Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Socs5 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Socs5 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SOCS5 mRNA | CTD | PMID:22206623 | Socs5 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Socs5 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of SOCS5 mRNA | CTD | PMID:17555576 | Socs5 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Socs5 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS5 mRNA | CTD | PMID:17942748 | Socs5 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of SOCS5 mRNA | CTD | PMID:17942748 | Socs5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SOCS5 mRNA | CTD | PMID:17101203 | Socs5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SOCS5 mRNA | CTD | PMID:33387578 and PMID:34747641 | Socs5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Socs5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SOCS5 mRNA | CTD | PMID:21570461 | Socs5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SOCS5 mRNA | CTD | PMID:22298810 | Socs5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SOCS5 mRNA | CTD | PMID:19770486 | Socs5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SOCS5 mRNA | CTD | PMID:19933214 | Socs5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Socs5 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS5 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOCS5 promoter] | CTD | PMID:17942748 and PMID:19654925 | Socs5 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SOCS5 mRNA | CTD | PMID:20188158 | Socs5 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA | CTD | PMID:28628672 | Socs5 | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of SOCS5 mRNA | CTD | PMID:18648102 | Socs5 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SOCS5 mRNA | CTD | PMID:36041667 | Socs5 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Fenretinide results in increased expression of SOCS5 mRNA | CTD | PMID:28973697 | Socs5 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SOCS5 mRNA | CTD | PMID:24780913 | Socs5 | Rat | acrylamide | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of SOCS5 mRNA | CTD | PMID:32763439 | Socs5 | Rat | aflatoxin B1 | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SOCS5 mRNA | CTD | PMID:19770486 | Socs5 | Rat | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of SOCS5 mRNA | CTD | PMID:20488242 | Socs5 | Rat | all-trans-retinoic acid | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SOCS5 mRNA | CTD | PMID:23724009 | Socs5 | Rat | antirheumatic drug | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SOCS5 mRNA | CTD | PMID:24449571 | Socs5 | Rat | aristolochic acid A | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SOCS5 mRNA | CTD | PMID:33212167 | Socs5 | Rat | arsenite(3-) | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SOCS5 mRNA] | CTD | PMID:32406909 | Socs5 | Rat | benzo[a]pyrene | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SOCS5 mRNA | CTD | PMID:22228805 | Socs5 | Rat | benzo[a]pyrene | decreases methylation | ISO | SOCS5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SOCS5 5' UTR | CTD | PMID:27901495 | Socs5 | Rat | benzo[a]pyrene | affects methylation | ISO | SOCS5 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SOCS5 promoter | CTD | PMID:27901495 | Socs5 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | Socs5 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SOCS5 mRNA | CTD | PMID:25181051 more ... | Socs5 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SOCS5 mRNA | CTD | PMID:36041667 | Socs5 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SOCS5 gene | CTD | PMID:28505145 | Socs5 | Rat | bisphenol A | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA | CTD | PMID:28628672 | Socs5 | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SOCS5 mRNA | CTD | PMID:36041667 | Socs5 | Rat | bortezomib | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of SOCS5 mRNA | CTD | PMID:20977926 | Socs5 | Rat | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of SOCS5 promoter | CTD | PMID:22457795 | Socs5 | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of SOCS5 mRNA | CTD | PMID:33453195 | Socs5 | Rat | chromium(6+) | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression of SOCS5 mRNA | CTD | PMID:38479592 | Socs5 | Rat | cobalt dichloride | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of SOCS5 mRNA | CTD | PMID:19376846 | Socs5 | Rat | copper(II) sulfate | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SOCS5 mRNA | CTD | PMID:19549813 | Socs5 | Rat | coumestrol | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of SOCS5 mRNA | CTD | PMID:19167446 | Socs5 | Rat | crocidolite asbestos | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of SOCS5 mRNA | CTD | PMID:29279043 | Socs5 | Rat | curcumin | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | Curcumin results in decreased expression of SOCS5 protein | CTD | PMID:21397623 | Socs5 | Rat | cycloheximide | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Cycloheximide results in increased expression of SOCS5 mRNA | CTD | PMID:23237828 | Socs5 | Rat | dexamethasone | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA | CTD | PMID:28628672 | Socs5 | Rat | dicrotophos | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SOCS5 mRNA | CTD | PMID:28302478 | Socs5 | Rat | dorsomorphin | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS5 mRNA | CTD | PMID:27188386 | Socs5 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of SOCS5 mRNA | CTD | PMID:24793618 | Socs5 | Rat | folic acid | multiple interactions | ISO | Socs5 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SOCS5 mRNA | CTD | PMID:22206623 | Socs5 | Rat | folic acid | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SOCS5 mRNA | CTD | PMID:25629700 | Socs5 | Rat | formaldehyde | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SOCS5 mRNA | CTD | PMID:20655997 | Socs5 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SOCS5 mRNA | CTD | PMID:33387578 | Socs5 | Rat | glyphosate | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of SOCS5 mRNA | CTD | PMID:31295307 | Socs5 | Rat | hydrogen peroxide | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of SOCS5 mRNA | CTD | PMID:18951874 | Socs5 | Rat | hydrogen peroxide | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Hydrogen Peroxide results in decreased expression of SOCS5 mRNA | CTD | PMID:18951874 | Socs5 | Rat | indometacin | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of SOCS5 mRNA | CTD | PMID:16984733 | Socs5 | Rat | indometacin | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SOCS5 mRNA | CTD | PMID:28628672 | Socs5 | Rat | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of SOCS5 mRNA | CTD | PMID:20080153 | Socs5 | Rat | lipopolysaccharide | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased expression of SOCS5 mRNA | CTD | PMID:15919760 | Socs5 | Rat | melphalan | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Melphalan results in decreased expression of SOCS5 mRNA | CTD | PMID:22363485 | Socs5 | Rat | N-nitrosodiethylamine | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of SOCS5 mRNA | CTD | PMID:24535843 | Socs5 | Rat | paracetamol | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SOCS5 mRNA | CTD | PMID:21420995 | Socs5 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SOCS5 mRNA | CTD | PMID:33387578 | Socs5 | Rat | pirinixic acid | multiple interactions | ISO | Socs5 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SOCS5 mRNA and PPARA protein affects the reaction [pirinixic acid results in decreased expression of SOCS5 mRNA] | CTD | PMID:19710929 and PMID:21318169 | Socs5 | Rat | pirinixic acid | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SOCS5 mRNA | CTD | PMID:21318169 | Socs5 | Rat | sarin | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Sarin results in decreased expression of SOCS5 mRNA | CTD | PMID:19522546 | Socs5 | Rat | sarin | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Sarin results in increased expression of SOCS5 mRNA | CTD | PMID:19522546 | Socs5 | Rat | SB 431542 | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS5 mRNA | CTD | PMID:27188386 | Socs5 | Rat | silver atom | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | Silver results in decreased expression of SOCS5 mRNA | CTD | PMID:27131904 | Socs5 | Rat | silver(0) | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | Silver results in decreased expression of SOCS5 mRNA | CTD | PMID:27131904 | Socs5 | Rat | sodium arsenite | decreases expression | ISO | Socs5 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of SOCS5 mRNA | CTD | PMID:33933676 | Socs5 | Rat | sunitinib | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SOCS5 mRNA | CTD | PMID:31533062 | Socs5 | Rat | tamoxifen | affects expression | ISO | Socs5 (Mus musculus) | 6480464 | Tamoxifen affects the expression of SOCS5 mRNA | CTD | PMID:17555576 | Socs5 | Rat | testosterone | multiple interactions | ISO | Socs5 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:33848595 | Socs5 | Rat | testosterone | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of SOCS5 mRNA | CTD | PMID:33848595 | Socs5 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SOCS5 mRNA | CTD | PMID:34492290 | Socs5 | Rat | titanium dioxide | increases expression | ISO | Socs5 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SOCS5 mRNA | CTD | PMID:29264374 | Socs5 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SOCS5 mRNA | CTD | PMID:33387578 | Socs5 | Rat | trichostatin A | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SOCS5 mRNA | CTD | PMID:26272509 | Socs5 | Rat | trichostatin A | multiple interactions | ISO | SOCS5 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS5 mRNA | CTD | PMID:27188386 | Socs5 | Rat | triphenyl phosphate | affects expression | ISO | SOCS5 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SOCS5 mRNA | CTD | PMID:37042841 | Socs5 | Rat | urethane | increases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Urethane results in increased expression of SOCS5 mRNA | CTD | PMID:28818685 | Socs5 | Rat | valproic acid | decreases methylation | ISO | SOCS5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SOCS5 gene | CTD | PMID:29154799 | Socs5 | Rat | valproic acid | decreases expression | ISO | SOCS5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SOCS5 mRNA | CTD | PMID:23179753 | |