Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | focal epilepsy | | IAGP | RGD:21405148 | 8554872 | ClinVar Annotator: match by term: Focal-onset seizure | ClinVar | PMID:32581362 | genetic disease | | IAGP | RGD:151742014 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:28492532 | genetic disease | | IAGP | RGD:155918301 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | genetic disease | | IAGP | RGD:156104769 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:28492532 | genetic disease | | IAGP | RGD:151836127 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:28492532 | genetic disease | | IAGP | RGD:155979430 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:12835480 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:14393517 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11618419 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:156448772 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11618682 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:25741868 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11630397 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:12593727 more ... | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:13435983 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:25741868 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:41404946 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28889281 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:13521708 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:25741868, PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11659999 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11655289 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:15169245 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:15187205 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11629749 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11628205 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11620532 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11618288 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28896413 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28896416 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11632067 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11630528 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11626317 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11648395 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28896419 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28887918 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28888256 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:14688141 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28888249 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28888252 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:8566385 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:11675497 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11626977 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11617985 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:40889498 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:25741868 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11632092 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:8600706 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:11675497, PMID:20702779 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:11612998 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:8566386 | 8554872 | ClinVar Annotator: match by term: Immunodeficiency with hyper IgM type 3 | ClinVar | PMID:12584544 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28896421 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | immunodeficiency with hyper IgM type 3 | | IAGP | RGD:28901189 | 8554872 | ClinVar Annotator: match by term: Hyper-IgM Immunodeficiency Syndrome, Type 3 | ClinVar | PMID:28492532 | X-linked hyper IgM syndrome | | IAGP | RGD:11635540 | 8554872 | ClinVar Annotator: