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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dibenziodolium
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Accession:CHEBI:77986 term browser browse the term
Definition:An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Synonyms:exact_synonym: dibenzo[b,d]iodolium
 related_synonym: (1,1'-Biphenyl)-2,2'-diyliodonium;   2,2'-Biphenylyleneiodonium;   Diphenyleneiodonium;   Formula=C12H8I;   InChI=1S/C12H8I/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1-8H/q+1;   InChIKey=QFXKXRXFBRLLPQ-UHFFFAOYSA-N;   SMILES=[I+]1c2ccccc2-c2ccccc12
 xref: CAS:244-54-2;   LINCS:LSM-3467
 xref_mesh: MESH:C007517
 xref: PMID:24621828;   Reaxys:3905470


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dibenziodolium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] CTD PMID:18474546 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 ISO diphenyleneiodonium results in decreased expression of ACTA2 protein
diphenyleneiodonium promotes the reaction [mangostin results in decreased expression of ACTA2 protein]; mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]		 CTD PMID:30502394 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of ADIPOQ protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of ADIPOQ protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of ADIPOQ protein]; diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]
diphenyleneiodonium inhibits the reaction [Palmitates results in decreased expression of ADIPOQ mRNA]; diphenyleneiodonium inhibits the reaction [Palmitates results in decreased expression of ADIPOQ protein]		 CTD PMID:17471172 PMID:17668557 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
diphenyleneiodonium inhibits the reaction [AGT protein affects the localization of RHOA protein]; diphenyleneiodonium inhibits the reaction [AGT protein results in increased phosphorylation of PPP1R12A protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]		 CTD PMID:12606818 PMID:16569756 PMID:17391658 PMID:18250367 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]
diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]		 CTD PMID:25199686 PMID:26514923 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO diphenyleneiodonium inhibits the reaction [ALB protein results in increased abundance of Hydrogen Peroxide] CTD PMID:11961005 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein] CTD PMID:12023366 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of ATF2 protein] CTD PMID:14687664 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO diphenyleneiodonium inhibits the reaction [Resveratrol affects the expression of BCL2 protein] CTD PMID:31151226 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bsg basigin (Ok blood group) multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL18 protein results in increased expression of BSG mRNA] CTD PMID:19561311 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein] CTD PMID:23940760 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
diphenyleneiodonium inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Docetaxel results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid analog results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T analog results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP3 protein]
[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]		 CTD PMID:12606818 PMID:12754411 PMID:14732287 PMID:15331178 PMID:15799720 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 EXP
ISO		 [diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]
diphenyleneiodonium results in increased activity of CASP8 protein
diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP8 protein]		 CTD PMID:15799720 PMID:33577942 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO diphenyleneiodonium inhibits the reaction [ganoderic acid analog results in increased activity of CASP9 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T analog results in increased activity of CASP9 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T results in increased activity of CASP9 protein]; diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP9 protein] CTD PMID:26282491 PMID:33577942 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO diphenyleneiodonium inhibits the reaction [Patulin results in decreased activity of CAT protein] CTD PMID:33577942 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:14576080 PMID:16600694 PMID:17668557 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA] CTD PMID:28321046 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO diphenyleneiodonium inhibits the reaction [VAV2 protein affects the localization of CD38 protein]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased expression of and results in increased activity of CD38 protein] CTD PMID:23940720 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with diphenyleneiodonium] inhibits the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species] CTD PMID:22295117 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15978937 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of CEBPB protein] CTD PMID:25199686 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cldn4 claudin 4 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of CREB1 protein] CTD PMID:25199686 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; diphenyleneiodonium inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA mRNA]; diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA protein] CTD PMID:25726414 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]; diphenyleneiodonium inhibits the reaction [Aflatoxin B1 results in increased expression of CYBB protein]; diphenyleneiodonium inhibits the reaction [S100B protein results in increased expression of CYBB mRNA]
diphenyleneiodonium inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; diphenyleneiodonium inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]
diphenyleneiodonium inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CYBB protein]		 CTD PMID:17327432 PMID:23272707 PMID:29183754 PMID:30797899 PMID:34396909 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; diphenyleneiodonium inhibits the reaction [sodium arsenite promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]		 CTD PMID:26535918 PMID:26880746 PMID:34171359 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 EXP diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A2 protein]
diphenyleneiodonium results in decreased activity of CYP1A2 protein		 CTD PMID:26880746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 EXP diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]
diphenyleneiodonium results in decreased activity of CYP2E1 protein		 CTD PMID:26880746 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 EXP diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP3A2 protein]
diphenyleneiodonium results in decreased activity of CYP3A4 protein		 CTD PMID:26880746 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Dexamethasone results in increased activity of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of CYP3A23-3A1 protein] CTD PMID:26880746 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Des desmin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP diphenyleneiodonium inhibits the reaction [Paraquat affects the localization of DIABLO protein] CTD PMID:25947082 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased activity of DIO2 protein] CTD PMID:17615150 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA] CTD PMID:28321046 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein]; diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]
diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]		 CTD PMID:16391241 PMID:17391658 PMID:20691780 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP
ISO		 diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]
diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein]		 CTD PMID:16391241 PMID:26514923 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO diphenyleneiodonium inhibits the reaction [Air Pollutants results in increased expression of F3 mRNA]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA] CTD PMID:24752501 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Faslg Fas ligand multiple interactions EXP [diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased expression of FASL protein] CTD PMID:15799720 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO		 diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]
diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of FN1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]		 CTD PMID:15086456 PMID:16632126 PMID:17635749 PMID:31838053 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of FOS protein] CTD PMID:25199686 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [VEGFA protein results in increased phosphorylation of FOXO1 protein] CTD PMID:15308628 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions EXP diphenyleneiodonium affects the reaction [Glucose results in decreased expression of GNAI2 protein]; diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI2 protein] CTD PMID:18441196 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions EXP diphenyleneiodonium affects the reaction [Glucose results in decreased expression of GNAI3 protein]; diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein] CTD PMID:18441196 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO diphenyleneiodonium inhibits the reaction [Patulin results in decreased activity of GSR protein] CTD PMID:33577942 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gypa glycophorin A multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein] CTD PMID:20523355 NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO diphenyleneiodonium inhibits the reaction [Aflatoxin B1 results in increased expression of H2AX protein]; diphenyleneiodonium inhibits the reaction [niraparib results in increased expression of H2AX protein] CTD PMID:34396909 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
decreases expression		 ISO
EXP		 diphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HIF1A protein]
diphenyleneiodonium results in increased expression of HIF1A protein
diphenyleneiodonium results in decreased expression of HIF1A protein		 CTD PMID:12595275 PMID:21687637 PMID:21984483 PMID:23144690 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
multiple interactions		 ISO diphenyleneiodonium results in decreased secretion of HMGB1 protein
diphenyleneiodonium promotes the reaction [mangostin results in decreased secretion of HMGB1 protein]; mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]		 CTD PMID:30502394 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]
diphenyleneiodonium inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [monomethylarsonous acid results in increased expression of HMOX1 protein]		 CTD PMID:18336854 PMID:20934533 PMID:26945724 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP diphenyleneiodonium inhibits the reaction [Paraquat affects the localization of HTR2A protein] CTD PMID:25947082 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] CTD PMID:19632255 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions EXP diphenyleneiodonium results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides] CTD PMID:16307444 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [IL18 protein results in increased expression of BSG mRNA]
diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; diphenyleneiodonium inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]		 CTD PMID:19561311 PMID:27311643 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance		 ISO diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; diphenyleneiodonium inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL1B protein]
diphenyleneiodonium results in decreased susceptibility to IL1B protein
diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]		 CTD PMID:18403674 PMID:19005069 PMID:19281832 PMID:21211511 PMID:23940760 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of IL6 protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in increased expression of IL6 protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in increased expression of IL6 protein]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of IL6 mRNA]; diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein] CTD PMID:11950692 PMID:17668557 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [INS protein results in increased expression of TRPC6 protein] CTD PMID:22031853 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO diphenyleneiodonium inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] CTD PMID:16357311 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of JUN protein]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of JUN protein] CTD PMID:14687664 PMID:25199686 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lep leptin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein]; diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
diphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11880281 PMID:15978937 PMID:16571865 PMID:16632126 PMID:17384286 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein] CTD PMID:19767766 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
diphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11880281 PMID:15978937 PMID:16571865 PMID:16632126 PMID:17384286 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK8 protein] CTD PMID:21391979 PMID:26514923 PMID:30766661 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK9 protein] CTD PMID:21391979 PMID:26514923 PMID:30766661 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of MMP1 mRNA]; diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA] CTD PMID:17449795 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression
multiple interactions		 ISO diphenyleneiodonium results in decreased expression of MMP12 mRNA
diphenyleneiodonium inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]		 CTD PMID:23978445 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA] CTD PMID:16213474 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]
diphenyleneiodonium inhibits the reaction [RELA protein binds to MMP9 promoter]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; diphenyleneiodonium promotes the reaction [Doxorubicin results in increased expression of MMP9 mRNA]		 CTD PMID:15557194 PMID:16213474 PMID:19804834 PMID:23774252 PMID:26514923 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]] CTD PMID:22906169 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO diphenyleneiodonium inhibits the reaction [Resveratrol affects the expression of MYC protein] CTD PMID:31151226 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL1B protein affects the localization of NCF1 protein] CTD PMID:19281832 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which affects the localization of NFATC1 protein] CTD PMID:22564430 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions EXP [diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein] CTD PMID:15799720 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [phenethyl isothiocyanate affects the localization of NFE2L2 protein] CTD PMID:26945724 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity		 ISO diphenyleneiodonium inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]]
diphenyleneiodonium results in decreased activity of NFKB1 protein
diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]]		 CTD PMID:11950692 PMID:12477282 PMID:18922898 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
affects activity		 ISO diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
diphenyleneiodonium results in decreased activity of NOS2 protein
diphenyleneiodonium affects the activity of NOS2 protein		 CTD PMID:19005069 PMID:26880746 PMID:31306686 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein] CTD PMID:26906511 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 decreases activity
