RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: obesity
Accession: DOID:9970
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. (DO)
Synonyms: exact_synonym: obesity disorder narrow_synonym: ADCY3-RELATED CONDITION; MONOGENIC NON-SYNDROMIC OBESITY; MONOGENIC OBESITY; Maternal Obesity; NR0B2-RELATED CONDITION; OBESITY DUE TO MELANOCORTIN 4 RECEPTOR DEFICIENCY; OBESITY DUE TO SIM1 DEFICIENCY; OBESITY, MILD, EARLY-ONSET; Obesity, Late-Onset; Obesity, autosomal dominant; SIM1-RELATED CONDITION; severe obesity and type II diabetes broad_synonym: UCP3-related condition related_synonym: LEANNESS; MELANOCORTIN 4 RECEPTOR POLYMORPHISM; OBESITY, AGE AT ONSET OF; OBESITY, ASSOCIATION WITH; OBESITY, EARLY-ONSET, SUSCEPTIBILITY TO; OBESITY, RESISTANCE TO; OBESITY, SUSCEPTIBILITY TO; UCP3 polymorphism G/A; obesity, variation in xref: EFO:0001073 ; ICD10CM:E66.9 ; ICD9CM:278.00 ; MESH:D000079262 ; MESH:D009765 ; MIM:601665 ; MONDO:0011122 ; NCI:C159658 ; NCI:C3283
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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Aacs acetoacetyl-CoA synthetase
ISO mRNA:altered expression:thalamus, hypothalamus (rat)
RGD PMID:19219059 RGD:2326191
NCBI chrNW_004936558:327,822...373,474
G
Abca1 ATP binding cassette subfamily A member 1
disease_progression
ISO mRNA:increased expression:liver (rat)
RGD PMID:17287470 PMID:25612518 RGD:15045599 RGD:1601092
NCBI chrNW_004936559:7,177,887...7,312,660
G
Abcb11 ATP binding cassette subfamily B member 11
ISO RGD PMID:21726512 RGD:14688050
NCBI chrNW_004936469:10,521,576...10,599,005
G
Abcg5 ATP binding cassette subfamily G member 5
disease_progression
ISO mRNA:increased expression:liver (rat)
RGD PMID:25612518 RGD:15045599
NCBI chrNW_004936508:8,093,804...8,117,467
G
Abcg8 ATP binding cassette subfamily G member 8
ISO RGD PMID:15331430 RGD:1601095
NCBI chrNW_004936508:8,074,697...8,093,424
G
Acacb acetyl-CoA carboxylase beta
treatment
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:20882379 PMID:33310031 RGD:329955450
NCBI chrNW_004936769:950,970...1,053,671
G
Acadm acyl-CoA dehydrogenase medium chain
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936571:2,761,254...2,797,045
G
Ache acetylcholinesterase (Cartwright blood group)
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936543:856,678...862,080
G
Acly ATP citrate lyase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936490:16,758,001...16,798,152
G
Acox1 acyl-CoA oxidase 1
treatment
ISO RGD PMID:30298849 RGD:401960083
NCBI chrNW_004936594:1,115,607...1,140,085
G
Acp1 acid phosphatase 1
severity
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD PMID:2373509 PMID:9198310 RGD:1625289 RGD:2313187
NCBI chrNW_004936532:130,799...145,285
G
Acp5 acid phosphatase 5, tartrate resistant
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936659:1,598,252...1,642,615
G
Acsl1 acyl-CoA synthetase long chain family member 1
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:1543733 PMID:16788709 PMID:20882379 RGD:1625735 RGD:1625737
NCBI chrNW_004936554:4,425,518...4,484,853
G
Ada adenosine deaminase
ISO protein:increased expression:serum
RGD PMID:16501670 RGD:1624289
NCBI chrNW_004936530:2,217,713...2,224,070
G
Adarb1 adenosine deaminase RNA specific B1
ISO associated with Hyperphagia
RGD PMID:17567573 RGD:10450894
NCBI chrNW_004936778:1,056,259...1,137,772
G
Adcy3 adenylate cyclase 3
treatment
ISO ClinVar Annotator: match by term: ADCY3-related condition | ClinVar Annotator: match by term: Monogenic Obesity
ClinVar RGD PMID:9536098 PMID:17576681 PMID:25741868 PMID:28492532 PMID:30568259 RGD:407550184
NCBI chrNW_004936493:7,250,194...7,333,433
G
Adipoq adiponectin, C1Q and collagen domain containing
treatment
ISO associated with myocardial infarction; protein:decreased expression:plasma
RGD CTD
PMID:10092513 PMID:14617771 PMID:16092047 PMID:18303100 PMID:18651432 PMID:19606374 PMID:23731386 PMID:28843383 More...
RGD:14975146 RGD:1599149 RGD:2313239 RGD:5686809 RGD:5686813 RGD:8695927
NCBI chrNW_004936578:3,168,599...3,179,369
G
Adipor1 adiponectin receptor 1
ISO mRNA:decreased expression:lymphocyte
RGD PMID:16483885 PMID:17391161 RGD:1625761 RGD:1625763
NCBI chrNW_004936567:1,658,405...1,674,794
G
Adipor2 adiponectin receptor 2
severity
ISO mRNA:decreased expression:liver (rat)
RGD PMID:16483885 PMID:23838384 PMID:30131158 PMID:30225267 RGD:1625763 RGD:21406435 RGD:25824942 RGD:8695926
NCBI chrNW_004936606:1,911,104...2,007,109
G
Adm adrenomedullin
ISO mRNA, protein:increased expression:adipose tissue
RGD PMID:16793965 RGD:1625297
NCBI chrNW_004936528:8,005,223...8,007,586
G
Adora1 adenosine A1 receptor
ISO protein:increased expression:visceral adipose tissue:increased density of ligand binding sites on VAT in African American women compared to Caucasian women
RGD PMID:16507638 RGD:1625369
NCBI chrNW_004936567:1,430,128...1,508,626
G
Adra2b adrenoceptor alpha 2B
ISO RGD PMID:10404816 RGD:1300265
NCBI chrNW_004936744:249,673...253,040
G
Adrb1 adrenoceptor beta 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:12032746
NCBI chrNW_004936486:4,400,467...4,401,588
G
Adrb2 adrenoceptor beta 2
no_association
ISO DNA:polymorphisms: :p.R16G, p.Q27E
RGD CTD PMID:12161655 PMID:15687340 PMID:17027833 PMID:17221209 RGD:1601119 RGD:1601122 RGD:737773
NCBI chrNW_004936504:5,985,407...5,987,453
G
Adrb3 adrenoceptor beta 3
no_association
ISO DNA:missense mutation:cds:p.W64R rs4994 (human)
RGD OMIM ClinVar
PMID:7609750 PMID:7609752 PMID:8903328 PMID:8954053 PMID:9054940 PMID:9100608 PMID:9112025 PMID:9449691 PMID:9709965 PMID:9814483 PMID:9892244 PMID:10323390 PMID:10323402 PMID:10999801 PMID:11095426 PMID:11882399 PMID:15472194 PMID:25741868 More...
RGD:5684409
NCBI chrNW_004936710:1,410,589...1,413,279
G
Aff4 ALF transcription elongation factor 4
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:25730767
NCBI chrNW_004936647:2,242,476...2,342,409
G
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ISO RGD PMID:20068140 RGD:13838849
NCBI chrNW_004936646:1,865,154...1,881,614
G
Ager advanced glycosylation end-product specific receptor
ISO protein:decreased expression:plasma (human)
RGD PMID:22761461 PMID:23046363 RGD:7243247 RGD:7243250
NCBI chrNW_004936727:1,418,342...1,422,005
G
Agrp agouti related neuropeptide
ISO ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity, late-onset
OMIM ClinVar PMID:11602360 PMID:12213871 PMID:15054840 PMID:25741868
NCBI chrNW_004936475:17,927,991...17,929,377
G
Agt angiotensinogen
susceptibility
ISO DNA:polymorphism: :p.M235T
RGD PMID:16514903 PMID:16713443 RGD:1601142 RGD:1601143
NCBI chrNW_004936484:19,713,299...19,721,144
G
Agtr2 angiotensin II receptor type 2
ISO RGD PMID:15793237 RGD:2313554
NCBI chrNW_004936479:13,252,678...13,255,570
G
Ahi1 Abelson helper integration site 1
ISO mRNA:increased expression:vastus lateralis
RGD PMID:20045148 RGD:11537398
NCBI chrNW_004936560:2,881,631...3,057,256
G
Ahr aryl hydrocarbon receptor
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:27020609 PMID:30813227 PMID:31306034
NCBI chrNW_004936546:3,737,908...3,783,492
G
Ahsg alpha 2-HS glycoprotein
susceptibility
ISO protein:increased expression:serum
RGD PMID:17011519 PMID:19228823 RGD:1625793 RGD:2313809
NCBI chrNW_004936578:3,332,934...3,339,903
G
Ak1 adenylate kinase 1
ISO protein:increased expression:skeletal muscle
RGD PMID:15855311 RGD:1601154
NCBI chrNW_004936487:15,507,663...15,517,401
G
Akap1 A-kinase anchoring protein 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20975297
NCBI chrNW_004936490:5,829,728...5,842,217
G
Akt1 AKT serine/threonine kinase 1
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:19293429 PMID:23954404 RGD:408364952
NCBI chrNW_004936621:620,163...639,115
G
Akt2 AKT serine/threonine kinase 2
ISO protein:decreased expression:plantaris (rat)
RGD PMID:12663464 PMID:17923673 PMID:18508911 RGD:2313320 RGD:2313406 RGD:2313409
NCBI chrNW_004936661:2,652,568...2,694,039
G
Aldh1l1 aldehyde dehydrogenase 1 family member L1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936898:456,299...484,681
G
Aldh6a1 aldehyde dehydrogenase 6 family member A1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936488:3,320,357...3,340,463
G
Alms1 ALMS1 centrosome and basal body associated protein
ISO OMIM:601665
MouseDO
NCBI chrNW_004936491:17,152,759...17,342,648
G
Alox5ap arachidonate 5-lipoxygenase activating protein
ISO mRNA:increased expression:adipose tissue (mouse)
RGD PMID:17379835 PMID:19596146 RGD:2313884 RGD:2313913
NCBI chrNW_004936472:25,477,094...25,502,823
G
Amh anti-Mullerian hormone
ISO protein:decreased expression:serum
RGD PMID:17109858 RGD:1601182
NCBI chrNW_004936588:1,342,791...1,345,746
G
Ang angiogenin
ISO protein:increased expression:adipose tissue
RGD PMID:22748184 RGD:6892722
NCBI chrNW_004936880:39,372...40,070
G
Angptl4 angiopoietin like 4
resistance
ISO CTD Direct Evidence: therapeutic
RGD CTD PMID:17210919 PMID:28842503 RGD:1625353
NCBI chrNW_004936588:5,188,866...5,194,924
G
Angptl6 angiopoietin like 6
ISO OMIM:601665
MouseDO
NCBI chrNW_004936659:491,330...499,409
G
Apcdd1 APC down-regulated 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:28242765
NCBI chrNW_004936626:1,217,240...1,237,741
G
Apln apelin
ISO mRNA:increased expression:subcutaneous adipose tissue
RGD PMID:17594060 RGD:1626170
NCBI chrNW_004936479:1,889,930...1,899,811
G
Apoa1 apolipoprotein A1
ISO protein:decreased expression
RGD PMID:9933608 PMID:12725089 RGD:1601185 RGD:2313959
NCBI chrNW_004936542:2,111,055...2,112,626
G
Apoa2 apolipoprotein A2
ISO protein:increased expression:serum
RGD PMID:9002300 PMID:9933608 RGD:1601191 RGD:2313959
NCBI chrNW_004936903:520,420...521,726
G
Apoa5 apolipoprotein A5
ISO DNA:SNP: :rs662799 (human)
RGD PMID:25606423 RGD:329901774
NCBI chrNW_004936542:2,069,683...2,071,344
G
Apob apolipoprotein B
ISO associated with Insulin Resistance;protein:increased expression:plasma
RGD PMID:16752182 PMID:19592617 RGD:1601202 RGD:2313974
NCBI chrNW_004936493:10,509,118...10,549,144
G
Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1
ISO mRNA:increased expression:liver
RGD PMID:8781289 RGD:1626278
NCBI chrNW_004939393:628...6,234
G
Apoc1 apolipoprotein C1
ISO RGD PMID:11723061 RGD:2313951
NCBI chrNW_004936706:1,519,248...1,520,102
G
Apoc2 apolipoprotein C2
ISO protein:increased expression:serum
RGD PMID:9002300 RGD:1601191
NCBI chrNW_004936706:1,531,219...1,531,921
G
Apoc3 apolipoprotein C3
ISO protein:increased expression:serum
RGD PMID:9002300 RGD:1601191
NCBI chrNW_004936542:2,106,927...2,108,412
G
Apod apolipoprotein D
ISO DNA:polymorphism
RGD PMID:7913935 RGD:2311179
NCBI chrNW_004936833:260,798...277,060
G
Apoe apolipoprotein E
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:9002300 PMID:17192461 PMID:20975297 RGD:1601191 RGD:1601230
NCBI chrNW_004936706:1,512,438...1,516,805
G
App amyloid beta precursor protein
treatment
ISO mRNA,protein:increased expression:adipocyte,plasma:
RGD PMID:19672057 RGD:10054260
NCBI chrNW_004936640:1,549,977...1,787,436
G
Aqp7 aquaporin 7
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:16325777
NCBI chrNW_004936524:1,898,635...1,915,078
G
Ar androgen receptor
susceptibility
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:repeat: :CAG
RGD MouseDO PMID:12532157 PMID:18805913 RGD:1601246 RGD:2306771
NCBI chrNW_004936635:485,903...647,820
G
Arl13b ARF like GTPase 13B
ISO protein:decreased expression:hypothalamus, cilium (mouse)
RGD PMID:22581473 RGD:11553936
NCBI chrNW_004936666:115,964...179,639
G
Asip agouti signaling protein
susceptibility
ISO DNA, mRNA:deletion, insertions, increased expression: multiple organs
RGD CTD MouseDO
PMID:1473152 PMID:7987393 PMID:8146154 PMID:25447408 PMID:25448685 PMID:32937126 More...