match by term: Hyperimmunoglobulin M syndrome | ClinVar | | X-linked hyper IgM syndrome | | IAGP | RGD:11627237 | 8554872 | ClinVar Annotator: match by term: Hyperimmunoglobulin M syndrome | ClinVar | | X-linked hyper IgM syndrome | | IAGP | RGD:11662455 | 8554872 | ClinVar Annotator: match by term: Hyperimmunoglobulin M syndrome | ClinVar | | X-linked hyper IgM syndrome | | IAGP | RGD:11630818 | 8554872 | ClinVar Annotator: match by term: Hyperimmunoglobulin M syndrome | ClinVar | | X-linked hyper IgM syndrome | | IAGP | RGD:11661368 | 8554872 | ClinVar Annotator: match by term: Hyperimmunoglobulin M syndrome | ClinVar | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. | Advani R, etal., J Clin Oncol. 2009 Sep 10;27(26):4371-7. doi: 10.1200/JCO.2008.21.3017. Epub 2009 Jul 27. |
| 2. | A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. | Beatty GL, etal., Clin Cancer Res. 2013 Nov 15;19(22):6286-95. doi: 10.1158/1078-0432.CCR-13-1320. Epub 2013 Aug 27. |
| 3. | CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. | Beatty GL, etal., Science. 2011 Mar 25;331(6024):1612-6. |
| 4. | Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. | Blair PA, etal., J Immunol. 2009 Mar 15;182(6):3492-502. doi: 10.4049/jimmunol.0803052. |
| 5. | A striking local esophageal cytokine expression profile in eosinophilic esophagitis. | Blanchard C, etal., J Allergy Clin Immunol. 2011 Jan;127(1):208-17, 217.e1-7. |
| 6. | CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility. | Blanco-Kelly F, etal., PLoS One. 2010 Jul 12;5(7):e11520. |
| 7. | Blocking the CD40-CD40L interaction by CD40-Ig reduces disease progress in murine myocarditis induced by CVB3. | Bo H, etal., Cardiovasc Pathol. 2010 Nov-Dec;19(6):371-6. doi: 10.1016/j.carpath.2009.10.002. Epub 2009 Nov 14. |
| 8. | The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease. | Borcherding F, etal., Am J Pathol. 2010 Apr;176(4):1816-27. Epub 2010 Feb 4. |
| 9. | A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. | Boumpas DT, etal., Arthritis Rheum. 2003 Mar;48(3):719-27. |
| 10. | CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure. | Campean V, etal., Atherosclerosis. 2007 Jan;190(1):156-66. Epub 2006 Feb 21. |
| 11. | The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus. | Caproni M, etal., J Rheumatol. 2007 Dec;34(12):2412-6. Epub 2007 Nov 15. |
| 12. | Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus. | Chen CR, etal., Thyroid. 2006 May;16(5):427-34. |
| 13. | Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin. | Chu Q, etal., Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. doi: 10.1111/j.1442-9071.2010.02437.x. |
| 14. | Potential role of soluble CD40 in the humoral immune response impairment of uraemic patients. | Contin C, etal., Immunology. 2003 Sep;110(1):131-40. |
| 15. | CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury. | de Ramon L, etal., Kidney Int. 2015 Sep;88(3):538-49. doi: 10.1038/ki.2015.146. Epub 2015 May 20. |
| 16. | Neuroprotective effect of AG490 in experimental traumatic brain injury of rats. | DU AL, etal., Chin Med J (Engl). 2013 Aug;126(15):2934-7. |
| 17. | Extracellular matrix-associated (GAGs, CTGF), angiogenic (VEGF) and inflammatory factors (MCP-1, CD40, IFN-gamma) in type 1 diabetes mellitus nephropathy. | Ellina O, etal., Clin Chem Lab Med. 2012 Jan;50(1):167-74. doi: 10.1515/cclm.2011.881. |
| 18. | Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. | Ferrari S, etal., Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12614-9. |
| 19. | Intracellular Abeta-oligomers and early inflammation in a model of Alzheimer's disease. | Ferretti MT, etal., Neurobiol Aging. 2011 Mar 15. |
| 20. | In vivo efficacy and toxicity of a single-chain immunotoxin targeted to CD40. | Francisco JA, etal., Blood. 1997 Jun 15;89(12):4493-500. |
| 21. | Agonistic properties and in vivo antitumor activity of the anti-CD40 antibody SGN-14. | Francisco JA, etal., Cancer Res. 2000 Jun 15;60(12):3225-31. |