multiple interactions		 ISO diphenyleneiodonium results in decreased activity of NOX1 protein
[diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; [diphenyleneiodonium results in decreased activity of NOX1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]		 CTD PMID:16393473 PMID:22307971 PMID:24912985 PMID:30797899 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] CTD PMID:26906511 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of PARK7 protein] CTD PMID:11811539 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein]
diphenyleneiodonium inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein]		 CTD PMID:14687664 PMID:25947082 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity		 ISO
EXP		 diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of POR protein]
diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]
diphenyleneiodonium results in decreased activity of POR protein		 CTD PMID:18206659 PMID:20934533 PMID:21215309 PMID:31356851 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP diphenyleneiodonium inhibits the reaction [AGT protein results in increased phosphorylation of PPP1R12A protein] CTD PMID:16569756 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP		 diphenyleneiodonium inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of PRKCD protein]; diphenyleneiodonium inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]
diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of PRKCD protein]		 CTD PMID:12821678 PMID:21362627 PMID:21420390 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO diphenyleneiodonium inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of PRKCE protein] CTD PMID:21420390 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of PTGS2 mRNA]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]		 CTD PMID:14687664 PMID:16024921 PMID:19804834 PMID:22288910 PMID:25199686 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP diphenyleneiodonium inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions EXP diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein] CTD PMID:16391241 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Fungal Polysaccharides results in increased activity of RAC1 protein] CTD PMID:24447977 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 diphenyleneiodonium inhibits the reaction [RELA protein binds to MMP9 promoter]; diphenyleneiodonium inhibits the reaction [TNF protein affects the localization of RELA protein]
diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of RELA protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]]; diphenyleneiodonium inhibits the reaction [VEGFA protein affects the localization of RELA protein]		 CTD PMID:11950692 PMID:12477282 PMID:15308628 PMID:19281832 PMID:19608869 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP diphenyleneiodonium inhibits the reaction [AGT protein affects the localization of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:16569756 PMID:18250367 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:21984483 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO diphenyleneiodonium inhibits the reaction [S100B protein results in increased expression of CYBB mRNA] CTD PMID:17327432 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein] CTD PMID:22442701 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [erastin results in increased expression of SESN2 protein] CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:31838053 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:31838053 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Snca synuclein alpha multiple interactions ISO [N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with diphenyleneiodonium] inhibits the reaction [SNCA protein mutant form results in increased susceptibility to Lipopolysaccharides] CTD PMID:21245015 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA] CTD PMID:10601319 PMID:21705328 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT3 protein] CTD PMID:19429262 PMID:20523355 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT5A protein]; diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT5A protein] CTD PMID:20523355 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO diphenyleneiodonium inhibits the reaction [Arsenic Trioxide results in decreased activity of TERT protein]; diphenyleneiodonium inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein] CTD PMID:18336854 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 mRNA]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
diphenyleneiodonium inhibits the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein]		 CTD PMID:14732287 PMID:17635749 PMID:23325087 PMID:31838053 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thpo thrombopoietin multiple interactions ISO diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT3 protein]; diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT5A protein] CTD PMID:20523355 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance		 ISO
EXP		 diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
diphenyleneiodonium results in decreased susceptibility to TNF protein
diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
diphenyleneiodonium inhibits the reaction [Palmitates results in increased expression of TNF mRNA]; diphenyleneiodonium inhibits the reaction [Palmitates results in increased expression of TNF protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; diphenyleneiodonium inhibits the reaction [TNF protein affects the localization of RELA protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein]		 CTD PMID:12388057 PMID:14576080 PMID:16632126 PMID:17471172 PMID:18474546 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
decreases expression		 ISO diphenyleneiodonium inhibits the reaction [INS protein results in increased expression of TRPC6 protein]
diphenyleneiodonium results in decreased expression of TRPC6 protein		 CTD PMID:22031853 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO diphenyleneiodonium promotes the reaction [NCX 4040 results in increased oxidation of TXN1 protein] CTD PMID:18922898 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Paraquat results in increased activity of TXNRD1 protein]; diphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid] CTD PMID:17229725 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Tyr tyrosinase multiple interactions ISO [diphenyleneiodonium co-treated with Benzo(a)pyrene] results in increased activity of TYR protein; diphenyleneiodonium promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of TYR protein] CTD PMID:34856342 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [VAV2 protein affects the localization of CD38 protein]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased expression of and results in increased activity of CD38 protein] CTD PMID:23940720 NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 PMID:19632255 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO diphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [VEGFA protein affects the localization of RELA protein]; diphenyleneiodonium inhibits the reaction [VEGFA protein results in increased phosphorylation of FOXO1 protein]
diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]		 CTD PMID:15308628 PMID:20116427 PMID:21687637 PMID:23144690 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Zfp143 zinc finger protein 143 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      molecular entity 19806
        ion 16690
          organic ion 9858
            organic cation 8908
              dibenziodolium 124
                dibenziodolium chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      p-block molecular entity 19756
                        carbon group molecular entity 19705
                          organic molecular entity 19702
                            organic ion 9858
                              organic cation 8908
                                dibenziodolium 124
                                  dibenziodolium chloride 0
paths to the root