TLR9 (toll like receptor 9) - Rat Genome Database

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Gene: TLR9 (toll like receptor 9) Homo sapiens
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Symbol: TLR9
Name: toll like receptor 9
RGD ID: 1346715
HGNC Page HGNC:15633
Description: Enables interleukin-1 receptor binding activity; pattern recognition receptor activity; and siRNA binding activity. Involved in several processes, including positive regulation of gene expression; positive regulation of intracellular signal transduction; and regulation of innate immune response. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasm. Is active in endoplasmic reticulum. Implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Biomarker of several diseases, including Human papillomavirus infectious disease; carcinoma (multiple); liver disease (multiple); lung disease (multiple); and nose disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD289; toll-like receptor 9
RGD Orthologs
Mouse
Rat
Chinchilla
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,221,080 - 52,225,645 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,221,080 - 52,225,645 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,255,096 - 52,259,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,230,138 - 52,235,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,230,137 - 52,233,247NCBI
Celera352,234,410 - 52,239,491 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef352,317,258 - 52,322,341 (-)NCBIHuRef
CHM1_1352,207,624 - 52,212,707 (-)NCBICHM1_1
T2T-CHM13v2.0352,253,966 - 52,258,531 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Achlorhydria  (IAGP)
acute kidney failure  (ISO)
acute necrotizing pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (IEP)
allergic bronchopulmonary aspergillosis  (IAGP,ISO)
allergic conjunctivitis  (IEP)
allergic rhinitis  (IEP)
anogenital venereal wart  (IEP)
asthma  (IAGP,IEP,ISO)
bacterial pneumonia  (ISO)
Brain Injuries  (EXP)
breast cancer  (IEP)
bronchiolitis obliterans  (IAGP)
cardiovascular system disease  (IAGP)
cervix uteri carcinoma in situ  (IEP)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
chronic granulomatous disease  (IEP)
Chronic Hepatitis B  (IAGP,IEP)
Chronic Hepatitis C  (IEP)
chronic kidney disease  (IAGP)
Chronic Periodontitis  (IEP)
congenital disorder of glycosylation In  (IAGP)
crescentic glomerulonephritis  (ISO)
Crohn's disease  (EXP)
cutaneous leishmaniasis  (IEP)
cystic fibrosis  (IAGP)
dermatomyositis  (IEP)
Experimental Autoimmune Neuritis  (ISO)
genetic disease  (IAGP)
Granuloma, Foreign-Body  (EXP)
Hearing Loss  (IAGP)
hepatitis B  (IAGP)
hepatitis C  (IAGP,IEP)
hepatocellular carcinoma  (EXP,IEP,IMP)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypergammaglobulinemia  (ISO)
IgA glomerulonephritis  (IAGP,ISO)
Inflammation  (EXP)
interstitial lung disease  (IEP)
Klebsiella Infections  (ISO)
Legionnaires' disease  (ISO)
Liver Injury  (ISO)
Lung Neoplasms  (IEP)
lung non-small cell carcinoma  (IEP)
lupus nephritis  (IAGP,IEP,ISO)
Malarial Anemia  (IAGP)
mastitis  (ISO)
membranoproliferative glomerulonephritis  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
Oral Lichen Planus  (IEP)
papillomavirus infectious disease  (IEP)
perinatal necrotizing enterocolitis  (ISO)
Pneumococcal Infections  (ISO)
Pneumococcal Meningitis  (ISO)
primary biliary cholangitis  (IEP)
proteinuria  (IAGP,ISO)
pulmonary fibrosis  (IEP)
pulmonary tuberculosis  (IAGP)
renal cell carcinoma  (IEP)
Respiratory Sounds  (IAGP)
Respiratory Tract Granuloma  (EXP,ISO)
Schistosomiasis Mansoni  (EXP)
sinusitis  (IEP)
squamous cell carcinoma  (IEP)
systemic lupus erythematosus  (IAGP,ISO)
Tracheoesophageal Fistula  (IAGP)
Transplant Rejection  (IAGP)
Triple Negative Breast Neoplasms  (EXP)
trypanosomiasis  (ISO)
ureteral obstruction  (ISO)
viral pneumonia  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA)
canonical NF-kappaB signal transduction  (IBA,IEA)
cellular response to chloroquine  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to metal ion  (IEA,ISO)
defense response to bacterium  (NAS)
defense response to virus  (IBA,IEA,ISO)
detection of molecule of bacterial origin  (IDA)
immune response  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA,TAS)
maintenance of gastrointestinal epithelium  (IEA,ISS)
male gonad development  (IEA,ISO)
microglial cell activation  (IEA,ISO)
MyD88-dependent toll-like receptor signaling pathway  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
obsolete regulation of nitrogen compound metabolic process  (IEA)
positive regulation of autophagy  (IEA,ISO)
positive regulation of B cell activation  (IDA)
positive regulation of B cell proliferation  (IDA)
positive regulation of canonical NF-kappaB signal transduction  (IDA)
positive regulation of chemokine production  (IDA)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (IDA)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IDA)
positive regulation of immunoglobulin production  (IDA)
positive regulation of inflammatory response  (IC)
positive regulation of interferon-alpha production  (IDA)
positive regulation of interferon-beta production  (IDA,IEA,ISS)
positive regulation of interleukin-10 production  (IEA,ISS)
positive regulation of interleukin-12 production  (IEA,ISS)
positive regulation of interleukin-18 production  (IEA,ISS)
positive regulation of interleukin-6 production  (IBA,IDA,IEA)
positive regulation of interleukin-8 production  (IDA)
positive regulation of intestinal epithelial cell development  (IEA,ISS)
positive regulation of JNK cascade  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of non-canonical NF-kappaB signal transduction  (IDA)
positive regulation of toll-like receptor 9 signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISS)
positive regulation of type II interferon production  (IDA)
regulation of B cell activation  (IEA,ISO)
regulation of B cell differentiation  (IDA)
regulation of dendritic cell cytokine production  (IEA,ISO)
regulation of inflammatory response  (IEA)
regulation of macromolecule metabolic process  (IEA)
regulation of primary metabolic process  (IEA)
regulation of protein phosphorylation  (IEA,ISO)
regulation of toll-like receptor 9 signaling pathway  (IDA)
response to virus  (IEA,ISO)
signal transduction  (IEA)
toll-like receptor 9 signaling pathway  (IDA)
toll-like receptor signaling pathway  (IBA,IDA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Albiger B, etal., Cell Microbiol. 2007 Mar;9(3):633-44. Epub 2006 Sep 27.
2. TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion. Bakker PJ, etal., PLoS One. 2015 Sep 11;10(9):e0137511. doi: 10.1371/journal.pone.0137511. eCollection 2015.
3. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
4. Hepatic expression of toll-like receptors 3, 4, and 9 in primary biliary cirrhosis and chronic hepatitis C. Benias PC, etal., Clin Res Hepatol Gastroenterol. 2012 Oct;36(5):448-54. doi: 10.1016/j.clinre.2012.07.001. Epub 2012 Sep 29.
5. Involvement of renal tubular Toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus. Benigni A, etal., Arthritis Rheum. 2007 May;56(5):1569-78.
6. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
7. Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila. Bhan U, etal., Infect Immun. 2008 Jul;76(7):2895-904. Epub 2008 Apr 21.
8. TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells. Bhan U, etal., J Immunol. 2007 Sep 15;179(6):3937-46.
9. Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. Bhan U, etal., PLoS One. 2010 Mar 26;5(3):e9896.
10. A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma. Bjornvold M, etal., Genes Immun. 2009 Mar;10(2):181-7. Epub 2009 Jan 15.
11. Expression of Toll-like receptors in healthy and allergic conjunctiva. Bonini S, etal., Ophthalmology. 2005 Sep;112(9):1528; discussion 1548-9.
12. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Bottcher T, etal., Neurosci Lett. 2003 Jun 19;344(1):17-20.
13. TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection. Carrera-Silva EA, etal., Mol Immunol. 2008 Aug;45(13):3580-8. doi: 10.1016/j.molimm.2008.05.004. Epub 2008 Jun 18.
14. Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation. Carvalho A, etal., Exp Hematol. 2009 Sep;37(9):1022-9. Epub 2009 Jun 17.
15. Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. Carvalho A, etal., J Infect Dis. 2008 Feb 15;197(4):618-21.
16. Blockade of TLR9 signaling in B cells impaired anti-dsDNA antibody production in mice induced by activated syngenic lymphocyte-derived DNA immunization. Chen M, etal., Mol Immunol. 2011 Jul;48(12-13):1532-9. doi: 10.1016/j.molimm.2011.04.016. Epub 2011 May 18.
17. Toll-like receptor 9 polymorphisms and Hepatitis B virus clearance in Moroccan chronic carriers. Chihab H, etal., Gene. 2019 Mar 1;687:212-218. doi: 10.1016/j.gene.2018.11.041. Epub 2018 Nov 16.
18. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Christensen SR, etal., Immunity. 2006 Sep;25(3):417-28.
19. Toll-like receptor expression on peripheral blood mononuclear cells in asthmatics; implications for asthma management. Chun E, etal., J Clin Immunol. 2010 May;30(3):459-64. Epub 2010 Jan 14.
20. Hepatitis C may enhance key amplifiers of psoriasis. Chun K, etal., J Eur Acad Dermatol Venereol. 2017 Apr;31(4):672-678. doi: 10.1111/jdv.13578. Epub 2016 May 17.
21. Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. Csak T, etal., Liver Int. 2014 Oct;34(9):1402-13. doi: 10.1111/liv.12537. Epub 2014 Apr 17.
22. Association between toll-like receptor expression and human papillomavirus type 16 persistence. Daud II, etal., Int J Cancer. 2011 Feb 15;128(4):879-86. doi: 10.1002/ijc.25400.
23. Expression of TLR4 and TLR9 mRNA in Lewis rats with experimental allergic neuritis. Deng YN and Zhou WB, Neuroimmunomodulation. 2007;14(6):337-43. Epub 2008 Apr 23.
24. Human lung cancer cells express functionally active Toll-like receptor 9. Droemann D, etal., Respir Res. 2005 Jan 4;6:1.
25. Evaluation of neonatal Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in HBV intrauterine transmission susceptibility. Gao Y, etal., Epidemiol Infect. 2015 Jul;143(9):1868-75. doi: 10.1017/S0950268814002921. Epub 2014 Nov 12.
26. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. Genuneit J, etal., Clin Exp Allergy. 2009 Dec;39(12):1875-88.
27. Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells. Gill R, etal., Shock. 2011 Feb;35(2):164-70. doi: 10.1097/SHK.0b013e3181eddcab.
28. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
29. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
30. Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease. Hartl D, etal., J Allergy Clin Immunol. 2008 Feb;121(2):375-382.e9. Epub 2007 Dec 26.
31. Effects of oligodeoxynucleotide with CCT repeats on chronic graft versus host disease induced experimental lupus nephritis in mice. He C, etal., Clin Immunol. 2011 Sep;140(3):300-6. doi: 10.1016/j.clim.2011.04.016. Epub 2011 May 4.
32. Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice. He C, etal., Rheumatol Int. 2012 Mar;32(3):633-8. doi: 10.1007/s00296-010-1630-z. Epub 2010 Dec 3.
33. A novel small-molecule enantiomeric analogue of traditional (-)-morphinans has specific TLR9 antagonist properties and reduces sterile inflammation-induced organ damage. Hoque R, etal., J Immunol. 2013 Apr 15;190(8):4297-304. doi: 10.4049/jimmunol.1202184. Epub 2013 Mar 15.
34. Reduced toll-like receptor 9 expression on peripheral CD14+ monocytes of chronic hepatitis B patients and its restoration by effective therapy. Huang YW, etal., Antivir Ther. 2014;19(7):637-43. doi: 10.3851/IMP2762. Epub 2014 Mar 12.
35. Toll-like receptor 9 mediates CpG oligonucleotide-induced cellular invasion. Ilvesaro JM, etal., Mol Cancer Res. 2008 Oct;6(10):1534-43. doi: 10.1158/1541-7786.MCR-07-2005.
36. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. Imaeda AB, etal., J Clin Invest. 2009 Feb;119(2):305-14. doi: 10.1172/JCI35958. Epub 2009 Jan 26.
37. TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response. Ito T, etal., Eur J Immunol. 2007 Oct;37(10):2847-55.
38. Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. Kastelijn EA, etal., J Heart Lung Transplant. 2010 Jun;29(6):665-71. Epub 2010 Mar 15.
39. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
40. CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo. Knuefermann P, etal., Respir Res. 2007 Oct 9;8:72.
41. A comprehensive genotype-phenotype interaction of different Toll-like receptor variations in a renal transplant cohort. Kruger B, etal., Clin Sci (Lond). 2010 Dec;119(12):535-44. doi: 10.1042/CS20100190.
42. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
43. Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children. Lachheb J, etal., Tissue Antigens. 2008 May;71(5):417-25. Epub 2008 Feb 28.
44. Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes. Lange NE, etal., BMC Med Genet. 2011 Feb 15;12:26.
45. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis. Lauriello M, etal., Int J Otolaryngol. 2012;2012:925164. doi: 10.1155/2012/925164. Epub 2012 Apr 10.
46. Increased toll-like receptor 9 expression in cervical neoplasia. Lee JW, etal., Mol Carcinog. 2007 Nov;46(11):941-7.
47. Small interfering RNA targeting Toll-like receptor 9 protects mice against polymicrobial septic acute kidney injury. Liu L, etal., Nephron Exp Nephrol. 2012;122(1-2):51-61. doi: 10.1159/000346953. Epub 2013 Mar 15.
48. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
49. The T-1237C polymorphism of the Toll-like receptor-9 gene is associated with chronic kidney disease in a Han Chinese population. Lu KC, etal., Tohoku J Exp Med. 2011;225(2):109-16.
50. Neutrophil Toll-Like Receptor 9 Expression and the Systemic Inflammatory Response in Acetaminophen-Induced Acute Liver Failure. Manakkat Vijay GK, etal., Crit Care Med. 2016 Jan;44(1):43-53. doi: 10.1097/CCM.0000000000001309.
51. [TLR9 expression is positively correlated with the levels of CD38, HLA-DR and CD95 on peripheral blood mononuclear cells in chronic HBV infected patients]. Mao X, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 May;32(5):660-5.
52. TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation. Meneghin A, etal., Histochem Cell Biol. 2008 Nov;130(5):979-92. Epub 2008 Jul 17.
53. TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival. Mridha AR, etal., Clin Sci (Lond). 2017 Jul 24;131(16):2145-2159. doi: 10.1042/CS20160838. Print 2017 Aug 15.
54. Polymorphisms in the Fc gamma receptor IIIA and Toll-like receptor 9 are associated with protection against severe malarial anemia and changes in circulating gamma interferon levels. Munde EO, etal., Infect Immun. 2012 Dec;80(12):4435-43. doi: 10.1128/IAI.00945-12. Epub 2012 Oct 8.
55. Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease. Ng MT, etal., Infect Immun. 2010 Mar;78(3):1345-52. Epub 2009 Dec 28.
56. Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1. Nickerson KM, etal., J Immunol. 2013 Apr 15;190(8):3889-94. doi: 10.4049/jimmunol.1203525. Epub 2013 Mar 6.
57. Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response. Papadimitraki ED, etal., Lupus. 2009 Aug;18(9):831-5. doi: 10.1177/0961203309103054.
58. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
59. Association between -1486 T>C and +1174 G>A single nucleotide polymorphisms in TLR9 gene and severity of lupus nephritis. Ramachandran R, etal., Indian J Nephrol. 2012 Mar;22(2):125-9. doi: 10.4103/0971-4065.97133.
60. Sinonasal epithelial cell expression of toll-like receptor 9 is decreased in chronic rhinosinusitis with polyps. Ramanathan M Jr, etal., Am J Rhinol. 2007 Jan-Feb;21(1):110-6.
61. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Ramanathan M Jr, etal., Am J Rhinol. 2008 Mar-Apr;22(2):115-21.