RGD:1625724
NCBI chrNW_004936561:6,341,667...6,346,440
G
Atp1a2 ATPase Na+/K+ transporting subunit alpha 2
susceptibility
ISO RGD PMID:16286513 RGD:1601250
NCBI chrNW_004936740:489,357...514,235
G
Atp4b ATPase H+/K+ transporting subunit beta
treatment
ISO RGD PMID:25822172 RGD:14696745
NCBI chrNW_004936472:168,745...173,996
G
Atp5f1b ATP synthase F1 subunit beta
treatment
ISO RGD PMID:26880535 RGD:13782133
NCBI chrNW_004936646:951,236...958,907
G
Atp5f1c ATP synthase F1 subunit gamma
ISO RGD PMID:19549744 RGD:14696798
NCBI chrNW_004936484:7,016,049...7,031,060
G
Atp5f1d ATP synthase F1 subunit delta
treatment
ISO RGD PMID:27874268 RGD:13792665
NCBI chrNW_004936588:612,255...614,894
G
Atp5mc2 ATP synthase membrane subunit c locus 2
ISO RGD PMID:26709097 RGD:11535661
NCBI chrNW_004936512:10,908,915...10,918,445
G
Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936474:27,638,637...27,663,348
G
Azgp1 alpha-2-glycoprotein 1, zinc-binding
ISO mRNA, protein:decreased expression:fat pad, liver,plasma
RGD PMID:19934249 PMID:21136593 PMID:29755407 RGD:153350147 RGD:153350156 RGD:153350157
NCBI chrNW_004936543:105,983...113,475
G
B2m beta-2-microglobulin
ISO protein:increased expression:urine
RGD PMID:15517379 RGD:1601309
NCBI chrNW_004936471:7,646,504...7,655,656
G
Bad BCL2 associated agonist of cell death
ISO protein:increased expression:heart left ventricle
RGD PMID:18070754 RGD:2292682
NCBI chrNW_004936599:4,924,349...4,933,683
G
Bambi BMP and activin membrane bound inhibitor
ISO mRNA:decreased expression:adipose tissue
RGD PMID:22187378 RGD:14390162
NCBI chrNW_004936613:3,098,549...3,103,868
G
Bbs1 Bardet-Biedl syndrome 1
no_association
ISO DNA:mutation: :p.M390R (human)
RGD MouseDO PMID:14993910 PMID:33722691 RGD:1601314 RGD:243065268
NCBI chrNW_004936599:3,059,274...3,076,853
G
Bbs2 Bardet-Biedl syndrome 2
susceptibility
ISO DNA:SNPs
RGD PMID:17003356 RGD:1601311
NCBI chrNW_004936475:8,785,914...8,810,490
G
Bbs4 Bardet-Biedl syndrome 4
onset
ISO DNA:SNPs
RGD MouseDO PMID:17003356 RGD:1601311
NCBI chrNW_004936471:31,962,500...32,019,516
G
Bche butyrylcholinesterase
ISO CTD Direct Evidence: marker/mechanism|therapeutic
CTD PMID:18452903 PMID:23000450 PMID:23073171 PMID:27163854
NCBI chrNW_004936707:1,784,338...1,913,401
G
Bcl2 BCL2 apoptosis regulator
ISO mRNA, protein:decreased expression:heart left ventricle
RGD PMID:18202171 RGD:2293027
NCBI chrNW_004936497:2,209,136...2,373,580
G
Bdkrb1 bradykinin receptor B1
ISO ob/ob mice mRNA:decreased expression:brown adipose tissue, heart mRNA:increased expression:white adipose tissue, hypothalamus
RGD PMID:17184856 RGD:1625733
NCBI chrNW_004936604:551,774...567,014
G
Bdnf brain derived neurotrophic factor
ISO ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: Obesity
ClinVar PMID:11840487 PMID:25741868 PMID:28492532
NCBI chrNW_004936540:5,530,081...5,582,765
G
Bnip3 BCL2 interacting protein 3
ISO RGD PMID:18070754 RGD:2292682
NCBI chrNW_004936486:18,449,371...18,460,435
G
Brd2 bromodomain containing 2
ISO RGD PMID:19883376 RGD:9586446
NCBI chrNW_004936476:25,807,179...25,818,914
G
Brs3 bombesin receptor subtype 3
ISO RGD PMID:9367152 RGD:734661
NCBI chrNW_004936513:10,784,181...10,788,679
G
C3 complement C3
treatment
ISO RGD PMID:23118029 RGD:7411625
NCBI chrNW_004936588:3,985,732...4,023,221
G
C5ar1 complement C5a receptor 1
treatment
ISO RGD PMID:23118029 RGD:7411625
NCBI chrNW_004936664:1,026,216...1,033,438
G
Ca3 carbonic anhydrase 3
ISO protein:decreased expression:adipocyte
RGD CTD PMID:8476041 PMID:20882379 RGD:408426009
NCBI chrNW_004936544:337,437...347,760
G
Cadm2 cell adhesion molecule 2
ISO DNA:SNP: :rs13078807 (human)
RGD PMID:31341224 RGD:15092077
NCBI chrNW_004936610:3,304,556...4,297,745
G
Canx calnexin
ISO protein:increased expression:subcutaneous adipose tissue
RGD PMID:18567819 RGD:2314284
NCBI chrNW_004936739:1,051,853...1,085,658
G
Capn10 calpain 10
ISO DNA:SNPs
RGD PMID:16752174 RGD:1625047
NCBI chrNW_004936745:1,029,514...1,039,524
G
Cartpt CART prepropeptide
no_association
ISO DNA:deletion, substitution: :1457delA, 1475A>G (human)
RGD OMIM ClinVar PMID:10574510 PMID:10805512 PMID:11522684 PMID:15326462 PMID:25741868 RGD:2313633 RGD:2313634
NCBI chrNW_004936549:4,717,337...4,719,523
G
Cast calpastatin
ISO ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity | ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: Obesity
ClinVar PMID:18604207 PMID:22210313 PMID:23383060 PMID:25741868 PMID:28492532
NCBI chrNW_004936523:6,688,153...6,798,184
G
Cav1 caveolin 1
ISO RGD PMID:22492718 RGD:6784520
NCBI chrNW_004936589:2,504,235...2,536,778
G
Cav2 caveolin 2
ISO RGD PMID:22492718 RGD:6784520
NCBI chrNW_004936589:2,553,932...2,561,186
G
Cckar cholecystokinin A receptor
ISO DNA:deletion
RGD PMID:9192855 PMID:9530226 RGD:7257724 RGD:734711
NCBI chrNW_004936477:3,306,898...3,314,659
G
Ccl5 C-C motif chemokine ligand 5
ISO protein:increased expression:serum
RGD PMID:18469848 RGD:2307038
NCBI chrNW_004936490:253,279...259,947
G
Ccr3 C-C motif chemokine receptor 3
ISO mRNA:increased expression:adipose tissue
RGD PMID:18492752 RGD:6483834
NCBI chrNW_004936596:223,660...224,739
G
Cd36 CD36 molecule (CD36 blood group)
ISO protein:increased expression:skeletal muscle, T-tubule
RGD PMID:20435456 PMID:22615812 PMID:23743348 PMID:25477422 RGD:11041118 RGD:11041132 RGD:6893497 RGD:6893542
NCBI chrNW_004936810:791,823...838,303
G
Cd40 CD40 molecule
treatment
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:21670556 PMID:29035695 RGD:7248753
NCBI chrNW_004936514:6,936,915...6,947,246
G
Cd40lg CD40 ligand
ISO protein:increased expression:serum
RGD PMID:20660932 PMID:21817098 RGD:5490592 RGD:5490970
NCBI chrNW_004936513:10,607,617...10,620,403
G
Cd68 CD68 molecule
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29035695
NCBI chrNW_004936595:858,289...861,131
G
Cdk4 cyclin dependent kinase 4
susceptibility
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:intron:IVS4-40G>A (human)
RGD PMID:19634152 RGD:2314609
NCBI chrNW_004936646:1,886,262...1,889,260
G
Cdkal1 CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase
ISO ClinVar Annotator: match by term: Obesity
ClinVar
NCBI chrNW_004936552:5,903,042...6,347,498
G
Cdkn1b cyclin dependent kinase inhibitor 1B
ISO protein:decreased expression:liver
RGD PMID:23357529 RGD:10045356
NCBI chrNW_004936587:4,573,166...4,578,480
G
Cdo1 cysteine dioxygenase type 1
ISO RGD PMID:16627576 RGD:2301355
NCBI chrNW_004936742:981,863...993,271
G
Cebpa CCAAT enhancer binding protein alpha
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:28242765
NCBI chrNW_004936570:2,513,561...2,516,213
G
Cenpo centromere protein O
ISO ClinVar Annotator: match by term: ADCY3-related condition | ClinVar Annotator: match by term: Monogenic Obesity
ClinVar PMID:9536098 PMID:17576681 PMID:25741868 PMID:28492532
NCBI chrNW_004936493:7,333,387...7,351,368
G
Cers1 ceramide synthase 1
ISO mRNA:increased expression:skeletal muscle cell
RGD PMID:30605666 RGD:156431060
NCBI chrNW_004936596:2,442,978...2,467,184
G
Cfd complement factor D
ISO mRNA, protein:decreased expression:adipocyte, serum
RGD PMID:2197880 PMID:14564690 RGD:1624324 RGD:1624327
NCBI chrNW_004936588:350,925...352,732
G
Cidea cell death inducing DFFA like effector a
ISO protein:amino acid substitution:V115F
RGD CTD PMID:16186410 PMID:20975297 RGD:1625390
NCBI chrNW_004936626:230,372...246,893
G
Cnr1 cannabinoid receptor 1
no_association
ISO CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17292652 PMID:17405839 PMID:18722357 PMID:19325539 PMID:19530697 PMID:31258545 More...
RGD:1626325 RGD:1626326 RGD:2314629 RGD:2314630 RGD:401827956
NCBI chrNW_004936510:3,779,930...3,806,615
G
Cntf ciliary neurotrophic factor
no_association
ISO DNA:point mutation:intron:G>A
RGD PMID:12404108 PMID:14747836 RGD:1626113 RGD:1626114
NCBI chrNW_004936581:3,710,171...3,715,753
G
Col1a1 collagen type I alpha 1 chain
ISO mRNA:increased expression:kidney (rat)
RGD PMID:28746409 RGD:401965413
NCBI chrNW_004936490:11,448,552...11,465,836
G
Col3a1 collagen type III alpha 1 chain
ISO mRNA:increased expression:kidney (rat)
RGD PMID:28746409 RGD:401965413
NCBI chrNW_004936506:8,886,494...8,923,921
G
Col4a1 collagen type IV alpha 1 chain
ISO mRNA:increased expression:kidney (rat)
RGD PMID:28746409 RGD:401965413
NCBI chrNW_004936472:2,416,043...2,543,561
G
Comt catechol-O-methyltransferase
susceptibility
ISO DNA:polymorphism:exon
RGD PMID:17497175 RGD:2289713
NCBI chrNW_004936619:3,847,059...3,883,866
G
Cpb2 carboxypeptidase B2
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression, increased activity:plasma
RGD CTD PMID:11836301 PMID:16959692 RGD:2313645
NCBI chrNW_004936857:577,067...609,855
G
Cpe carboxypeptidase E
no_association
ISO DNA:SNP:intron (rs1946816, rs4481204) (human)
RGD CTD MouseDO PMID:7663508 PMID:9662053 PMID:15358678 PMID:23434795 PMID:23900445 RGD:1626181 RGD:1626184 RGD:405650675
NCBI chrNW_004936555:531,842...641,905
G
Cps1 carbamoyl-phosphate synthase 1
ISO RGD PMID:15481768 RGD:2303517
NCBI chrNW_004936586:5,739,038...5,850,317
G
Cpt1a carnitine palmitoyltransferase 1A
treatment
ISO mRNA:decreased expression:liver
RGD PMID:16751799 PMID:33310031 RGD:2311345 RGD:329955450
NCBI chrNW_004936599:1,491,934...1,535,101
G
Crh corticotropin releasing hormone
ISO RGD PMID:11564446 RGD:5508830
NCBI chrNW_004936496:7,759,656...7,761,555
G
Crhbp corticotropin releasing hormone binding protein
ISO mRNA:decreased expression:anterior pituitary gland (rat)
RGD PMID:10600923 RGD:5508840
NCBI chrNW_004936549:64,866...78,272
G
Crhr1 corticotropin releasing hormone receptor 1
ISO DNA:SNP:CDS:861C>T (human)
RGD PMID:14724656 RGD:1626226
NCBI chrNW_004936541:2,288,847...2,333,129
G
Crp C-reactive protein
disease_progression
ISO mRNA:increased expression:liver (rat)
RGD CTD PMID:20660932 PMID:24042701 PMID:25612518 RGD:15045599 RGD:5490970
NCBI chrNW_004936740:885,855...888,854
G
Cs citrate synthase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936646:676,926...704,988
G
Ctf1 cardiotrophin 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:21803294
NCBI chrNW_004936501:13,286,821...13,291,280
G
Ctsc cathepsin C
ISO RGD PMID:3705543 RGD:1599645
NCBI chrNW_004936736:1,201,343...1,240,311
G
Ctss cathepsin S
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:21156398
NCBI chrNW_004936580:963,176...991,732
G
Cx3cr1 C-X3-C motif chemokine receptor 1
ISO DNA:SNP: :p.T280M (human)
RGD PMID:20523302 RGD:4891903
NCBI chrNW_004936473:28,508,726...28,535,640
G
Cxcr4 C-X-C motif chemokine receptor 4
ISO RGD PMID:25016030 RGD:13673852
NCBI chrNW_004936469:39,794,613...39,798,448
G
Dcn decorin
ISO RGD PMID:17244723 RGD:1600551
NCBI chrNW_004936507:7,887,259...7,923,055
G
Ddhd2 DDHD domain containing 2
ISO ClinVar Annotator: match by term: Obesity
ClinVar
PMID:23176823 PMID:24337409 PMID:24517879 PMID:25417924 PMID:25741868 PMID:28492532 PMID:31302745 PMID:32488064 PMID:37420318 More...
NCBI chrNW_004936710:1,593,899...1,616,572
G
Ddit3 DNA damage inducible transcript 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:26655953
NCBI chrNW_004936646:1,665,019...1,669,212
G
Deaf1 DEAF1 transcription factor
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868 PMID:28492532
NCBI chrNW_004936888:473,651...497,152
G
Defb1 defensin beta 1
ISO mRNA:decreased expression:kidney
RGD PMID:11340353 RGD:4892260
NCBI chrNW_004936615:4,780,229...4,790,516
G
Dgat1 diacylglycerol O-acyltransferase 1
treatment
ISO DNA:polymorphism:C97T
RGD PMID:10802663 PMID:14569040 PMID:18183944 RGD:10401058 RGD:1625597 RGD:734536
NCBI chrNW_004936470:7,916,438...7,926,089
G
Dio2 iodothyronine deiodinase 2
no_association
ISO protein:substitution:Thr92Ala
RGD PMID:17077128 RGD:1626439
NCBI chrNW_004936488:8,769,555...8,783,157
G
Dip2c disco interacting protein 2 homolog C
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936484:13,587,541...13,752,361
G
Dixdc1 DIX domain containing 1
ISO ClinVar Annotator: match by term: Obesity
ClinVar
NCBI chrNW_004936612:2,440,357...2,518,596
G
Dnm1l dynamin 1 like
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:26825290 PMID:27328748 PMID:28492532
NCBI chrNW_004936607:3,576,357...3,632,423
G
Dnmt3a DNA methyltransferase 3 alpha
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:24614070 PMID:25741868 PMID:28492532
NCBI chrNW_004936493:6,963,406...7,013,256
G
Dpyd dihydropyrimidine dehydrogenase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936537:1,660,461...2,439,305
G
Drd1 dopamine receptor D1
treatment
ISO protein:increased serine phosphorylation:renal proximal tubule, membrane (rat)
RGD PMID:15983225 PMID:17191082 RGD:7248449 RGD:7248552
NCBI chrNW_004936609:790,647...795,187
G
Drd2 dopamine receptor D2
ISO mRNA:decreased expression:ventral tegmental area (rat)
RGD PMID:15939106 PMID:17108814 PMID:18477764 RGD:1600904 RGD:1600905 RGD:2311581
NCBI chrNW_004936612:1,094,686...1,154,149
G
Drd4 dopamine receptor D4
ISO protein:decreased expression:kidney (rat)
RGD PMID:20810614 RGD:7248616
NCBI chrNW_004936888:468,334...471,254
G
Dusp1 dual specificity phosphatase 1
susceptibility
ISO RGD PMID:16814733 RGD:2298673
NCBI chrNW_004936609:2,688,170...2,691,057
G
Ech1 enoyl-CoA hydratase 1
treatment
ISO RGD PMID:31961704 RGD:21408561
NCBI chrNW_004936661:1,780,706...1,785,864
G
Echs1 enoyl-CoA hydratase, short chain 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936486:19,488,619...19,496,583
G
Edn1 endothelin 1
ISO DNA:polymorphism:exon:p.K198N (human)
RGD PMID:17444275 RGD:1625065
NCBI chrNW_004936534:885,489...892,292
G
Efnb1 ephrin B1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:24098442
NCBI chrNW_004936777:434,729...447,778
G
Egfr epidermal growth factor receptor
ISO protein:decreased phosphorylation:liver (mouse)
RGD PMID:3624263 RGD:5131534
NCBI chrNW_004936678:365,005...560,546
G
Ehd1 EH domain containing 1
ISO RGD PMID:21365757 RGD:8661255
NCBI chrNW_004936599:4,451,207...4,473,078
G
Elovl6 ELOVL fatty acid elongase 6
ISO mRNA,protein:increased expression:liver:
RGD PMID:31988048 RGD:21403676
NCBI chrNW_004936563:1,224,392...1,344,707
G
Emc1 ER membrane protein complex subunit 1
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:26572623 PMID:26942288 PMID:28492532 PMID:29271071
NCBI chrNW_004936474:5,512,100...5,539,198
G
Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1
susceptibility
ISO ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity disorder
OMIM ClinVar
PMID:8960499 PMID:9662402 PMID:10453738 PMID:10480624 PMID:11739459 PMID:11771660 PMID:12881724 PMID:14671192 PMID:14988267 PMID:15001634 PMID:15126519 PMID:15605415 PMID:15677494 PMID:16025115 PMID:16315058 PMID:16369898 PMID:16607460 PMID:16609882 PMID:16968801 PMID:18950909 PMID:20016754 PMID:20137773 PMID:20981035 PMID:22539483 PMID:24033266 PMID:25741868 PMID:27238374 PMID:27467858 PMID:28377967 PMID:28492532 PMID:28973083 PMID:29244957 PMID:29979387 PMID:33005041 PMID:35738466 More...
NCBI chrNW_004937067:194,375...246,607
G
Entpd6 ectonucleoside triphosphate diphosphohydrolase 6
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936620:598,677...627,766
G
Ep300 E1A binding protein p300
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:26441656
NCBI chrNW_004936492:696,982...778,132
G
Esr1 estrogen receptor 1
ISO CTD Direct Evidence: marker/mechanism
RGD CTD PMID:11095962 PMID:20667977 PMID:22230815 RGD:8553065 RGD:8553199
NCBI chrNW_004936489:4,616,839...4,887,179
G
Esr2 estrogen receptor 2
ISO RGD PMID:22230815 RGD:8553199
NCBI chrNW_004936495:7,956,168...8,018,356
G
Esrra estrogen related receptor alpha
no_association
ISO RGD PMID:16755280 RGD:1625637
NCBI chrNW_004936599:4,898,534...4,922,758
G
Etfdh electron transfer flavoprotein dehydrogenase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936576:5,140,577...5,165,527
G
F2 coagulation factor II, thrombin
ISO CTD Direct Evidence: marker/mechanism
RGD CTD PMID:21210148 PMID:22841818 PMID:23628972 RGD:5147773 RGD:7387310
NCBI chrNW_004936562:2,371,725...2,388,617
G
F7 coagulation factor VII
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD PMID:9258277 PMID:14513073 PMID:16739871 PMID:19329212 RGD:1625710 RGD:2312379 RGD:2312395 RGD:2312404
NCBI chrNW_004936472:505,751...515,375
G
Faah fatty acid amide hydrolase
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:15809662 PMID:19103437 PMID:20716455 RGD:1625726
NCBI chrNW_004936474:27,419,211...27,441,061
G
Fabp1 fatty acid binding protein 1
ISO Western diet-induced obesity; DNA:mutation::Fabp1 knockout mice
RGD PMID:17058218 RGD:1626440
NCBI chrNW_004936712:738,361...743,073
G
Fabp2 fatty acid binding protein 2
onset
ISO DNA:polymorphism:CDS:p.A54T (human)
RGD PMID:14981227 PMID:15620432 PMID:17211557 RGD:1578458 RGD:1626400 RGD:1626407
NCBI chrNW_004936869:146,567...149,929
G
Fabp3 fatty acid binding protein 3
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:decreased expression:skeletal muscle
RGD PMID:17515913 RGD:2307328
NCBI chrNW_004936474:14,576,582...14,584,362
G
Fabp4 fatty acid binding protein 4
ISO RGD PMID:8910278 RGD:737747
NCBI chrNW_004936656:2,722,970...2,727,383
G
Fadd Fas associated via death domain
ISO protein:increased expression:heart left ventricle
RGD PMID:18202171 RGD:2293027
NCBI chrNW_004936599:633,501...639,412
G
Fads1 fatty acid desaturase 1
ISO protein:decreased expression:microsomes, liver
RGD PMID:8446010 RGD:1625421
NCBI chrNW_004936581:1,312,199...1,327,046
G
Fanca FA complementation group A
ISO RGD PMID:22482891 RGD:11046266
NCBI chrNW_004936641:281,119...319,796
G
Fancc FA complementation group C
ISO RGD PMID:22482891 RGD:11046266
NCBI chrNW_004936626:3,980,311...4,147,042
G
Fasn fatty acid synthase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936594:5,591,785...5,609,886
G
Fbxo11 F-box protein 11
ISO ClinVar Annotator: match by term: Obesity
ClinVar
NCBI chrNW_004936508:4,622,695...4,708,694
G
Fgf21 fibroblast growth factor 21
ISO CTD Direct Evidence: therapeutic
CTD PMID:24184811 PMID:26797127
NCBI chrNW_004936664:2,826,823...2,828,330
G
Fgfr1 fibroblast growth factor receptor 1
ISO mRNA:increased expression:adipose tissue:
RGD PMID:21430024 RGD:10402094
NCBI chrNW_004936710:1,760,365...1,815,269
G
Fgg fibrinogen gamma chain
ISO protein:decreased expression:plasma
RGD PMID:22134356 RGD:11352709
NCBI chrNW_004936576:1,343,657...1,352,085
G
Fggy FGGY carbohydrate kinase domain containing
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29220483
NCBI chrNW_004936522:2,196,664...2,589,311
G
Fos Fos proto-oncogene, AP-1 transcription factor subunit
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:27071101
NCBI chrNW_004936488:4,384,710...4,388,118
G
Foxa2 forkhead box A2
ISO RGD PMID:12865419 RGD:1627574
NCBI chrNW_004936620:2,966,341...2,969,349
G
Foxc2 forkhead box C2
ISO DNA:polymorphism:5'ut:-512C>T(human)
RGD PMID:15601967 RGD:1601218
NCBI chrNW_004936641:2,236,224...2,238,501
G
Foxo3 forkhead box O3
ISO protein:increased expression:myocardium:
RGD CTD PMID:16467659 PMID:23954404 RGD:10402201
NCBI chrNW_004936564:4,788,036...4,907,600
G
Ftl ferritin light chain
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936664:2,976,325...2,977,878
G
Fto FTO alpha-ketoglutarate dependent dioxygenase
severity
ISO CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17496892 PMID:19079260 PMID:19079261 PMID:19151714 PMID:19918250 PMID:21076408 PMID:21919686 PMID:23111453 PMID:23134754 PMID:25606423 PMID:29540276 PMID:31801409 PMID:32420297 PMID:35945320 More...