| 22. | The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. | Gandhi KS, etal., Hum Mol Genet. 2010 Jun 1;19(11):2134-43. Epub 2010 Feb 27. |
| 23. | CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. | Gao D, etal., Gut. 2005 Jan;54(1):70-7. |
| 24. | Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target. | Gocmen AY, etal., Appl Physiol Nutr Metab. 2011 Jun;36(3):323-30. doi: 10.1139/h11-022. Epub 2011 May 16. |
| 25. | Effect of atorvastatin on atherosclerotic plaque formation and platelet activation in hypercholesterolemic rats. | Gocmen AY, etal., Can J Physiol Pharmacol. 2013 Sep;91(9):680-5. doi: 10.1139/cjpp-2012-0325. Epub 2013 Apr 8. |
| 26. | Loss of CD40 endogenous S-nitrosylation during inflammatory response in endotoxemic mice and patients with sepsis. | Godoy LC, etal., Shock. 2010 Jun;33(6):626-33. |
| 27. | Attenuation of experimental autoimmune myocarditis by si-RNA mediated CD40 silencing. | Gong X, etal., Int Heart J. 2014;55(6):539-45. Epub 2014 Oct 7. |
| 28. | The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules. | Green KA, etal., J Virol. 2002 Dec;76(24):13106-10. |
| 29. | CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes. | Haase C and Markholst H, Ann N Y Acad Sci. 2007 Jun;1107:373-9. |
| 30. | Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis. | Haller ST, etal., Hypertension. 2013 Apr;61(4):894-900. doi: 10.1161/HYPERTENSIONAHA.111.00685. Epub 2013 Feb 11. |
| 31. | Platelet expression of CD40/CD40 ligand and its relation to inflammatory markers and adhesion molecules in patients with atrial fibrillation. | Hammwohner M, etal., Exp Biol Med (Maywood). 2007 Apr;232(4):581-9. |
| 32. | Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. | Hang L, etal., J Immunol. 2010 Sep 15;185(6):3184-9. Epub 2010 Aug 11. |
| 33. | Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. | Hayashi C, etal., J Innate Immun. 2010;2(4):334-43. Epub 2010 May 10. |
| 34. | House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells. | Hongjia L, etal., Cell Biochem Funct. 2010 Oct;28(7):597-603. |
| 35. | Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. | Horton HM, etal., Blood. 2010 Oct 21;116(16):3004-12. Epub 2010 Jul 8. |
| 36. | Role of the CD40 locus in Graves' disease. | Houston FA, etal., Thyroid. 2004 Jul;14(7):506-9. |
| 37. | Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. | Hsiao JY, etal., Eur J Endocrinol. 2008 Nov;159(5):617-21. doi: 10.1530/EJE-08-0410. Epub 2008 Aug 28. |
| 38. | STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma. | Hsieh YY, etal., Int J Biol Sci. 2009;5(1):74-81. Epub 2009 Jan 9. |
| 39. | CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. | Ishikawa M, etal., Circulation. 2005 Apr 5;111(13):1690-6. Epub 2005 Mar 28. |
| 40. | Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses. | Jackaman C and Nelson DJ, Cancer Immunol Immunother. 2012 Apr;61(4):549-60. doi: 10.1007/s00262-011-1120-5. Epub 2011 Oct 15. |
| 41. | Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection. | Jiang X, etal., Immunology. 2010 Apr;129(4):556-66. Epub 2009 Sep 11. |
| 42. | Bicistronic adenovirus-mediated gene transfer of CTLA4Ig gene and CD40Ig gene result in indefinite survival of islet xenograft. | Jin YZ and Xie SS, Transplant Proc. 2003 Dec;35(8):3165-6. |
| 43. | Association of genetic polymorphisms in CD40 with susceptibility to SLE in the Korean population. | Joo YB, etal., Rheumatology (Oxford). 2013 Apr;52(4):623-30. doi: 10.1093/rheumatology/kes339. Epub 2012 Dec 18. |
| 44. | New targets of pemphigus vulgaris antibodies identified by protein array technology. | Kalantari-Dehaghi M, etal., Exp Dermatol. 2011 Feb;20(2):154-6. doi: 10.1111/j.1600-0625.2010.01193.x. |
| 45. | Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury. | Ke B, etal., Mol Ther. 2004 Jan;9(1):38-45. |