62. Intranasal CpG therapy attenuated experimental fungal asthma in a TLR9-dependent and -independent manner. Ramaprakash H and Hogaboam CM, Int Arch Allergy Immunol. 2010;152(2):98-112. Epub 2009 Dec 16.
63. Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice. Ramaprakash H, etal., Infect Immun. 2009 Jan;77(1):108-19. Epub 2008 Oct 20.
64. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
65. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
66. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
67. Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma. Ronkainen H, etal., J Exp Clin Cancer Res. 2011 Sep 19;30:84. doi: 10.1186/1756-9966-30-84.
68. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
69. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
70. TLR4 and TLR9 are induced in oral lichen planus. Siponen M, etal., J Oral Pathol Med. 2012 Nov;41(10):741-7. doi: 10.1111/j.1600-0714.2012.01169.x. Epub 2012 Jun 5.
71. Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction. Skuginna V, etal., PLoS One. 2011 Apr 22;6(4):e19204. doi: 10.1371/journal.pone.0019204.
72. Association studies of Toll-like receptor gene polymorphisms with allograft survival in renal transplant recipients of North India. Srivastava P, etal., Clin Transplant. 2012 Jul-Aug;26(4):581-8. doi: 10.1111/j.1399-0012.2011.01577.x. Epub 2012 Jan 17.
73. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. Stadlbauer V, etal., J Hepatol. 2008 Jun;48(6):945-51. Epub 2008 Mar 25.
74. Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia. Stanke F, etal., J Med Genet. 2011 Jan;48(1):24-31. Epub 2010 Sep 12.
75. Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis. Summers SA, etal., Am J Pathol. 2010 Nov;177(5):2234-44. doi: 10.2353/ajpath.2010.100153. Epub 2010 Sep 16.
76. Toll-like receptor 9 affects severity of IgA nephropathy. Suzuki H, etal., J Am Soc Nephrol. 2008 Dec;19(12):2384-95. doi: 10.1681/ASN.2007121311. Epub 2008 Sep 5.
77. The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. Tuon FF, etal., J Dermatol Sci. 2010 Jul;59(1):55-7. doi: 10.1016/j.jdermsci.2010.04.009. Epub 2010 May 20.
78. Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background. Valverde-Villegas JM, etal., Hum Immunol. 2017 Feb;78(2):221-226. doi: 10.1016/j.humimm.2017.01.001. Epub 2017 Jan 4.
79. Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. van Well GT, etal., PLoS One. 2012;7(5):e35837. doi: 10.1371/journal.pone.0035837. Epub 2012 May 25.
80. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Velez DR, etal., Hum Genet. 2010 Jan;127(1):65-73. Epub 2009 Sep 22.
81. Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. Xu CJ, etal., Mol Biol Rep. 2009 Nov;36(8):2245-8. Epub 2009 Jan 7.
82. Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma. Xu N, etal., Acta Pharmacol Sin. 2008 Feb;29(2):239-44. doi: 10.1111/j.1745-7254.2008.00711.x.
83. Toll-like receptor 9 is expressed in rat pancreas and is involved in cerulein-induced pancreatitis. Zeng YJ, etal., Pancreas. 2008 Mar;36(2):212-4.
84. Phosphorothioate-modified CpG oligodeoxynucleotide (CpG ODN) induces apoptosis of human hepatocellular carcinoma cells independent of TLR9. Zhang Y, etal., Cancer Immunol Immunother. 2014 Apr;63(4):357-67. doi: 10.1007/s00262-014-1518-y. Epub 2014 Jan 23.
85. Increased expression of Toll-like receptors 4 and 9 in human lung cancer. Zhang YB, etal., Mol Biol Rep. 2009 Jul;36(6):1475-81. Epub 2008 Sep 2.
86. Expression of toll-like receptor 9 in peripheral blood mononuclear cells from patients with different hepatitis B and C viral loads. Zhou J, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Jun;29(3):313-7. doi: 10.1007/s11596-009-0310-2. Epub 2009 Jun 10.
87. Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population. Zhou XJ, etal., Clin Exp Rheumatol. 2010 May-Jun;28(3):397-400. Epub 2010 Jun 23.
88. Protective effect of CpG-DNA against mastitis induced by Staphylococcus aureus infection in a rat model. Zhu YM, etal., Int Immunopharmacol. 2007 Apr;7(4):435-43. Epub 2006 Nov 27.
Additional References at PubMed
PMID:9435236   PMID:11022119   PMID:11022120   PMID:11130078   PMID:11561001   PMID:11564765   PMID:11782555   PMID:11867692   PMID:11909637   PMID:11970999   PMID:11976718   PMID:12477932  
PMID:12560217   PMID:12573264   PMID:12600829   PMID:12660731   PMID:12689944   PMID:12724322   PMID:12734363   PMID:12778475   PMID:12867418   PMID:12925853   PMID:12941697   PMID:12975309  
PMID:14625308   PMID:14694183   PMID:14716310   PMID:14751759   PMID:14987294   PMID:15107846   PMID:15153500   PMID:15207506   PMID:15276183   PMID:15294971   PMID:15307186   PMID:15356140  
PMID:15489334   PMID:15585868   PMID:15607737   PMID:15723075   PMID:15730519   PMID:15790341   PMID:15860583   PMID:15878652   PMID:16002719   PMID:16024265   PMID:16024789   PMID:16125159  
PMID:16164440   PMID:16230478   PMID:16237063   PMID:16286015   PMID:16371473   PMID:16394009   PMID:16424230   PMID:16428738   PMID:16437636   PMID:16575840   PMID:16608528   PMID:16731773  
PMID:16779724   PMID:16847112   PMID:16849519   PMID:16864658   PMID:16920494   PMID:16951309   PMID:16971956   PMID:16990271   PMID:17000223   PMID:17040905   PMID:17075805   PMID:17128265  
PMID:17142771   PMID:17145922   PMID:17192395   PMID:17229603   PMID:17258734   PMID:17292969   PMID:17295441   PMID:17301562   PMID:17325049   PMID:17328813   PMID:17344245   PMID:17360657  
PMID:17373717   PMID:17473064   PMID:17474147   PMID:17482427   PMID:17516623   PMID:17534115   PMID:17573724   PMID:17636117   PMID:17703412   PMID:17768129   PMID:17854429   PMID:17854755  
PMID:17878374   PMID:17893430   PMID:17894360   PMID:17914947   PMID:17932028   PMID:17964520   PMID:17984204   PMID:17986857   PMID:18036648   PMID:18092352   PMID:18160420   PMID:18208876  
PMID:18253698   PMID:18262306   PMID:18318750   PMID:18332208   PMID:18394314   PMID:18406377   PMID:18437017   PMID:18524824   PMID:18535206   PMID:18539711   PMID:18568766   PMID:18595521  
PMID:18606688   PMID:18686608   PMID:18769358   PMID:18776592   PMID:18806803   PMID:18810425   PMID:18818748   PMID:18832675   PMID:18841790   PMID:18946062   PMID:19019335   PMID:19033535  
PMID:19034349   PMID:19050243   PMID:19079358   PMID:19096003   PMID:19120473   PMID:19129482   PMID:19201477   PMID:19211891   PMID:19247692   PMID:19254290   PMID:19258923   PMID:19264973  
PMID:19275920   PMID:19284650   PMID:19289178   PMID:19297619   PMID:19299739   PMID:19317913   PMID:19319670   PMID:19337058   PMID:19362685   PMID:19367581   PMID:19390575   PMID:19401392  
PMID:19406482   PMID:19423540   PMID:19459480   PMID:19505919   PMID:19527514   PMID:19564354   PMID:19601804   PMID:19618291   PMID:19620253   PMID:19627277   PMID:19639721   PMID:19714766  
PMID:19723394   PMID:19724876   PMID:19740627   PMID:19745833   PMID:19789190   PMID:19794067   PMID:19796535   PMID:19809335   PMID:19810822   PMID:19840968   PMID:19844589   PMID:19854217  
PMID:19855253   PMID:19903791   PMID:19906293   PMID:19913121   PMID:19914718   PMID:19924287   PMID:19948975   PMID:20026892   PMID:20041977   PMID:20044998   PMID:20054821   PMID:20100933  
PMID:20130217   PMID:20132814   PMID:20137629   PMID:20181802   PMID:20194452   PMID:20197609   PMID:20207250   PMID:20227772   PMID:20237496   PMID:20307689   PMID:20331378   PMID:20348497  
