SPHK2 (sphingosine kinase 2) - Rat Genome Database
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Gene: SPHK2 (sphingosine kinase 2) Homo sapiens
Analyze
Symbol: SPHK2
Name: sphingosine kinase 2
RGD ID: 1317131
HGNC Page HGNC
Description: Exhibits kinase activity; nucleosomal histone binding activity; and sphingosine-1-phosphate receptor activity. Involved in several processes, including histone acetylation; regulation of histone modification; and sphingolipid biosynthetic process. Localizes to several cellular components, including cytosol; nucleoplasm; and nucleosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: SK 2; SK-2; sphingosine kinase type 2; sphingosine kinase type 2 isoform; SPK 2; SPK-2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,619,291 - 48,630,717 (+)EnsemblGRCh38hg38GRCh38
GRCh381948,619,409 - 48,630,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,122,763 - 49,133,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,814,360 - 53,825,474 (+)NCBINCBI36hg18NCBI36
Build 341953,814,359 - 53,825,473NCBI
Celera1945,987,413 - 45,998,527 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBIHuRef
CHM1_11949,124,423 - 49,135,537 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (IEA,ISO)
brain development  (IEA,ISO)
cellular response to phorbol 13-acetate 12-myristate  (IDA)
female pregnancy  (IEA,ISO)
histone H2A-K5 acetylation  (IDA)
histone H2B-K12 acetylation  (IDA)
lipid phosphorylation  (IEA)
negative regulation of cell growth  (IEA,ISO,ISS)
negative regulation of histone deacetylase activity  (IDA)
negative regulation of histone deacetylation  (IDA)
phosphorylation  (IBA,IEA)
positive regulation of apoptotic process  (IBA,IDA,IEA,ISO)
positive regulation of calcium ion import  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of ceramide biosynthetic process  (IDA,IEA,ISO)
positive regulation of cytokine production involved in immune response  (IEA,ISS)
positive regulation of gene expression, epigenetic  (IDA)
positive regulation of histone H3-K9 acetylation  (IDA)
positive regulation of interleukin-13 production  (IEA,ISS)
positive regulation of interleukin-6 production  (IEA,ISS)
positive regulation of mast cell activation involved in immune response  (ISO,ISS)
positive regulation of mast cell degranulation  (IEA,ISO,ISS)
positive regulation of protein kinase C signaling  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISS)
regulation of ATP biosynthetic process  (IEA,ISO,ISS)
regulation of cytochrome-c oxidase activity  (IEA,IMP,ISO)
regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO,ISS)
regulation of reactive oxygen species biosynthetic process  (IEA,ISO,ISS)
sphinganine-1-phosphate biosynthetic process  (IBA,IDA,IEA,ISO)
sphingolipid biosynthetic process  (TAS)
sphingolipid metabolic process  (IBA)
sphingosine biosynthetic process  (IBA,IGI,IMP)
sphingosine metabolic process  (IEA,ISO,ISS)
sphingosine-1-phosphate receptor signaling pathway  (IEA)

Cellular Component
cytoplasm  (IBA,IDA,ISO)
cytosol  (IDA,IEA,ISO,TAS)
endoplasmic reticulum  (IEA,ISO,ISS)
intracellular membrane-bounded organelle  (IBA)
lysosomal membrane  (HDA)
membrane  (IBA,IDA,ISO)
mitochondrial inner membrane  (IEA,ISO)
mitochondrion  (ISO,ISS)
nucleoplasm  (IDA)
nucleosome  (IDA)
nucleus  (IDA,ISO)

References

Additional References at PubMed
PMID:10751414   PMID:11230166   PMID:11777919   PMID:12391145   PMID:12477932   PMID:14596938   PMID:14702039   PMID:15489334   PMID:15951439   PMID:16103110   PMID:16118219   PMID:16316995  
PMID:16344560   PMID:16888242   PMID:17311928   PMID:17635916   PMID:17895250   PMID:17897319   PMID:18178871   PMID:18263879   PMID:19168031   PMID:19240026   PMID:19490468   PMID:19729656  
PMID:20197547   PMID:20237496   PMID:20959514   PMID:21307639   PMID:21495716   PMID:21620961   PMID:21706498   PMID:21707492   PMID:21873635   PMID:21926972   PMID:23106337   PMID:23128233  
PMID:23314175   PMID:23359503   PMID:23881266   PMID:23918304   PMID:24140934   PMID:24163370   PMID:24385109   PMID:24422628   PMID:24486401   PMID:24686171   PMID:24709100   PMID:24903384  
PMID:25010828   PMID:25455157   PMID:25808826   PMID:26209696   PMID:26337959   PMID:26494858   PMID:26628299   PMID:26733171   PMID:26822263   PMID:26886371   PMID:27021309   PMID:27223438  