| 46. | Breaking of CD8+ T cell tolerance through in vivo ligation of CD40 results in inhibition of chronic graft-versus-host disease and complete donor cell engraftment. | Kim J, etal., J Immunol. 2008 Nov 15;181(10):7380-9. |
| 47. | Enhanced immunity by NeuEDhsp70 DNA vaccine Is needed to combat an aggressive spontaneous metastatic breast cancer. | Kim JH, etal., Mol Ther. 2005 Jun;11(6):941-9. |
| 48. | Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse. | Komura K, etal., Ann Rheum Dis. 2008 Jun;67(6):867-72. Epub 2007 Sep 6. |
| 49. | Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. | Kosaka A, etal., Cancer Immunol Immunother. 2014 Aug;63(8):847-57. doi: 10.1007/s00262-014-1561-8. Epub 2014 May 31. |
| 50. | CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. | Krimmer DI, etal., Allergy. 2009 Jul;64(7):1074-82. Epub 2009 Feb 12. |
| 51. | CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population. | Kuo HC, etal., ScientificWorldJournal. 2012;2012:520865. doi: 10.1100/2012/520865. Epub 2012 May 2. |
| 52. | Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients. | Lehmann C, etal., PLoS One. 2010 Jun 14;5(6):e11110. |
| 53. | Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo. | Liu C, etal., J Immunother. 2012 Apr;35(3):276-82. doi: 10.1097/CJI.0b013e31824e7f43. |
| 54. | [Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats]. | Liu Y, etal., Zhong Yao Cai. 2009 Mar;32(3):380-3. |
| 55. | Decoy oligodeoxynucleotide against STAT transcription factors decreases allergic inflammation in a rat asthma model. | Luhrmann A, etal., Exp Lung Res. 2010 Mar;36(2):85-93. doi: 10.3109/01902140903144138. |
| 56. | Flow cytometric investigation of CD40-CD40 ligand system in preeclampsia and normal pregnancy. | Lukanov TH, etal., Clin Appl Thromb Hemost. 2010 Jun;16(3):306-12. doi: 10.1177/1076029608331229. Epub 2009 Feb 15. |
| 57. | Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. | Mai G, etal., Transplant Proc. 2005 Jan-Feb;37(1):460-2. |
| 58. | Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera. | Malik F, etal., Eur J Cancer. 2009 May;45(8):1494-509. doi: 10.1016/j.ejca.2009.01.034. Epub 2009 Mar 5. |
| 59. | IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. | Martin DL, etal., J Immunol. 2000 Jan 15;164(2):779-85. |
| 60. | Effect of enhanced glycemic control with saxagliptin on endothelial nitric oxide release and CD40 levels in obese rats. | Mason RP, etal., J Atheroscler Thromb. 2011;18(9):774-83. Epub 2011 Jun 13. |
| 61. | CD40 ligand (CD154) takes part in regulation of the transition to mononuclear cell dominance during peritonitis. | Mazar J, etal., Kidney Int. 2005 Apr;67(4):1340-9. |
| 62. | Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes. | Meabed MH, etal., Hematology. 2007 Aug;12(4):301-7. |
| 63. | Monocytes are activated in patients with myelodysplastic syndromes and can contribute to bone marrow failure through CD40-CD40L interactions with T helper cells. | Meers S, etal., Leukemia. 2007 Dec;21(12):2411-9. Epub 2007 Sep 6. |
| 64. | Prognostic value of cytotoxic T-lymphocytes and CD40 in biopsies with early renal allograft rejection. | Mengel M, etal., Transpl Int. 2004 Jul;17(6):293-300. Epub 2004 Jun 19. |
| 65. | Involvement of CD40-CD40L signaling in postischemic lung injury. | Moore TM, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Dec;283(6):L1255-62. Epub 2002 Aug 9. |
| 66. | Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency. | Morales-Aza B, etal., Blood. 2009 Apr 30;113(18):4206-12. Epub 2009 Feb 6. |
| 67. | Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses. | Murphy WJ, etal., J Immunol. 2003 Mar 1;170(5):2727-33. |
| 68. | Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. | Murray HW, etal., Infect Immun. 2003 Nov;71(11):6453-62. |
| 69. | Serum CD40/CD40L system in Graves' disease and Hashimoto's thyroiditis related to soluble Fas, FasL and humoral markers of autoimmune response. | Mysliwiec J, etal., Immunol Invest. 2007;36(3):247-57. |