RGD:329812007 RGD:329812010 RGD:329812016 RGD:329812040 RGD:329845887 RGD:329901774 RGD:329951013 RGD:329951016
NCBI chrNW_004936475:6,321,725...6,689,410
G
Fxn frataxin
ISO DNA:deletion:exon (mouse)
RGD PMID:17404227 RGD:2307045
NCBI chrNW_004936503:5,323,206...5,343,228
G
G6pd glucose-6-phosphate dehydrogenase
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:liver
RGD PMID:15923630 PMID:19230846 RGD:2307340 RGD:2307347
NCBI chrNW_004936809:1,269,900...1,285,853
G
Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6
ISO DNA:polymorphism:3' utr:1519T>C, abdominal obesity and hypercortisolism
RGD PMID:12080446 RGD:1626491
NCBI chrNW_004936515:1,982,415...1,997,740
G
Gal galanin and GMAP prepropeptide
no_association
ISO protein:increased expression:plasma
RGD PMID:11220530 PMID:15930442 RGD:1624334 RGD:1625748
NCBI chrNW_004936599:1,563,270...1,567,618
G
Galr1 galanin receptor 1
no_association
ISO RGD PMID:15930442 RGD:1625748
NCBI chrNW_004936616:2,007,339...2,020,737
G
Gapdh glyceraldehyde-3-phosphate dehydrogenase
treatment
ISO RGD PMID:27987997 RGD:13792668
NCBI chrNW_004936709:1,243,149...1,247,782
G
Gas7 growth arrest specific 7
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19270708
NCBI chrNW_004936595:2,890,336...3,011,314
G
Gcg glucagon
ISO CTD Direct Evidence: therapeutic
CTD PMID:20065960
NCBI chrNW_004936469:16,906,658...16,916,045
G
Gck glucokinase
ISO DNA, mRNA, protein:hypermethylation, increased expression:liver
RGD PMID:21239437 RGD:7488967
NCBI chrNW_004936478:19,104,477...19,118,915
G
Gckr glucokinase regulator
no_association
ISO DNA:mutations:CDS:no association with mutations P446L, R590Y, R227X or R518Q in obese French patients despite localization of gene within a QTL for obesity-related phenotypes
RGD PMID:12739015 RGD:1626607
NCBI chrNW_004936493:5,080,517...5,101,892
G
Gfpt1 glutamine--fructose-6-phosphate transaminase 1
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:11118009 PMID:20882379 RGD:1625423
NCBI chrNW_004936491:13,603,256...13,665,298
G
Ghrl ghrelin and obestatin prepropeptide
susceptibility
ISO ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity, age at onset of
OMIM ClinVar PMID:11502844 PMID:12050239 PMID:12161552 PMID:16204371 PMID:25741868
NCBI chrNW_004936602:3,037,862...3,044,863
G
Ghsr growth hormone secretagogue receptor
ISO DNA:point mutation:exon:F279L
RGD PMID:16511600 RGD:1625270
NCBI chrNW_004936593:268,736...273,623
G
Gip gastric inhibitory polypeptide
ISO associated with Polycystic Ovary Syndrome; protein:increased expression:plasma (human)
RGD PMID:3546047 PMID:18063845 PMID:19375579 RGD:2312547 RGD:2312551 RGD:2312588
NCBI chrNW_004936490:12,487,025...12,492,214
G
Gipr gastric inhibitory polypeptide receptor
susceptibility
ISO mRNA:reduced expression:fat tissue (human)
RGD PMID:12068290 PMID:17395281 PMID:17971513 PMID:19254363 RGD:2312612 RGD:2312615 RGD:2312616 RGD:737714
NCBI chrNW_004936706:2,052,069...2,062,722
G
Gja5 gap junction protein alpha 5
ISO mRNA, protein:decreased expression:mesenteric artery
RGD PMID:18324386 RGD:7207466
NCBI chrNW_004936867:269,477...279,549
G
Gldc glycine decarboxylase
ISO ClinVar Annotator: match by term: Obesity
ClinVar
PMID:10873393 PMID:11286506 PMID:12126939 PMID:15670722 PMID:15791207 PMID:17361008 PMID:20301531 PMID:25741868 PMID:26179960 PMID:27362913 PMID:28492532 More...
NCBI chrNW_004936539:1,008,340...1,095,044
G
Glp1r glucagon like peptide 1 receptor
ISO DNA:SNP:intron (rs2268641) (human)
RGD PMID:15279492 PMID:23900445 RGD:1624351 RGD:405650675
NCBI chrNW_004936476:20,541,812...20,580,454
G
Glrx glutaredoxin
ISO protein:increased expression:renal visceral adipose:
RGD PMID:23404913 RGD:9686064
NCBI chrNW_004936523:7,535,650...7,544,339
G
Glul glutamate-ammonia ligase
ISO protein:increased activity:skeletal muscle:activity is increased in Zucker fa/fa genetically obese but not dietary obese (fa/?) rats vs non-obese (fa/?) rats
RGD CTD PMID:15481771 PMID:20882379 RGD:2301479
NCBI chrNW_004936481:7,293,301...7,301,416
G
Gnb3 G protein subunit beta 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:15961981 PMID:16141801
NCBI chrNW_004936709:970,169...977,059
G
Gpam glycerol-3-phosphate acyltransferase, mitochondrial
ISO mRNA:increased expression:pancreatic islet
RGD PMID:9032096 RGD:2313659
NCBI chrNW_004936486:2,754,753...2,823,600
G
Gpr12 G protein-coupled receptor 12
ISO OMIM:601665
MouseDO
NCBI chrNW_004936472:22,115,933...22,119,674
G
Gpr17 G protein-coupled receptor 17
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:34144038
NCBI chrNW_004936469:43,652,244...43,656,661
G
Gpt2 glutamic--pyruvic transaminase 2
ISO protein:increased expression, activity:liver:
RGD PMID:25865565 RGD:11342811
NCBI chrNW_004936475:262,558...299,766
G
Gpx1 glutathione peroxidase 1
treatment
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:15184668 PMID:30298849 RGD:401960083
NCBI chrNW_004936529:997,943...999,123
G
Gpx3 glutathione peroxidase 3
treatment
ISO CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:11328671 PMID:18562625 PMID:19212806 PMID:19270708 PMID:21535898 PMID:21862610 PMID:31791316 More...
RGD:2307430 RGD:2312633 RGD:401827913 RGD:401827923 RGD:5683906
NCBI chrNW_004936647:3,904,787...3,914,223
G
Gria4 glutamate ionotropic receptor AMPA type subunit 4
ISO ClinVar Annotator: match by term: Obesity
ClinVar
NCBI chrNW_004936551:2,426,840...2,760,042
G
Gucy2c guanylate cyclase 2C
ISO OMIM:601665
MouseDO
NCBI chrNW_004936587:2,742,911...2,811,139
G
Hadh hydroxyacyl-CoA dehydrogenase
ISO protein:increased expression:skeletal muscle
RGD CTD PMID:16088331 PMID:20882379 RGD:2302228
NCBI chrNW_004936818:575,272...623,496
G
Hcrt hypocretin neuropeptide precursor
ISO mRNA:increased expression:perifornical nucleus
RGD CTD PMID:12560202 PMID:15970339 PMID:16135994 PMID:27071101 RGD:1358428 RGD:1600932 RGD:1600933
NCBI chrNW_004936490:17,007,001...17,008,363
G
Hdac4 histone deacetylase 4
ISO mRNA,protein:decreased expression:mononuclear cell, adipose tissue:
RGD PMID:24086512 RGD:9681453
NCBI chrNW_004936745:1,730,743...1,942,071
G
Hfe homeostatic iron regulator
ISO associated with Diabetes Mellitus, Type 2;DNA:missense mutations:CDS:p.C282Y, p.H63D (human)
RGD PMID:10705106 RGD:1601449
NCBI chrNW_004936671:1,940,079...1,947,574
G
Hgf hepatocyte growth factor
ISO protein:increased expression:serum
RGD PMID:12706940 RGD:1642704
NCBI chrNW_004936734:354,798...428,356
G
Hif1a hypoxia inducible factor 1 subunit alpha
ISO associated with hepatocellular carcinoma;RNA:decreased expression:liver:
RGD PMID:31321740 RGD:155882550
NCBI chrNW_004936495:5,770,988...5,816,157
G
Hk1 hexokinase 1
susceptibility
ISO RGD PMID:131232 PMID:12524468 RGD:1601527 RGD:1601528
NCBI chrNW_004936521:9,067,062...9,139,112
G
Hk2 hexokinase 2
ISO mRNA:increased expression:gastrocnemius
RGD CTD PMID:11319725 PMID:16555472 PMID:20882379 RGD:1624365 RGD:2313227
NCBI chrNW_004936556:1,054,143...1,113,425
G
Hmga2 high mobility group AT-hook 2
ISO RGD PMID:10742101 RGD:1601569
NCBI chrNW_004936545:3,944,419...3,958,289
G
Hmgb2 high mobility group box 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936516:4,536,664...4,539,331
G
Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1
ISO protein:decreased activity:liver (rat)
RGD PMID:1685984 RGD:2326155
NCBI chrNW_004936480:18,862,288...18,882,614
G
Hmox1 heme oxygenase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:18334666 PMID:18375438 PMID:19171794
NCBI chrNW_004936492:5,042,353...5,049,216
G
Hoxb5 homeobox B5
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:22484627
NCBI chrNW_004936490:12,793,485...12,796,219
G
Hrh3 histamine receptor H3
ISO RGD PMID:17189541 RGD:1626405
NCBI chrNW_004936514:9,862,104...9,865,614
G
Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:15131764 PMID:16612591 PMID:16914598 PMID:17628001 PMID:21786805 RGD:1625071 RGD:1625072 RGD:1625073
NCBI chrNW_004936557:3,358,809...3,403,461
G
Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2
resistance
ISO transgenic mice expressing human HSD11B2
RGD PMID:15793240 PMID:17208436 RGD:1625081 RGD:1625083
NCBI chrNW_004936475:17,882,663...17,888,708
G
Hspa5 heat shock protein family A (Hsp70) member 5
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:26655953
NCBI chrNW_004936487:13,348,465...13,352,717
G
Htr1b 5-hydroxytryptamine receptor 1B
ISO protein:increase expression:arcuate nucleus
RGD PMID:10564740 RGD:1626450
NCBI chrNW_004936890:154,252...157,044
G
Htr2a 5-hydroxytryptamine receptor 2A
no_association
ISO DNA:SNP:intron (rs912127) (human)
RGD CTD PMID:16328014 PMID:16491645 PMID:17097612 PMID:23900445 RGD:1624369 RGD:1624370 RGD:405650675
NCBI chrNW_004936565:335,238...394,683
G
Htr2c 5-hydroxytryptamine receptor 2C
susceptibility
ISO DNA:polymorphism:promoter:-759C>T
RGD CTD PMID:15048662 PMID:17016522 PMID:17702092 PMID:19142110 RGD:1624982 RGD:1624991
NCBI chrNW_004936499:1,002,083...1,109,446
G
Icam1 intercellular adhesion molecule 1
ISO protein:increased secretion:plasma (human)
RGD CTD PMID:11782876 PMID:20004360 PMID:20973827 RGD:4145329 RGD:4145463
NCBI chrNW_004936659:616,570...627,172
G
Idh1 isocitrate dehydrogenase (NADP(+)) 1
ISO RGD PMID:14969338 RGD:1626475
NCBI chrNW_004936950:334,894...349,221
G
Ido1 indoleamine 2,3-dioxygenase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:27020609
NCBI chrNW_004936843:658,058...672,662
G
Ifng interferon gamma
ISO associated with Asthma;protein:increased expression:serum
RGD PMID:19575934 RGD:2311494
NCBI chrNW_004936545:6,139,130...6,144,543
G
Igf1r insulin like growth factor 1 receptor
ISO mRNA:decreased expression:heart (rat)
RGD PMID:11009458 RGD:12904882
NCBI chrNW_004936483:4,563,995...4,860,231
G
Igf2 insulin like growth factor 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:11528401
NCBI chrNW_004936816:972,902...981,232
G
Igfbp2 insulin like growth factor binding protein 2
ISO CTD Direct Evidence: marker/mechanism
RGD CTD PMID:17259371 PMID:17426323 PMID:22537059 RGD:1626478 RGD:1626479
NCBI chrNW_004936586:671,760...696,783
G
Igfbp3 insulin like growth factor binding protein 3
ISO mRNA, protein:decreased expression:pancreatic fat pad
RGD PMID:22067319 RGD:10402755
NCBI chrNW_004936478:20,511,490...20,518,251
G
Igfbp6 insulin like growth factor binding protein 6
ISO human transgene overexpressed in mouse brain
RGD PMID:15889232 RGD:2301717
NCBI chrNW_004936512:10,415,004...10,419,698
G
Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta
ISO protein:increased expression:liver:
RGD PMID:15685173 RGD:10045952
NCBI chrNW_004936785:358,128...406,751
G
Il10 interleukin 10
ISO protein:increase expression:serum
RGD PMID:18787467 PMID:28843383 RGD:14975146 RGD:2308945
NCBI chrNW_004936557:5,834,874...5,838,502
G
Il15 interleukin 15
ISO mRNA, protein:altered expression:skeletal muscle, plasma
RGD PMID:18697873 RGD:2313573
NCBI chrNW_004936535:6,344,348...6,358,803
G
Il18 interleukin 18
treatment
ISO RGD PMID:16732281 PMID:20490358 RGD:14695532 RGD:7175343
NCBI chrNW_004936612:2,306,963...2,325,086
G
Il1b interleukin 1 beta
treatment
ISO protein:increased expression:plasma (mouse)
RGD PMID:16567518 PMID:20490358 PMID:23150506 PMID:24146106 PMID:28843383 RGD:10450599 RGD:14975146 RGD:1626637 RGD:7175086 RGD:7175343
NCBI chrNW_004936783:1,251,678...1,256,807
G
Il1rn interleukin 1 receptor antagonist
ISO mRNA, protein:increased expression:adipose tissue
RGD PMID:12716739 PMID:12975454 RGD:1626664 RGD:1626665
NCBI chrNW_004936783:1,447,158...1,466,331
G
Il3 interleukin 3
ISO protein: decreased expression: plasma
RGD PMID:21203453 RGD:5686875
NCBI chrNW_004936647:3,102,922...3,104,758
G
Il6 interleukin 6
ISO DNA:polymorphism>promoter:174G>C
RGD CTD PMID:16493118 PMID:19228869 PMID:20141834 PMID:21826222 PMID:24042701 RGD:10402828 RGD:1601582 RGD:2307257
NCBI chrNW_004936549:7,015,595...7,016,246
G
Il6r interleukin 6 receptor
susceptibility
ISO DNA:SNP, haplotypes:promoter:-208G>A (rs4845617) (human)
RGD PMID:12917504 PMID:16817825 PMID:17434052 PMID:17984249 RGD:10402807 RGD:1625428 RGD:1625429 RGD:1625430
NCBI chrNW_004936580:4,055,438...4,081,876
G
Il7 interleukin 7
ISO CTD Direct Evidence: therapeutic
CTD PMID:20376352
NCBI chrNW_004936702:110,625...162,957
G
Inpp5e inositol polyphosphate-5-phosphatase E
treatment
ISO CTD Direct Evidence: marker/mechanism
RGD CTD PMID:19668215 PMID:23349329 RGD:12911211
NCBI chrNW_004936669:1,377,005...1,385,287
G
Inppl1 inositol polyphosphate phosphatase like 1
ISO DNA:SNPs: :rs2276047,snp8,rs9886(human)
RGD PMID:15220217 RGD:1626127
NCBI chrNW_004936498:1,524,128...1,539,680
G
Ins insulin
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:2777199 PMID:8923850 PMID:11528401 PMID:29035695
NCBI chrNW_004936816:1,002,137...1,003,357
G
Irs1 insulin receptor substrate 1
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:22982470 PMID:23954404 RGD:7207062
NCBI chrNW_004936525:9,064,442...9,125,972
G
Itgam integrin subunit alpha M
ISO protein:increased expression:monocyte (human)
RGD CTD PMID:21446916 PMID:29035695 RGD:329901665
NCBI chrNW_004936543:8,460,526...8,508,524
G
Itih4 inter-alpha-trypsin inhibitor heavy chain 4
ISO RGD PMID:22134356 RGD:11352709
NCBI chrNW_004936473:3,573,282...3,589,345
G
Jak2 Janus kinase 2
ISO protein:decreased expression:hypothalamus
RGD PMID:14630696 PMID:23397595 RGD:10411893 RGD:1627661
NCBI chrNW_004936503:111,722...243,627
G
Kcnh2 potassium voltage-gated channel subfamily H member 2
ISO ClinVar Annotator: match by term: Obesity
ClinVar
PMID:7889573 PMID:9024139 PMID:9927399 PMID:10753933 PMID:10973849 PMID:11113008 PMID:11468227 PMID:11668638 PMID:11854117 PMID:12354768 PMID:15051636 PMID:15840476 PMID:16432067 PMID:17160940 PMID:17445409 PMID:18441445 PMID:18593567 PMID:19716085 PMID:19841300 PMID:22581653 PMID:22949429 PMID:23303164 PMID:24606995 PMID:24623279 PMID:24667783 PMID:25741868 PMID:26847485 PMID:28492532 PMID:29672598 PMID:30246897 More...