PMID:20363151   PMID:20364327   PMID:20375564   PMID:20375566   PMID:20399690   PMID:20406964   PMID:20422193   PMID:20438785   PMID:20442853   PMID:20452482   PMID:20500814   PMID:20503287  
PMID:20514021   PMID:20559388   PMID:20588308   PMID:20592251   PMID:20595247   PMID:20622911   PMID:20628086   PMID:20635795   PMID:20646321   PMID:20646633   PMID:20659127   PMID:20667457  
PMID:20673868   PMID:20674764   PMID:20696081   PMID:20713890   PMID:20797905   PMID:20811701   PMID:20819670   PMID:20821041   PMID:20843333   PMID:20843814   PMID:20935225   PMID:20977567  
PMID:20978888   PMID:20980519   PMID:21048031   PMID:21048937   PMID:21050493   PMID:21057083   PMID:21059889   PMID:21068441   PMID:21086718   PMID:21115235   PMID:21129170   PMID:21132533  
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PMID:21823020   PMID:21833528   PMID:21843566   PMID:21844166   PMID:21850017   PMID:21866115   PMID:21873635   PMID:21876325   PMID:21903422   PMID:21908428   PMID:21911421   PMID:21926972  
PMID:21940676   PMID:21968308   PMID:21968713   PMID:21977996   PMID:21978158   PMID:21990957   PMID:22001237   PMID:22014045   PMID:22041559   PMID:22046272   PMID:22055432   PMID:22057691  
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PMID:22847512   PMID:22853846   PMID:22893852   PMID:22898741   PMID:22908309   PMID:22931661   PMID:22932083   PMID:22948021   PMID:22948541   PMID:22952899   PMID:22964787   PMID:23009111  
PMID:23021866   PMID:23043436   PMID:23071157   PMID:23091345   PMID:23103284   PMID:23123793   PMID:23133627   PMID:23135998   PMID:23179584   PMID:23182970   PMID:23183093   PMID:23219390  
PMID:23221735   PMID:23237868   PMID:23266611   PMID:23276930   PMID:23289794   PMID:23296704   PMID:23369718   PMID:23383065   PMID:23406596   PMID:23407387   PMID:23425749   PMID:23467704  
PMID:23472199   PMID:23490285   PMID:23497207   PMID:23564191   PMID:23592712   PMID:23593431   PMID:23617757   PMID:23651260   PMID:23673637   PMID:23677790   PMID:23711330   PMID:23724117  
PMID:23731219   PMID:23752229   PMID:23758740   PMID:23766695   PMID:23776537   PMID:23816930   PMID:23826189   PMID:23827939   PMID:23855294   PMID:23857366   PMID:23893288   PMID:23913633  
PMID:23953621   PMID:23957925   PMID:23962979   PMID:23964786   PMID:23967355   PMID:23974051   PMID:23974872   PMID:23990988   PMID:23994589   PMID:24004541   PMID:24007656   PMID:24053111  
PMID:24067965   PMID:24080302   PMID:24091496   PMID:24168509   PMID:24176007   PMID:24184955   PMID:24212717   PMID:24269682   PMID:24301797   PMID:24375473   PMID:24390332   PMID:24409285  
PMID:24459426   PMID:24470136   PMID:24504675   PMID:24532514   PMID:24571477   PMID:24574405   PMID:24582318   PMID:24610369   PMID:24612681   PMID:24647486   PMID:24692849   PMID:24709112  
PMID:24722226   PMID:24747071   PMID:24788552   PMID:24801457   PMID:24801688   PMID:24865418   PMID:24886842   PMID:24906089   PMID:24912772   PMID:24919757   PMID:24987851   PMID:24990399  
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PMID:25735984   PMID:25744504   PMID:25780037   PMID:25790192   PMID:25796310   PMID:25844529   PMID:25862837   PMID:25889916   PMID:25891128   PMID:25892310   PMID:25892855   PMID:25912131  
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PMID:26313906   PMID:26339055   PMID:26340429   PMID:26361369   PMID:26371257   PMID:26371589   PMID:26416273   PMID:26426362   PMID:26462624   PMID:26466955   PMID:26504005   PMID:26505293  
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PMID:30215163   PMID:30218032   PMID:30239236   PMID:30239551   PMID:30277474   PMID:30321082   PMID:30345020   PMID:30348730   PMID:30357962   PMID:30373864   PMID:30424735   PMID:30431116  
PMID:30508414   PMID:30587483   PMID:30610847   PMID:30651082   PMID:30745168   PMID:30793925   PMID:30824926   PMID:30846988   PMID:31002145   PMID:31170232   PMID:31278284   PMID:31279905  
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PMID:32372371   PMID:32439701   PMID:32547554   PMID:32638255   PMID:32658127   PMID:32729323   PMID:32753695   PMID:32871478   PMID:32939755   PMID:32967147   PMID:33143777   PMID:33247440  
PMID:33354779   PMID:33369094   PMID:33372855   PMID:33382388   PMID:33389882   PMID:33472905   PMID:33512408   PMID:33643304   PMID:33800897   PMID:33910419   PMID:33939072   PMID:33939146  
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PMID:34906906   PMID:34931613   PMID:35158151   PMID:35239059   PMID:35275698   PMID:35311536   PMID:35343654   PMID:35416307   PMID:35487288   PMID:35575727   PMID:35635169   PMID:35670957  
PMID:35716851   PMID:35848907   PMID:35905120   PMID:35967300   PMID:35990685   PMID:36233099   PMID:36260448   PMID:36271773   PMID:36377984   PMID:36450527   PMID:36563560   PMID:36633945  
PMID:36915050   PMID:36926756   PMID:37062109   PMID:37097031   PMID:37139337   PMID:37265090   PMID:37414396   PMID:37648664   PMID:37850718   PMID:37875868   PMID:37881888   PMID:37894915  
PMID:38105756  


Genomics

Comparative Map Data
TLR9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,221,080 - 52,225,645 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,221,080 - 52,225,645 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,255,096 - 52,259,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,230,138 - 52,235,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,230,137 - 52,233,247NCBI
Celera352,234,410 - 52,239,491 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef352,317,258 - 52,322,341 (-)NCBIHuRef
CHM1_1352,207,624 - 52,212,707 (-)NCBICHM1_1
T2T-CHM13v2.0352,253,966 - 52,258,531 (-)NCBIT2T-CHM13v2.0
Tlr9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,099,797 - 106,104,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,099,797 - 106,104,082 (+)EnsemblGRCm39 Ensembl
GRCm389106,222,598 - 106,226,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,222,598 - 106,226,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,124,929 - 106,129,207 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369106,080,699 - 106,084,977 (+)NCBIMGSCv36mm8
Celera9105,848,890 - 105,853,167 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.46NCBI
Tlr9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,743,407 - 115,747,523 (+)NCBIGRCr8
mRatBN7.28106,864,680 - 106,868,796 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,864,680 - 106,868,796 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,489,116 - 112,493,226 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,688,285 - 110,692,395 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,531,077 - 108,535,188 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,916,122 - 114,920,171 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,916,122 - 114,920,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,279,020 - 114,283,069 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8106,185,754 - 106,189,869 (+)NCBICelera
Cytogenetic Map8q32NCBI
Tlr9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,828,775 - 3,832,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555323,828,645 - 3,832,699 (-)NCBIChiLan1.0ChiLan1.0