PMID:27517489   PMID:27588496   PMID:28108260   PMID:28319085   PMID:28465486   PMID:28514442   PMID:28682313   PMID:28807595   PMID:28950390   PMID:28975989   PMID:29057430   PMID:29145490  
PMID:29321083   PMID:29615132   PMID:29678573   PMID:29697136   PMID:29748384   PMID:29955024   PMID:29991026   PMID:30021386   PMID:30077738   PMID:30185808   PMID:30227139   PMID:30250299  
PMID:30251698   PMID:30452878   PMID:30456838   PMID:30463717   PMID:30478856   PMID:30869582   PMID:31003959   PMID:31128248   PMID:31157539   PMID:31247144   PMID:31477835   PMID:31954175  
PMID:32814053  


Genomics

Comparative Map Data
SPHK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,619,291 - 48,630,717 (+)EnsemblGRCh38hg38GRCh38
GRCh381948,619,409 - 48,630,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,122,763 - 49,133,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,814,360 - 53,825,474 (+)NCBINCBI36hg18NCBI36
Build 341953,814,359 - 53,825,473NCBI
Celera1945,987,413 - 45,998,527 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBIHuRef
CHM1_11949,124,423 - 49,135,537 (+)NCBICHM1_1
Sphk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,358,887 - 45,367,426 (-)NCBIGRCm39mm39
GRCm39 Ensembl745,358,891 - 45,367,426 (-)Ensembl
GRCm38745,709,463 - 45,718,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,709,467 - 45,718,002 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,964,833 - 52,973,372 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,578,303 - 45,585,957 (-)NCBImm8
Celera741,172,020 - 41,180,543 (-)NCBICelera
Cytogenetic Map7B3NCBI
Sphk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,180,872 - 96,188,592 (-)NCBI
Rnor_6.0 Ensembl1101,692,973 - 101,697,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,692,972 - 101,700,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,771,785 - 102,779,436 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,178,615 - 96,182,920 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,256,726 - 96,261,031 (-)NCBI
Celera190,434,071 - 90,438,377 (-)NCBICelera
Cytogenetic Map1q22NCBI
Sphk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,917,301 - 1,928,493 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,921,479 - 1,929,450 (-)NCBIChiLan1.0ChiLan1.0
SPHK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,213,166 - 54,224,033 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,213,166 - 54,224,767 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,620,980 - 45,631,786 (+)NCBIMhudiblu_PPA_v0panPan3
SPHK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1107,680,599 - 107,689,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11107,681,425 - 107,689,790 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sphk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366642,668,708 - 2,676,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,979,012 - 53,986,770 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,982,911 - 53,986,779 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,726,086 - 49,734,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPHK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,865,921 - 41,881,889 (+)NCBI
ChlSab1.1 Ensembl641,867,139 - 41,881,268 (+)Ensembl
Sphk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,246,328 - 5,254,247 (-)NCBI

Position Markers
RH75877  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,133,839 - 49,134,049UniSTSGRCh37
Build 361953,825,651 - 53,825,861RGDNCBI36
Celera1945,998,704 - 45,998,914RGD
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map19q13.2UniSTS
HuRef1945,513,375 - 45,513,585UniSTS
SHGC-36947  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,123,736 - 49,123,815UniSTSGRCh37
Build 361953,815,548 - 53,815,627RGDNCBI36
Celera1945,988,600 - 45,988,679RGD
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13UniSTS
HuRef1945,502,926 - 45,503,005UniSTS
TNG Radiation Hybrid Map1918559.0UniSTS
Stanford-G3 RH Map192462.0UniSTS
GeneMap99-GB4 RH Map19255.29UniSTS
Whitehead-RH Map19342.0UniSTS
NCBI RH Map19541.0UniSTS
GeneMap99-G3 RH Map192473.0UniSTS
RH47213  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,133,293 - 49,133,412UniSTSGRCh37
Build 361953,825,105 - 53,825,224RGDNCBI36
Celera1945,998,158 - 45,998,277RGD
