Igf2 (insulin like growth factor 2) - Rat Genome Database

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Gene: Igf2 (insulin like growth factor 2) Ictidomys tridecemlineatus
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Symbol: Igf2
Name: insulin like growth factor 2
RGD ID: 12639894
Description: ENCODES a protein that exhibits growth factor activity (ortholog); insulin receptor binding (ortholog); insulin-like growth factor receptor binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); cellular response to mechanical stimulus (ortholog); embryonic placenta development (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); adrenocortical carcinoma (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: insulin like growth factor 2, transcript variant X1; insulin like growth factor 2, transcript variant X2; insulin like growth factor 2, transcript variant X3; insulin like growth factor 2, transcript variant X4; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,719,158 - 1,727,419 (-)NCBI
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
alcoholic neuropathy  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bone development disease  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
choriocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
developmental and epileptic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
Diaphragmatic Hernia  (ISO)
early infantile epileptic encephalopathy  (ISO)
Embryo Loss  (ISO)
Ependymomas  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Fetal Growth Retardation  (ISO)
Gastrointestinal Diseases  (ISO)
Growth Disorders  (ISO)
Hepatic Echinococcosis  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hypoglycemia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
immunodeficiency 39  (ISO)
inflammatory bowel disease  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Lung Injury  (ISO)
maturity-onset diabetes of the young  (ISO)
Memory Disorders  (ISO)
meningitis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
placenta disease  (ISO)
polyhydramnios  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-malignant neoplasm  (ISO)
Radiation Injuries, Experimental  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Silver-Russell syndrome  (ISO)
Silver-Russell Syndrome 3  (ISO)
Spontaneous Abortions  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ventricular septal defect  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
cellular response to mechanical stimulus  (ISO)
embryonic placenta development  (ISO)
embryonic placenta morphogenesis  (ISO)
exocrine pancreas development  (ISO)
female pregnancy  (ISO)
in utero embryonic development  (ISO)
insulin receptor signaling pathway via phosphatidylinositol 3-kinase  (ISO)
memory  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of glycogen (starch) synthase activity  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
regulation of histone modification  (ISO)
regulation of muscle cell differentiation  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to radiation  (ISO)
response to xenobiotic stimulus  (ISO)
spongiotrophoblast cell proliferation  (ISO)
striated muscle cell differentiation  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Igf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,719,158 - 1,727,419 (-)NCBI
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,129,112 - 2,141,238 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,129,117 - 2,149,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,150,342 - 2,170,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,923 - 2,127,409 (-)NCBINCBI36hg18NCBI36
Build 34112,110,531 - 2,116,578NCBI
Celera112,186,838 - 2,207,338 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,940,869 - 1,961,095 (-)NCBIHuRef
CHM1_1112,148,973 - 2,169,786 (-)NCBICHM1_1
Igf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,204,505 - 142,220,566 (-)NCBIGRCm39mm39
GRCm39 Ensembl7142,204,503 - 142,220,553 (-)Ensembl
GRCm387142,650,768 - 142,666,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,650,766 - 142,666,816 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,836,673 - 149,846,940 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,460,158 - 142,468,879 (-)NCBImm8
Celera7142,407,105 - 142,417,364 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.99NCBI
Igf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,814,409 - 197,831,802 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)Ensembl
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBICelera
Cytogenetic Map1q41NCBI
Igf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,880,471 - 13,888,566 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,880,525 - 13,907,963 (-)NCBIChiLan1.0ChiLan1.0
IGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,202,764 - 2,228,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBIMhudiblu_PPA_v0panPan3
IGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,294,036 - 46,311,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,294,019 - 46,311,982 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,906,773 - 44,921,790 (-)NCBI
ROS_Cfam_1.01846,973,499 - 46,991,455 (-)NCBI
UMICH_Zoey_3.11846,425,198 - 46,440,216 (-)NCBI
UNSW_CanFamBas_1.01846,005,530 - 46,020,544 (-)NCBI
UU_Cfam_GSD_1.01846,751,952 - 46,766,988 (-)NCBI
IGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.121,469,183 - 1,496,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap2pNCBI
IGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,937,414 - 1,951,238 (-)NCBI
ChlSab1.1 Ensembl11,936,830 - 1,945,388 (-)Ensembl
Vero_WHO_p1.0NW_02366603899,135,565 - 99,144,253 (-)NCBI
Igf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005340768   ⟹   XP_005340825
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,158 - 1,727,275 (-)NCBI
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005340769   ⟹   XP_005340826
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,160 - 1,724,893 (-)NCBI
SpeTri2.0NW_004936816972,902 - 979,161 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021720523   ⟹   XP_021576198
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,158 - 1,727,165 (-)NCBI
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040283953   ⟹   XP_040139887
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,158 - 1,727,309 (-)NCBI
RefSeq Acc Id: XM_040283954   ⟹   XP_040139888
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,766 - 1,727,419 (-)NCBI
RefSeq Acc Id: XM_040283955   ⟹   XP_040139889
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,158 - 1,723,137 (-)NCBI
RefSeq Acc Id: XM_040283956   ⟹   XP_040139890
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,158 - 1,724,375 (-)NCBI
RefSeq Acc Id: XM_040283957   ⟹   XP_040139891
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,719,158 - 1,724,658 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005340825   ⟸   XM_005340768
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005340826   ⟸   XM_005340769
- Peptide Label: isoform X6
- UniProtKB: I3N2V4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021576198   ⟸   XM_021720523
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_040139887   ⟸   XM_040283953
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040139891   ⟸   XM_040283957
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040139890   ⟸   XM_040283956
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040139889   ⟸   XM_040283955
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040139888   ⟸   XM_040283954
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028435 ENTREZGENE
Ensembl Protein ENSSTOP00000018700 ENTREZGENE
NCBI Gene Igf2 ENTREZGENE
UniProt I3N2V4 ENTREZGENE