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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Jak-Stat signaling pathway
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Accession:PW:0000209 term browser browse the term
Definition:The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand- triggered signaling through the various receptors.
Synonyms:related_synonym: receptor signaling pathway via JAK-STAT
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Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:04630 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04630 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04630 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Bcl2l1 Bcl2-like 1 IEA KEGG rno:04630 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Cbl Cbl proto-oncogene IEA KEGG rno:04630 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B IEA KEGG rno:04630 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cblc Cbl proto-oncogene C IEA KEGG rno:04630 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:04630 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 IEA KEGG rno:04630 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 IEA KEGG rno:04630 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cish cytokine inducible SH2-containing protein IEA KEGG rno:04630 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250 		JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 IEA KEGG rno:04630 NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605 		JBrowse link
G Cntf ciliary neurotrophic factor IEA KEGG rno:04630 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877 		JBrowse link
G Cntfr ciliary neurotrophic factor receptor IEA KEGG rno:04630 NCBI chr 5:56,823,448...56,861,049
Ensembl chr 5:56,823,965...56,841,392 		JBrowse link
G Crebbp CREB binding protein IEA KEGG rno:04630 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 IEA KEGG rno:04630 NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642 		JBrowse link
G Csf2 colony stimulating factor 2 IEA KEGG rno:04630 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha IEA KEGG rno:04630 NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta IEA KEGG rno:04630 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157 		JBrowse link
G Csf3 colony stimulating factor 3 IEA KEGG rno:04630 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Csf3r colony stimulating factor 3 receptor IEA KEGG rno:04630 NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881 		JBrowse link
G Ctf1 cardiotrophin 1 IEA KEGG rno:04630 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Ep300 E1A binding protein p300 IEA KEGG rno:04630 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epo erythropoietin IEA KEGG rno:04630 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Epor erythropoietin receptor IEA KEGG rno:04630 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G Gh1 growth hormone 1 IEA KEGG rno:04630 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Ghr growth hormone receptor IEA KEGG rno:04630 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG rno:04630 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Ifna1 interferon, alpha 1 IEA KEGG rno:04630 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG rno:04630 NCBI chr 5:103,258,617...103,259,195 JBrowse link
G Ifna4 interferon, alpha 4 IEA KEGG rno:04630 NCBI chr 5:103,069,174...103,070,120
Ensembl chr 5:103,069,483...103,070,052 		JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 IEA KEGG rno:04630 NCBI chr 5:103,524,733...103,525,302
Ensembl chr 5:103,524,733...103,525,302 		JBrowse link
G Ifna5 interferon, alpha 5 IEA KEGG rno:04630 NCBI chr 5:103,187,852...103,188,430 JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 IEA KEGG rno:04630 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
G Ifnb1 interferon beta 1 IEA KEGG rno:04630 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma IEA KEGG rno:04630 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 IEA KEGG rno:04630 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Ifngr2 interferon gamma receptor 2 IEA KEGG rno:04630 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005 		JBrowse link
G Ifnk interferon kappa IEA KEGG rno:04630 NCBI chr 5:49,732,073...49,734,281
Ensembl chr 5:49,732,073...49,734,281 		JBrowse link
G Ifnl3 interferon, lambda 3 IEA KEGG rno:04630 NCBI chr 1:83,814,456...83,816,096
Ensembl chr 1:83,814,564...83,816,096 		JBrowse link
G Ifnlr1 interferon, lambda receptor 1 IEA KEGG rno:04630 NCBI chr 5:147,919,547...147,942,328
Ensembl chr 5:147,919,908...147,942,332 		JBrowse link
G Il10 interleukin 10 IEA KEGG rno:04630 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha IEA KEGG rno:04630 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta IEA KEGG rno:04630 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074 		JBrowse link
G Il11 interleukin 11 IEA KEGG rno:04630 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 IEA KEGG rno:04630 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408 		JBrowse link
G Il12a interleukin 12A IEA KEGG rno:04630 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B IEA KEGG rno:04630 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 IEA KEGG rno:04630 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 IEA KEGG rno:04630 NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289 		JBrowse link
