HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) - Rat Genome Database

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Gene: HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) Homo sapiens
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Symbol: HLA-DRB1
Name: major histocompatibility complex, class II, DR beta 1
RGD ID: 1349823
HGNC Page HGNC:4948
Description: Enables several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of immune response; regulation of gene expression; and regulation of leukocyte differentiation. Located in bounding membrane of organelle; external side of plasma membrane; and immunological synapse. Part of MHC class II protein complex. Implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Biomarker of toxic shock syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DR-16; DR-8; DR1; DR16; DR5; DR8; DRB1; DRw10; DRw11; DRw8; DW2.2/DR2.2; FLJ75017; FLJ76359; HLA class II antigen beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR-beta 1; HLA-DR1B; HLA-DRB; HLA-DRB1*; human leucocyte antigen DRB1; leucocyte antigen DR beta 1 chain; leucocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1 precursor; MHC class II antigen; MHC class II antigen HLA-DR13; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; SS1
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   MULTSCL5_H   MULTSCL19_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,578,775 - 32,589,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,577,902 - 32,589,848 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,546,552 - 32,557,625 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,654,527 - 32,665,559 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,654,526 - 32,665,559NCBI
Cytogenetic Map6p21.32NCBI
CHM1_1632,549,025 - 32,560,089 (-)NCBICHM1_1
T2T-CHM13v2.0632,408,987 - 32,422,414 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IAGP)
Actinic Prurigo  (IAGP)
acute disseminated encephalomyelitis  (IAGP)
Addison's disease  (IAGP)
allergic asthma  (IAGP)
allergic bronchopulmonary aspergillosis  (IAGP)
allergic disease  (EXP,IAGP)
Alport syndrome  (IAGP)
alveolar echinococcosis  (IAGP)
Alzheimer's disease  (IMP)
Amebic Liver Abscess  (IAGP)
angioedema  (EXP)
ankylosing spondylitis  (IAGP)
anti-basement membrane glomerulonephritis  (IAGP)
antiphospholipid syndrome  (IAGP)
aspirin-induced respiratory disease  (IAGP)
asthma  (EXP,IAGP)
atrophic gastritis  (IAGP)
autistic disorder  (EXP,IAGP)
autoimmune disease  (IAGP)
autoimmune hepatitis  (IAGP)
autoimmune polyendocrine syndrome  (IAGP)
autoimmune polyendocrine syndrome type 2  (IAGP)
autoimmune thrombocytopenic purpura  (IAGP)
autoimmune thyroiditis  (IAGP,IMP)
bacterial infectious disease  (IAGP)
Behcet's disease  (IAGP)
berylliosis  (EXP)
breast cancer  (IAGP)
breast carcinoma  (IAGP)
celiac disease  (IAGP)
cerebral infarction  (IAGP)
cervix uteri carcinoma in situ  (IAGP)
Chagas Cardiomyopathy  (IAGP)
Chagas disease  (IAGP)
Chemical and Drug Induced Liver Injury  (EXP)
choreatic disease  (IAGP)
Chronic Hepatitis B  (IAGP)
Chronic Hepatitis C  (IAGP)
cicatricial pemphigoid  (IAGP)
COVID-19  (HEP)
Crohn's disease  (EXP)
cystic echinococcosis  (IAGP)
diabetic angiopathy  (IAGP)
diabetic retinopathy  (IAGP)
drug allergy  (EXP)
End Stage Liver Disease  (IAGP)
endometriosis  (IAGP)
eosinophilia-myalgia syndrome  (EXP)
Experimental Arthritis  (IMP)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Liver Cirrhosis  (ISO)
Germ Cell and Embryonal Neoplasms  (IAGP)
glaucoma  (IAGP)
Graves' disease  (IAGP)
Hantavirus hemorrhagic fever with renal syndrome  (IAGP)
Hashimoto Disease  (IAGP)
Helicobacter Infections  (IAGP)
hepatitis C  (IAGP)
HIV Seropositivity  (IAGP)
human immunodeficiency virus infectious disease  (IAGP)
Human Influenza  (IMP)
hypothyroidism  (IAGP)
Idiopathic Hypersomnolence  (IAGP)