TLR9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,529,322 - 37,547,117 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,529,401 - 37,539,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,542,340 - 37,547,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,510,887 - 37,521,504 (+)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha2037,523,889 - 37,528,666 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,879,856 - 37,897,682 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,892,901 - 37,897,671 (+)EnsemblROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl2037,879,518 - 37,890,512 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,243,558 - 37,254,192 (+)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.12037,256,577 - 37,261,354 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,665,125 - 37,669,902 (+)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.02037,652,111 - 37,662,740 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,950,172 - 37,954,949 (+)NCBIUU_Cfam_GSD_1.0
UU_Cfam_GSD_1.02037,936,949 - 37,947,576 (+)NCBIUU_Cfam_GSD_1.0
TLR9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,349,609 - 34,357,673 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,353,444 - 34,370,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,634,343 - 37,652,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in TLR9
61 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3
pathogenic
NM_017442.3(TLR9):c.1540G>A (p.Gly514Ser) single nucleotide variant Malignant melanoma [RCV000066137] Chr3:52222776 [GRCh38]
Chr3:52256792 [GRCh37]
Chr3:52231832 [NCBI36]
Chr3:3p21.2
not provided
NM_017442.3(TLR9):c.2185G>A (p.Glu729Lys) single nucleotide variant Malignant melanoma [RCV000060846] Chr3:52222131 [GRCh38]
Chr3:52256147 [GRCh37]
Chr3:52231187 [NCBI36]
Chr3:3p21.2
not provided
GRCh38/hg38 3p21.2-14.3(chr3:51394434-55064449)x1 copy number loss See cases [RCV000143631] Chr3:51394434..55064449 [GRCh38]
Chr3:51431865..55098476 [GRCh37]
Chr3:51406905..55073516 [NCBI36]
Chr3:3p21.2-14.3
likely pathogenic
GRCh37/hg19 3p21.2-14.2(chr3:52086599-59689209)x1 copy number loss See cases [RCV000239886] Chr3:52086599..59689209 [GRCh37]
Chr3:3p21.2-14.2
pathogenic
GRCh37/hg19 3p21.2(chr3:52257338-52264976)x3 copy number gain See cases [RCV000449360] Chr3:52257338..52264976 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.2944C>T (p.Arg982Trp) single nucleotide variant Inborn genetic diseases [RCV003281863] Chr3:52221372 [GRCh38]
Chr3:52255388 [GRCh37]
Chr3:3p21.2
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_017442.4(TLR9):c.1711G>A (p.Val571Met) single nucleotide variant not provided [RCV000884426] Chr3:52222605 [GRCh38]
Chr3:52256621 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.2151C>A (p.Ala717=) single nucleotide variant not provided [RCV000881869] Chr3:52222165 [GRCh38]
Chr3:52256181 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.441C>A (p.Ser147=) single nucleotide variant not provided [RCV000881115] Chr3:52223875 [GRCh38]
Chr3:52257891 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.696C>T (p.Ile232=) single nucleotide variant not provided [RCV000949692] Chr3:52223620 [GRCh38]
Chr3:52257636 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.192T>C (p.Asn64=) single nucleotide variant not provided [RCV000885053] Chr3:52224124 [GRCh38]
Chr3:52258140 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.3093C>T (p.Ala1031=) single nucleotide variant not provided [RCV000886122] Chr3:52221223 [GRCh38]
Chr3:52255239 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.1929C>T (p.Leu643=) single nucleotide variant not provided [RCV000925203] Chr3:52222387 [GRCh38]
Chr3:52256403 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.1644G>A (p.Glu548=) single nucleotide variant not provided [RCV000941502] Chr3:52222672 [GRCh38]
Chr3:52256688 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.13C>T (p.Arg5Cys) single nucleotide variant not provided [RCV000971495] Chr3:52224303 [GRCh38]
Chr3:52258319 [GRCh37]
Chr3:3p21.2
benign
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1
pathogenic
NM_017442.4(TLR9):c.1915C>T (p.Arg639Cys) single nucleotide variant Inborn genetic diseases [RCV003271085] Chr3:52222401 [GRCh38]
Chr3:52256417 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1800G>T (p.Leu600=) single nucleotide variant not provided [RCV000914864] Chr3:52222516 [GRCh38]
Chr3:52256532 [GRCh37]
Chr3:3p21.2
likely benign
GRCh37/hg19 3p21.2-21.1(chr3:52195134-52869037)x1 copy number loss not provided [RCV000848455] Chr3:52195134..52869037 [GRCh37]
Chr3:3p21.2-21.1
pathogenic
GRCh37/hg19 3p21.2-21.1(chr3:51247306-53069942)x3 copy number gain not provided [RCV001005434] Chr3:51247306..53069942 [GRCh37]
Chr3:3p21.2-21.1
uncertain significance
NC_000003.11:g.(?_52018081)_(53845433_?)del deletion not provided [RCV003105312] Chr3:52018081..53845433 [GRCh37]
Chr3:3p21.2-21.1
uncertain significance
NM_017442.4(TLR9):c.1262A>T (p.Asp421Val) single nucleotide variant not provided [RCV000959560] Chr3:52223054 [GRCh38]
Chr3:52257070 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.2412G>A (p.Gln804=) single nucleotide variant not provided [RCV000912388] Chr3:52221904 [GRCh38]
Chr3:52255920 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.1689C>T (p.Gly563=) single nucleotide variant not provided [RCV000911602] Chr3:52222627 [GRCh38]
Chr3:52256643 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.2588G>A (p.Arg863Gln) single nucleotide variant not provided [RCV000956636] Chr3:52221728 [GRCh38]
Chr3:52255744 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.548C>G (p.Pro183Arg) single nucleotide variant Tracheoesophageal fistula [RCV001172304] Chr3:52223768 [GRCh38]
Chr3:52257784 [GRCh37]
Chr3:3p21.2
likely pathogenic
GRCh37/hg19 3p21.2-21.1(chr3:51975459-52561678)x4 copy number gain not provided [RCV001259685] Chr3:51975459..52561678 [GRCh37]
Chr3:3p21.2-21.1
uncertain significance
NC_000003.11:g.(?_52109903)_(53164416_?)del deletion RFT1-congenital disorder of glycosylation [RCV003122979] Chr3:52109903..53164416 [GRCh37]
Chr3:3p21.2-21.1
uncertain significance
NM_017442.4(TLR9):c.1755C>A (p.Asn585Lys) single nucleotide variant Inborn genetic diseases [RCV002728530] Chr3:52222561 [GRCh38]
Chr3:52256577 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.816C>A (p.Phe272Leu) single nucleotide variant Inborn genetic diseases [RCV002772470] Chr3:52223500 [GRCh38]
Chr3:52257516 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2606C>G (p.Pro869Arg) single nucleotide variant Inborn genetic diseases [RCV002794555] Chr3:52221710 [GRCh38]
Chr3:52255726 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.649A>G (p.Asn217Asp) single nucleotide variant Inborn genetic diseases [RCV002733343] Chr3:52223667 [GRCh38]
Chr3:52257683 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2419C>T (p.Arg807Cys) single nucleotide variant Inborn genetic diseases [RCV002703702] Chr3:52221897 [GRCh38]
Chr3:52255913 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.3031A>G (p.Met1011Val) single nucleotide variant Inborn genetic diseases [RCV002950545] Chr3:52221285 [GRCh38]
Chr3:52255301 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.3043A>G (p.Arg1015Gly) single nucleotide variant Inborn genetic diseases [RCV002760113] Chr3:52221273 [GRCh38]
Chr3:52255289 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.14G>A (p.Arg5His) single nucleotide variant Inborn genetic diseases [RCV002744339] Chr3:52224302 [GRCh38]