NCBI chrNW_004936527:6,380,222...6,412,390
G
Kcnma1 potassium calcium-activated channel subfamily M alpha 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:27605626
NCBI chrNW_004936521:2,000,113...2,706,010
G
Kctd15 potassium channel tetramerization domain containing 15
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19079261
NCBI chrNW_004936570:2,080,549...2,096,929
G
Kdm3a lysine demethylase 3A
ISO OMIM:601665
RGD MouseDO PMID:19875498 RGD:9590220
NCBI chrNW_004936712:1,053,210...1,097,845
G
Kif4a kinesin family member 4A
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936762:1,062,570...1,194,192
G
Kitlg KIT ligand
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:23954404
NCBI chrNW_004936507:5,566,144...5,650,412
G
Lactb lactamase beta
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:18344982
NCBI chrNW_004936471:23,713,144...23,732,214
G
Lbp lipopolysaccharide binding protein
treatment
ISO CTD Direct Evidence: marker/mechanism
RGD CTD PMID:19917068 PMID:23349936 RGD:9685197
NCBI chrNW_004936561:3,017,471...3,035,481
G
Lcn2 lipocalin 2
ISO mRNA:decreased expression:ovary, testicle
RGD PMID:18292240 PMID:21143924 PMID:32627017 RGD:126790490 RGD:126790530 RGD:2316514
NCBI chrNW_004936487:15,721,752...15,725,396
G
Ldlr low density lipoprotein receptor
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:25554529
NCBI chrNW_004936659:1,259,405...1,300,545
G
Lep leptin
treatment
ISO mouse protein in a rat model
RGD ClinVar PMID:10029567 PMID:15910756 PMID:23793169 PMID:25741868 PMID:28492532 RGD:10053612 RGD:10053638 RGD:1643130
NCBI chrNW_004936479:15,394,966...15,411,334
G
Lepr leptin receptor
disease_progression
ISO compared to BN
RGD ClinVar
PMID:8666155 PMID:9545018 PMID:11354636 PMID:11380591 PMID:11443193 PMID:12006639 PMID:16284652 PMID:17785359 PMID:18204169 PMID:18490929 PMID:20159938 PMID:21393862 PMID:21744741 PMID:22331430 PMID:25741868 PMID:26467025 PMID:27465994 PMID:28492532 PMID:33568522 More...
RGD:10412018 RGD:10412023 RGD:12911217 RGD:401965412 RGD:5128855 RGD:7365117
NCBI chrNW_004936591:5,771,371...5,846,177
G
Leprot leptin receptor overlapping transcript
ISO ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity
ClinVar PMID:25741868 PMID:28492532
NCBI chrNW_004936692:2,840,461...2,850,756
G
Lipc lipase C, hepatic type
ISO protein:altered expression:liver, plasma (rat)
RGD PMID:11544558 PMID:12843191 RGD:2308784 RGD:2308835
NCBI chrNW_004936471:19,604,083...19,733,721
G
Lipe lipase E, hormone sensitive type
ISO mRNA:decreased expression:white fat
RGD PMID:17712951 RGD:2313580
NCBI chrNW_004936706:122,939...139,506
G
Lipg lipase G, endothelial type
ISO protein:increased expression:plasma
RGD PMID:16772345 RGD:1641819
NCBI chrNW_004936497:13,406,402...13,429,833
G
LOC101955831 heat shock 70 kDa protein 1
ISO DNA:SNP:CDS:homozygous P2/P2 allele at position 1267 (p<0.000001)
RGD PMID:11319647 RGD:1626642
NCBI chrNW_004936727:1,718,952...1,721,691
G
LOC101960314 cytochrome b5
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936616:4,176,576...4,210,276
G
LOC101961000 cytochrome c oxidase subunit 7C, mitochondrial
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936469:5,337,331...5,339,716
G
LOC101967786 L-xylulose reductase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936594:5,532,264...5,534,129
G
LOC101968793 glucosamine-6-phosphate isomerase 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19079261
NCBI chrNW_004936482:11,382,358...11,423,823
G
LOC101968921 angiotensin-converting enzyme
no_association
ISO protein:increased expression:liver
RGD PMID:17164796 PMID:19361967 RGD:1601115 RGD:2325227
NCBI chrNW_004936541:4,157,847...4,178,156
G
LOC101969021 somatotropin
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:8923850
NCBI chrNW_004936541:4,524,397...4,528,234
G
LOC101970101 cytochrome P450 1B1
ISO CTD Direct Evidence: therapeutic
CTD PMID:27036855
NCBI chrNW_004936663:345,021...355,188
G
LOC101970551 inhibitor of carbonic anhydrase
ISO RGD PMID:16267817 RGD:1601520
NCBI chrNW_004936529:6,856,042...6,895,989
G
LOC101970831 serotransferrin
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936529:6,917,762...6,947,512
G
LOC101971027 neuroendocrine secretory protein 55
ISO ClinVar Annotator: match by term: Obesity
ClinVar
PMID:11784876 PMID:12970262 PMID:21525160 PMID:23281139 PMID:23796510 PMID:25741868 PMID:25802881 PMID:28492532 PMID:29059381 More...
NCBI chrNW_004936530:1,353,432...1,407,437
G
LOC101972957 vitamin D 25-hydroxylase
ISO associated with hypertension:DNA:SNP:CDS: rs12794714 (human)
RGD PMID:34906413 RGD:401900724
NCBI chrNW_004936528:3,881,630...3,897,613
G
LOC101973029 cytochrome P450 2E1
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:17049493 PMID:23954404 RGD:1626307
NCBI chrNW_004936486:19,691,822...19,702,684
G
LOC101973421 amine oxidase copper containing 3
ISO RGD PMID:17977742 RGD:2313916
NCBI chrNW_004936490:17,549,836...17,564,867
G
LOC101973430 cytochrome b-c1 complex subunit 2, mitochondrial
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936501:6,947,985...6,968,846
G
LOC101973720 rap guanine nucleotide exchange factor 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936512:5,636,197...5,659,606
G
LOC101975674 cytochrome P450 26B1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936491:16,010,394...16,028,852
G
LOC101976500 haptoglobin
treatment
ISO protein:increased expression:serum
RGD PMID:11807829 PMID:15181041 PMID:17161237 PMID:19917068 RGD:1626339 RGD:1626346 RGD:1626349 RGD:9685197
NCBI chrNW_004936475:21,841,054...21,845,821
G
LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
susceptibility
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms:promoter, intron:g.-1260C>A, g.2838T>C (human)
RGD PMID:17223345 RGD:2307312
NCBI chrNW_004936646:1,899,686...1,904,104
G
Lpl lipoprotein lipase
treatment
ISO mRNA:increased expression:white fat
RGD CTD PMID:17712951 PMID:18344982 PMID:18952837 PMID:27160499 PMID:28514832 RGD:13793401 RGD:13794378 RGD:2313300 RGD:2313580
NCBI chrNW_004936555:4,084,099...4,108,219
G
Mapk1 mitogen-activated protein kinase 1
ISO protein:increased phosphorylation:endometrium (human)
RGD PMID:20074784 RGD:13782055
NCBI chrNW_004936619:1,889,841...1,932,646
G
Mapk3 mitogen-activated protein kinase 3
ISO protein:increased phosphorylation:endometrium (human)
RGD PMID:20074784 RGD:13782055
NCBI chrNW_004936501:12,342,670...12,390,650
G
Mapt microtubule associated protein tau
ISO RGD PMID:25257559 RGD:13800921
NCBI chrNW_004936541:2,381,411...2,479,984
G
Mc3r melanocortin 3 receptor
susceptibility
ISO ClinVar Annotator: match by term: Obesity
ClinVar RGD PMID:16123355 RGD:6484587
NCBI chrNW_004936875:172,764...174,446
G
Mc4r melanocortin 4 receptor
ISO ClinVar Annotator: match by term: ADCY3-related condition | ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity due to melanocortin 4 receptor deficiency | ClinVar Annotator: match by term: Obesity, autosomal dominant | ClinVar Annotator: match by term: SIM1-related condition
ClinVar
PMID:8392067 PMID:9267995 PMID:10078568 PMID:10199800 PMID:10577903 PMID:10585465 PMID:10592235 PMID:10903341 PMID:10903343 PMID:11443223 PMID:11487744 PMID:12032748 PMID:12364414 PMID:12364415 PMID:12499395 PMID:12588803 PMID:12629567 PMID:12646665 PMID:12646666 PMID:12690102 PMID:12815165 PMID:12851297 PMID:12959994 PMID:12970296 PMID:14633862 PMID:14764812 PMID:14764818 PMID:14973783 PMID:15037865 PMID:15126516 PMID:15448103 PMID:15466016 PMID:15486053 PMID:15585384 PMID:15805150 PMID:15975705 PMID:16030156 PMID:16032553 PMID:16083993 PMID:16094248 PMID:16231025 PMID:16274851 PMID:16289450 PMID:16469222 PMID:16492696 PMID:16507637 PMID:16611215 PMID:16614075 PMID:16616374 PMID:16710097 PMID:16752916 PMID:16886960 PMID:16960181 PMID:17185898 PMID:17286227 PMID:17306938 PMID:17356525 PMID:17357083 PMID:17418015 PMID:17492953 PMID:17517246 PMID:17519222 PMID:17579204 PMID:17587397 PMID:17590021 PMID:17628007 PMID:17668051 PMID:17986382 PMID:18559663 PMID:18801902 PMID:18835933 PMID:18997677 PMID:19011902 PMID:19091795 PMID:19179454 PMID:19184404 PMID:19244934 PMID:19284607 PMID:19298524 PMID:19301229 PMID:19400288 PMID:19417090 PMID:19696756 PMID:19766264 PMID:19889825 PMID:20462274 PMID:20631012 PMID:20696697 PMID:20826565 PMID:20966905 PMID:20975296 PMID:21085626 PMID:21404042 PMID:22106157 PMID:22447289 PMID:22463805 PMID:22688572 PMID:22822657 PMID:23146882 PMID:23251400 PMID:23505181 PMID:23791567 PMID:24248383 PMID:24276017 PMID:24385306 PMID:24426828 PMID:24512492 PMID:24611737 PMID:24705671 PMID:24780838 PMID:24890885 PMID:25076858 PMID:25136332 PMID:25332687 PMID:25741868 PMID:25741869 PMID:26047380 PMID:26179253 PMID:26238496 PMID:26244670 PMID:26467025 PMID:26588347 PMID:26666384 PMID:26782456 PMID:26788538 PMID:27222505 PMID:27654141 PMID:28166811 PMID:28218067 PMID:28492532 PMID:29031731 PMID:29273807 PMID:29311635 PMID:29679223 PMID:29758564 PMID:29861388 PMID:29970488 PMID:30048591 PMID:30068297 PMID:30586318 PMID:30719650 PMID:30811542 PMID:30926952 PMID:30991789 PMID:31002796 PMID:31118516 PMID:31841602 PMID:31947684 PMID:32185475 PMID:32534219 PMID:32916307 PMID:32952152 PMID:32971154 PMID:33761344 PMID:33889637 PMID:35562395 PMID:36775011 PMID:38528040 More...
NCBI chrNW_004936497:4,636,370...4,638,205
G
Mchr1 melanin concentrating hormone receptor 1
ISO mRNA:increased expression:hypothalamus
RGD PMID:15363890 RGD:1624360
NCBI chrNW_004936492:1,153,895...1,156,980
G
Me1 malic enzyme 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19270708
NCBI chrNW_004936510:7,425,983...7,571,090
G
Mfn2 mitofusin 2
ISO mRNA:decreased expression:skeletal muscle tissue (human)
RGD PMID:12598526 PMID:25336449 RGD:12880438 RGD:1601412
NCBI chrNW_004936474:767,754...795,258
G
Mgrn1 mahogunin ring finger 1
ISO RGD PMID:16638826 RGD:1641947
NCBI chrNW_004936530:4,647,550...4,693,143
G
Mif macrophage migration inhibitory factor
ISO DNA:polymorphisms:promoter
RGD PMID:15472203 PMID:16247506 RGD:1641950 RGD:1641953
NCBI chrNW_004936619:1,207,058...1,208,010
G
Mkks MKKS centrosomal shuttling protein
no_association
ISO protein:substitution:A242S possible contribution
RGD MouseDO PMID:10973251 PMID:15483080 RGD:1581208 RGD:1601414
NCBI chrNW_004936485:9,089,118...9,114,396
G
Mmp19 matrix metallopeptidase 19
ISO mRNA:increased expression:adipose tissue
RGD PMID:12529376 PMID:15169894 RGD:1642022 RGD:1642023
NCBI chrNW_004936646:298,854...304,479
G
Mmp9 matrix metallopeptidase 9
ISO protein:increased expression:plasma
RGD CTD PMID:17512313 PMID:21156398 RGD:1642026
NCBI chrNW_004936514:7,038,240...7,045,873
G
Mmut methylmalonyl-CoA mutase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936476:11,208,251...11,241,648
G
Mrap2 melanocortin 2 receptor accessory protein 2
ISO ClinVar Annotator: match by term: Monogenic Obesity
ClinVar PMID:25741868
NCBI chrNW_004936510:6,905,870...6,945,583
G
Mrc1 mannose receptor C-type 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29035695
NCBI chrNW_004936520:9,463,007...9,547,321
G
Mt3 metallothionein 3
ISO RGD PMID:21726645 RGD:6480475
NCBI chrNW_004936475:8,864,512...8,866,516
G
Mtch2 mitochondrial carrier 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19079261
NCBI chrNW_004936562:1,622,341...1,644,191
G
Mtor mechanistic target of rapamycin kinase
ISO mRNA, protein:decreased expression:hypothalamus
RGD PMID:25807795 RGD:11570513
NCBI chrNW_004936474:158,376...282,310
G
Mttp microsomal triglyceride transfer protein
susceptibility
ISO DNA:polymorphisms
RGD PMID:15635487 RGD:1625486
NCBI chrNW_004936520:3,337,726...3,417,818
G
Myc MYC proto-oncogene, bHLH transcription factor
ISO mRNA:decreased expression:pancreas (rat)
RGD PMID:22421529 RGD:7240547
NCBI chrNW_004936470:20,480,844...20,485,955
G
Myh10 myosin heavy chain 10
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936595:1,697,283...1,832,571
G
Myh9 myosin heavy chain 9
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868 PMID:31064749
NCBI chrNW_004936492:4,384,215...4,466,229
G
Myod1 myogenic differentiation 1
ISO mRNA:decreased expression:plantaris
RGD PMID:18508911 PMID:22349736 RGD:2313320 RGD:9686079
NCBI chrNW_004936528:1,407,187...1,409,683
G
Myog myogenin
ISO mRNA:decreased expression:plantaris
RGD PMID:18508911 RGD:2313320
NCBI chrNW_004936567:1,507,042...1,509,814
G
Nampt nicotinamide phosphoribosyltransferase
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:17618961 PMID:23834033 RGD:1642336
NCBI chrNW_004936479:17,682,070...17,716,713
G
Ncf2 neutrophil cytosolic factor 2
ISO protein:increased expression:artery
RGD PMID:17515452 RGD:2314435
NCBI chrNW_004936481:6,300,894...6,325,878
G
Ncoa1 nuclear receptor coactivator 1
ISO OMIM:601665
MouseDO
NCBI chrNW_004936493:7,368,393...7,605,754
G
Ncoa3 nuclear receptor coactivator 3
ISO DNA:polymorphism:CDS:C-terminus polyglutamine repeat, combination of long polyglutamine repeat in NCOA3 and homozygous A1/A1 Progesterone Receptor genotype associated with obesity in 301 postmenopausal women with breast cancer
RGD PMID:14557830 RGD:1642050
NCBI chrNW_004936514:5,900,135...5,967,862
G
Ndufb6 NADH:ubiquinone oxidoreductase subunit B6
ISO mRNA:decreased expression:epididymal fat pad
RGD PMID:20559011 RGD:13822707
NCBI chrNW_004936524:1,231,744...1,243,783
G
Negr1 neuronal growth regulator 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19079261
NCBI chrNW_004936591:112,864...903,598
G
Neil1 nei like DNA glycosylase 1
ISO CTD Direct Evidence: marker/mechanism
CTD MouseDO PMID:16446448 PMID:21285402
NCBI chrNW_004936471:34,184,273...34,192,675
G
Neurod1 neuronal differentiation 1
ISO mRNA:increased expression:pancreas
RGD PMID:15979049 RGD:1625044
NCBI chrNW_004936509:10,421,821...10,425,927
G
Nfe2l2 NFE2 like bZIP transcription factor 2
ISO protein:decreased expression:hepatocyte:
RGD PMID:32102936 RGD:21201281
NCBI chrNW_004936509:6,589,967...6,621,171
G
Nhlh2 nescient helix-loop-helix 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20808804
NCBI chrNW_004936627:1,130,064...1,135,092
G
Nmb neuromedin B
susceptibility
ISO DNA:polymorphism:CDS:217C>A, amino acid P73T, associated with disinhibition toward food (p=0.03), susceptibility to hunger (p=0.01) and increased percent body fat (p<0.05)
RGD PMID:1709601 PMID:11194934 PMID:15585758 RGD:1642059 RGD:1642062 RGD:1642063
NCBI chrNW_004936483:16,712,382...16,715,397
G
Nmu neuromedin U
susceptibility
ISO DNA:polymorphisms:cds:p.R165W,p.A19E
RGD PMID:15448684 PMID:16984985 PMID:17706946 RGD:1642093 RGD:1642094 RGD:1642095
Ensembl chrNW_004936482:17,936,467...17,961,711
G
Nnt nicotinamide nucleotide transhydrogenase
ISO protein:decreased expression:gastrocnemius, soleus
RGD PMID:25761734 RGD:13513980
NCBI chrNW_004936480:18,599,037...18,692,097
G
Nos1 nitric oxide synthase 1
ISO RGD PMID:16316351 RGD:1642132
NCBI chrNW_004936558:5,162,471...5,302,488
G
Nos2 nitric oxide synthase 2
ISO protein:increased expression:liver, gastrocnemius muscle, adipose tissue (mouse)
RGD PMID:18098375 PMID:21896669 RGD:4891935 RGD:5509059
NCBI chrNW_004936538:4,052,277...4,097,051
G
Nos3 nitric oxide synthase 3
treatment
ISO protein:decreased expression:artery
RGD PMID:17623751 PMID:29180887 RGD:13504728 RGD:2292133
NCBI chrNW_004936527:6,427,147...6,445,770
G
Nox4 NADPH oxidase 4
treatment
ISO RGD PMID:30298849 RGD:401960083
NCBI chrNW_004936736:230,465...394,859
G
Npc1 NPC intracellular cholesterol transporter 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19151714
NCBI chrNW_004936550:2,983,172...3,032,222
G
Nppa natriuretic peptide A
ISO associated with Heart Failure;
RGD PMID:23566312 RGD:7247714
NCBI chrNW_004936474:671,362...673,610
G
Nppb natriuretic peptide B
treatment
ISO associated with Diabetes Mellitus, Type 2
RGD PMID:21959345 PMID:24009719 PMID:33310031 RGD:329955450 RGD:5685647 RGD:7327171
NCBI chrNW_004936474:683,325...684,662
G
Npy neuropeptide Y
ISO mRNA, protein:increased expression:hypothalamus
RGD PMID:17447163 RGD:10448938
NCBI chrNW_004936478:1,289,437...1,296,819
G
Npy1r neuropeptide Y receptor Y1
susceptibility
ISO CTD Direct Evidence: marker/mechanism
CTD RGD MouseDO PMID:9861026 PMID:17447163 PMID:20975297 RGD:10448938 RGD:1642306
NCBI chrNW_004936555:2,267,727...2,276,673
G
Npy2r neuropeptide Y receptor Y2
ISO DNA:SNP:promoter:−4448C>A, NCBI refSNP ID=rs12649641; Danish white subjects
RGD PMID:17019604 PMID:17447163 RGD:10448938 RGD:1642379
NCBI chrNW_004936576:1,932,526...1,939,560
G
Npy5r neuropeptide Y receptor Y5
susceptibility
ISO DNA:SNP:utr (Y5R1c52) (human)
RGD CTD PMID:10849579 PMID:17447163 PMID:23900445 RGD:10448938 RGD:1625493 RGD:405650675
NCBI chrNW_004936555:2,248,699...2,252,637
G
Nqo1 NAD(P)H quinone dehydrogenase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:17405841
NCBI chrNW_004936475:19,771,384...19,785,034
G
Nr0b2 nuclear receptor subfamily 0 group B member 2
ISO ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: NR0B2-related condition | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity, mild, early-onset
OMIM ClinVar
PMID:2716767 PMID:11136233 PMID:15459958 PMID:20233523 PMID:25741868 PMID:28492532 PMID:33094510 PMID:35460704 More...
