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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:Jak-Stat signaling pathway
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Accession:PW:0000209 term browser browse the term
Definition:The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand- triggered signaling through the various receptors.
Synonyms:related_synonym: receptor signaling pathway via JAK-STAT
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Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:04630 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04630 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04630 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Bcl2l1 Bcl2-like 1 IEA KEGG rno:04630 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Cbl Cbl proto-oncogene IEA KEGG rno:04630 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067 		JBrowse link
G Cblb Cbl proto-oncogene B IEA KEGG rno:04630 NCBI chr11:62,058,829...62,225,904
Ensembl chr11:62,061,653...62,225,778 		JBrowse link
G Cblc Cbl proto-oncogene C IEA KEGG rno:04630 NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:88,567,932...88,584,709 		JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:04630 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccnd2 cyclin D2 IEA KEGG rno:04630 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301 		JBrowse link
G Ccnd3 cyclin D3 IEA KEGG rno:04630 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033 		JBrowse link
G Cish cytokine inducible SH2-containing protein IEA KEGG rno:04630 NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986 		JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 IEA KEGG rno:04630 NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:210,937,255...210,947,064 		JBrowse link
G Cntf ciliary neurotrophic factor IEA KEGG rno:04630 NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488 		JBrowse link
G Cntfr ciliary neurotrophic factor receptor IEA KEGG rno:04630 NCBI chr 5:61,619,326...61,657,359
Ensembl chr 5:61,619,326...61,645,795 		JBrowse link
G Crebbp CREB binding lysine acetyltransferase IEA KEGG rno:04630 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 IEA KEGG rno:04630 NCBI chr14:118,932...123,632
Ensembl chr14:115,497...123,631 		JBrowse link
G Csf2 colony stimulating factor 2 IEA KEGG rno:04630 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha IEA KEGG rno:04630 NCBI chr14:113,219...118,808
Ensembl chr14:113,225...118,117 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta IEA KEGG rno:04630 NCBI chr 7:111,756,950...111,782,089
Ensembl chr 7:111,757,405...111,784,654 		JBrowse link
G Csf3 colony stimulating factor 3 IEA KEGG rno:04630 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Csf3r colony stimulating factor 3 receptor IEA KEGG rno:04630 NCBI chr 5:143,583,126...143,604,382
Ensembl chr 5:143,583,213...143,602,411 		JBrowse link
G Ctf1 cardiotrophin 1 IEA KEGG rno:04630 NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395 		JBrowse link
G Ep300 EP300 lysine acetyltransferase IEA KEGG rno:04630 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Epo erythropoietin IEA KEGG rno:04630 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Epor erythropoietin receptor IEA KEGG rno:04630 NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:28,765,746...28,770,322 		JBrowse link
G Gh1 growth hormone 1 IEA KEGG rno:04630 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859 		JBrowse link
G Ghr growth hormone receptor IEA KEGG rno:04630 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG rno:04630 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Ifna1 interferon, alpha 1 IEA KEGG rno:04630 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG rno:04630 NCBI chr 5:108,374,363...108,374,941
Ensembl chr 5:108,374,363...108,374,941 		JBrowse link
G Ifna4 interferon, alpha 4 IEA KEGG rno:04630 NCBI chr 5:108,115,064...108,116,010
Ensembl chr 5:108,115,064...108,116,010 		JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 IEA KEGG rno:04630 NCBI chr 5:108,640,546...108,641,115 JBrowse link
G Ifna5 interferon, alpha 5 IEA KEGG rno:04630 NCBI chr 5:108,233,736...108,234,314
Ensembl chr 5:108,233,736...108,234,314 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 IEA KEGG rno:04630 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205 		JBrowse link
G Ifnb1 interferon beta 1 IEA KEGG rno:04630 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Ifng interferon gamma IEA KEGG rno:04630 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ifngr1 interferon gamma receptor 1 IEA KEGG rno:04630 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437 		JBrowse link