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map19q13.2UniSTS
HuRef1945,512,829 - 45,512,948UniSTS
GeneMap99-GB4 RH Map19265.99UniSTS
NCBI RH Map19533.0UniSTS
D15S1477  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q32-q35UniSTS
Cytogenetic Map5q11UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map10p12.1-p11.2UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map1q25UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map1q22UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map14q31-q32UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map16p13.13-p13.12UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map13q13.1UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map1q42.11UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map11q24UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic Map2q14UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map11q14.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q23UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map13q12.1UniSTS
Cytogenetic Map6p21.32UniSTS
Cytogenetic Map2q31UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map3p21.2UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map15q11-q13UniSTS
Cytogenetic Map19pUniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map9q22.3UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map8q11.21UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map10q23.2UniSTS
Cytogenetic Map7p22.3UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map1q31.3UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map9p13UniSTS
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map6q25.2-q25.3UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map17q24UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map20q13UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map17q22-q23UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.3UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map12q23.1UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map13q11UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map3p25-p24UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic MapXq22.1UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map3p12UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic MapXp11.2UniSTS
Cytogenetic Map11q13.1-q13.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map7q21-q22UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map10q23.31UniSTS
Cytogenetic Map6p21.1-p12.2UniSTS
Cytogenetic Map12q14.1UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map1p35UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map8q23.1UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map14q11.1UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map19p13.3-p13.2UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map9p22UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map9p22.1UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map12q15UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map12q21.1UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic Map20p11.23UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map14q21.2UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map12p13.2UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic MapXp11.22UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map12q11-q12UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map2p24UniSTS
Cytogenetic Map8q24.21UniSTS
Cytogenetic Map12q22-q23.1UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map15q21-q22UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map10q23UniSTS
Cytogenetic Map1p22UniSTS
Cytogenetic Map16p13.13UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q11.2UniSTS
Cytogenetic Map7p14-p13UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map6q22-q23UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map4q21.22UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map16p12.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q13.1-q13.3UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map10q25UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map15q21-q23UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic MapXq22.3UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map5q35UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map3q25.31UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map1p22.1UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map11q23.2UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map12q24.11UniSTS