| 70. | A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis. | Nieters A, etal., Int J Cancer. 2011 Mar 15;128(6):1481-5. doi: 10.1002/ijc.25420. |
| 71. | CD40 expression on antigen presenting cells and correlation with disease severity in atopic dermatitis. | Oflazoglu E, etal., Eur J Dermatol. 2008 Sep-Oct;18(5):527-33. Epub 2008 Aug 8. |
| 72. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 73. | Circulating myeloid dendritic cell directly isolated from patients with chronic myelogenous leukemia are functional and carry the bcr-abl translocation. | Orsini E, etal., Leuk Res. 2006 Jul;30(7):785-94. Epub 2006 Mar 9. |
| 74. | Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors. | Otahal P, etal., J Immunol. 2007 Nov 15;179(10):6686-95. |
| 75. | Effect of CD40 ligand and other immunomodulators on Pneumocystis carinii infection in rat model. | Oz HS, etal., Microb Pathog. 2000 Sep;29(3):187-90. |
| 76. | Impact of residual renal function and HCV seropositivity on plasma CD40/CD40L system and oxidative status in haemodialysis patients. | Pawlak K, etal., Clin Biochem. 2010 Dec;43(18):1393-8. doi: 10.1016/j.clinbiochem.2010.09.002. Epub 2010 Sep 21. |
| 77. | Role of CD40-CVD40L in mouse severe malaria. | Piguet PF, etal., Am J Pathol. 2001 Aug;159(2):733-42. |
| 78. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 79. | Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. | Plant D, etal., Ann Rheum Dis. 2010 Aug;69(8):1548-53. Epub 2010 May 24. |
| 80. | CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus. | Puliaev R, etal., J Immunol. 2008 Jul 1;181(1):47-61. |
| 81. | Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immunodeficient (SCID) mice. | Resetkova E, etal., Thyroid. 1996 Aug;6(4):267-73. |
| 82. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 83. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 84. | RGD HPO Phenotype Annotation Pipeline | RGD automated import pipeline for human HPO-to-gene-to-disease annotations |
| 85. | In vivo therapeutic efficacy of intra-renal CD40 silencing in a model of humoral acute rejection. | Ripoll E, etal., Gene Ther. 2011 Oct;18(10):945-52. doi: 10.1038/gt.2011.39. Epub 2011 Apr 7. |
| 86. | CD40 Gene Silencing Reduces the Progression of Experimental Lupus Nephritis Modulating Local Milieu and Systemic Mechanisms. | Ripoll E, etal., PLoS One. 2013 Jun 14;8(6):e65068. doi: 10.1371/journal.pone.0065068. Print 2013. |
| 87. | Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach. | Rodenburg W, etal., Proteomics Clin Appl. 2010 Jul;4(6-7):603-12. doi: 10.1002/prca.200900175. Epub 2010 Mar 24. |
| 88. | Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. | Ruth AJ, etal., J Am Soc Nephrol. 2003 Nov;14(11):2813-22. |
| 89. | An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. | Ruth AJ, etal., J Immunol. 2004 Jul 1;173(1):136-44. |
| 90. | Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies. | Seko Y, etal., Circ Res. 1998 Aug 24;83(4):463-9. |
| 91. | Expression of costimulatory molecules B7-1, B7-2, and CD40 in the heart of patients with acute myocarditis and dilated cardiomyopathy. | Seko Y, etal., Circulation. 1998 Feb 24;97(7):637-9. |
| 92. | Expression of tumour necrosis factor (TNF) receptor/ligand superfamily co-stimulatory molecules CD40, CD30L, CD27L, and OX40L in murine hearts with chronic ongoing myocarditis caused by coxsackie virus B3. | Seko Y, etal., J Pathol. 1999 Aug;188(4):423-30. doi: 10.1002/(SICI)1096-9896(199908)188:4<423::AID-PATH373>3.0.CO;2-8. |
| 93. | Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China. | Shuang C, etal., PLoS One. 2011;6(8):e23762. doi: 10.1371/journal.pone.0023762. Epub 2011 Aug 30. |
| 94. | A novel allergen-specific therapy for allergy using CD40-silenced dendritic cells. | Suzuki M, etal., J Allergy Clin Immunol. 2010 Mar;125(3):737-43, 743.e1-743.e6. |
| 95. | Semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor. | Tjomsland V, etal., PLoS One. 2010 Oct 15;5(10):e13441. |