G Ifngr2 interferon gamma receptor 2 IEA KEGG rno:04630 NCBI chr11:44,265,703...44,283,975
Ensembl chr11:44,265,703...44,283,975 		JBrowse link
G Ifnk interferon kappa IEA KEGG rno:04630 NCBI chr 5:54,528,304...54,530,511
Ensembl chr 5:54,528,304...54,530,511 		JBrowse link
G Ifnl3 interferon, lambda 3 IEA KEGG rno:04630 NCBI chr 1:92,941,988...92,943,628 JBrowse link
G Ifnlr1 interferon, lambda receptor 1 IEA KEGG rno:04630 NCBI chr 5:153,203,597...153,225,911
Ensembl chr 5:153,203,597...153,225,911 		JBrowse link
G Il10 interleukin 10 IEA KEGG rno:04630 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha IEA KEGG rno:04630 NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:54,459,882...54,475,028 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta IEA KEGG rno:04630 NCBI chr11:44,132,471...44,154,062
Ensembl chr11:44,132,189...44,154,053 		JBrowse link
G Il11 interleukin 11 IEA KEGG rno:04630 NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 IEA KEGG rno:04630 NCBI chr 5:61,727,650...61,737,265
Ensembl chr 5:61,727,931...61,737,264 		JBrowse link
G Il12a interleukin 12A IEA KEGG rno:04630 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B IEA KEGG rno:04630 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 IEA KEGG rno:04630 NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,654,207...18,666,824 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 IEA KEGG rno:04630 NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937 		JBrowse link
G Il13 interleukin 13 IEA KEGG rno:04630 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 IEA KEGG rno:04630 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:120,214,075...120,274,461 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 IEA KEGG rno:04630 NCBI chr  X:115,814,620...115,886,080
Ensembl chr  X:115,814,622...115,841,455 		JBrowse link
G Il15 interleukin 15 IDA
IEA 		KEGG
RGD		 PMID:8942753 rno:04630, RGD:5024920 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha IMP RGD PMID:19747902 RGD:5001122 NCBI chr17:71,712,141...71,742,072
Ensembl chr17:71,712,141...71,742,149 		JBrowse link
G Il19 interleukin 19 IEA KEGG rno:04630 NCBI chr13:44,949,989...44,958,714
Ensembl chr13:44,949,989...44,958,714 		JBrowse link
G Il2 interleukin 2 IEA KEGG rno:04630 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il20 interleukin 20 IEA KEGG rno:04630 NCBI chr13:44,933,249...44,936,893
Ensembl chr13:44,933,249...44,936,893 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha IEA KEGG rno:04630 NCBI chr 1:16,243,683...16,313,229
Ensembl chr 1:16,243,801...16,313,221 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta IEA KEGG rno:04630 NCBI chr 8:109,858,108...109,896,066
Ensembl chr 8:109,854,012...109,889,363 		JBrowse link
G Il21 interleukin 21 IEA KEGG rno:04630 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:122,045,240...122,055,142 		JBrowse link
G Il21r interleukin 21 receptor IEA KEGG rno:04630 NCBI chr 1:189,598,682...189,626,340
Ensembl chr 1:189,598,558...189,626,342 		JBrowse link
G Il22 interleukin 22 IEA KEGG rno:04630 NCBI chr 7:55,687,061...55,691,526
Ensembl chr 7:55,686,896...55,692,201 		JBrowse link
G Il22ra1 interleukin 22 receptor subunit alpha 1 IEA KEGG rno:04630 NCBI chr 5:153,245,067...153,269,865
Ensembl chr 5:153,245,002...153,271,683 		JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 IEA KEGG rno:04630 NCBI chr 1:16,172,238...16,228,009
Ensembl chr 1:16,184,113...16,197,950 		JBrowse link
G Il23a interleukin 23 subunit alpha IEA KEGG rno:04630 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Il23r interleukin 23 receptor IEA KEGG rno:04630 NCBI chr 4:97,910,230...98,003,759
Ensembl chr 4:97,909,972...98,004,110 		JBrowse link
G Il24 interleukin 24 IEA KEGG rno:04630 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha IEA KEGG rno:04630 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta IEA KEGG rno:04630 NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:111,913,828...111,928,537 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma IEA KEGG rno:04630 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:70,435,343...70,439,161 		JBrowse link
G Il3 interleukin 3 IEA KEGG rno:04630 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810 		JBrowse link
G Il3ra interleukin 3 receptor subunit alpha IEA KEGG rno:04630 NCBI chr12:21,431,848...21,437,336
Ensembl chr12:21,431,848...21,437,250 		JBrowse link
G Il4 interleukin 4 IEA KEGG rno:04630 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il4r interleukin 4 receptor IEA KEGG rno:04630 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636 		JBrowse link