idiopathic pulmonary fibrosis  (IAGP)
infectious mononucleosis  (IAGP)
JMP syndrome  (IAGP)
Juvenile Pauciarticular Chronic Arthritis  (IAGP)
juvenile rheumatoid arthritis  (IAGP)
latex allergy  (IAGP)
leprosy  (IAGP)
liver cirrhosis  (IAGP)
lupus nephritis  (IAGP)
membranous glomerulonephritis  (EXP)
Meniere's disease  (IAGP)
mixed connective tissue disease  (IAGP)
Multibacillary Leprosy  (IAGP)
multidrug-resistant tuberculosis  (IAGP)
multiple sclerosis  (EXP,IAGP)
myasthenia gravis  (IAGP)
Mycobacterium Infections  (IAGP)
myositis  (IAGP)
narcolepsy  (EXP,IAGP)
Nasal Polyps  (IAGP)
nephrotic syndrome  (EXP)
neuromyelitis optica  (IAGP)
non-Hodgkin lymphoma  (EXP)
optic neuritis  (IMP)
Oropharyngeal Neoplasms  (EXP)
Ovarian Neoplasms  (IAGP)
pancreatitis  (EXP)
papillomavirus infectious disease  (IAGP)
paracoccidioidomycosis  (IAGP)
Parkinson's disease  (IAGP)
pemphigus  (IAGP)
peptic ulcer disease  (IAGP)
PERITONEAL GLIOMATOSIS  (IAGP)
Pneumocystis Infections  (ISO)
polyneuropathy  (IAGP)
primary progressive multiple sclerosis  (IAGP)
prostate cancer  (IAGP)
proteinuria  (EXP)
Pulmonary Atresia  (IAGP)
pulmonary sarcoidosis  (IAGP)
pulmonary tuberculosis  (IAGP)
pure red-cell aplasia  (IAGP)
Recurrent Respiratory Papillomatosis  (IAGP)
renal cell carcinoma  (IAGP)
retinopathy of prematurity  (IAGP)
rheumatic fever  (IAGP)
rheumatic heart disease  (IAGP)
rheumatoid arthritis  (EXP,IAGP)
sarcoidosis  (EXP,IAGP)
schistosomiasis  (IAGP)
schizophrenia  (EXP)
sensorineural hearing loss  (IAGP)
severe acute respiratory syndrome  (IAGP)
Sjogren's syndrome  (IAGP)
Stroke  (IAGP)
Sudden Hearing Loss  (IAGP)
sympathetic ophthalmia  (IAGP)
systemic lupus erythematosus  (EXP,IAGP)
Takayasu's arteritis  (IAGP)
temporal arteritis  (IAGP)
thromboangiitis obliterans  (IAGP)
toxic shock syndrome  (IEP)
Trichiasis  (IAGP)
tuberculosis  (IAGP)
Tubulointerstitial Nephritis and Uveitis  (IAGP)
type 1 diabetes mellitus  (EXP,IAGP)
typhoid fever  (EXP,IAGP)
ulcerative colitis  (EXP)
urticaria  (EXP,IAGP)
Uterine Cervical Neoplasms  (IAGP)
uveitis  (IAGP)
uveoparotid fever  (IAGP)
visceral leishmaniasis  (EXP)
vitiligo  (IAGP)
Vogt-Koyanagi-Harada disease  (IAGP)
vulva cancer  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (EXP)
3,7-dihydropurine-6-thione  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
auranofin  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beryllium sulfate  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
cefepime  (EXP)
celecoxib  (EXP)
choline  (ISO)
ciprofloxacin  (EXP)
clindamycin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
D-penicillamine  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (ISO)
diltiazem  (EXP)
diquat  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
epoxiconazole  (ISO)
ethylbenzene  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
flutamide  (ISO)
fulvestrant  (EXP)
gefitinib  (EXP)
genistein  (ISO)
gentamycin  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hexachlorobenzene  (ISO)
hydrochlorothiazide  (EXP)
irinotecan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
lead(0)  (EXP)
lumiracoxib  (EXP)
mercaptopurine  (EXP,ISO)
metronidazole  (EXP)
monosodium L-glutamate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nitric oxide  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
palladium  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (ISO)
perfluorobutyric acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
purine-6-thiol  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
antigen processing and presentation  (IEA)
antigen processing and presentation of endogenous peptide antigen via MHC class II  (IDA)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IBA,IDA,ISO)
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  (IEA)
cytoskeleton organization  (IEA)