Chr3:52258318 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2359C>T (p.Arg787Trp) single nucleotide variant Inborn genetic diseases [RCV002767619] Chr3:52221957 [GRCh38]
Chr3:52255973 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.424C>T (p.Pro142Ser) single nucleotide variant Inborn genetic diseases [RCV002713600] Chr3:52223892 [GRCh38]
Chr3:52257908 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.3052C>A (p.His1018Asn) single nucleotide variant Inborn genetic diseases [RCV002916579] Chr3:52221264 [GRCh38]
Chr3:52255280 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2714G>A (p.Arg905His) single nucleotide variant Inborn genetic diseases [RCV002698442] Chr3:52221602 [GRCh38]
Chr3:52255618 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2929C>T (p.Arg977Cys) single nucleotide variant Inborn genetic diseases [RCV002954795] Chr3:52221387 [GRCh38]
Chr3:52255403 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2917C>T (p.Pro973Ser) single nucleotide variant Inborn genetic diseases [RCV002743134] Chr3:52221399 [GRCh38]
Chr3:52255415 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1399A>G (p.Arg467Gly) single nucleotide variant Inborn genetic diseases [RCV002916578] Chr3:52222917 [GRCh38]
Chr3:52256933 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2248A>G (p.Ser750Gly) single nucleotide variant Inborn genetic diseases [RCV002956087] Chr3:52222068 [GRCh38]
Chr3:52256084 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.2869C>T (p.Arg957Cys) single nucleotide variant Inborn genetic diseases [RCV002873359] Chr3:52221447 [GRCh38]
Chr3:52255463 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.163C>A (p.His55Asn) single nucleotide variant Inborn genetic diseases [RCV002939716] Chr3:52224153 [GRCh38]
Chr3:52258169 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1336G>T (p.Val446Phe) single nucleotide variant Inborn genetic diseases [RCV002809499] Chr3:52222980 [GRCh38]
Chr3:52256996 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.487C>A (p.Leu163Ile) single nucleotide variant Inborn genetic diseases [RCV002714396] Chr3:52223829 [GRCh38]
Chr3:52257845 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.272A>G (p.His91Arg) single nucleotide variant Inborn genetic diseases [RCV002898030] Chr3:52224044 [GRCh38]
Chr3:52258060 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.406A>G (p.Met136Val) single nucleotide variant Inborn genetic diseases [RCV002656959] Chr3:52223910 [GRCh38]
Chr3:52257926 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2033A>T (p.Lys678Ile) single nucleotide variant Inborn genetic diseases [RCV002725169] Chr3:52222283 [GRCh38]
Chr3:52256299 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2380G>A (p.Gly794Ser) single nucleotide variant Inborn genetic diseases [RCV003201726] Chr3:52221936 [GRCh38]
Chr3:52255952 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1253G>A (p.Arg418His) single nucleotide variant Inborn genetic diseases [RCV003203869] Chr3:52223063 [GRCh38]
Chr3:52257079 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2576G>A (p.Arg859Gln) single nucleotide variant Inborn genetic diseases [RCV003260254] Chr3:52221740 [GRCh38]
Chr3:52255756 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.54C>G (p.Ile18Met) single nucleotide variant Inborn genetic diseases [RCV003208119] Chr3:52224262 [GRCh38]
Chr3:52258278 [GRCh37]
Chr3:3p21.2
likely benign
NM_017442.4(TLR9):c.2936G>A (p.Arg979His) single nucleotide variant Inborn genetic diseases [RCV003208733] Chr3:52221380 [GRCh38]
Chr3:52255396 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1945C>T (p.Arg649Cys) single nucleotide variant Inborn genetic diseases [RCV003265148] Chr3:52222371 [GRCh38]
Chr3:52256387 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1588C>T (p.His530Tyr) single nucleotide variant Inborn genetic diseases [RCV003310407] Chr3:52222728 [GRCh38]
Chr3:52256744 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2668G>A (p.Glu890Lys) single nucleotide variant not provided [RCV003322153] Chr3:52221648 [GRCh38]
Chr3:52255664 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1276C>T (p.Arg426Cys) single nucleotide variant Inborn genetic diseases [RCV003342959] Chr3:52223040 [GRCh38]
Chr3:52257056 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.278A>G (p.Asn93Ser) single nucleotide variant Inborn genetic diseases [RCV003368434] Chr3:52224038 [GRCh38]
Chr3:52258054 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1311G>T (p.Met437Ile) single nucleotide variant Inborn genetic diseases [RCV003364415] Chr3:52223005 [GRCh38]
Chr3:52257021 [GRCh37]
Chr3:3p21.2
uncertain significance
GRCh37/hg19 3p21.2-14.2(chr3:51149374-59265315)x1 copy number loss not specified [RCV003986409] Chr3:51149374..59265315 [GRCh37]
Chr3:3p21.2-14.2
pathogenic
NM_017442.4(TLR9):c.739C>T (p.Arg247Cys) single nucleotide variant Inborn genetic diseases [RCV003364738] Chr3:52223577 [GRCh38]
Chr3:52257593 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.1527G>A (p.Ser509=) single nucleotide variant not provided [RCV000956765] Chr3:52222789 [GRCh38]
Chr3:52256805 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.1149G>A (p.Thr383=) single nucleotide variant not provided [RCV000956766] Chr3:52223167 [GRCh38]
Chr3:52257183 [GRCh37]
Chr3:3p21.2
benign
NM_017442.4(TLR9):c.590G>C (p.Gly197Ala) single nucleotide variant Inborn genetic diseases [RCV002778343] Chr3:52223726 [GRCh38]
Chr3:52257742 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2629G>A (p.Asp877Asn) single nucleotide variant Inborn genetic diseases [RCV003201023] Chr3:52221687 [GRCh38]
Chr3:52255703 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2378C>T (p.Pro793Leu) single nucleotide variant Inborn genetic diseases [RCV003378923] Chr3:52221938 [GRCh38]
Chr3:52255954 [GRCh37]
Chr3:3p21.2
uncertain significance
NM_017442.4(TLR9):c.2502G>T (p.Met834Ile) single nucleotide variant Inborn genetic diseases [RCV003377107] Chr3:52221814 [GRCh38]
Chr3:52255830 [GRCh37]
Chr3:3p21.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:609
Count of miRNA genes:290
Interacting mature miRNAs:301
Transcripts:ENST00000360658, ENST00000597542
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
PMC128073P9  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37352,257,646 - 52,257,876UniSTSGRCh37
Build 36352,232,686 - 52,232,916RGDNCBI36
Celera352,236,958 - 52,237,188RGD
Cytogenetic Map3p21.3UniSTS
HuRef352,319,808 - 52,320,038UniSTS
PMC55404P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37352,257,916 - 52,258,175UniSTSGRCh37
Build 36352,232,956 - 52,233,215RGDNCBI36
Celera352,237,228 - 52,237,487RGD
Cytogenetic Map3p21.3UniSTS
HuRef352,320,078 - 52,320,337UniSTS
TLR9_1094  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37352,255,183 - 52,256,079UniSTSGRCh37
Build 36352,230,223 - 52,231,119RGDNCBI36
Celera352,234,495 - 52,235,391RGD
HuRef352,317,345 - 52,318,241UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 39 282 7 367 5 3 22 11 7 5
Low 1983 2022 977 183 824 44 3468 1660 2732 57 1101 1165 139 1080 2414