G Il5 interleukin 5 IEA KEGG rno:04630 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il5ra interleukin 5 receptor subunit alpha IEA KEGG rno:04630 NCBI chr 4:141,186,749...141,221,348
Ensembl chr 4:141,171,158...141,220,943 		JBrowse link
G Il6 interleukin 6 IEA KEGG rno:04630 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Il6r interleukin 6 receptor IEA KEGG rno:04630 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer IEA KEGG rno:04630 NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182 		JBrowse link
G Il7 interleukin 7 IEA KEGG rno:04630 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389 		JBrowse link
G Il7r interleukin 7 receptor IEA KEGG rno:04630 NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027 		JBrowse link
G Il9 interleukin 9 IEA KEGG rno:04630 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,117,028...8,120,151 		JBrowse link
G Il9r interleukin 9 receptor IEA KEGG rno:04630 NCBI chr10:15,936,156...15,947,613
Ensembl chr10:15,936,156...15,947,613 		JBrowse link
G Irf1 interferon regulatory factor 1 IMP RGD PMID:20980260 RGD:5128774 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947 		JBrowse link
G Irf9 interferon regulatory factor 9 IEA KEGG rno:04630 NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879 		JBrowse link
G Jak1 Janus kinase 1 TAS
IEA
ISO 		KEGG
RGD		 PMID:12087100 PMID:17312100 rno:04630, RGD:1299183, RGD:1625126 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Jak2 Janus kinase 2 IEA
ISO
IDA 		KEGG
RGD		 PMID:17312100 PMID:11064147 PMID:12107179 rno:04630, RGD:1625126, RGD:1624963, RGD:632386 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jak3 Janus kinase 3 ISS
IEA
ISO 		KEGG
RGD		 PMID:8143863 PMID:17312100 rno:04630, RGD:729028, RGD:1625126 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222 		JBrowse link
G Lep leptin IEA KEGG rno:04630 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor IEA KEGG rno:04630 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lif LIF, interleukin 6 family cytokine IEA KEGG rno:04630 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053 		JBrowse link
G Lifr LIF receptor subunit alpha IEA KEGG rno:04630 NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364 		JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor IEA KEGG rno:04630 NCBI chr 5:137,259,288...137,281,540
Ensembl chr 5:137,259,288...137,272,177 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:04630 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Osm oncostatin M IEA KEGG rno:04630 NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827 		JBrowse link
G Osmr oncostatin M receptor IEA KEGG rno:04630 NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO
IEA 		KEGG
RGD		 PMID:14607831 PMID:16426581 rno:04630, RGD:1357941, RGD:2290530 NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:72,233,566...72,334,315 		JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 ISO
IEA 		KEGG
RGD		 PMID:16426581 rno:04630, RGD:2290530 NCBI chr18:72,883,008...72,989,486
Ensembl chr18:72,882,890...73,006,662 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISS
IEA
ISO 		KEGG
RGD		 PMID:14607831 PMID:16426581 rno:04630, RGD:1357941, RGD:2290530 NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:186,921,428...186,936,714 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO
IEA 		KEGG
RGD		 PMID:14607831 PMID:16426581 rno:04630, RGD:1357941, RGD:2290530 NCBI chr 7:9,197,032...9,210,557
Ensembl chr 7:9,196,896...9,210,527 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04630 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04630 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04630 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04630 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04630 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04630 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04630 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:04630 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764 		JBrowse link
G Prl prolactin IEA KEGG rno:04630 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Prlr prolactin receptor IEA KEGG rno:04630 NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:11818507 RGD:633057 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO RGD PMID:16426581 RGD:2290530 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO
IEA 		KEGG
RGD		 PMID:16426581 rno:04630, RGD:2290530 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO RGD PMID:16426581 RGD:2290530 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO
IEA 		KEGG