epidermis development  (TAS)
humoral immune response  (IMP)
immune response  (IDA,IEA,IMP,NAS,TAS)
immune system process  (IEA)
inflammatory response to antigenic stimulus  (IDA)
macrophage differentiation  (IDA)
myeloid dendritic cell antigen processing and presentation  (IDA)
negative regulation of inflammatory response to antigenic stimulus  (IDA)
negative regulation of T cell proliferation  (IMP)
negative regulation of type II interferon production  (IMP)
peptide antigen assembly with MHC class II protein complex  (IBA,IDA)
positive regulation of canonical NF-kappaB signal transduction  (IDA)
positive regulation of CD4-positive, alpha-beta T cell activation  (IDA)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (IDA)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of immune response  (IBA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of MAPK cascade  (IDA)
positive regulation of memory T cell differentiation  (IDA)
positive regulation of monocyte differentiation  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of T cell activation  (IBA)
positive regulation of T cell mediated cytotoxicity  (IDA)
positive regulation of T cell mediated immune response to tumor cell  (IDA)
positive regulation of viral entry into host cell  (IDA)
protein tetramerization  (IDA)
regulation of interleukin-10 production  (IDA)
regulation of interleukin-4 production  (IDA)
regulation of T-helper cell differentiation  (IDA)
response to dexamethasone  (ISO)
response to organic substance  (ISO)
response to type II interferon  (ISO)
signal transduction  (IMP,NAS)
T cell receptor signaling pathway  (IDA)
T-helper 1 type immune response  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal aortic aneurysm  (IAGP)
Abdominal pain  (IAGP)
Abnormal blistering of the skin  (IAGP)
Abnormal bowel sounds  (IAGP)
Abnormal cardiac ventricular function  (IAGP)
Abnormal cerebrospinal fluid morphology  (IAGP)
Abnormal circulating protein concentration  (IAGP)
Abnormal conjunctiva morphology  (IAGP)
Abnormal liver parenchyma morphology  (IAGP)
Abnormal lung morphology  (IAGP)
Abnormal lymph node morphology  (IAGP)
Abnormal mitral valve morphology  (IAGP)
Abnormal nasal mucosa morphology  (IAGP)
Abnormal peritoneum morphology  (IAGP)
Abnormal pigmentation of the oral mucosa  (IAGP)
Abnormal platelet count  (IAGP)
Abnormal pleura morphology  (IAGP)
Abnormal pulmonary interstitial morphology  (IAGP)
Abnormal rapid eye movement sleep  (IAGP)
Abnormal reproductive system morphology  (IAGP)
Abnormal salivary gland morphology  (IAGP)
Abnormal skin morphology  (IAGP)
Abnormality of connective tissue  (IAGP)
Abnormality of salivation  (IAGP)
Abnormality of skin pigmentation  (IAGP)
Abnormality of T cell physiology  (IAGP)
Abnormality of the adrenal glands  (IAGP)
Abnormality of the eye  (IAGP)
Abnormality of the gastrointestinal tract  (IAGP)
Abnormality of the musculature  (IAGP)
Abnormality of the skin  (IAGP)
Abnormality of the thyroid gland  (IAGP)
Abnormality of the upper respiratory tract  (IAGP)
Abnormality of thrombocytes  (IAGP)
Abnormality of vision  (IAGP)
Adrenocorticotropic hormone excess  (IAGP)
Adult onset  (IAGP)
Alopecia  (IAGP)
Amaurosis fugax  (IAGP)
Anemia  (IAGP)
Anorexia  (IAGP)
Anterior uveitis  (IAGP)
Anti-La/SS-B antibody positivity  (IAGP)
Anti-U1 ribonucleoprotein antibody positivity  (IAGP)
Antineutrophil antibody positivity  (IAGP)
Antinuclear antibody positivity  (IAGP)
Aortic dissection  (IAGP)
Arrhythmia  (IAGP)
Arterial thrombosis  (IAGP)
Arteritis  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Asthma  (IAGP)
Ataxia  (IAGP)
Atypical behavior  (IAGP)
Autoimmune antibody positivity  (IAGP)
Autoimmunity  (IAGP)
Autosomal dominant inheritance  (IAGP)
Back pain  (IAGP)
Blindness  (IAGP)
Blurred vision  (IAGP)
Bone cyst  (IAGP)
Bradykinesia  (IAGP)
Bronchiectasis  (IAGP)
