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Gene: CD40 (CD40 molecule) Homo sapiens
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Symbol: CD40
Name: CD40 molecule
Description: Exhibits ubiquitin protein ligase binding activity. Involved in several processes, including CD40 signaling pathway; positive regulation of signal transduction; and regulation of transcription, DNA-templated. Localizes to cell surface and extracellular exosome. Implicated in several diseases, including Kawasaki disease; arthritis (multiple); autoimmune hypersensitivity disease (multiple); hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); bronchial disease (multiple); hematologic cancer (multiple); and inflammatory bowel disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD40 antigen (TNF receptor superfamily member 5); CD40 molecule TNF receptor superfamily member 5; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40L receptor; CDW40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Orthologs:
Mus musculus (house mouse) : Cd40 (CD40 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd40 (CD40 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd40 (CD40 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD40 (CD40 molecule)
Canis lupus familiaris (dog) : CD40 (CD40 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd40 (CD40 molecule)
Sus scrofa (pig) : CD40 (CD40 molecule)
Chlorocebus sabaeus (African green monkey) : CD40 (CD40 molecule)
Heterocephalus glaber (naked mole-rat) : Cd40 (CD40 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2046,118,278 - 46,129,863 (+)EnsemblGRCh38hg38GRCh38
GRCh382046,118,242 - 46,129,858 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372044,746,899 - 44,758,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,180,313 - 44,191,791 (+)NCBINCBI36hg18NCBI36
Celera2041,458,363 - 41,469,842 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2041,488,189 - 41,499,674 (+)NCBIHuRef
CHM1_12044,649,527 - 44,661,003 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on CD40
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1604657
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.