RGD		 PMID:16426581 rno:04630, RGD:2290530 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISS
IEA 		KEGG
RGD		 PMID:12039028 rno:04630, RGD:1357935 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISS
IEA 		KEGG
RGD		 PMID:12039028 rno:04630, RGD:1357935 NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISS
IEA 		KEGG
RGD		 PMID:12039028 rno:04630, RGD:1357935 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 ISO
IEA 		KEGG
RGD		 PMID:14607831 rno:04630, RGD:1357941 NCBI chr15:23,003,130...23,017,615
Ensembl chr15:23,002,883...23,022,499 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO
IEA 		KEGG
RGD		 PMID:14607831 rno:04630, RGD:1357941 NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:13,234,062...13,273,883 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 ISO RGD PMID:14607831 RGD:1357941 NCBI chr18:84,386,587...84,413,927
Ensembl chr18:84,384,573...84,414,053 		JBrowse link
G Socs7 suppressor of cytokine signaling 7 ISO
IEA 		KEGG
RGD		 PMID:14607831 rno:04630, RGD:1357941 NCBI chr10:82,848,525...82,885,201
Ensembl chr10:82,848,612...82,885,201 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG rno:04630 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG rno:04630 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811 		JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 IEA KEGG rno:04630 NCBI chr 3:124,437,230...124,504,358
Ensembl chr 3:124,437,230...124,504,358 		JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 IEA KEGG rno:04630 NCBI chr14:98,350,577...98,452,143
Ensembl chr14:98,350,290...98,452,143 		JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 IEA KEGG rno:04630 NCBI chr 1:93,586,259...93,597,692
Ensembl chr 1:93,586,259...93,598,254 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 IEA KEGG rno:04630 NCBI chr15:89,106,809...89,111,926
Ensembl chr15:89,103,731...89,115,074 		JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 IEA KEGG rno:04630 NCBI chr12:21,777,090...21,786,280
Ensembl chr12:21,776,005...21,786,804 		JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 IEA KEGG rno:04630 NCBI chr18:30,687,633...30,702,546
Ensembl chr18:30,687,039...30,704,173 		JBrowse link
G Stam signal transducing adaptor molecule IEA KEGG rno:04630 NCBI chr17:82,028,779...82,074,717
Ensembl chr17:82,028,703...82,075,013 		JBrowse link
G Stam2 signal transducing adaptor molecule 2 IEA KEGG rno:04630 NCBI chr 3:57,597,557...57,643,915
Ensembl chr 3:57,597,559...57,643,915 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 IDA
IEA
ISO 		KEGG
RGD		 PMID:12191995 PMID:17312100 rno:04630, RGD:1299060, RGD:1625126 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 ISO
IEA 		KEGG
RGD		 PMID:12039028 PMID:17312100 rno:04630, RGD:1357935, RGD:1625126 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:1,287,024...1,303,459 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 TAS
IEA
ISO 		KEGG
RGD		 PMID:12087100 PMID:17312100 rno:04630, RGD:1299183, RGD:1625126 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO
IEA 		KEGG
RGD		 PMID:12039028 PMID:17312100 rno:04630, RGD:1357935, RGD:1625126 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISS
IEA
ISO
IDA 		KEGG
RGD		 PMID:12039028 PMID:17312100 PMID:11064147 rno:04630, RGD:1357935, RGD:1625126, RGD:1624963 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IDA
IEA
ISO 		KEGG
RGD		 PMID:12193540 PMID:17312100 PMID:11064147 rno:04630, RGD:628356, RGD:1625126, RGD:1624963 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO
IEA 		KEGG
RGD		 PMID:12039028 PMID:17312100 rno:04630, RGD:1357935, RGD:1625126 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Tpo thyroid peroxidase IEA KEGG rno:04630 NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793 		JBrowse link
G Tslp thymic stromal lymphopoietin IEA KEGG rno:04630 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
G Tyk2 tyrosine kinase 2 ISO RGD PMID:12039028 PMID:17312100 RGD:1357935, RGD:1625126 NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:27,916,496...27,943,278 		JBrowse link
altered Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 ISS RGD PMID:12032773 RGD:1357939 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jak3 Janus kinase 3 ISS RGD PMID:12032773 RGD:1357939 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway pertinent to immunity 793
        Jak-Stat signaling pathway 143
          altered Jak-Stat signaling pathway 2
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      kinase mediated signaling pathway 602
        tyrosine-specific protein kinase mediated signaling pathway 143
          Jak-Stat signaling pathway 143
            altered Jak-Stat signaling pathway 2
paths to the root