Cytogenetic Map9q21.12UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map20p11.22-p11.1UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map2q24.3UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map6q15UniSTS
Cytogenetic Map5q35.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map7q11.21UniSTS
Cytogenetic Map5q35.1UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map4q21.21UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic MapXq21.1UniSTS
Cytogenetic Map10p11.21UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map8p11.2UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map22q12UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map17q21.32UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map11q23.1-q23.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map13q32.2UniSTS
Cytogenetic Map17qUniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map5q21.3UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic Map6p24.2UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5914
Count of miRNA genes:1097
Interacting mature miRNAs:1409
Transcripts:ENST00000245222, ENST00000340932, ENST00000426514, ENST00000443164, ENST00000593308, ENST00000597434, ENST00000598088, ENST00000598574, ENST00000599029, ENST00000599033, ENST00000599748, ENST00000600537, ENST00000601704, ENST00000601712
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1379 779 1162 175 721 175 1381 556 2873 142 1118 1075 6 315 918 2
Low 1053 2186 561 447 1211 289 2974 1629 835 275 330 533 165 889 1870 2
Below cutoff 19 15 8 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001204158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001204159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001204160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006723292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011527133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011527134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB100373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF245447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI224962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA926908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB053266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB367710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF107108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC039411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH961880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000245222   ⟹   ENSP00000245222
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,619,506 - 48,630,405 (+)Ensembl
RefSeq Acc Id: ENST00000340932   ⟹   ENSP00000341091
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,619,291 - 48,630,406 (+)Ensembl
RefSeq Acc Id: ENST00000426514   ⟹   ENSP00000410044
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,620,515 - 48,629,773 (+)Ensembl
RefSeq Acc Id: ENST00000593308   ⟹   ENSP00000470679
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,624,428 - 48,626,175 (+)Ensembl
RefSeq Acc Id: ENST00000597434   ⟹   ENSP00000471111
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,624,006 - 48,630,717 (+)Ensembl
RefSeq Acc Id: ENST00000598088   ⟹   ENSP00000469158
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,619,534 - 48,630,405 (+)Ensembl
RefSeq Acc Id: ENST00000598574
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,625,029 - 48,626,814 (+)Ensembl
RefSeq Acc Id: ENST00000599029   ⟹   ENSP00000472983
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,624,969 - 48,630,717 (+)Ensembl
RefSeq Acc Id: ENST00000599033
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,624,472 - 48,626,301 (+)Ensembl
RefSeq Acc Id: ENST00000599748   ⟹   ENSP00000471205
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,624,952 - 48,630,405 (+)Ensembl
RefSeq Acc Id: ENST00000600537   ⟹   ENSP00000470092
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,619,452 - 48,629,916 (+)Ensembl
RefSeq Acc Id: ENST00000601704   ⟹   ENSP00000469448