| 96. | Increased adipose tissue expression of proinflammatory CD40, MKK4 and JNK in patients with very severe chronic obstructive pulmonary disease. | Tkacova R, etal., Respiration. 2011;81(5):386-93. Epub 2010 Aug 12. |
| 97. | Impaired immune responses in the lungs of aged mice following influenza infection. | Toapanta FR and Ross TM, Respir Res. 2009 Nov 18;10:112. |
| 98. | A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. | Tomer Y, etal., Thyroid. 2002 Dec;12(12):1129-35. |
| 99. | CD40 is a prognostic marker in primary cutaneous malignant melanoma. | van den Oord JJ, etal., Am J Pathol. 1996 Dec;149(6):1953-61. |
| 100. | A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis. | Vazgiourakis VM, etal., Ann Rheum Dis. 2011 Sep 12. |
| 101. | Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy. | Veber D, etal., J Neuroimmunol. 2006 Jul;176(1-2):24-33. Epub 2006 May 22. |
| 102. | Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. | Vonderheide RH, etal., J Clin Oncol. 2007 Mar 1;25(7):876-83. |
| 103. | The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study. | Wang M, etal., DNA Cell Biol. 2011 Mar;30(3):173-8. Epub 2010 Nov 22. |
| 104. | DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. | Wang Y, etal., Kidney Int. 2013 Feb;83(2):223-32. doi: 10.1038/ki.2012.374. Epub 2012 Dec 5. |
| 105. | Tumor regression by anti-CD40 and interleukin-2: role of CD40 in hematopoietic cells and organ-specific effects. | Welniak LA, etal., Biol Blood Marrow Transplant. 2004 Aug;10(8):534-9. |
| 106. | Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice. | Westwood JA, etal., J Transl Med. 2010 Apr 28;8:42. doi: 10.1186/1479-5876-8-42. |
| 107. | The expression of CD40-CD40L and activities of matrix metalloproteinases in atherosclerotic rats. | Wu M and Li YG, Mol Cell Biochem. 2006 Jan;282(1-2):141-6. |
| 108. | Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. | Xu J, etal., J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):140-6. |
| 109. | Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice. | Yan J, etal., Hepatology. 2011 May;53(5):1455-67. doi: 10.1002/hep.24270. |
| 110. | Zinc finger protein A20 protects rats against chronic liver allograft dysfunction. | Yang J, etal., World J Gastroenterol. 2012 Jul 21;18(27):3537-50. doi: 10.3748/wjg.v18.i27.3537. |
| 111. | Interruption of CD40 Pathway Improves Efficacy of Transplanted Endothelial Progenitor Cells in Monocrotaline Induced Pulmonary Arterial Hypertension. | YanYun P, etal., Cell Physiol Biochem. 2015;36(2):683-96. |
| 112. | Association between serum levels of soluble CD40/CD40 ligand and organ damage in hypertensive patients. | Yuan M, etal., Clin Exp Pharmacol Physiol. 2010 Aug;37(8):848-51. |
| 113. | Soluble CD40 and soluble CD40L concentrations in the serum and the cerebrospinal fluid of patients with tick borne encephalitis and neuroborreliosis | Zajkowska JM, etal., Neurol Neurochir Pol. 2006 Jan-Feb;40(1):22-7. |
| 114. | A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: A case-control study. | Zervou MI, etal., Hum Immunol. 2011 Sep;72(9):761-5. Epub 2011 May 24. |
| 115. | Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells. | Zheng X, etal., J Immunol. 2010 Jun 1;184(11):6457-64. Epub 2010 Apr 30. |
| 116. | Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis. | Zhou Q, etal., Infect Immun. 2006 Apr;74(4):2161-8. |
| 117. | [Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis]. | Zhu P and Zou LP, Zhongguo Dang Dai Er Ke Za Zhi. 2009 May;11(5):354-6. |
| 118. | [A study of costimulatory molecules in allergic allergic rhinitis patients]. | Zhu R, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Sep;22(17):780-2, 784. |
| 119. | B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis in Lewis rats. | Zhu W, etal., Neurobiol Dis. 2007 Mar;25(3):642-8. Epub 2006 Dec 22. |
Additional References at PubMed
| PMID:1701063 | PMID:2475341 | PMID:2998589 | PMID:3487090 | PMID:7516405 | PMID:7516669 | PMID:7518550 | PMID:7522634 | PMID:7527023 | PMID:7530216 | PMID:7533327 | PMID:7538666 |