NCBI chrNW_004936474:11,316,857...11,319,669
G
Nr1h2 nuclear receptor subfamily 1 group H member 2
disease_progression
ISO DNA:polymorphism:multiple
RGD PMID:17108812 PMID:20939869 PMID:25612518 RGD:13506790 RGD:15045599 RGD:1626248
NCBI chrNW_004936889:223,137...229,968
G
Nr1h3 nuclear receptor subfamily 1 group H member 3
disease_progression
ISO DNA:polymorphism:multiple
RGD PMID:17108812 PMID:25612518 RGD:15045599 RGD:1626248
NCBI chrNW_004936562:1,937,665...1,946,680
G
Nr1h4 nuclear receptor subfamily 1 group H member 4
disease_progression
ISO mRNA:increased expression:liver (rat)
RGD PMID:25612518 RGD:15045599
NCBI chrNW_004936492:13,315,265...13,365,186
G
Nr1i2 nuclear receptor subfamily 1 group I member 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20869355
NCBI chrNW_004936536:6,691,590...6,726,421
G
Nr1i3 nuclear receptor subfamily 1 group I member 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20869355
NCBI chrNW_004936903:527,838...533,930
G
Nr3c1 nuclear receptor subfamily 3 group C member 1
no_association
ISO associated with Depressive Disorder, Major;DNA:SNP:intron:IVS2+646C>G (human)
RGD PMID:16725041 PMID:18246526 PMID:20723946 RGD:1601498 RGD:4892206 RGD:7174717
NCBI chrNW_004936504:10,960,069...11,056,834
G
Nr3c2 nuclear receptor subfamily 3 group C member 2
treatment
ISO RGD PMID:30298849 RGD:401960083
NCBI chrNW_004936535:1,139,687...1,467,469
G
Nrf1 nuclear respiratory factor 1
treatment
ISO mRNA:decreased expression:left ventricle myocardium (rat)
RGD PMID:33310031 RGD:329955450
NCBI chrNW_004936579:5,424,049...5,560,355
G
Nrxn1 neurexin 1
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936508:1,889,640...2,954,039
G
Ntrk2 neurotrophic receptor tyrosine kinase 2
ISO ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936680:267,850...621,467
G
Nucb2 nucleobindin 2
ISO protein:increased expression:adipose tissue:
RGD PMID:22641054 RGD:9831187
NCBI chrNW_004936528:1,726,879...1,763,483
G
Nudc nuclear distribution C, dynein complex regulator
ISO ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: NR0B2-related condition | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity, mild, early-onset | ClinVar Annotator: match by term: UCP3-related condition
ClinVar
PMID:2716767 PMID:11136233 PMID:15459958 PMID:20233523 PMID:25741868 PMID:28492532 PMID:33094510 PMID:35460704 More...
NCBI chrNW_004936474:11,327,986...11,341,357
G
Ogg1 8-oxoguanine DNA glycosylase
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29709520
NCBI chrNW_004936602:3,411,106...3,418,826
G
Oprm1 opioid receptor mu 1
treatment
ISO DNA:hypermethylation:promoter, peripheral blood mononuclear cell
RGD PMID:16876155 PMID:31258545 RGD:401827956 RGD:401842391
NCBI chrNW_004936489:6,506,207...6,567,136
G
Otc ornithine transcarbamylase
ISO protein:increased activity:liver (rat)
RGD PMID:1330956 RGD:4144087
NCBI chrNW_004936502:5,234,253...5,291,891
G
Oxct1 3-oxoacid CoA-transferase 1
ISO mRNA:decreased expression:thalamus (rat)
RGD PMID:19219059 RGD:2326191
NCBI chrNW_004936518:924,840...1,057,201
G
Pacs1 phosphofurin acidic cluster sorting protein 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:23563609
NCBI chrNW_004936599:3,345,242...3,379,634
G
Parp1 poly(ADP-ribose) polymerase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20561897
NCBI chrNW_004936526:3,102,468...3,147,601
G
Pax8 paired box 8
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936783:1,523,658...1,553,464
G
Pck1 phosphoenolpyruvate carboxykinase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936530:361,872...367,005
G
Pcsk1 proprotein convertase subtilisin/kexin type 1
ISO ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity | ClinVar Annotator: match by term: Monogenic Obesity | ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868 PMID:28492532
NCBI chrNW_004936523:7,009,966...7,050,300
G
Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor
ISO protein:increased expression:brainstem
RGD PMID:11680901 PMID:15012590 RGD:1642350 RGD:1642351
NCBI chrNW_004936721:783,973...787,712
G
Pde3a phosphodiesterase 3A
ISO mRNA:decreased expression:heart
RGD PMID:9648839 RGD:2300415
NCBI chrNW_004936548:5,758,634...6,072,195
G
Pde9a phosphodiesterase 9A
treatment
ISO RGD PMID:34618683 RGD:242170038
NCBI chrNW_004936500:1,201,843...1,266,818
G
Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1
ISO protein:decreased activity:circulating lymphocytes
RGD PMID:15897476 RGD:1642637
NCBI chrNW_004936544:7,008,882...7,017,446
G
Pdx1 pancreatic and duodenal homeobox 1
ISO mRNA:increased expression:exocrine pancreas (human)
RGD PMID:15979049 RGD:1625044
NCBI chrNW_004936472:23,102,534...23,107,127
G
Pex11a peroxisomal biogenesis factor 11 alpha
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:30585412
NCBI chrNW_004936483:15,474,484...15,480,527
G
Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936484:8,356,523...8,434,529
G
Pgf placental growth factor
ISO associated with pancreatic cancer;protein:increased expression:plasma (human)
RGD PMID:16020476 PMID:16769024 PMID:26861455 RGD:14349030 RGD:1642384 RGD:1642385
NCBI chrNW_004936488:4,098,187...4,111,108
G
Pgr progesterone receptor
ISO DNA:polymorphism:CDS:PROGINS polymorphism, combination of long polyglutamine repeat in NCOA3 and homozygous A1/A1 PGR PROGINS genotype associated with obesity in 301 postmenopausal women with breast cancer
RGD PMID:14557830 RGD:1642050
NCBI chrNW_004936551:6,498,553...6,573,212
G
Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ISO RGD PMID:21949398 RGD:6482700
NCBI chrNW_004936479:17,084,006...17,112,264
G
Pik3r1 phosphoinositide-3-kinase regulatory subunit 1
ISO protein:decreased expression:soleus
RGD PMID:9399964 PMID:16123202 RGD:1625218 RGD:1625220
NCBI chrNW_004936480:1,188,408...1,273,210
G
Pklr pyruvate kinase L/R
ISO mRNA, protein:decreased expression:liver
RGD PMID:12958186 RGD:1625583
NCBI chrNW_004936580:4,770,977...4,799,316
G
Plat plasminogen activator, tissue type
ISO RGD PMID:12818410 RGD:2311677
NCBI chrNW_004936785:476,200...503,371
G
Plaur plasminogen activator, urokinase receptor
ISO RGD PMID:21372607 RGD:6484121
NCBI chrNW_004936706:840,968...855,552
G
Plin1 perilipin 1
susceptibility
ISO DNA:snp:intron:g.11482G>A (human)
RGD CTD PMID:11371650 PMID:15001633 PMID:15985482 RGD:1581041 RGD:737723
NCBI chrNW_004936483:15,457,299...15,470,674
G
Plscr3 phospholipid scramblase 3
ISO OMIM:601665
MouseDO
NCBI chrNW_004936595:674,754...679,979
G
Pmch pro-melanin concentrating hormone
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:12355323 PMID:12453827 PMID:15363890 RGD:1624360 RGD:1642486
NCBI chrNW_004936492:11,947,489...11,948,896
G
Pnpla3 patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
ISO RGD PMID:11431482 RGD:14985224
NCBI chrNW_004936718:1,620,034...1,638,315
G
Pogz pogo transposable element derived with ZNF domain
ISO ClinVar Annotator: match by term: Obesity
ClinVar
NCBI chrNW_004936580:1,613,425...1,650,849
G
Pomc proopiomelanocortin
susceptibility
ISO ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity, early-onset, susceptibility to
OMIM ClinVar
PMID:8302318 PMID:9620771 PMID:9768693 PMID:10193875 PMID:11941477 PMID:12165561 PMID:14557433 PMID:16459314 PMID:18091355 PMID:18697863 PMID:19221669 PMID:20349035 PMID:23293326 PMID:23649472 PMID:25741868 PMID:27906547 PMID:28492532 PMID:29970488 More...
NCBI chrNW_004936493:7,060,747...7,065,276
G
Pon2 paraoxonase 2
ISO protein:increased expression:white adipose tissue
RGD PMID:21365757 RGD:8661255
NCBI chrNW_004936585:4,862,378...4,894,061
G
Ppara peroxisome proliferator activated receptor alpha
treatment
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:11089532 PMID:30738174 PMID:33310031 RGD:329955450
NCBI chrNW_004936629:3,672,445...3,725,645
G
Ppard peroxisome proliferator activated receptor delta
ISO CTD Direct Evidence: therapeutic
CTD PMID:16168052 PMID:20176998
NCBI chrNW_004936476:23,799,285...23,886,606
G
Pparg peroxisome proliferator activated receptor gamma
susceptibility
ISO DNA:polymorphism
OMIM RGD ClinVar
PMID:9467001 PMID:9792554 PMID:10381354 PMID:10523018 PMID:10622252 PMID:10690291 PMID:10851250 PMID:14569127 PMID:14616762 PMID:14671186 PMID:15254591 PMID:18683148 PMID:22461176 PMID:25157153 PMID:25741868 PMID:28492532 PMID:30298849 More...
RGD:2301847 RGD:401960083
NCBI chrNW_004936602:1,230,907...1,368,588
G
Ppargc1a PPARG coactivator 1 alpha
treatment
ISO mRNA:increased expression:retroperitoneal fat pad (rat)
RGD PMID:22401878 PMID:23180161 PMID:23256146 PMID:33310031 RGD:329955450 RGD:7241848 RGD:7242011 RGD:7242183
NCBI chrNW_004936477:4,881,230...5,488,208
G
Ppargc1b PPARG coactivator 1 beta
resistance
ISO DNA:polymorphism: :p.A203P
RGD ClinVar PMID:15863669 RGD:1642501
NCBI chrNW_004936504:5,099,334...5,198,279
G
Ppia peptidylprolyl isomerase A
ISO mRNA:increased expression:blood (human)
RGD PMID:32496587 RGD:150383342
NCBI chrNW_004936478:19,669,727...19,673,355
G
Ppm1l protein phosphatase, Mg2+/Mn2+ dependent 1L
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:18344982
NCBI chrNW_004936708:724,878...1,006,405
G
Prg2 proteoglycan 2, pro eosinophil major basic protein
ISO mRNA:decreased expression:placenta (human)
RGD PMID:28125591 RGD:40902990
NCBI chrNW_004936581:5,101,041...5,103,175
G
Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29367455
NCBI chrNW_004936541:7,845,876...7,863,677
G
Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20975297
NCBI chrNW_004936479:16,894,068...16,988,879
G
Prkcb protein kinase C beta
ISO mRNA, protein:increased expression:mononuclear cell
RGD PMID:17180352 RGD:1625512
NCBI chrNW_004936501:8,410,273...8,729,238
G
Prkcd protein kinase C delta
ISO protein:decreased expression:heart ventricle
RGD PMID:11478406 RGD:1642533
NCBI chrNW_004936473:3,892,625...3,923,467
G
Prkch protein kinase C eta
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:23563609
NCBI chrNW_004936495:5,426,243...5,638,250
G
Prkci protein kinase C iota
ISO OMIM:601665
MouseDO
NCBI chrNW_004936593:2,170,539...2,236,904
G
Prkg1 protein kinase cGMP-dependent 1
ISO protein:increased expression:kidney, glomerulus
RGD PMID:23454089 RGD:7777114
NCBI chrNW_004936787:330,390...1,491,994
G
Prl prolactin
ISO RGD PMID:8388614 RGD:1642559
NCBI chrNW_004936552:7,204,298...7,212,632
G
Prlh prolactin releasing hormone
ISO OMIM:601665
RGD MouseDO PMID:15854142 RGD:1641829
Ensembl chrNW_004936525:770,177...770,863
G
Prlhr prolactin releasing hormone receptor
ISO RGD PMID:15854142 RGD:1641829
NCBI chrNW_004936486:8,177,111...8,181,663
G
Prmt7 protein arginine methyltransferase 7
ISO ClinVar Annotator: match by term: Obesity disorder
ClinVar PMID:25741868 PMID:26437029 PMID:27718516 PMID:28492532 PMID:28902392
NCBI chrNW_004936475:18,632,022...18,667,515
G
Prox1 prospero homeobox 1
ISO OMIM:601665
MouseDO
NCBI chrNW_004936628:4,185,712...4,240,680
G
Ptgs2 prostaglandin-endoperoxide synthase 2
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:21156398 PMID:21978752 RGD:5508307
NCBI chrNW_004936481:3,821,564...3,828,086
G
Ptpn1 protein tyrosine phosphatase non-receptor type 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:10744717 PMID:20075852
NCBI chrNW_004936514:4,065,455...4,083,847
G
Ptprf protein tyrosine phosphatase receptor type F
ISO protein:increased expression:skeletal muscle:increased 42% in insulin-resistant obese (fa/fa) and 50% in diabetic (ZDF/Drt-fa/fa) Zucker rats (P<0.05)
RGD PMID:7666792 PMID:7769120 PMID:9218523 RGD:1642727 RGD:1642732 RGD:1642733
NCBI chrNW_004936474:24,908,103...24,984,678
G
Pyy peptide YY
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:10898754 PMID:11825645 PMID:16368708
NCBI chrNW_004936541:470,806...471,518
G
Rab21 RAB21, member RAS oncogene family
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936568:814,647...846,426
G
Rai1 retinoic acid induced 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:15459175 PMID:19116176
NCBI chrNW_004936741:1,332,353...1,408,116
G
Rarres2 retinoic acid receptor responder 2
ISO protein:increased expression:serum:
RGD PMID:30873215 PMID:31284705 RGD:15036824 RGD:15036825
NCBI chrNW_004936527:5,949,161...5,952,367
G
Rb1 RB transcriptional corepressor 1
ISO mRNA:decreased expression:adipose tissue
RGD PMID:23315497 RGD:8547988
NCBI chrNW_004936565:1,596,227...1,746,706
G
Rbp4 retinol binding protein 4
ameliorates
ISO mRNA, protein:decreased expression:adipose tissue, serum
RGD PMID:17292720 PMID:18401839 PMID:21585349 RGD:2302016 RGD:329845862 RGD:329853312
NCBI chrNW_004936601:1,401,215...1,410,195
G
Rela RELA proto-oncogene, NF-kB subunit
ISO RGD PMID:18356846 RGD:2298856
NCBI chrNW_004936599:3,800,142...3,810,583
G
Ren renin
ISO mRNA:increased expression:abdomen, subcutaneous adipose tissue, mesenchymal stem cell (human)
RGD PMID:22648117 RGD:6784503
NCBI chrNW_004936567:598,044...607,628
G
Retn resistin
ISO mRNA, protein:increased expression:subcutaneous adipose tissue, serum
RGD PMID:11201732 PMID:17598818 PMID:22816026 RGD:7207072 RGD:7207155 RGD:7207158
NCBI chrNW_004936588:4,705,295...4,706,653
G
Rhoa ras homolog family member A
ISO protein:increased expression:membrane, aorta, skeletal muscle
RGD PMID:16267124 RGD:2298881
NCBI chrNW_004936529:1,000,050...1,045,655
G
Rps6kb1 ribosomal protein S6 kinase B1
ISO protein:increased phosphorylation:skeletal muscle
RGD PMID:15604215 RGD:1642978
NCBI chrNW_004936490:3,441,046...3,492,917
G
Rspo1 R-spondin 1
ISO mRNA:decreased expression:ventromedial nucleus of hypothalamus
RGD PMID:30649980 RGD:597830031
NCBI chrNW_004936474:19,826,808...19,846,453
G
Rsrc2 arginine and serine rich coiled-coil 2
ISO ClinVar Annotator: match by term: Obesity
ClinVar
NCBI chrNW_004936558:2,024,414...2,042,550
G
Rxra retinoid X receptor alpha
susceptibility
ISO RGD PMID:15936932 RGD:1643104
NCBI chrNW_004936669:2,735,111...2,763,060
G
Ryr1 ryanodine receptor 1
ISO ClinVar Annotator: match by term: Obesity disorder
ClinVar PMID:25741868 PMID:28492532
NCBI chrNW_004936801:1,185,615...1,298,416
G
Sat1 spermidine/spermine N1-acetyltransferase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936624:756,761...759,979
G
Scaper S-phase cyclin A associated protein in the ER
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868 PMID:30723319
NCBI chrNW_004936471:35,414,507...35,834,438
G
Sdc1 syndecan 1
ISO mRNA:increased expression:liver
RGD PMID:11522680 RGD:1643129
NCBI chrNW_004936493:11,177,804...11,199,678
G
Sdc3 syndecan 3
ISO ClinVar Annotator: match by term: Obesity, association with
OMIM ClinVar PMID:17018662
NCBI chrNW_004936474:14,203,322...14,209,187
G
Selp selectin P
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:altered localization:platelet
RGD PMID:19228864 RGD:2312291
NCBI chrNW_004936481:17,076,660...17,112,501
G
Serpina12 serpin family A member 12
treatment
ISO RGD PMID:16030142 RGD:1547845
NCBI chrNW_004936846:83,727...92,392
G
Serpine1 serpin family E member 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:23819014
NCBI chrNW_004936543:1,032,543...1,040,956
G
Serpinf1 serpin family F member 1
ISO protein:increased expression:serum (rat)
RGD PMID:17491674 PMID:24424059 RGD:2312347 RGD:8633067
NCBI chrNW_004936538:7,885,816...7,898,308
G
Sftpb surfactant protein B
ISO protein:increased expression:lung
RGD PMID:15136884 RGD:4143472
NCBI chrNW_004936712:1,614,979...1,621,207
G
Sh2b1 SH2B adaptor protein 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19079261
NCBI chrNW_004936501:11,840,227...11,849,742
G
Sim1 SIM bHLH transcription factor 1
ISO ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity due to SIM1 deficiency | ClinVar Annotator: match by term: SIM1-related condition | ClinVar Annotator: match by term: UCP3-related condition
ClinVar
PMID:2152513 PMID:16924270 PMID:19401419 PMID:21512513 PMID:23778136 PMID:23778139 PMID:24097297 PMID:25234154 PMID:25741868 PMID:26795956 PMID:28492532 PMID:29216354 PMID:30926952 PMID:30991789 PMID:33434169 More...