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,624,343 - 48,626,358 (+)Ensembl
RefSeq Acc Id: ENST00000601712   ⟹   ENSP00000471180
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1948,619,450 - 48,628,651 (+)Ensembl
RefSeq Acc Id: NM_001204158   ⟹   NP_001191087
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,506 - 48,630,405 (+)NCBI
GRCh371949,122,548 - 49,133,974 (+)NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBI
CHM1_11949,124,423 - 49,135,537 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001204159   ⟹   NP_001191088
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,506 - 48,630,405 (+)NCBI
GRCh371949,122,548 - 49,133,974 (+)NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBI
CHM1_11949,124,665 - 49,135,537 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001204160   ⟹   NP_001191089
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,625,029 - 48,630,405 (+)NCBI
GRCh371949,122,548 - 49,133,974 (+)NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBI
CHM1_11949,130,083 - 49,135,537 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001243876   ⟹   NP_001230805
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,506 - 48,630,405 (+)NCBI
GRCh371949,122,548 - 49,133,974 (+)NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBI
CHM1_11949,124,423 - 49,135,537 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020126   ⟹   NP_064511
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,506 - 48,630,405 (+)NCBI
GRCh371949,122,548 - 49,133,974 (+)NCBI
Build 361953,814,360 - 53,825,474 (+)NCBI Archive
HuRef1945,501,739 - 45,513,199 (+)NCBI
CHM1_11949,124,423 - 49,135,537 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006723292   ⟹   XP_006723355
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,624,336 - 48,630,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011527133   ⟹   XP_011525435
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,534 - 48,630,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011527134   ⟹   XP_011525436
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,624,343 - 48,630,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027008   ⟹   XP_016882497
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,625,080 - 48,630,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027010   ⟹   XP_016882499
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,409 - 48,630,405 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001191087 (Get FASTA)   NCBI Sequence Viewer  
  NP_001191088 (Get FASTA)   NCBI Sequence Viewer  
  NP_001191089 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230805 (Get FASTA)   NCBI Sequence Viewer  
  NP_064511 (Get FASTA)   NCBI Sequence Viewer  
  XP_006723355 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525435 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525436 (Get FASTA)   NCBI Sequence Viewer  
  XP_016882497 (Get FASTA)   NCBI Sequence Viewer  
  XP_016882499 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF74124 (Get FASTA)   NCBI Sequence Viewer  
  AAH06161 (Get FASTA)   NCBI Sequence Viewer  
  AAH10671 (Get FASTA)   NCBI Sequence Viewer  
  ABK81123 (Get FASTA)   NCBI Sequence Viewer  
  BAA91280 (Get FASTA)   NCBI Sequence Viewer  
  BAC11085 (Get FASTA)   NCBI Sequence Viewer  
  BAC55583 (Get FASTA)   NCBI Sequence Viewer  
  BAG53695 (Get FASTA)   NCBI Sequence Viewer  
  BAG62249 (Get FASTA)   NCBI Sequence Viewer  
  BAH12667 (Get FASTA)   NCBI Sequence Viewer  
  CAB66636 (Get FASTA)   NCBI Sequence Viewer  
  CBH26133 (Get FASTA)   NCBI Sequence Viewer  
  CBX51413 (Get FASTA)   NCBI Sequence Viewer  
  EAW52365 (Get FASTA)   NCBI Sequence Viewer  
  EAW52366 (Get FASTA)   NCBI Sequence Viewer  
  EAW52367 (Get FASTA)   NCBI Sequence Viewer  
  EAW52368 (Get FASTA)   NCBI Sequence Viewer  
  EAW52369 (Get FASTA)   NCBI Sequence Viewer  
  EAW52370 (Get FASTA)   NCBI Sequence Viewer  
  EAW52371 (Get FASTA)   NCBI Sequence Viewer  
  Q9NRA0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_064511   ⟸   NM_020126
- Peptide Label: isoform a
- UniProtKB: Q9NRA0 (UniProtKB/Swiss-Prot),   A0A024QZH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191087   ⟸   NM_001204158
- Peptide Label: isoform b
- UniProtKB: Q9NRA0 (UniProtKB/Swiss-Prot),   B3KV83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191088   ⟸   NM_001204159