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| PMID:20067533 | PMID:20081875 | PMID:20107176 | PMID:20118277 | PMID:20127135 | PMID:20137882 | PMID:20219786 | PMID:20233754 | PMID:20237496 | PMID:20303602 | PMID:20368992 | PMID:20371189 |
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| PMID:21041727 | PMID:21054240 | PMID:21071692 | PMID:21103345 | PMID:21138731 | PMID:21200133 | PMID:21223957 | PMID:21239998 | PMID:21282461 | PMID:21285457 | PMID:21337550 | PMID:21383499 |
| PMID:21403646 | PMID:21410936 | PMID:21415255 | PMID:21567389 | PMID:21741080 | PMID:21813202 | PMID:21832282 | PMID:21833088 | PMID:21866398 | PMID:21873635 | PMID:21922073 | PMID:21976957 |
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| PMID:22564647 | PMID:22687258 | PMID:22706687 | PMID:22722990 | PMID:22731751 | PMID:22783574 | PMID:22803080 | PMID:22814930 | PMID:22820189 | PMID:22851860 | PMID:22863718 | PMID:22888137 |
| PMID:22904686 | PMID:22952582 | PMID:22965071 | PMID:23000501 | PMID:23002440 | PMID:23073798 | PMID:23092922 | PMID:23100517 | PMID:23128233 | PMID:23166616 | PMID:23257401 | PMID:23334419 |
| PMID:23400328 | PMID:23419881 | PMID:23429328 | PMID:23456134 | PMID:23463508 | PMID:23509150 | PMID:23528588 | PMID:23528589 | PMID:23604864 | PMID:23613777 | PMID:23669336 | PMID:23686494 |
| PMID:23751348 | PMID:23824909 | PMID:23858029 | PMID:23918987 | PMID:23924922 | PMID:23954880 | PMID:23981064 | PMID:24107910 | PMID:24120361 | PMID:24122029 | PMID:24189063 | PMID:24202305 |
| PMID:24260396 | PMID:24358353 | PMID:24390342 | PMID:24452203 | PMID:24632372 | PMID:24657679 | PMID:24679691 | PMID:24719952 | PMID:24801648 | PMID:24810049 | PMID:24812060 | PMID:24828072 |
| PMID:24866241 | PMID:24885116 | PMID:24912008 | PMID:24931231 | PMID:24945092 | PMID:25004625 | PMID:25024369 | PMID:25051892 | PMID:25163469 | PMID:25301451 | PMID:25305459 | PMID:25324844 |
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| PMID:25908480 | PMID:25910212 | PMID:25936345 | PMID:25977307 | PMID:25992978 | PMID:26054744 | PMID:26068105 | PMID:26210919 | PMID:26268734 | PMID:26289938 | PMID:26305332 | PMID:26462153 |
| PMID:26474561 | PMID:26545336 | PMID:26658005 | PMID:26779844 | PMID:26821950 | PMID:26823861 | PMID:26871637 | PMID:26901523 | PMID:27031714 | PMID:27063419 | PMID:27077111 | PMID:27090943 |
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| PMID:31515488 | PMID:31570051 | PMID:31615434 | PMID:31642196 | PMID:31921199 | PMID:32041822 | PMID:32111053 | PMID:32296183 | PMID:32345091 | PMID:32407843 | PMID:32419081 | PMID:32687490 |
| PMID:32700598 | PMID:33180391 | PMID:33371207 | PMID:33674076 | PMID:33837301 | PMID:33875006 | PMID:33961781 | PMID:33968033 | PMID:34010245 | PMID:34084166 | PMID:34167573 | PMID:34625948 |
| PMID:34678319 | PMID:34830445 | PMID:34867801 | PMID:34871197 | PMID:35031307 | PMID:35107652 | PMID:36011296 | PMID:36051533 | PMID:36217029 | PMID:36520044 |
Genomics
Comparative Map Data
| CD40 (Homo sapiens - human) |
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| Cd40 (Mus musculus - house mouse) |
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| Cd40 (Rattus norvegicus - Norway rat) |
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| Cd40 (Chinchilla lanigera - long-tailed chinchilla) |
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| CD40 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| CD40 (Canis lupus familiaris - dog) |
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| Cd40 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| CD40 (Sus scrofa - pig) |
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| CD40 (Chlorocebus sabaeus - green monkey) |
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| Cd40 (Heterocephalus glaber - naked mole-rat) |
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Variants
.
Variants in CD40
104 total Variants 
|