G Il13 interleukin 13 IEA KEGG rno:04630 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 IEA KEGG rno:04630 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 IEA KEGG rno:04630 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il15 interleukin 15 IDA
IEA		 KEGG
RGD		 PMID:8942753 rno:04630, RGD:5024920 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha IMP RGD PMID:19747902 RGD:5001122 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il19 interleukin 19 IEA KEGG rno:04630 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Il2 interleukin 2 IEA KEGG rno:04630 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il20 interleukin 20 IEA KEGG rno:04630 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha IEA KEGG rno:04630 NCBI chr 1:14,424,215...14,494,226
Ensembl chr 1:14,451,228...14,493,602 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta IEA KEGG rno:04630 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942 		JBrowse link
G Il21 interleukin 21 IEA KEGG rno:04630 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il21r interleukin 21 receptor IEA KEGG rno:04630 NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522 		JBrowse link
G Il22 interleukin 22 IEA KEGG rno:04630 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186 		JBrowse link
G Il22ra1 interleukin 22 receptor subunit alpha 1 IEA KEGG rno:04630 NCBI chr 5:147,961,496...147,986,296
Ensembl chr 5:147,961,349...147,986,296 		JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 IEA KEGG rno:04630 NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:14,364,489...14,377,844 		JBrowse link
G Il23a interleukin 23 subunit alpha IEA KEGG rno:04630 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il23r interleukin 23 receptor IEA KEGG rno:04630 NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021 		JBrowse link
G Il24 interleukin 24 IEA KEGG rno:04630 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha IEA KEGG rno:04630 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta IEA KEGG rno:04630 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma IEA KEGG rno:04630 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il3 interleukin 3 IEA KEGG rno:04630 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il3ra interleukin 3 receptor subunit alpha IEA KEGG rno:04630 NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484 		JBrowse link
G Il4 interleukin 4 IEA KEGG rno:04630 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor IEA KEGG rno:04630 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il5 interleukin 5 IEA KEGG rno:04630 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il5ra interleukin 5 receptor subunit alpha IEA KEGG rno:04630 NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544 		JBrowse link
G Il6 interleukin 6 IEA KEGG rno:04630 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor IEA KEGG rno:04630 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer IEA KEGG rno:04630 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Il7 interleukin 7 IEA KEGG rno:04630 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Il7r interleukin 7 receptor IEA KEGG rno:04630 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Il9 interleukin 9 IEA KEGG rno:04630 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Il9r interleukin 9 receptor IEA KEGG rno:04630 NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990 		JBrowse link
G Irf1 interferon regulatory factor 1 IMP RGD PMID:20980260 RGD:5128774 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irf9 interferon regulatory factor 9 IEA KEGG rno:04630 NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236 		JBrowse link
G Jak1 Janus kinase 1 TAS
IEA
ISO		 KEGG
RGD		 PMID:12087100 PMID:17312100 rno:04630, RGD:1299183, RGD:1625126 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 IEA
ISO
IDA		 KEGG
RGD		 PMID:17312100 PMID:11064147 PMID:12107179 rno:04630, RGD:1625126, RGD:1624963, RGD:632386 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jak3 Janus kinase 3 ISS
IEA
ISO		 KEGG
RGD		 PMID:8143863 PMID:17312100 rno:04630, RGD:729028, RGD:1625126 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lep leptin IEA KEGG rno:04630 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor IEA KEGG rno:04630 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lif LIF, interleukin 6 family cytokine IEA KEGG rno:04630 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Lifr LIF receptor subunit alpha IEA KEGG rno:04630 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor IEA KEGG rno:04630 NCBI chr 5:131,973,895...131,987,472
Ensembl chr 5:131,973,895...131,986,797 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:04630 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Osm oncostatin M IEA KEGG rno:04630 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Osmr oncostatin M receptor IEA KEGG rno:04630 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO
IEA		 KEGG
RGD		 PMID:14607831 PMID:16426581 rno:04630, RGD:1357941, RGD:2290530 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 ISO
IEA		 KEGG
RGD		 PMID:16426581 rno:04630, RGD:2290530 NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISS
IEA
ISO		 KEGG
RGD		 PMID:14607831 PMID:16426581 rno:04630, RGD:1357941, RGD:2290530 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO
IEA		 KEGG
RGD		 PMID:14607831 PMID:16426581 rno:04630, RGD:1357941, RGD:2290530 NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04630 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04630 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04630 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04630 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04630 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04630 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04630 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:04630 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
G Prl prolactin IEA KEGG rno:04630 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prlr prolactin receptor IEA KEGG rno:04630 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:11818507 RGD:633057 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO RGD PMID:16426581 RGD:2290530 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO
IEA		 KEGG
RGD		 PMID:16426581 rno:04630, RGD:2290530 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO RGD PMID:16426581 RGD:2290530 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO
IEA		 KEGG
RGD		 PMID:16426581 rno:04630, RGD:2290530 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISS
IEA		 KEGG
RGD		 PMID:12039028 rno:04630, RGD:1357935 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISS
IEA		 KEGG
RGD		 PMID:12039028 rno:04630, RGD:1357935 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISS
IEA		 KEGG
RGD		 PMID:12039028 rno:04630, RGD:1357935 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 ISO
IEA		 KEGG
RGD		 PMID:14607831 rno:04630, RGD:1357941 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO
IEA		 KEGG
RGD		 PMID:14607831 rno:04630, RGD:1357941 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 ISO RGD PMID:14607831 RGD:1357941 NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219 		JBrowse link
G Socs7 suppressor of cytokine signaling 7 ISO
IEA		 KEGG
RGD		 PMID:14607831 rno:04630, RGD:1357941 NCBI chr10:82,352,159...82,388,829
Ensembl chr10:82,351,680...82,388,830 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG rno:04630 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG rno:04630 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 IEA KEGG rno:04630 NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718 		JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 IEA KEGG rno:04630 NCBI chr14:94,149,210...94,250,787
Ensembl chr14:94,148,837...94,249,162 		JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 IEA KEGG rno:04630 NCBI chr 1:84,458,779...84,470,425
Ensembl chr 1:84,459,314...84,470,249 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 IEA KEGG rno:04630 NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 IEA KEGG rno:04630 NCBI chr12:16,663,188...16,673,124
Ensembl chr12:16,663,389...16,672,531 		JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 IEA KEGG rno:04630 NCBI chr18:30,436,513...30,451,426
Ensembl chr18:30,436,443...30,453,004 		JBrowse link
G Stam signal transducing adaptor molecule IEA KEGG rno:04630 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Stam2 signal transducing adaptor molecule 2 IEA KEGG rno:04630 NCBI chr 3:37,186,145...37,234,810
Ensembl chr 3:37,186,145...37,234,812 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 IDA
IEA
ISO		 KEGG
RGD		 PMID:12191995 PMID:17312100 rno:04630, RGD:1299060, RGD:1625126 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 ISO
IEA		 KEGG
RGD		 PMID:12039028 PMID:17312100 rno:04630, RGD:1357935, RGD:1625126 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 TAS
IEA
ISO		 KEGG
RGD		 PMID:12087100 PMID:17312100 rno:04630, RGD:1299183, RGD:1625126 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO
IEA		 KEGG
RGD		 PMID:12039028 PMID:17312100 rno:04630, RGD:1357935, RGD:1625126 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISS
IEA
ISO
IDA		 KEGG
RGD		 PMID:12039028 PMID:17312100 PMID:11064147 rno:04630, RGD:1357935, RGD:1625126, RGD:1624963 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IDA
IEA
ISO		 KEGG
RGD		 PMID:12193540 PMID:17312100 PMID:11064147 rno:04630, RGD:628356, RGD:1625126, RGD:1624963 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO
IEA		 KEGG
RGD		 PMID:12039028 PMID:17312100 rno:04630, RGD:1357935, RGD:1625126 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tpo thyroid peroxidase IEA KEGG rno:04630 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Tslp thymic stromal lymphopoietin IEA KEGG rno:04630 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Tyk2 tyrosine kinase 2 ISO RGD PMID:12039028 PMID:17312100 RGD:1357935, RGD:1625126 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
altered Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 ISS RGD PMID:12032773 RGD:1357939 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jak3 Janus kinase 3 ISS RGD PMID:12032773 RGD:1357939 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to immunity 793
        Jak-Stat signaling pathway 143
          altered Jak-Stat signaling pathway 2
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      kinase mediated signaling pathway 601
        tyrosine-specific protein kinase mediated signaling pathway 143
          Jak-Stat signaling pathway 143
            altered Jak-Stat signaling pathway 2
paths to the root