescent cell antigen-like domains 1)
Lims2  (LIM and senescent cell antigen like domains 2)
Nck2  (non-catalytic region of tyrosine kinase adaptor protein 2)
Parva  (parvin, alpha)
Parvb  (parvin, beta)
Parvg  (parvin, gamma)
Pxn  (paxillin)

Genes (Homo sapiens)
ILK  (integrin linked kinase)
ILKAP  (ILK associated serine/threonine phosphatase)
LIMS1  (LIM zinc finger domain containing 1)
LIMS2  (LIM zinc finger domain containing 2)
NCK2  (NCK adaptor protein 2)
PARVA  (parvin alpha)
PARVB  (parvin beta)
PARVG  (parvin gamma)
PXN  (paxillin)


Additional Information