RGD Reference Report - FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. - Rat Genome Database

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FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.

Authors: Wu, Q  Ortegon, AM  Tsang, B  Doege, H  Feingold, KR  Stahl, A 
Citation: Wu Q, etal., Mol Cell Biol. 2006 May;26(9):3455-67.
RGD ID: 1642790
Pubmed: PMID:16611988   (View Abstract at PubMed)
PMCID: PMC1447434   (View Article at PubMed Central)
DOI: DOI:10.1128/MCB.26.9.3455-3467.2006   (Journal Full-text)

Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues. In adipocytes and skeletal muscle, FATP1 translocates from an intracellular compartment to the plasma membrane in response to insulin. Here we show that insulin-stimulated fatty acid uptake is completely abolished in FATP1-null adipocytes and greatly reduced in skeletal muscle of FATP1-knockout animals while basal LCFA uptake by both tissues was unaffected. Moreover, loss of FATP1 function altered regulation of postprandial serum LCFA, causing a redistribution of lipids from adipocyte tissue and muscle to the liver, and led to a complete protection from diet-induced obesity and insulin desensitization. This is the first in vivo evidence that insulin can regulate the uptake of LCFA by tissues via FATP1 activation and that FATPs determine the tissue distribution of dietary lipids. The strong protection against diet-induced obesity and insulin desensitization observed in FATP1-null animals suggests FATP1 as a novel antidiabetic target.




  
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Original Reference(s)
SLC27A1HumanMetabolic Syndrome susceptibilityISORGD:1553168 RGD 
Slc27a1RatMetabolic Syndrome susceptibilityISORGD:1553168 RGD 
Slc27a1MouseMetabolic Syndrome susceptibilityIAGP DNA:gene knockout::Slc27a1-/- mice resistant to diet-induced obesity and metabolic syndromeRGD 
SLC27A1Humanobesity susceptibilityISORGD:1553168 RGD 
Slc27a1Ratobesity susceptibilityISORGD:1553168 RGD 
Slc27a1Mouseobesity susceptibilityIAGP DNA:gene knockout::Slc27a1-/- mice resistant to diet-induced obesity and metabolic syndromeRGD 


Genes (Rattus norvegicus)
Slc27a1  (solute carrier family 27 member 1)

Genes (Mus musculus)
Slc27a1  (solute carrier family 27 (fatty acid transporter), member 1)

Genes (Homo sapiens)
SLC27A1  (solute carrier family 27 member 1)