- Peptide Label: isoform a
- UniProtKB: Q9NRA0 (UniProtKB/Swiss-Prot),   A0A024QZH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191089   ⟸   NM_001204160
- Peptide Label: isoform c
- UniProtKB: Q9NRA0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001230805   ⟸   NM_001243876
- Peptide Label: isoform d
- UniProtKB: B3KV83 (UniProtKB/TrEMBL),   E9PCV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006723355   ⟸   XM_006723292
- Peptide Label: isoform X3
- UniProtKB: Q9NRA0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525435   ⟸   XM_011527133
- Peptide Label: isoform X2
- UniProtKB: Q9NRA0 (UniProtKB/Swiss-Prot),   A0A024QZH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011525436   ⟸   XM_011527134
- Peptide Label: isoform X3
- UniProtKB: Q9NRA0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016882499   ⟸   XM_017027010
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016882497   ⟸   XM_017027008
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000410044   ⟸   ENST00000426514
RefSeq Acc Id: ENSP00000471111   ⟸   ENST00000597434
RefSeq Acc Id: ENSP00000469158   ⟸   ENST00000598088
RefSeq Acc Id: ENSP00000472983   ⟸   ENST00000599029
RefSeq Acc Id: ENSP00000471205   ⟸   ENST00000599748
RefSeq Acc Id: ENSP00000245222   ⟸   ENST00000245222
RefSeq Acc Id: ENSP00000470092   ⟸   ENST00000600537
RefSeq Acc Id: ENSP00000471180   ⟸   ENST00000601712
RefSeq Acc Id: ENSP00000469448   ⟸   ENST00000601704
RefSeq Acc Id: ENSP00000341091   ⟸   ENST00000340932
RefSeq Acc Id: ENSP00000470679   ⟸   ENST00000593308
Protein Domains
DAGKc

Promoters
RGD ID:13204973
Promoter ID:EPDNEW_H26069
Type:initiation region
Name:SPHK2_4
Description:sphingosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26070  EPDNEW_H26071  EPDNEW_H26073  EPDNEW_H26074  EPDNEW_H26072  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,283 - 48,619,343EPDNEW
RGD ID:13204977
Promoter ID:EPDNEW_H26070
Type:initiation region
Name:SPHK2_1
Description:sphingosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26069  EPDNEW_H26071  EPDNEW_H26073  EPDNEW_H26074  EPDNEW_H26072  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,506 - 48,619,566EPDNEW
RGD ID:13204981
Promoter ID:EPDNEW_H26071
Type:initiation region
Name:SPHK2_5
Description:sphingosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26069  EPDNEW_H26070  EPDNEW_H26073  EPDNEW_H26074  EPDNEW_H26072  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,619,630 - 48,619,690EPDNEW
RGD ID:13204989
Promoter ID:EPDNEW_H26072
Type:initiation region
Name:SPHK2_3
Description:sphingosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26069  EPDNEW_H26070  EPDNEW_H26071  EPDNEW_H26073  EPDNEW_H26074  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,620,516 - 48,620,576EPDNEW
RGD ID:13204983
Promoter ID:EPDNEW_H26073
Type:initiation region
Name:SPHK2_6
Description:sphingosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26069  EPDNEW_H26070  EPDNEW_H26071  EPDNEW_H26074  EPDNEW_H26072  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,624,886 - 48,624,946EPDNEW
RGD ID:13204985
Promoter ID:EPDNEW_H26074
Type:initiation region
Name:SPHK2_2
Description:sphingosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26069  EPDNEW_H26070  EPDNEW_H26071  EPDNEW_H26073  EPDNEW_H26072  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,625,029 - 48,625,089EPDNEW
RGD ID:6796007
Promoter ID:HG_KWN:30457
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000340932,   ENST00000406269,   NM_000979,   NM_020126,   UC002PJS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361953,814,136 - 53,814,692 (-)MPROMDB
RGD ID:6796061
Promoter ID:HG_KWN:30459
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat,   Lymphoblastoid
Transcripts:UC002PJU.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361953,818,991 - 53,819,492 (+)MPROMDB
RGD ID:6796062
Promoter ID:HG_KWN:30460
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:UC002PJV.1,   UC002PJW.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361953,819,066 - 53,819,566 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33(chr19:48577651-48839042)x3 copy number gain See cases [RCV000135686] Chr19:48577651..48839042 [GRCh38]