NCBI chrNW_004936651:1,841,040...1,911,944
G
Sirt1 sirtuin 1
treatment
ISO CTD Direct Evidence: therapeutic
CTD RGD PMID:24135502 PMID:24184811 PMID:24773342 RGD:9585762 RGD:9586064
NCBI chrNW_004936521:10,296,097...10,316,673
G
Sirt3 sirtuin 3
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:21901160 PMID:23956348 RGD:9586047
NCBI chrNW_004936888:63,131...78,536
G
Sirt6 sirtuin 6
ISO protein:decreased expression:ovary
RGD PMID:24135502 RGD:9586064
NCBI chrNW_004936588:2,387,162...2,394,066
G
Slc10a1 solute carrier family 10 member 1
disease_progression
ISO mRNA:increased expression:liver (rat)
RGD PMID:25612518 RGD:15045599
NCBI chrNW_004936495:12,958,983...12,975,755
G
Slc16a7 solute carrier family 16 member 7
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936646:3,482,148...3,647,466
G
Slc22a1 solute carrier family 22 member 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20956498
NCBI chrNW_004936489:11,534,095...11,556,759
G
Slc22a2 solute carrier family 22 member 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:27401566
NCBI chrNW_004936489:11,605,403...11,627,786
G
Slc22a3 solute carrier family 22 member 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:27401566
NCBI chrNW_004936489:11,693,755...11,774,380
G
Slc27a1 solute carrier family 27 member 1
susceptibility
ISO DNA:gene knockout::Slc27a1-/- mice resistant to diet-induced obesity and metabolic syndrome
RGD PMID:15281014 PMID:16611988 RGD:1642790 RGD:1642794
NCBI chrNW_004936596:3,426,807...3,451,259
G
Slc27a4 solute carrier family 27 member 4
ISO mRNA:increased expression:subcutaneous adipose tissue
RGD PMID:15168018 RGD:1625638
NCBI chrNW_004936487:15,877,075...15,905,752
G
Slc2a1 solute carrier family 2 member 1
treatment
ISO associated with Polycystic Ovary Syndrome
RGD PMID:24842895 RGD:12879503
NCBI chrNW_004936474:24,205,878...24,236,611
G
Slc32a1 solute carrier family 32 member 1
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936561:2,709,580...2,714,313
G
Slc6a1 solute carrier family 6 member 1
ISO RGD PMID:11191352 RGD:1643191
NCBI chrNW_004936602:2,359,151...2,397,346
G
Slc6a14 solute carrier family 6 member 14
susceptibility
ISO DNA:SNPs
RGD PMID:15331564 RGD:1625271
NCBI chrNW_004936479:13,024,831...13,051,908
G
Slc6a3 solute carrier family 6 member 3
no_association
ISO DNA:polymorphism
RGD PMID:12490667 PMID:16674552 RGD:1625653 RGD:1625655
NCBI chrNW_004936815:359,775...400,690
G
Slc9a3 solute carrier family 9 member A3
ISO protein:decreased expression:kidney cortex
RGD PMID:16757903 RGD:1625672
NCBI chrNW_004936815:963,715...999,280
G
Smarca4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868 PMID:28492532
NCBI chrNW_004936659:1,152,846...1,246,718
G
Snap25 synaptosome associated protein 25
ISO OMIM:601665
MouseDO
NCBI chrNW_004936485:9,198,744...9,279,854
G
Socs1 suppressor of cytokine signaling 1
ISO mRNA, protein:increased expression:white fat
RGD PMID:11027633 RGD:2298920
NCBI chrNW_004936530:9,312,965...9,315,593
G
Socs3 suppressor of cytokine signaling 3
ISO DNA:SNP:utr (rs4969170) (human)
RGD PMID:11027633 PMID:15331532 PMID:16920065 PMID:23900445 RGD:1625676 RGD:2298920 RGD:2313790 RGD:405650675
NCBI chrNW_004936594:2,932,297...2,935,358
G
Sod1 superoxide dismutase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:24042701
NCBI chrNW_004936500:10,345,154...10,352,873
G
Sod2 superoxide dismutase 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:16317704 PMID:23956348 PMID:30738174
NCBI chrNW_004936489:11,178,338...11,191,601
G
Sorbs1 sorbin and SH3 domain containing 1
ISO DNA:SNP: :p.T228A (human)
RGD PMID:11532984 RGD:1642744
NCBI chrNW_004936636:3,834,887...4,066,293
G
Sparc secreted protein acidic and cysteine rich
ISO mRNA:increased expression:adipose tissue
RGD PMID:11294850 RGD:2300062
NCBI chrNW_004936515:11,026,156...11,046,812
G
Sqle squalene epoxidase
ISO RGD PMID:15556298 RGD:1581399
NCBI chrNW_004936470:22,726,793...22,752,429
G
Srd5a1 steroid 5 alpha-reductase 1
ISO mRNA:increased expression:liver (rat)
RGD PMID:20098742 RGD:4891511
NCBI chrNW_004936634:758,231...798,809
G
Srebf1 sterol regulatory element binding transcription factor 1
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936741:1,408,669...1,419,717
G
Srebf2 sterol regulatory element binding transcription factor 2
ISO protein:increased expression:fat cell, nucleus
RGD PMID:9786926 RGD:2308843
NCBI chrNW_004936492:115,923...174,614
G
Stat3 signal transducer and activator of transcription 3
ISO DNA:SNP:rs4796793 (human)
RGD PMID:23397595 PMID:23900445 RGD:10411893 RGD:405650675
NCBI chrNW_004936490:17,119,189...17,178,402
G
Stat4 signal transducer and activator of transcription 4
treatment
ISO RGD PMID:20978234 RGD:5509594
NCBI chrNW_004936506:7,091,982...7,185,938
G
Stk11 serine/threonine kinase 11
ISO protein:decreased expression:gastrocnemius
RGD PMID:16352671 RGD:1601389
NCBI chrNW_004936588:579,816...601,033
G
Sts steroid sulfatase
ISO CTD Direct Evidence: therapeutic
CTD PMID:24497646
NCBI chrNW_004936644:1,328,327...1,395,856
G
Sucla2 succinate-CoA ligase ADP-forming subunit beta
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936565:1,313,150...1,355,693
G
Suclg2 succinate-CoA ligase GDP-forming subunit beta
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:20882379
NCBI chrNW_004936603:243,113...378,526
G
Szt2 SZT2 subunit of KICSTOR complex
ISO ClinVar Annotator: match by term: Obesity
ClinVar PMID:25741868
NCBI chrNW_004936474:24,788,175...24,837,471
G
Tbc1d1 TBC1 domain family member 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:16893906 PMID:18325908 PMID:18931681
NCBI chrNW_004936482:5,874,358...6,087,474
G
Tbx3 T-box transcription factor 3
ISO ClinVar Annotator: match by term: Obesity disorder
ClinVar PMID:28492532
NCBI chrNW_004936558:7,230,361...7,243,651
G
Tbxa2r thromboxane A2 receptor
ISO mRNA:increased expression:carotid artery
RGD PMID:12409963 RGD:1601447
NCBI chrNW_004936588:2,040,712...2,044,635
G
Tfam transcription factor A, mitochondrial
treatment
ISO mRNA:decreased expression:left ventricle myocardium (rat)
RGD PMID:21862610 PMID:33310031 RGD:329955450 RGD:5683906
NCBI chrNW_004936614:4,595,973...4,605,040
G
Tfrc transferrin receptor
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:17062801 PMID:20882379
NCBI chrNW_004936784:696,738...728,385
G
Tgfb1 transforming growth factor beta 1
severity
ISO protein:increased expression:platelet
RGD PMID:15944724 PMID:16253647 PMID:16477387 RGD:1601561 RGD:1601563 RGD:1601579
NCBI chrNW_004936661:3,742,080...3,758,266
G
Th tyrosine hydroxylase
resistance
ISO DNA:polymorphism:intron:g.1170_1173dupTCAT (human)
RGD PMID:16251897 RGD:1601632
NCBI chrNW_004936794:478,651...486,887
G
Thbd thrombomodulin
severity
ISO protein:increased expression:plasma
RGD PMID:16651309 RGD:1601640
NCBI chrNW_004936620:2,563,900...2,568,117
G
Thbs1 thrombospondin 1
ISO mRNA,protein:increased expression:mononuclear cell, adipose tissue:
RGD PMID:24086512 RGD:9681453
NCBI chrNW_004936471:3,064,466...3,081,125
G
Timp1 TIMP metallopeptidase inhibitor 1
ISO protein:increased expression:plasma
RGD PMID:17512313 RGD:1642026
NCBI chrNW_004936502:13,345,936...13,350,170
G
Tlr2 toll like receptor 2
ISO RGD PMID:18787058 RGD:2312681
NCBI chrNW_004936576:522,234...531,660
G
Tlr4 toll like receptor 4
susceptibility
ISO RGD PMID:17053832 PMID:19144836 RGD:1620653 RGD:2312510
NCBI chrNW_004936487:6,519,140...6,532,018
G
Tmem18 transmembrane protein 18
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:19079261
NCBI chrNW_004936532:369,794...374,936
G
Tnf tumor necrosis factor
treatment
ISO CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9502777 PMID:11328671 PMID:20141834 PMID:24146106 PMID:28843383 PMID:29035695 More...
RGD:10450599 RGD:14975146
NCBI chrNW_004936727:1,936,066...1,937,766
G
Tnfrsf1a TNF receptor superfamily member 1A
ISO protein:increased expression:serum
RGD PMID:12935365 RGD:1624179
NCBI chrNW_004936709:1,407,327...1,421,448
G
Tnfrsf1b TNF receptor superfamily member 1B
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:11782876
NCBI chrNW_004936474:908,414...935,765
G
Trpv1 transient receptor potential cation channel subfamily V member 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:17347480
NCBI chrNW_004936677:277,304...326,907
G
Tsc1 TSC complex subunit 1
ISO DNA:hypermethylation:promoter
RGD PMID:25807795 RGD:11570513
NCBI chrNW_004936487:19,331,183...19,386,841
G
Tub TUB bipartite transcription factor
susceptibility
ISO DNA:splice-site mutation
RGD MouseDO PMID:8612280 PMID:8772727 RGD:1625564 RGD:1625565
NCBI chrNW_004936528:9,829,889...9,912,645
G
Tyk2 tyrosine kinase 2
ISO OMIM:601665
MouseDO
NCBI chrNW_004936659:681,463...704,484
G
Ucn urocortin
treatment
ISO RGD PMID:17932219 RGD:1642774
NCBI chrNW_004936493:5,258,574...5,260,692
G
Ucp1 uncoupling protein 1
no_association
ISO CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD PMID:8968850 PMID:15592485 RGD:1624977
NCBI chrNW_004936535:7,258,146...7,265,475
G
Ucp2 uncoupling protein 2
susceptibility
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:11381268 PMID:17870627 RGD:2313512 RGD:737761
NCBI chrNW_004936498:3,059,700...3,066,112
G
Ucp3 uncoupling protein 3
no_association
ISO DNA:polymorphism:exon (human)
OMIM RGD ClinVar
PMID:9700198 PMID:9769326 PMID:10431807 PMID:10480626 PMID:10618503 PMID:18249216 PMID:21544083 PMID:25741868 PMID:28492532 More...