Below cutoff 225 654 526 271 469 249 624 484 847 109 150 158 25 124 367 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_033933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB045180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB445673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC097637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF245704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF246972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF259262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF259263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ019999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU170539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU170540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU170541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU170542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU170543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ946876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF584053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC624802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC712876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC720580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC720581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC720582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC720993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG322604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON146433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  ON146434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000360658   ⟹   ENSP00000353874
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl352,221,080 - 52,225,645 (-)Ensembl
RefSeq Acc Id: NM_017442   ⟹   NP_059138
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38352,221,080 - 52,225,645 (-)NCBI
GRCh37352,255,096 - 52,260,179 (-)ENTREZGENE
Build 36352,230,138 - 52,235,219 (-)NCBI Archive
HuRef352,317,258 - 52,322,341 (-)ENTREZGENE
CHM1_1352,207,624 - 52,212,707 (-)NCBI
T2T-CHM13v2.0352,253,966 - 52,258,531 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_059138 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF72189 (Get FASTA)   NCBI Sequence Viewer  
  AAF72190 (Get FASTA)   NCBI Sequence Viewer  
  AAF78037 (Get FASTA)   NCBI Sequence Viewer  
  AAG01734 (Get FASTA)   NCBI Sequence Viewer  
  AAH32713 (Get FASTA)   NCBI Sequence Viewer  
  AAQ89443 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95513 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95514 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95515 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95516 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95517 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95518 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95519 (Get FASTA)   NCBI Sequence Viewer  
  AAZ95520 (Get FASTA)   NCBI Sequence Viewer  
  ABW37074 (Get FASTA)   NCBI Sequence Viewer  
  ABW37075 (Get FASTA)   NCBI Sequence Viewer  
  ABW37076 (Get FASTA)   NCBI Sequence Viewer  
  ABW37077 (Get FASTA)   NCBI Sequence Viewer  
  ABW37078 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41818 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41819 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41820 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41821 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41822 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41823 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41824 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41825 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41826 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41827 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41828 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41829 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41830 (Get FASTA)   NCBI Sequence Viewer  
  ACQ41831 (Get FASTA)   NCBI Sequence Viewer  
  AVX47207 (Get FASTA)   NCBI Sequence Viewer  
  AVX47208 (Get FASTA)   NCBI Sequence Viewer  
  AVX47209 (Get FASTA)   NCBI Sequence Viewer  
  AVX47210 (Get FASTA)   NCBI Sequence Viewer  
  AVX47211 (Get FASTA)   NCBI Sequence Viewer  
  AVX47212 (Get FASTA)   NCBI Sequence Viewer  
  AVX47213 (Get FASTA)   NCBI Sequence Viewer  
  AVX47214 (Get FASTA)   NCBI Sequence Viewer  
  AVX47215 (Get FASTA)   NCBI Sequence Viewer  
  AVX47216 (Get FASTA)   NCBI Sequence Viewer  
  AVX47217 (Get FASTA)   NCBI Sequence Viewer  
  AVX47218 (Get FASTA)   NCBI Sequence Viewer  
  AVX47219 (Get FASTA)   NCBI Sequence Viewer  
  AVX47220 (Get FASTA)   NCBI Sequence Viewer  
  AVX47221 (Get FASTA)   NCBI Sequence Viewer  
  AVX47222 (Get FASTA)   NCBI Sequence Viewer  
  AVX47223 (Get FASTA)   NCBI Sequence Viewer  
  AVX47224 (Get FASTA)   NCBI Sequence Viewer  
  AVX47225 (Get FASTA)   NCBI Sequence Viewer  
  AVX47226 (Get FASTA)   NCBI Sequence Viewer  
  AVX47227 (Get FASTA)   NCBI Sequence Viewer  
  AVX47228 (Get FASTA)   NCBI Sequence Viewer  
  AVX47229 (Get FASTA)   NCBI Sequence Viewer  
  AVX47230 (Get FASTA)   NCBI Sequence Viewer  
  AVX47231 (Get FASTA)   NCBI Sequence Viewer  
  AVX47232 (Get FASTA)   NCBI Sequence Viewer  
  AVX47233 (Get FASTA)   NCBI Sequence Viewer  
  AVX47234 (Get FASTA)   NCBI Sequence Viewer  
  AVX47235 (Get FASTA)   NCBI Sequence Viewer  
  AVX47236 (Get FASTA)   NCBI Sequence Viewer  
  AVX47237 (Get FASTA)   NCBI Sequence Viewer  
  AVX47238 (Get FASTA)   NCBI Sequence Viewer  
  AVX47239 (Get FASTA)   NCBI Sequence Viewer  
  AVX47240 (Get FASTA)   NCBI Sequence Viewer  
  AVX47241 (Get FASTA)   NCBI Sequence Viewer  
  AVX47242 (Get FASTA)   NCBI Sequence Viewer  
  AVX47243 (Get FASTA)   NCBI Sequence Viewer  
  AVX47244 (Get FASTA)   NCBI Sequence Viewer  
  AVX47245 (Get FASTA)   NCBI Sequence Viewer  
  AVX47246 (Get FASTA)   NCBI Sequence Viewer  
  AVX47247 (Get FASTA)   NCBI Sequence Viewer  
  AVX47248 (Get FASTA)   NCBI Sequence Viewer  
  AVX47249 (Get FASTA)   NCBI Sequence Viewer  
  AVX47250 (Get FASTA)   NCBI Sequence Viewer  
  AVX47251 (Get FASTA)   NCBI Sequence Viewer  
  AVX47252 (Get FASTA)   NCBI Sequence Viewer  
  AVX47253 (Get FASTA)   NCBI Sequence Viewer  
  AVX47254 (Get FASTA)   NCBI Sequence Viewer  
  AVX47255 (Get FASTA)   NCBI Sequence Viewer  
  AVX47256 (Get FASTA)   NCBI Sequence Viewer  
  AVX47257 (Get FASTA)   NCBI Sequence Viewer  
  AVX47258 (Get FASTA)   NCBI Sequence Viewer  
  AVX47259 (Get FASTA)   NCBI Sequence Viewer  
  AVX47260 (Get FASTA)   NCBI Sequence Viewer  
  AVX47261 (Get FASTA)   NCBI Sequence Viewer  
  AVX47262 (Get FASTA)   NCBI Sequence Viewer  
  AVX47263 (Get FASTA)   NCBI Sequence Viewer  
  AVX47264 (Get FASTA)   NCBI Sequence Viewer  
  AVX47265 (Get FASTA)   NCBI Sequence Viewer  
  AVX47266 (Get FASTA)   NCBI Sequence Viewer  
  AVX47267 (Get FASTA)   NCBI Sequence Viewer  
  AVX47268 (Get FASTA)   NCBI Sequence Viewer  
  AVX47269 (Get FASTA)   NCBI Sequence Viewer  
  AVX47270 (Get FASTA)   NCBI Sequence Viewer  
  AVX47271 (Get FASTA)   NCBI Sequence Viewer  
  AVX47272 (Get FASTA)   NCBI Sequence Viewer  
  AVX47273 (Get FASTA)   NCBI Sequence Viewer  
  AVX47274 (Get FASTA)   NCBI Sequence Viewer  
  AVX47275 (Get FASTA)   NCBI Sequence Viewer  
  AVX47276 (Get FASTA)   NCBI Sequence Viewer  
  AVX47277 (Get FASTA)   NCBI Sequence Viewer  
  AVX47278 (Get FASTA)   NCBI Sequence Viewer  
  AVX47279 (Get FASTA)   NCBI Sequence Viewer  
  AVX47280 (Get FASTA)   NCBI Sequence Viewer  