Carious teeth  (IAGP)
Cataplexy  (IAGP)
Cataract  (IAGP)
Cerebral ischemia  (IAGP)
Cheilitis  (IAGP)
Chest pain  (IAGP)
Chorea  (IAGP)
Chorioretinitis  (IAGP)
Chylothorax  (IAGP)
Clubbing  (IAGP)
CNS demyelination  (IAGP)
Conductive hearing impairment  (IAGP)
Congestive heart failure  (IAGP)
Cough  (IAGP)
Crackles  (IAGP)
Crazy paving pattern  (IAGP)
Cutaneous photosensitivity  (IAGP)
Cyanosis  (IAGP)
Dacryocystitis  (IAGP)
Decreased circulating complement C3 concentration  (IAGP)
Decreased circulating complement C4 concentration  (IAGP)
Decreased circulating cortisol level  (IAGP)
Decreased DLCO  (IAGP)
Decreased liver function  (IAGP)
Depression  (IAGP)
Diabetes insipidus  (IAGP)
Diabetes mellitus  (IAGP)
Diplopia  (IAGP)
Discoid lupus rash  (IAGP)
Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis  (IAGP)
Dyspareunia  (IAGP)
Dysphagia  (IAGP)
Dyspnea  (IAGP)
Eczema  (IAGP)
Elevated bronchoalveolar lavage fluid lymphocyte proportion  (IAGP)
Elevated circulating C-reactive protein concentration  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Emotional lability  (IAGP)
Emphysema  (IAGP)
Enlarged lacrimal glands  (IAGP)
Enlargement of parotid gland  (IAGP)
Eosinophilia  (IAGP)
Epiphora  (IAGP)
Epistaxis  (IAGP)
Erythema  (IAGP)
Erythema nodosum  (IAGP)
Excessive daytime somnolence  (IAGP)
Facial palsy  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Flexion contracture  (IAGP)
Foam cells  (IAGP)
Foot joint contracture  (IAGP)
Gangrene  (IAGP)
Gastroesophageal reflux  (IAGP)
Gastrointestinal infarctions  (IAGP)
Generalized lymphadenopathy  (IAGP)
Glaucoma  (IAGP)
Glomerulonephritis  (IAGP)
Glossitis  (IAGP)
Hallucinations  (IAGP)
Headache  (IAGP)
Hearing impairment  (IAGP)
Heart block  (IAGP)
Hematuria  (IAGP)
Hemiplegia  (IAGP)
Hemolytic anemia  (IAGP)
Hemoptysis  (IAGP)
Hepatic failure  (IAGP)
Hepatomegaly  (IAGP)
Hypercalcemia  (IAGP)
Hypercalciuria  (IAGP)
Hyperhidrosis  (IAGP)
Hyperpigmentation of the skin  (IAGP)
Hypertension  (IAGP)
Hypertensive crisis  (IAGP)
Hyperthyroidism  (IAGP)
Hypopigmentation of the skin  (IAGP)
Hypopigmented skin patches  (IAGP)
Hypothermia  (IAGP)
Hypothyroidism  (IAGP)
Hypoxemia  (IAGP)
Impaired mastication  (IAGP)
Incoordination  (IAGP)
Increased circulating antibody level  (IAGP)
Increased circulating IgE level  (IAGP)
Increased circulating lactate dehydrogenase concentration  (IAGP)
Increased CSF protein concentration  (IAGP)
Increased T cell count  (IAGP)
Inflammation of the large intestine  (IAGP)
Insomnia  (IAGP)
Intraalveolar phospholipid accumulation  (IAGP)
Iridocyclitis  (IAGP)
Ischemic stroke  (IAGP)
Joint contracture of the hand  (IAGP)
Joint stiffness  (IAGP)
Joint swelling  (IAGP)
Juvenile rheumatoid arthritis  (IAGP)
Keratoconjunctivitis sicca  (IAGP)
Leukopenia  (IAGP)
Lupus nephritis  (IAGP)
Lymphadenopathy  (IAGP)
Lymphedema  (IAGP)
Lymphoma  (IAGP)
Macule  (IAGP)
Maculopapular exanthema  (IAGP)
Malabsorption  (IAGP)
Malar rash  (IAGP)
Mediastinal lymphadenopathy  (IAGP)
Meningitis  (IAGP)
Motor conduction block  (IAGP)
Mucosal telangiectasiae  (IAGP)
Muscle weakness  (IAGP)
Myalgia  (IAGP)
Myocarditis  (IAGP)
Myositis  (IAGP)
Narrow foramen obturatorium  (IAGP)
Nasal polyposis  (IAGP)
Nausea and vomiting  (IAGP)
Nephrocalcinosis  (IAGP)
Nephrolithiasis  (IAGP)
Night sweats  (IAGP)
Non-Mendelian inheritance  (IAGP)
Nystagmus  (IAGP)
Obesity  (IAGP)
Oliguria  (IAGP)
Ophthalmoparesis  (IAGP)
Optic atrophy  (IAGP)
Optic neuropathy  (IAGP)
Oral ulcer  (IAGP)
Osteolysis  (IAGP)
Pancytopenia  (IAGP)
Paresthesia  (IAGP)
Parkinsonism  (IAGP)
Parotitis  (IAGP)
Peptic ulcer  (IAGP)
Pericardial effusion  (IAGP)
Pericarditis  (IAGP)
Peripheral neuropathy  (IAGP)
Photophobia  (IAGP)
Pleural effusion  (IAGP)
Pneumothorax  (IAGP)
Polyneuropathy  (IAGP)
Portal hypertension  (IAGP)
Proteinuria  (IAGP)