RGD:2313506 RGD:2313526
NCBI chrNW_004936498:3,082,575...3,095,739
G
Ulk4 unc-51 like kinase 4
ISO ClinVar Annotator: match by term: Obesity
ClinVar
NCBI chrNW_004936473:30,034,159...30,536,450
G
Vcam1 vascular cell adhesion molecule 1
ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD PMID:19260948 RGD:2312763
NCBI chrNW_004936748:785,491...802,791
G
Vgf VGF nerve growth factor inducible
ISO CTD Direct Evidence: therapeutic
CTD PMID:12177191
NCBI chrNW_004936543:1,059,292...1,062,384
G
Vhl von Hippel-Lindau tumor suppressor
ISO associated with hepatocellular carcinoma;RNA:decreased expression:liver:
RGD PMID:31321740 RGD:155882550
NCBI chrNW_004936602:3,135,790...3,140,622
G
Vldlr very low density lipoprotein receptor
susceptibility
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:11557677 PMID:20975297 RGD:1625568
NCBI chrNW_004936503:2,407,040...2,440,366
G
Vwf von Willebrand factor
ISO protein:increased expression:plasma
RGD PMID:16631442 PMID:16739871 RGD:1625710 RGD:1625711
NCBI chrNW_004936709:1,578,137...1,741,877
G
Wnt10b Wnt family member 10B
ISO DNA:SNP:CDS:amino acid C256Y, mutant unable to activate WNT/beta-catenin signaling pathway
RGD PMID:16477437 PMID:17578883 RGD:2300029 RGD:2326237
NCBI chrNW_004936512:6,768,240...6,774,172
G
Wnt3a Wnt family member 3A
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:28242765
NCBI chrNW_004936864:150,742...179,205
G
Xdh xanthine dehydrogenase
treatment
ISO RGD PMID:7616299 RGD:13210504
NCBI chrNW_004936493:1,762,814...1,824,501
G
Zbtb7b zinc finger and BTB domain containing 7B
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936580:4,546,139...4,560,157
G
Zc3h10 zinc finger CCCH-type containing 10
ISO CTD Direct Evidence: therapeutic
CTD PMID:31775033
NCBI chrNW_004936646:528,455...534,267
G
Zfhx3 zinc finger homeobox 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936475:21,005,242...21,235,992
G
Zfr2 zinc finger RNA binding protein 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936588:2,154,277...2,175,308
G
Znf711 zinc finger protein 711
ISO ClinVar Annotator: match by term: Monogenic Obesity
ClinVar PMID:25741868
NCBI chrNW_004936547:5,999,792...6,026,719
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:15199296
NCBI chrNW_004936557:3,358,809...3,403,461
G
LOC101972957 vitamin D 25-hydroxylase
ISO DNA:SNP:CDS: rs12794714 (human)
RGD PMID:34906413 RGD:401900724
NCBI chrNW_004936528:3,881,630...3,897,613
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Ctf1 cardiotrophin 1
ISO MouseDO
NCBI chrNW_004936501:13,286,821...13,291,280
G
Gucy2c guanylate cyclase 2C
ISO MouseDO
NCBI chrNW_004936587:2,742,911...2,811,139
G
Lep leptin
ISO MouseDO
NCBI chrNW_004936479:15,394,966...15,411,334
G
Neil1 nei like DNA glycosylase 1
ISO MouseDO
NCBI chrNW_004936471:34,184,273...34,192,675
G
Ppara peroxisome proliferator activated receptor alpha
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:15309680
NCBI chrNW_004936629:3,672,445...3,725,645
G
Pparg peroxisome proliferator activated receptor gamma
ISO MouseDO
NCBI chrNW_004936602:1,230,907...1,368,588
G
Ppargc1a PPARG coactivator 1 alpha
ISO mRNA:increased expression:gastrocnemius muscle (rat)
RGD PMID:23320128 RGD:7241841
NCBI chrNW_004936477:4,881,230...5,488,208
G
Prkci protein kinase C iota
ISO MouseDO
NCBI chrNW_004936593:2,170,539...2,236,904
G
Sirt3 sirtuin 3
ISO MouseDO
NCBI chrNW_004936888:63,131...78,536
G
Slc2a9 solute carrier family 2 member 9
ISO MouseDO
NCBI chrNW_004936477:16,700,915...16,836,424
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO protein:increased oxidation:cardiac muscle cell
RGD PMID:23997093 RGD:13782087
NCBI chrNW_004936558:3,300,941...3,357,595
G
Bax BCL2 associated X, apoptosis regulator
treatment
ISO RGD PMID:27131981 RGD:13792503
NCBI chrNW_004936664:2,968,103...2,973,652
G
Bcl2 BCL2 apoptosis regulator
treatment
ISO RGD PMID:27131981 RGD:13792503
NCBI chrNW_004936497:2,209,136...2,373,580
G
Fadd Fas associated via death domain
treatment
ISO RGD PMID:27131981 RGD:13792503
NCBI chrNW_004936599:633,501...639,412
G
Fas Fas cell surface death receptor
ISO RGD PMID:30172001 RGD:13792561
NCBI chrNW_004936735:209,369...234,582
G
Lep leptin
ISO OMIM:605552
MouseDO
NCBI chrNW_004936479:15,394,966...15,411,334
G
Lpl lipoprotein lipase
treatment
ISO RGD PMID:26996629 RGD:13794382
NCBI chrNW_004936555:4,084,099...4,108,219
G
Mttp microsomal triglyceride transfer protein
ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 1
ClinVar PMID:8533758 PMID:9671739 PMID:16721486 PMID:25741868 PMID:28492532
NCBI chrNW_004936520:3,337,726...3,417,818
G
Tlr2 toll like receptor 2
susceptibility
ISO RGD PMID:19841034 RGD:15090861
NCBI chrNW_004936576:522,234...531,660
G
Tp53inp1 tumor protein p53 inducible nuclear protein 1
ISO OMIM:605552
MouseDO
NCBI chrNW_004936544:7,882,710...7,891,668
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Ahdc1 AT-hook DNA binding motif containing 1
ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3
ClinVar PMID:25741868 PMID:29696776 PMID:33644933
NCBI chrNW_004936474:11,824,692...11,846,355
G
Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B
ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 | ClinVar Annotator: match by term: CENTRAL OBESITY, TYPE 2 DIABETES, HYPERTENSION, AND EARLY-ONSET CORONARY ARTERY DISEASE | ClinVar Annotator: match by term: DYRK1B-related condition
OMIM ClinVar
PMID:9536098 PMID:17576681 PMID:24827035 PMID:25741868 PMID:28492532 PMID:32041611 More...
NCBI chrNW_004936661:2,436,702...2,444,758
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Phf6 PHD finger protein 6
ISO ClinVar Annotator: match by term: Borjeson-Forssman-Lehmann syndrome | ClinVar Annotator: match by term: MENTAL RETARDATION, X-LINKED, SYNDROMIC, BORJESON-FORSSMAN-LEHMANN TYPE | ClinVar Annotator: match by term: Mental deficiency, epilepsy and endocrine disorders | ClinVar Annotator: match by term: PHF6-related condition
OMIM ClinVar
PMID:12415272 PMID:13871358 PMID:15241480 PMID:15466013 PMID:15580208 PMID:15994862 PMID:18414213 PMID:23906836 PMID:24092917 PMID:24728327 PMID:25099957 PMID:25741868 PMID:25741869 PMID:26467025 PMID:26648834 PMID:27633282 PMID:27698851 PMID:28492532 PMID:28539120 PMID:28554332 PMID:30403997 PMID:30630810 PMID:33772537 PMID:34041787 PMID:35662002 PMID:36008597 PMID:36999477 More...
NCBI chrNW_004936691:716,723...767,960
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Aff4 ALF transcription elongation factor 4
ISO ClinVar Annotator: match by term: AFF4-related condition | ClinVar Annotator: match by term: Cognitive impairment - coarse facies - heart defects - obesity - pulmonary involvement - short stature - skeletal dysplasia syndrome
OMIM ClinVar
PMID:9536098 PMID:17576681 PMID:25730767 PMID:25741868 PMID:28492532 PMID:29758562 PMID:31058441 PMID:34782754 More...
NCBI chrNW_004936647:2,242,476...2,342,409
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Trip12 thyroid hormone receptor interactor 12
ISO ClinVar Annotator: match by term: Clark-Baraitser syndrome | ClinVar Annotator: match by term: TRIP12-related condition
OMIM ClinVar
PMID:3812552 PMID:25363768 PMID:25741868 PMID:27848077 PMID:28251352 PMID:28492532 PMID:28660352 PMID:29758562 PMID:31814248 More...
NCBI chrNW_004936525:6,539,234...6,690,457
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Ankrd46 ankyrin repeat domain 46
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:42,755,799...42,782,479
G
Atp6v1c1 ATPase H+ transporting V1 subunit C1
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,626,523...40,675,435
G
Azin1 antizyme inhibitor 1
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,801,943...40,832,543
G
Baalc BAALC binder of MAP3K1 and KLF4
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,506,596...40,590,537
G
Cthrc1 collagen triple helix repeat containing 1
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,381,215...40,392,105
G
Dcaf13 DDB1 and CUL4 associated factor 13
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,321,103...40,357,001
G
Dcstamp dendrocyte expressed seven transmembrane protein
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:39,664,573...39,671,532
G
Dpys dihydropyrimidinase
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:39,564,431...39,637,394
G
Fbxo43 F-box protein 43
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:43,091,516...43,100,973
G
Fzd6 frizzled class receptor 6
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,416,254...40,454,717
G
Grhl2 grainyhead like transcription factor 2
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:41,856,683...41,961,666
G
Kcns2 potassium voltage-gated channel modifier subfamily S member 2
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:15141358 PMID:16648375 PMID:20461111 PMID:28492532
NCBI chrNW_004936470:44,455,117...44,460,193
G
Klf10 KLF transcription factor 10
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,980,487...40,986,880
G
LOC101970194 cytochrome c oxidase subunit 6C
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:43,269,744...43,280,886
G
Lrp12 LDL receptor related protein 12
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:39,459,395...39,542,125
G
Myo7a myosin VIIA
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:9382091 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532
NCBI chrNW_004936498:5,758,572...5,824,526
G
Ncald neurocalcin delta
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:41,573,238...41,852,349
G
Nipal2 NIPA like domain containing 2
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:44,588,211...44,645,860
G
Odf1 outer dense fiber of sperm tails 1
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:41,069,033...41,078,020
G
Osr2 odd-skipped related transciption factor 2
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:15141358 PMID:16648375 PMID:20461111 PMID:28492532
NCBI chrNW_004936470:44,024,497...44,032,429
G
Pabpc1 poly(A) binding protein cytoplasmic 1
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:42,628,890...42,670,311
G
Polr2k RNA polymerase II, I and III subunit K
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:43,079,377...43,083,251
G
Pop1 POP1 homolog, ribonuclease P/MRP subunit
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:44,676,798...44,710,397
G
Rgs22 regulator of G protein signaling 22
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:43,135,410...43,225,788
G
Rims2 regulating synaptic membrane exocytosis 2
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:39,725,092...40,270,268
G
Rnf19a ring finger protein 19A, RBR E3 ubiquitin protein ligase
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:42,965,790...43,007,487
G
Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:41,354,387...41,401,308
G
Slc25a32 solute carrier family 25 member 32
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:40,357,066...40,370,514
G
Snx31 sorting nexin 31
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:42,684,346...42,743,001
G
Spag1 sperm associated antigen 1
ISO ClinVar Annotator: match by term: Cohen syndrome | ClinVar Annotator: match by term: VPS13B-related condition
ClinVar PMID:25741868 PMID:28492532
NCBI chrNW_004936470:43,015,688...43,078,158
G
Stk3 serine/threonine kinase 3
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:15141358 PMID:16648375 PMID:20461111 PMID:28492532
NCBI chrNW_004936470:44,159,449...44,436,295
G
Ubr5 ubiquitin protein ligase E3 component n-recognin 5
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:41,222,782...41,345,755
G
Vps13b vacuolar protein sorting 13 homolog B
ISO ClinVar Annotator: match by term: Cohen syndrome | ClinVar Annotator: match by term: PEPPER SYNDROME | ClinVar Annotator: match by term: Pepper syndrome | ClinVar Annotator: match by term: VPS13B-related condition
OMIM ClinVar
PMID:9536098 PMID:11169562 PMID:12730828 PMID:15141358 PMID:15154116 PMID:15173253 PMID:15211651 PMID:15498460 PMID:15691367 PMID:15918062 PMID:16199547 PMID:16648375 PMID:16917849 PMID:17383910 PMID:17576681 PMID:17786118 PMID:17990063 PMID:18414213 PMID:18655112 PMID:19006247 PMID:19190672 PMID:19533689 PMID:19763152 PMID:20307669 PMID:20461111 PMID:20656880 PMID:20683995 PMID:20921020 PMID:21330571 PMID:21659346 PMID:21850686 PMID:21865173 PMID:22382802 PMID:22406018 PMID:22527104 PMID:22700954 PMID:22855652 PMID:23033978 PMID:23188044 PMID:23352163 PMID:23757202 PMID:24033266 PMID:24123366 PMID:24311531 PMID:24334746 PMID:24334764 PMID:25060287 PMID:25326635 PMID:25356970 PMID:25472526 PMID:25502226 PMID:25525159 PMID:25533962 PMID:25640679 PMID:25741868 PMID:26104215 PMID:26133662 PMID:26193622 PMID:26395554 PMID:26443248 PMID:26467025 PMID:26539891 PMID:26938784 PMID:27175599 PMID:27353947 PMID:27380831 PMID:27533158 PMID:27829003 PMID:28041643 PMID:28341476 PMID:28492532 PMID:28559085 PMID:28631888 PMID:28832562 PMID:29149870 PMID:29431110 PMID:29453417 PMID:29634382 PMID:29706646 PMID:29758347 PMID:30138938 PMID:30290665 PMID:30602132 PMID:30792901 PMID:30843084 PMID:31444703 PMID:31580008 PMID:31736247 PMID:31943017 PMID:31965297 PMID:32170714 PMID:32384097 PMID:32483926 PMID:32505691 PMID:32581362 PMID:32860008 PMID:32919079 PMID:32959227 PMID:33023636 PMID:33025479 PMID:33217554 PMID:33584783 PMID:33994118 PMID:34006472 PMID:34353225 PMID:34425733 PMID:34426522 PMID:35052368 PMID:35488281 PMID:35599849 PMID:35690661 More...
NCBI chrNW_004936470:43,281,905...43,952,523
G
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:42,444,671...42,470,548
G
Zfpm2 zinc finger protein, FOG family member 2
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:38,432,894...38,857,656
G
Znf706 zinc finger protein 706
ISO ClinVar Annotator: match by term: Cohen syndrome
ClinVar PMID:28492532
NCBI chrNW_004936470:42,245,657...42,253,492
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Lep leptin
ISO ClinVar Annotator: match by term: LEP-related condition | ClinVar Annotator: match by term: Leptin dysfunction | ClinVar Annotator: match by term: Obesity due to congenital leptin deficiency
OMIM ClinVar
PMID:9202122 PMID:9500540 PMID:9745435 PMID:12393845 PMID:15070752 PMID:15472169 PMID:15937081 PMID:19427251 PMID:20140086 PMID:20307995 PMID:25551525 PMID:25741868 PMID:26186301 PMID:27075752 PMID:28209183 PMID:28377240 PMID:28492532 PMID:32349990 PMID:37314706 More...
NCBI chrNW_004936479:15,394,966...15,411,334
G
Lepr leptin receptor
ISO ClinVar Annotator: match by term: Obesity due to congenital leptin deficiency
ClinVar PMID:25741868
NCBI chrNW_004936591:5,771,371...5,846,177
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Irak1bp1 interleukin 1 receptor associated kinase 1 binding protein 1
ISO ClinVar Annotator: match by term: DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHISM | ClinVar Annotator: match by term: PHIP-related disorder
ClinVar
PMID:9536098 PMID:17576681 PMID:23033978 PMID:25741868 PMID:28492532 PMID:29209020 PMID:31167805 PMID:32801363 PMID:33004838 PMID:37961033 PMID:39825153 More...
NCBI chrNW_004936510:11,220,194...11,242,485
G
Phip pleckstrin homology domain interacting protein
ISO ClinVar Annotator: match by term: DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHISM | ClinVar Annotator: match by term: PHIP-related disorder
OMIM ClinVar
PMID:9536098 PMID:16199547 PMID:17576681 PMID:23033978 PMID:25741868 PMID:27479843 PMID:27900362 PMID:28191889 PMID:28263302 PMID:28492532 PMID:29209020 PMID:30018425 PMID:30564305 PMID:31167805 PMID:32492392 PMID:32801363 PMID:33004838 PMID:34773373 PMID:37961033 PMID:39825153 More...
NCBI chrNW_004936510:11,076,790...11,198,483
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Lepr leptin receptor
ISO ClinVar Annotator: match by term: LEPR-related condition | ClinVar Annotator: match by term: Leptin receptor deficiency
OMIM ClinVar
PMID:8666155 PMID:9144432 PMID:9287054 PMID:9537324 PMID:9860295 PMID:11354636 PMID:11380591 PMID:11443193 PMID:12006639 PMID:12646666 PMID:15585384 PMID:16284652 PMID:17229951 PMID:17785359 PMID:18212354 PMID:18490929 PMID:18703626 PMID:21393862 PMID:21744741 PMID:22331430 PMID:22810975 PMID:23616257 PMID:23760429 PMID:24319006 PMID:24611737 PMID:25741868 PMID:25751111 PMID:26094658 PMID:26467025 PMID:28432296 PMID:28492532 PMID:29970488 PMID:30926952 PMID:31237021 PMID:33221380 PMID:33660144 PMID:34097736 PMID:37140700 More...
NCBI chrNW_004936591:5,771,371...5,846,177
G
Leprot leptin receptor overlapping transcript
ISO ClinVar Annotator: match by term: Leptin receptor deficiency
ClinVar PMID:25741868 PMID:28492532
NCBI chrNW_004936692:2,840,461...2,850,756
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Eif2s3 eukaryotic translation initiation factor 2 subunit gamma
ISO ClinVar Annotator: match by term: EIF2S3-related condition | ClinVar Annotator: match by term: MEHMO syndrome
OMIM ClinVar
PMID:23063529 PMID:25741868 PMID:25741869 PMID:27333055 PMID:28055140 PMID:28492532 PMID:30878599 More...