  AVX47281 (Get FASTA)   NCBI Sequence Viewer  
  AVX47282 (Get FASTA)   NCBI Sequence Viewer  
  AVX47283 (Get FASTA)   NCBI Sequence Viewer  
  AVX47284 (Get FASTA)   NCBI Sequence Viewer  
  AVX47285 (Get FASTA)   NCBI Sequence Viewer  
  AVX47286 (Get FASTA)   NCBI Sequence Viewer  
  AVX47287 (Get FASTA)   NCBI Sequence Viewer  
  AVX47288 (Get FASTA)   NCBI Sequence Viewer  
  AVX47289 (Get FASTA)   NCBI Sequence Viewer  
  AVX47290 (Get FASTA)   NCBI Sequence Viewer  
  AVX47291 (Get FASTA)   NCBI Sequence Viewer  
  AVX47292 (Get FASTA)   NCBI Sequence Viewer  
  AVX47293 (Get FASTA)   NCBI Sequence Viewer  
  AVX47294 (Get FASTA)   NCBI Sequence Viewer  
  AVX47295 (Get FASTA)   NCBI Sequence Viewer  
  AVX47296 (Get FASTA)   NCBI Sequence Viewer  
  AVX47297 (Get FASTA)   NCBI Sequence Viewer  
  AVX47298 (Get FASTA)   NCBI Sequence Viewer  
  AVX47299 (Get FASTA)   NCBI Sequence Viewer  
  AVX47300 (Get FASTA)   NCBI Sequence Viewer  
  AVX47301 (Get FASTA)   NCBI Sequence Viewer  
  AVX47302 (Get FASTA)   NCBI Sequence Viewer  
  AVX47303 (Get FASTA)   NCBI Sequence Viewer  
  AVX47304 (Get FASTA)   NCBI Sequence Viewer  
  AVX47305 (Get FASTA)   NCBI Sequence Viewer  
  AVX47306 (Get FASTA)   NCBI Sequence Viewer  
  AVX47307 (Get FASTA)   NCBI Sequence Viewer  
  AVX47308 (Get FASTA)   NCBI Sequence Viewer  
  AVX47309 (Get FASTA)   NCBI Sequence Viewer  
  AVX47310 (Get FASTA)   NCBI Sequence Viewer  
  AVX47311 (Get FASTA)   NCBI Sequence Viewer  
  AVX47312 (Get FASTA)   NCBI Sequence Viewer  
  AVX47313 (Get FASTA)   NCBI Sequence Viewer  
  AVX47314 (Get FASTA)   NCBI Sequence Viewer  
  AVX47315 (Get FASTA)   NCBI Sequence Viewer  
  AVX47316 (Get FASTA)   NCBI Sequence Viewer  
  AVX47317 (Get FASTA)   NCBI Sequence Viewer  
  AVX47318 (Get FASTA)   NCBI Sequence Viewer  
  AVX47319 (Get FASTA)   NCBI Sequence Viewer  
  AVX47320 (Get FASTA)   NCBI Sequence Viewer  
  AVX47321 (Get FASTA)   NCBI Sequence Viewer  
  AVX47322 (Get FASTA)   NCBI Sequence Viewer  
  AVX47323 (Get FASTA)   NCBI Sequence Viewer  
  AVX47324 (Get FASTA)   NCBI Sequence Viewer  
  AVX47325 (Get FASTA)   NCBI Sequence Viewer  
  AVX47326 (Get FASTA)   NCBI Sequence Viewer  
  AVX47327 (Get FASTA)   NCBI Sequence Viewer  
  AVX47328 (Get FASTA)   NCBI Sequence Viewer  
  AVX47329 (Get FASTA)   NCBI Sequence Viewer  
  AVX47330 (Get FASTA)   NCBI Sequence Viewer  
  AVX47331 (Get FASTA)   NCBI Sequence Viewer  
  AVX47332 (Get FASTA)   NCBI Sequence Viewer  
  AVX47333 (Get FASTA)   NCBI Sequence Viewer  
  AVX47334 (Get FASTA)   NCBI Sequence Viewer  
  AVX47335 (Get FASTA)   NCBI Sequence Viewer  
  AVX47336 (Get FASTA)   NCBI Sequence Viewer  
  AVX47337 (Get FASTA)   NCBI Sequence Viewer  
  AVX47338 (Get FASTA)   NCBI Sequence Viewer  
  AVX47339 (Get FASTA)   NCBI Sequence Viewer  
  AVX47340 (Get FASTA)   NCBI Sequence Viewer  
  AVX47341 (Get FASTA)   NCBI Sequence Viewer  
  AVX47342 (Get FASTA)   NCBI Sequence Viewer  
  AVX47343 (Get FASTA)   NCBI Sequence Viewer  
  AVX47344 (Get FASTA)   NCBI Sequence Viewer  
  AVX47345 (Get FASTA)   NCBI Sequence Viewer  
  AVX47346 (Get FASTA)   NCBI Sequence Viewer  
  AVX47347 (Get FASTA)   NCBI Sequence Viewer  
  AVX47348 (Get FASTA)   NCBI Sequence Viewer  
  AVX47349 (Get FASTA)   NCBI Sequence Viewer  
  AVX47350 (Get FASTA)   NCBI Sequence Viewer  
  AVX47351 (Get FASTA)   NCBI Sequence Viewer  
  BAB19259 (Get FASTA)   NCBI Sequence Viewer  
  BAG55070 (Get FASTA)   NCBI Sequence Viewer  
  CCQ43550 (Get FASTA)   NCBI Sequence Viewer  
  EAW65191 (Get FASTA)   NCBI Sequence Viewer  
  EAW65193 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000353874
  ENSP00000353874.2
GenBank Protein Q9NR96 (Get FASTA)   NCBI Sequence Viewer  
  WCJ12568 (Get FASTA)   NCBI Sequence Viewer  
  WCJ12569 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059138   ⟸   NM_017442
- Peptide Label: precursor
- UniProtKB: Q9NYC2 (UniProtKB/Swiss-Prot),   Q9HD70 (UniProtKB/Swiss-Prot),   Q9HD69 (UniProtKB/Swiss-Prot),   Q9HD68 (UniProtKB/Swiss-Prot),   Q6UVZ2 (UniProtKB/Swiss-Prot),   D1CS56 (UniProtKB/Swiss-Prot),   B3Y661 (UniProtKB/Swiss-Prot),   Q9NYC3 (UniProtKB/Swiss-Prot),   Q9NR96 (UniProtKB/Swiss-Prot),   B6CH46 (UniProtKB/TrEMBL),   C3W5P5 (UniProtKB/TrEMBL),   D1CS61 (UniProtKB/TrEMBL),   D1CS62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000353874   ⟸   ENST00000360658
Protein Domains
TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NR96-F1-model_v2 AlphaFold Q9NR96 1-1032 view protein structure

Promoters
RGD ID:6864614
Promoter ID:EPDNEW_H5472
Type:initiation region
Name:TLR9_2
Description:toll like receptor 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5473  EPDNEW_H5474  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38352,222,215 - 52,222,275EPDNEW
RGD ID:6864616
Promoter ID:EPDNEW_H5473
Type:initiation region
Name:TLR9_1
Description:toll like receptor 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5472  EPDNEW_H5474  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38352,225,636 - 52,225,696EPDNEW
RGD ID:6864618
Promoter ID:EPDNEW_H5474
Type:multiple initiation site
Name:TLR9_3
Description:toll like receptor 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5472  EPDNEW_H5473  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38352,226,275 - 52,226,335EPDNEW
RGD ID:6801785
Promoter ID:HG_KWN:45207
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_017442
Position:
Human AssemblyChrPosition (strand)Source
Build 36352,234,746 - 52,235,857 (-)MPROMDB
RGD ID:6801783
Promoter ID:HG_KWN:45208
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:UC003DDB.1,   UC003DDC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36352,238,681 - 52,239,827 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15633 AgrOrtholog
COSMIC TLR9 COSMIC
Ensembl Genes ENSG00000239732 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000360658 ENTREZGENE
  ENST00000360658.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000239732 GTEx
HGNC ID HGNC:15633 ENTREZGENE
Human Proteome Map TLR9 Human Proteome Map
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54106 UniProtKB/Swiss-Prot
NCBI Gene 54106 ENTREZGENE
OMIM 605474 OMIM
PANTHER PTHR47410:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TOLL-LIKE RECEPTOR 7-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38010 PharmGKB
PRINTS LEURICHRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R4P858_HUMAN UniProtKB/TrEMBL
  A0A2R4P8E0_HUMAN UniProtKB/TrEMBL
  B3Y661 ENTREZGENE
  B6CH46 ENTREZGENE, UniProtKB/TrEMBL
  C3W5P5 ENTREZGENE, UniProtKB/TrEMBL
  D1CS56 ENTREZGENE
  D1CS61 ENTREZGENE, UniProtKB/TrEMBL
  D1CS62 ENTREZGENE, UniProtKB/TrEMBL
  L0R5D6_HUMAN UniProtKB/TrEMBL
  L8E8B9_HUMAN UniProtKB/TrEMBL
  Q6UVZ2 ENTREZGENE
  Q9HD68 ENTREZGENE
  Q9HD69 ENTREZGENE
  Q9HD70 ENTREZGENE
  Q9NR96 ENTREZGENE
  Q9NYC2 ENTREZGENE
  Q9NYC3 ENTREZGENE
  TLR9_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B3Y661 UniProtKB/Swiss-Prot
  D1CS56 UniProtKB/Swiss-Prot
  Q6UVZ2 UniProtKB/Swiss-Prot
  Q9HD68 UniProtKB/Swiss-Prot
  Q9HD69 UniProtKB/Swiss-Prot
  Q9HD70 UniProtKB/Swiss-Prot
  Q9NYC2 UniProtKB/Swiss-Prot
  Q9NYC3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 TLR9  toll like receptor 9  TLR9  toll-like receptor 9  Symbol and/or name change 5135510 APPROVED