Proximal muscle weakness  (IAGP)
Psoriasiform dermatitis  (IAGP)
Ptosis  (IAGP)
Pulmonary arterial hypertension  (IAGP)
Pulmonary artery atresia  (IAGP)
Pulmonary fibrosis  (IAGP)
Pulmonary infiltrates  (IAGP)
Pyuria  (IAGP)
Raynaud phenomenon  (IAGP)
Recurrent infections  (IAGP)
Recurrent pharyngitis  (IAGP)
Renal insufficiency  (IAGP)
Restrictive ventilatory defect  (IAGP)
Reticulocytopenia  (IAGP)
Retinopathy  (IAGP)
Sacroiliac arthritis  (IAGP)
Scarring  (IAGP)
Seizure  (IAGP)
Serositis  (IAGP)
Skin nodule  (IAGP)
Skin plaque  (IAGP)
Skin rash  (IAGP)
Skin ulcer  (IAGP)
Sleep abnormality  (IAGP)
Slurred speech  (IAGP)
Spasticity  (IAGP)
Splenomegaly  (IAGP)
Sporadic  (IAGP)
Subcutaneous nodule  (IAGP)
Sudden cardiac death  (IAGP)
Syncope  (IAGP)
Systemic lupus erythematosus  (IAGP)
Telangiectasia of the skin  (IAGP)
Thrombocytopenia  (IAGP)
Transient global amnesia  (IAGP)
Tubulointerstitial nephritis  (IAGP)
Type I diabetes mellitus  (IAGP)
Upper airway obstruction  (IAGP)
Urinary hesitancy  (IAGP)
Urinary incontinence  (IAGP)
Urticaria  (IAGP)
Uveitis  (IAGP)
Vasculitis  (IAGP)
Ventricular tachycardia  (IAGP)
Vertigo  (IAGP)
Visual field defect  (IAGP)
Visual impairment  (IAGP)
Visual loss  (IAGP)
Weight loss  (IAGP)
Xerostomia  (IAGP)
References

References - curated
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36. Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women. Cuzick J, etal., Br J Cancer. 2000 Apr;82(7):1348-52.
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39. Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. Davidson EJ, etal., Cancer Res. 2003 Jan 15;63(2):400-3.
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66. MICA4/HLA-DRB1*04/TNF1 haplotype is associated with mixed connective tissue disease in Swedish patients. Hassan AB, etal., Hum Immunol. 2003 Feb;64(2):290-6.
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106. HLA class II antigens positively and negatively associated with hepatosplenic schistosomiasis in a Chinese population. McManus DP, etal., Int J Parasitol. 2001 May 15;31(7):674-80. doi: 10.1016/s0020-7519(01)00132-1.
107. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Mignot E, etal., Am J Hum Genet. 2001 Mar;68(3):686-99. Epub 2001 Feb 13.
108. HLA-DRB1*04 and DRB1*14 alleles are associated with susceptibility to pemphigus among Japanese. Miyagawa S, etal., J Invest Dermatol. 1997 Nov;109(5):615-8. doi: 10.1111/1523-1747.ep12337585.
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113. Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. Morgan AW, etal., Arthritis Res Ther. 2006;8(4):R109.
114. Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity. Moriguchi M, etal., Metabolism. 2011 Jun;60(6):761-6. Epub 2010 Sep 9.
115. HLA-DRB1 and HLA-DQB1 genes on susceptibility to and protection from allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Muro M, etal., Microbiol Immunol. 2013 Mar;57(3):193-7. doi: 10.1111/1348-0421.12020.
116. Associations of MHC class II alleles in Norwegian primary Sjogren's syndrome patients: implications for development of autoantibodies to the Ro52 autoantigen. Nakken B, etal., Scand J Immunol. 2001 Oct;54(4):428-33.
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121. Genetic analysis of HLA- and HPA-typing in idiopathic (autoimmune) thrombocytopenic purpura patients treated with cepharanthin. Nomura S, etal., Autoimmunity. 1999;30(2):99-105.
122. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. O'Hanlon TP, etal., Medicine (Baltimore). 2006 Mar;85(2):111-27.
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124. Molecular analysis of HLA class II-associated susceptibility to neuroinflammatory diseases in Korean children. Oh HH, etal., J Korean Med Sci. 2004 Jun;19(3):426-30. doi: 10.3346/jkms.2004.19.3.426.
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