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Gene: SHARPIN (SHANK associated RH domain interactor) Homo sapiens
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Symbol: SHARPIN
Name: SHANK associated RH domain interactor
Description: Exhibits polyubiquitin modification-dependent protein binding activity. Involved in protein linear polyubiquitination and regulation of signal transduction. Localizes to the LUBAC complex and cytosol; PARTICIPATES IN integrin mediated signaling pathway; nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH antirheumatic drug; doxorubicin; valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp434N1923; hSIPL1; SHANK-associated RH domain interactor; shank-associated RH domain-interacting protein; shank-interacting protein-like 1; SIPL1
Orthologs:
Mus musculus (house mouse) : Sharpin (SHANK-associated RH domain interacting protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sharpin (SHANK-associated RH domain interactor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sharpin (SHANK associated RH domain interactor)
Pan paniscus (bonobo/pygmy chimpanzee) : SHARPIN (SHANK associated RH domain interactor)
Canis lupus familiaris (dog) : SHARPIN (SHANK associated RH domain interactor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sharpin (SHANK associated RH domain interactor)
Sus scrofa (pig) : SHARPIN (SHANK associated RH domain interactor)
Chlorocebus sabaeus (green monkey) : SHARPIN (SHANK associated RH domain interactor)
Heterocephalus glaber (naked mole-rat) : Sharpin (SHANK associated RH domain interactor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl8144,098,633 - 144,108,124 (-)Ensembl
GRCh388144,098,637 - 144,104,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,153,536 - 145,159,140 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,225,524 - 145,231,128 (-)NCBINCBI36hg18NCBI36
Celera8141,491,053 - 141,496,661 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,429,413 - 140,435,021 (-)NCBIHuRef
CHM1_18145,193,744 - 145,199,521 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SHARPIN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603608
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.