Chr19:49080908..49342299 [GRCh37]
Chr19:53772720..54034111 [NCBI36]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
NM_020126.5(SPHK2):c.445G>A (p.Glu149Lys) single nucleotide variant not provided [RCV000905152] Chr19:48626296 [GRCh38]
Chr19:49129553 [GRCh37]
Chr19:19q13.33
benign
NM_020126.5(SPHK2):c.1311G>A (p.Ser437=) single nucleotide variant not provided [RCV000924393] Chr19:48629119 [GRCh38]
Chr19:49132376 [GRCh37]
Chr19:19q13.33
likely benign
NM_020126.5(SPHK2):c.1140C>T (p.Pro380=) single nucleotide variant not provided [RCV000897737] Chr19:48628948 [GRCh38]
Chr19:49132205 [GRCh37]
Chr19:19q13.33
benign
NM_020126.5(SPHK2):c.1516G>T (p.Ala506Ser) single nucleotide variant not provided [RCV000881164] Chr19:48629324 [GRCh38]
Chr19:49132581 [GRCh37]
Chr19:19q13.33
benign
NM_020126.5(SPHK2):c.1510C>T (p.Pro504Ser) single nucleotide variant not provided [RCV000958775] Chr19:48629318 [GRCh38]
Chr19:49132575 [GRCh37]
Chr19:19q13.33
likely benign
NM_020126.5(SPHK2):c.747G>T (p.Leu249=) single nucleotide variant not provided [RCV000892751] Chr19:48628060 [GRCh38]
Chr19:49131317 [GRCh37]
Chr19:19q13.33
benign
NM_020126.5(SPHK2):c.735G>C (p.Ser245=) single nucleotide variant not provided [RCV000915791] Chr19:48628048 [GRCh38]
Chr19:49131305 [GRCh37]
Chr19:19q13.33
likely benign
GRCh37/hg19 19q13.33(chr19:48119589-49595956)x3 copy number gain not provided [RCV000848800] Chr19:48119589..49595956 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
NM_020126.5(SPHK2):c.1590C>G (p.Asp530Glu) single nucleotide variant not provided [RCV000963023] Chr19:48629398 [GRCh38]
Chr19:49132655 [GRCh37]
Chr19:19q13.33
likely benign
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42
not provided
NM_020126.5(SPHK2):c.1961C>A (p.Pro654His) single nucleotide variant not provided [RCV000891217] Chr19:48629769 [GRCh38]
Chr19:49133026 [GRCh37]
Chr19:19q13.33
benign
GRCh37/hg19 19q13.33(chr19:48854319-49430535)x3 copy number gain not provided [RCV001259943] Chr19:48854319..49430535 [GRCh37]
Chr19:19q13.33
likely pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18859 AgrOrtholog
COSMIC SPHK2 COSMIC
Ensembl Genes ENSG00000063176 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000245222 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000341091 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000410044 UniProtKB/TrEMBL
  ENSP00000469158 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000469448 UniProtKB/TrEMBL
  ENSP00000470092 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000470679 UniProtKB/TrEMBL
  ENSP00000471111 UniProtKB/TrEMBL
  ENSP00000471180 UniProtKB/TrEMBL
  ENSP00000471205 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000472983 UniProtKB/TrEMBL
Ensembl Transcript ENST00000245222 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000340932 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000426514 UniProtKB/TrEMBL
  ENST00000593308 UniProtKB/TrEMBL
  ENST00000597434 UniProtKB/TrEMBL
  ENST00000598088 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000599029 UniProtKB/TrEMBL
  ENST00000599748 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000600537 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000601704 UniProtKB/TrEMBL
  ENST00000601712 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000063176 GTEx
HGNC ID HGNC:18859 ENTREZGENE
Human Proteome Map SPHK2 Human Proteome Map
InterPro ATP-NAD_kinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:56848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 56848 ENTREZGENE
OMIM 607092 OMIM
Pfam DAGK_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38719 PharmGKB
PROSITE DAGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DAGKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024QZH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A075B7A1_HUMAN UniProtKB/TrEMBL
  B3KV83 ENTREZGENE, UniProtKB/TrEMBL
  E7ET12_HUMAN UniProtKB/TrEMBL
  E9PCV4 ENTREZGENE, UniProtKB/TrEMBL
  M0QXX5_HUMAN UniProtKB/TrEMBL
  M0QZP3_HUMAN UniProtKB/TrEMBL
  M0R0E9_HUMAN UniProtKB/TrEMBL
  M0R344_HUMAN UniProtKB/TrEMBL
  Q9NRA0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0T4C8 UniProtKB/Swiss-Prot
  B4DU87 UniProtKB/Swiss-Prot
  Q9BRN1 UniProtKB/Swiss-Prot
  Q9H0Q2 UniProtKB/Swiss-Prot
  Q9NWU7 UniProtKB/Swiss-Prot