NCBI chrNW_004936624:516,206...535,749
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Acss2 acyl-CoA synthetase short chain family member 2
treatment
ISO RGD PMID:22384010 RGD:13831306
NCBI chrNW_004936561:5,794,685...5,842,619
G
Adcy3 adenylate cyclase 3
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29311637
NCBI chrNW_004936493:7,250,194...7,333,433
G
Ager advanced glycosylation end-product specific receptor
treatment
ISO RGD PMID:22828946 RGD:7243249
NCBI chrNW_004936727:1,418,342...1,422,005
G
Apln apelin
ISO protein:increased expression:plasma
RGD PMID:15970339 PMID:19756893 RGD:1600932 RGD:2313938
NCBI chrNW_004936479:1,889,930...1,899,811
G
Aqp7 aquaporin 7
ISO mRNA:decreased expression:subcutaneous adipose tissue
RGD PMID:17566090 RGD:1626289
NCBI chrNW_004936524:1,898,635...1,915,078
G
Bbs4 Bardet-Biedl syndrome 4
susceptibility
ISO DNA:SNPs
RGD PMID:17003356 RGD:1601311
NCBI chrNW_004936471:31,962,500...32,019,516
G
Bdnf brain derived neurotrophic factor
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:21708048
NCBI chrNW_004936540:5,530,081...5,582,765
G
Cck cholecystokinin
ISO protein:decreased expression:plasma:associated with Metabolic Syndrome X (MeSH:D024821)
RGD PMID:17443025 RGD:1625798
NCBI chrNW_004936695:2,776,705...2,782,280
G
Cpe carboxypeptidase E
ISO mRNA:increased expression:visceral abdominal fat:significantly higher expression in visceral fat than subcutaneous fat of morbidly obese subjects
RGD PMID:12530526 RGD:1626182
NCBI chrNW_004936555:531,842...641,905
G
Ctnnbl1 catenin beta like 1
no_association
ISO DNA:snps:introns:IVS7+3134G>T, IVS7-79A>G (rs6013029, rs6020846) (human)
RGD PMID:19228371 PMID:19245693 RGD:9850251 RGD:9850253
NCBI chrNW_004936561:3,434,232...3,589,341
G
Ghrl ghrelin and obestatin prepropeptide
ISO RGD PMID:19188925 RGD:2313745
NCBI chrNW_004936602:3,037,862...3,044,863
G
Hif1a hypoxia inducible factor 1 subunit alpha
ISO mRNA:increased expression:subcutaneous adipose tissue
RGD PMID:16046292 RGD:1626320
NCBI chrNW_004936495:5,770,988...5,816,157
G
Il1rn interleukin 1 receptor antagonist
ISO protein:increased expression:serum
RGD PMID:11889184 RGD:1626666
NCBI chrNW_004936783:1,447,158...1,466,331
G
Kcnma1 potassium calcium-activated channel subfamily M alpha 1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:21708048
NCBI chrNW_004936521:2,000,113...2,706,010
G
Ksr2 kinase suppressor of ras 2
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:29273807
NCBI chrNW_004936558:4,786,148...5,146,062
G
Lep leptin
ISO CTD Direct Evidence: marker/mechanism|therapeutic
CTD PMID:9500540 PMID:15070752
NCBI chrNW_004936479:15,394,966...15,411,334
G
Lepr leptin receptor
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:9537324
NCBI chrNW_004936591:5,771,371...5,846,177
G
LOC101973029 cytochrome P450 2E1
ISO protein:increased activity::3x higher activity in morbidly obese subjects compared to non-obese, activity decreased proportionally with weight loss, activity measured as total oral chlorzoxazone clearance
RGD PMID:12883487 RGD:1626305
NCBI chrNW_004936486:19,691,822...19,702,684
G
Lpin1 lipin 1
ISO RGD PMID:17563064 RGD:1641822
NCBI chrNW_004936532:7,596,279...7,654,139
G
Mc4r melanocortin 4 receptor
ISO CTD Direct Evidence: marker/mechanism
CTD RGD PMID:11443223 PMID:12588803 PMID:29273807 PMID:29311635 RGD:1600750 RGD:1600755
NCBI chrNW_004936497:4,636,370...4,638,205
G
Mchr1 melanin concentrating hormone receptor 1
onset
ISO DNA:SNP:promoter
RGD PMID:16186414 RGD:1624359
NCBI chrNW_004936492:1,153,895...1,156,980
G
Nppb natriuretic peptide B
ISO protein:increased expression:serum
RGD PMID:17273651 RGD:1642195
NCBI chrNW_004936474:683,325...684,662
G
Npy2r neuropeptide Y receptor Y2
ISO DNA:SNP:CDS:NCBI refSNP IDs=rs1047214, rs2880415 coding for silent Ile variants; Pima Indians, males only
RGD PMID:15855352 RGD:1642381
NCBI chrNW_004936576:1,932,526...1,939,560
G
Ntrk2 neurotrophic receptor tyrosine kinase 2
onset
ISO protein:substitution:Y722C;severe early-onset
RGD PMID:16702999 RGD:1626135
NCBI chrNW_004936680:267,850...621,467
G
Pparg peroxisome proliferator activated receptor gamma
ISO ClinVar Annotator: match by term: Morbid obesity
ClinVar PMID:9753710 PMID:10690291 PMID:25157153 PMID:25741868 PMID:28492532
NCBI chrNW_004936602:1,230,907...1,368,588
G
Ucp3 uncoupling protein 3
ISO ClinVar Annotator: match by term: OBESITY, SEVERE
ClinVar PMID:9769326 PMID:25741868 PMID:28492532
NCBI chrNW_004936498:3,082,575...3,095,739
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Cep19 centrosomal protein 19
ISO ClinVar Annotator: match by term: CEP19-related condition | ClinVar Annotator: match by term: Morbid obesity and spermatogenic failure
OMIM ClinVar PMID:24268657 PMID:25741868 PMID:28492532
NCBI chrNW_004936784:1,284,215...1,289,362
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Inpp5e inositol polyphosphate-5-phosphatase E
ISO ClinVar Annotator: match by term: INPP5E-related condition | ClinVar Annotator: match by term: MORM syndrome
OMIM ClinVar
PMID:9536098 PMID:15786477 PMID:17576681 PMID:19668215 PMID:19668216 PMID:23034536 PMID:23386033 PMID:23847139 PMID:25741868 PMID:25818971 PMID:25999675 PMID:26075876 PMID:26092869 PMID:26748598 PMID:27081510 PMID:27353947 PMID:27401686 PMID:28125082 PMID:28454995 PMID:28492532 PMID:28497568 PMID:28559085 PMID:28771248 PMID:29052317 PMID:29186038 PMID:29230161 PMID:29555955 PMID:29915382 PMID:29987673 PMID:30202406 PMID:32483926 PMID:33749171 PMID:34188062 PMID:34234304 PMID:34906470 PMID:36460718 PMID:36909829 More...
NCBI chrNW_004936669:1,377,005...1,385,287
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Ahcy adenosylhomocysteinase
ISO ClinVar Annotator: match by term: Obesity and hypopigmentation
ClinVar PMID:36536132
NCBI chrNW_004936561:6,314,797...6,333,961
G
Asip agouti signaling protein
ISO ClinVar Annotator: match by term: Obesity and hypopigmentation
ClinVar PMID:36536132
NCBI chrNW_004936561:6,341,667...6,346,440
G
Itch itchy E3 ubiquitin protein ligase
ISO ClinVar Annotator: match by term: Obesity and hypopigmentation
ClinVar PMID:36536132
NCBI chrNW_004936561:6,140,236...6,265,734
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Ntrk2 neurotrophic receptor tyrosine kinase 2
ISO ClinVar Annotator: match by term: NTRK2-related condition | ClinVar Annotator: match by term: Obesity, hyperphagia, and developmental delay
OMIM ClinVar
PMID:9536098 PMID:15494731 PMID:17576681 PMID:25741868 PMID:27884935 PMID:28492532 PMID:29100083 PMID:35061034 More...
NCBI chrNW_004936680:267,850...621,467
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Apoa1 apolipoprotein A1
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:25137265
NCBI chrNW_004936542:2,111,055...2,112,626
G
Apoa5 apolipoprotein A5
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:25137265
NCBI chrNW_004936542:2,069,683...2,071,344
G
Cetp cholesteryl ester transfer protein
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:25137265
NCBI chrNW_004936475:9,115,126...9,133,071
G
Fto FTO alpha-ketoglutarate dependent dioxygenase
treatment
ISO DNA:SNP: :rs17817449 (human)
RGD CTD PMID:25137265 PMID:26849546 RGD:11054066
NCBI chrNW_004936475:6,321,725...6,689,410
G
Gpr17 G protein-coupled receptor 17
ISO CTD Direct Evidence: marker/mechanism
CTD PMID:34144038
NCBI chrNW_004936469:43,652,244...43,656,661
G
Rbp4 retinol binding protein 4
ISO protein:increased expression:blood plasma (human)
RGD PMID:25356519 RGD:329853302
NCBI chrNW_004936601:1,401,215...1,410,195
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Atp10a ATPase phospholipid transporting 10A (putative)
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936471:40,868,114...40,976,707
G
Gabra5 gamma-aminobutyric acid type A receptor subunit alpha5
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936471:39,781,451...39,856,766
G
Gabrb3 gamma-aminobutyric acid type A receptor subunit beta3
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936471:39,791,633...40,193,049
G
Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma3
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936471:39,184,683...39,256,439
G
Ghrl ghrelin and obestatin prepropeptide
ISO RGD PMID:15057669 RGD:12905043
NCBI chrNW_004936602:3,037,862...3,044,863
G
Hcrt hypocretin neuropeptide precursor
ISO protein:decreased expression:cerebrospinal fluid
RGD PMID:15613151 RGD:1600935
NCBI chrNW_004936490:17,007,001...17,008,363
G
Herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:25741868 PMID:28492532 PMID:28631899
NCBI chrNW_004936471:38,419,147...38,606,312
G
Htr2c 5-hydroxytryptamine receptor 2C
ISO OMIM:176270
MouseDO
NCBI chrNW_004936499:1,002,083...1,109,446
G
Magel2 MAGE family member L2
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:25741868 PMID:27195816 PMID:28281571 PMID:28492532 PMID:28631899
NCBI chrNW_004936805:882,296...886,442
G
Mkrn3 makorin ring finger protein 3
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936805:933,791...936,023
G
Ndn necdin, MAGE family member
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:25741868 PMID:28631899
NCBI chrNW_004936805:849,218...850,894
G
Oca2 OCA2 melanosomal transmembrane protein
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936471:38,612,450...38,952,150
G
Snrpn small nuclear ribonucleoprotein polypeptide N
susceptibility
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar RGD PMID:8723064 PMID:28631899 RGD:1601354
NCBI chrNW_004936805:86,244...91,074
G
Snurf SNRPN upstream open reading frame
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936805:88,553...105,497
G
Ube3a ubiquitin protein ligase E3A
ISO ClinVar Annotator: match by term: Prader-Willi syndrome
ClinVar PMID:28631899
NCBI chrNW_004936471:41,187,665...41,290,345
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Pomc proopiomelanocortin
susceptibility
ISO ClinVar Annotator: match by term: Obesity, adrenal insufficiency, and red hair due to POMC deficiency | ClinVar Annotator: match by term: POMC-related condition | ClinVar Annotator: match by term: Proopiomelanocortin deficiency
OMIM ClinVar
PMID:8302318 PMID:9620771 PMID:9768693 PMID:10193875 PMID:10652501 PMID:11941477 PMID:12165561 PMID:14557433 PMID:16459314 PMID:18091355 PMID:18697863 PMID:18765507 PMID:19221669 PMID:20349035 PMID:23293326 PMID:23649472 PMID:24890885 PMID:25741868 PMID:27906547 PMID:28492532 PMID:29970488 PMID:34097736 PMID:35574020 More...
NCBI chrNW_004936493:7,060,747...7,065,276
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Cast calpastatin
ISO ClinVar Annotator: match by term: OBESITY AND ENDOCRINOPATHY DUE TO IMPAIRED PROCESSING OF PROHORMONES | ClinVar Annotator: match by term: Obesity due to prohormone convertase I deficiency | ClinVar Annotator: match by term: PCSK1-related condition | ClinVar Annotator: match by term: Proprotein convertase 1/3 deficiency
ClinVar
PMID:9207799 PMID:14617756 PMID:16199547 PMID:17595246 PMID:22210313 PMID:23383060 PMID:23562752 PMID:23800642 PMID:24041679 PMID:24135795 PMID:24280991 PMID:24932808 PMID:25272002 PMID:25741868 PMID:26207343 PMID:26786350 PMID:27187081 PMID:27391121 PMID:28377240 PMID:28492532 PMID:30383237 PMID:35574020 More...
NCBI chrNW_004936523:6,688,153...6,798,184
G
Pcsk1 proprotein convertase subtilisin/kexin type 1
ISO ClinVar Annotator: match by term: OBESITY AND ENDOCRINOPATHY DUE TO IMPAIRED PROCESSING OF PROHORMONES | ClinVar Annotator: match by term: Obesity due to prohormone convertase I deficiency | ClinVar Annotator: match by term: PCSK1-related condition | ClinVar Annotator: match by term: Proprotein convertase 1/3 deficiency
OMIM ClinVar
PMID:9207799 PMID:14617756 PMID:16199547 PMID:17595246 PMID:22210313 PMID:23383060 PMID:23562752 PMID:23800642 PMID:24041679 PMID:24135795 PMID:24280991 PMID:24932808 PMID:25272002 PMID:25741868 PMID:26207343 PMID:26786350 PMID:27187081 PMID:27391121 PMID:28377240 PMID:28492532 PMID:30383237 PMID:35574020 More...
NCBI chrNW_004936523:7,009,966...7,050,300
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Ric3 RIC3 acetylcholine receptor chaperone
ISO ClinVar Annotator: match by term: Retinal dystrophy and obesity | ClinVar Annotator: match by term: TUB-related condition
ClinVar
PMID:9536098 PMID:16199547 PMID:17576681 PMID:24375934 PMID:25741868 PMID:28492532 PMID:31785789 PMID:32037395 PMID:33057194 PMID:34906470 PMID:36498982 More...
NCBI chrNW_004936528:9,790,594...9,829,120
G
Tub TUB bipartite transcription factor
ISO ClinVar Annotator: match by term: Retinal dystrophy and obesity | ClinVar Annotator: match by term: TUB-related condition
OMIM ClinVar
PMID:9536098 PMID:16199547 PMID:17576681 PMID:24375934 PMID:25741868 PMID:28492532 PMID:31785789 PMID:32037395 PMID:33057194 PMID:34906470 PMID:36498982 More...
NCBI chrNW_004936528:9,829,889...9,912,645
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Cyfip1 cytoplasmic FMR1 interacting protein 1
ISO associated with Fragile X Syndrome;mRNA:decreased expression:leukocyte (human)
RGD PMID:17435464 RGD:11558012
NCBI chrNW_004936471:38,264,455...38,331,995
G
Magel2 MAGE family member L2
ISO ClinVar Annotator: match by term: MAGEL2-related condition | ClinVar Annotator: match by term: Schaaf-Yang syndrome
OMIM ClinVar
PMID:24076603 PMID:24088041 PMID:25326635 PMID:25473036 PMID:25590979 PMID:25741868 PMID:26365340 PMID:26633545 PMID:27195816 PMID:27632685 PMID:28281571 PMID:28492532 PMID:29359444 PMID:29581464 PMID:29599419 PMID:29660409 PMID:30302899 PMID:31152388 PMID:31397880 PMID:31680349 PMID:31791363 PMID:32021601 PMID:32860008 PMID:33371171 More...
NCBI chrNW_004936805:882,296...886,442
G
Sim1 SIM bHLH transcription factor 1
ISO ClinVar Annotator: match by term: Schaaf-Yang syndrome
ClinVar
NCBI chrNW_004936651:1,841,040...1,911,944
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Gfap glial fibrillary acidic protein
ISO ClinVar Annotator: match by term: Spastic paraplegia, intellectual disability, nystagmus, and obesity
ClinVar
PMID:11138011 PMID:11567214 PMID:15732097 PMID:17065456 PMID:17383133 PMID:17894839 PMID:21533827 PMID:23432455 PMID:24427505 PMID:25741868 PMID:26486469 More...
NCBI chrNW_004936541:1,265,915...1,275,232
G
Kidins220 kinase D interacting substrate 220
ISO ClinVar Annotator: match by term: Spastic paraplegia, intellectual disability, nystagmus, and obesity
OMIM ClinVar
PMID:9536098 PMID:17576681 PMID:25741868 PMID:27005418 PMID:28492532 PMID:28934391 PMID:29667355 PMID:32909676 More...
NCBI chrNW_004936532:5,270,338...5,368,160
G
Lrba LPS responsive beige-like anchor protein
ISO ClinVar Annotator: match by term: Spastic paraplegia, intellectual disability, nystagmus, and obesity
ClinVar PMID:25741868
NCBI chrNW_004936689:429,907...1,080,226
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Hdac8 histone deacetylase 8
ISO DNA:snp:intron:c.164+5G>A (human)
RGD PMID:22889856 RGD:13208817
NCBI chrNW_004936762:1,425,337...1,652,058
G
Las1l LAS1 like ribosome biogenesis factor
ISO ClinVar Annotator: match by term: LAS1L-related condition | ClinVar Annotator: match by term: Wilson-Turner syndrome
OMIM ClinVar PMID:1746601 PMID:24647030 PMID:25644381 PMID:25741868 PMID:28492532
NCBI chrNW_004936635:2,560,586...2,580,309
G
Zc3h12b zinc finger CCCH-type containing 12B
ISO ClinVar Annotator: match by term: Wilson-Turner syndrome
ClinVar
NCBI chrNW_004936635:2,580,693...2,690,297
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
disease
14638
Nutritional and Metabolic Diseases
7079
nutrition disease
785
overnutrition
587
obesity
587
Abdominal Obesity +
23
Ayazi Syndrome
0
Biemond Syndrome II
0
Borjeson-Forssman-Lehmann syndrome
1
CHOPS Syndrome
1
Camera Marugo Cohen Syndrome
0
Clark-Baraitser syndrome
1
Cohen syndrome
36
Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome
0
DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES
2
MEHMO syndrome
1
MOMES Syndrome
0
MORM Syndrome
1
Macrosomia Obesity Macrocephaly Ocular Abnormalities
0
Metabolically Benign Obesity
0
Midface Hypoplasia, Obesity, Developmental Delay, and Neonatal Hypotonia
0
Obesity Hypoventilation Syndrome
0
Obesity and Hypopigmentation
3
Obesity, Hyperphagia, and Developmental Delay
1
Pediatric Obesity
6
Prader-Willi syndrome +
17
Prolactin Deficiency with Obesity and Enlarged Testes
0
Proopiomelanocortin Deficiency
1
Retinal Dystrophy and Obesity
2
SPASTIC PARAPLEGIA, INTELLECTUAL DISABILITY, NYSTAGMUS, AND OBESITY
3
Short Stature-Obesity Syndrome
0
Vasquez Hurst Sotos Syndrome
0
Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome
0
Wilson-Turner syndrome
3
Young Hughes Syndrome
0
morbid obesity +
28
proprotein convertase 1/3 deficiency
2
Path 2
disease
14638
Nutritional and Metabolic Diseases
7079
disease of metabolism
7079
acquired metabolic disease
2155
nutrition disease
785
overnutrition
587
obesity
587
Abdominal Obesity +
23
Ayazi Syndrome
0
Biemond Syndrome II
0
Borjeson-Forssman-Lehmann syndrome
1
CHOPS Syndrome
1
Camera Marugo Cohen Syndrome
0
Clark-Baraitser syndrome
1
Cohen syndrome
36
Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome
0
DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES
2
MEHMO syndrome
1
MOMES Syndrome
0
MORM Syndrome
1
Macrosomia Obesity Macrocephaly Ocular Abnormalities
0
Metabolically Benign Obesity
0
Midface Hypoplasia, Obesity, Developmental Delay, and Neonatal Hypotonia
0
Obesity Hypoventilation Syndrome
0
Obesity and Hypopigmentation
3
Obesity, Hyperphagia, and Developmental Delay
1
Pediatric Obesity
6
Prader-Willi syndrome +
17
Prolactin Deficiency with Obesity and Enlarged Testes
0
Proopiomelanocortin Deficiency
1
Retinal Dystrophy and Obesity
2
SPASTIC PARAPLEGIA, INTELLECTUAL DISABILITY, NYSTAGMUS, AND OBESITY
3
Short Stature-Obesity Syndrome
0
Vasquez Hurst Sotos Syndrome
0
Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome
0
Wilson-Turner syndrome
3
Young Hughes Syndrome
0
morbid obesity +
28
proprotein convertase 1/3 deficiency
2
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