Cd36 (CD36 molecule (CD36 blood group)) - Rat Genome Database

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Pathways
Gene: Cd36 (CD36 molecule (CD36 blood group)) Ictidomys tridecemlineatus
Analyze
Symbol: Cd36
Name: CD36 molecule (CD36 blood group)
RGD ID: 12548073
Description: ENCODES a protein that exhibits oleic acid binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN cell-cell adhesion via plasma-membrane adhesion molecules (ortholog); cellular response to insulin stimulus (ortholog); digestive tract development (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Alzheimer's disease (ortholog); FOUND IN apical part of cell (ortholog); caveola (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CD36 molecule; CD36 molecule, transcript variant X1; CD36 molecule, transcript variant X2; CD36 molecule, transcript variant X3; CD36 molecule, transcript variant X4; CD36 molecule, transcript variant X5; platelet glycoprotein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511862,188,852 - 62,269,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936810758,182 - 838,365 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936810791,823 - 838,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
blood platelet disease  (ISO)
brain ischemia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebral malaria  (ISO)
chronic myeloid leukemia  (ISO)
colitis  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
essential thrombocythemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
glucose intolerance  (ISO)
granulomatosis with polyangiitis  (ISO)
Hematoma  (ISO)
hemolytic-uremic syndrome  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
inclusion body myositis  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Knee Osteoarthritis  (ISO)
liver cirrhosis  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Mycobacterium Infections  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
nephrosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteopetrosis  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 10  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polycystic ovary syndrome  (ISO)
polycythemia vera  (ISO)
primary immunodeficiency disease  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
Retroperitoneal Fibrosis  (ISO)
rheumatic heart disease  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Staphylococcal Infections  (ISO)
steatotic liver disease  (ISO)
Tachycardia  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IEA)
amyloid-beta clearance by cellular catabolic process  (IEA)
apoptotic cell clearance  (IEA)
cell adhesion  (IEA)
cell surface receptor signaling pathway  (IEA)
cell-cell adhesion via plasma-membrane adhesion molecules  (ISO)
cellular response to amyloid-beta  (IEA)
cellular response to bacterial lipopeptide  (IEA)
cellular response to diacyl bacterial lipopeptide  (IEA)
cellular response to hydroperoxide  (IEA)
cellular response to insulin stimulus  (ISO)
cellular response to lipopolysaccharide  (IEA)
cellular response to lipoteichoic acid  (IEA)
cellular response to low-density lipoprotein particle stimulus  (IEA)
cellular response to oxidative stress  (IEA)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA)
cGMP-mediated signaling  (IEA)
cholesterol import  (IEA)
cholesterol transport  (IEA)
defense response to Gram-positive bacterium  (IEA)
digestive tract development  (ISO)
eating behavior  (ISO)
energy homeostasis  (IEA)
fatty acid metabolic process  (ISO)
fatty acid oxidation  (ISO)
fatty acid transport  (IEA,ISO)
intestinal absorption  (IEA)
intestinal cholesterol absorption  (IEA)
lipid storage  (IEA)
lipid transport  (IEA)
lipid transport across blood-brain barrier  (IEA)
lipoprotein transport  (IEA)
long-chain fatty acid import across plasma membrane  (IEA)
long-chain fatty acid import into cell  (IEA)
long-chain fatty acid metabolic process  (ISO)
long-chain fatty acid transport  (IEA,ISO)
low-density lipoprotein particle clearance  (IEA)
low-density lipoprotein particle mediated signaling  (IEA)
MAPK cascade  (IEA)
maternal placenta development  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of protein import into nucleus  (IEA)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
nitric oxide-cGMP-mediated signaling  (IEA)
oxidised low-density lipoprotein particle clearance  (IEA)
phagocytosis, recognition  (IEA)
plasma lipoprotein particle clearance  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of blood coagulation  (IEA)
positive regulation of blood microparticle formation  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of cholesterol storage  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of macrophage cytokine production  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (IEA)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of triglyceride metabolic process  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
receptor internalization  (IEA)
receptor-mediated endocytosis  (IEA)
regulation of action potential  (IEA)
regulation of protein-containing complex assembly  (IEA)
regulation of removal of superoxide radicals  (IEA)
regulation of toll-like receptor signaling pathway  (IEA)
response to activity  (ISO)
response to bacterium  (IEA)
response to estradiol  (ISO)
response to fatty acid  (IEA)
response to growth hormone  (ISO)
response to linoleic acid  (IEA)
response to lipid  (IEA)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to stilbenoid  (IEA)
response to vitamin B3  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of taste  (IEA)
short-chain fatty acid transport  (IEA)
triglyceride metabolic process  (ISO)
triglyceride transport  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Cd36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511862,188,852 - 62,269,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936810758,182 - 838,365 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936810791,823 - 838,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38780,602,207 - 80,679,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl780,369,575 - 80,679,277 (+)Ensemblhg38GRCh38
GRCh37780,231,523 - 80,308,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36780,069,459 - 80,144,262 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34779,912,607 - 79,950,974NCBI
Celera774,932,098 - 75,009,206 (+)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef774,834,319 - 74,911,371 (+)NCBIHuRef
CHM1_1780,162,020 - 80,239,042 (+)NCBICHM1_1
T2T-CHM13v2.0781,853,488 - 81,930,588 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2779,562,929 - 79,640,010 (+)NCBI
Cd36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39517,986,680 - 18,093,828 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl517,986,688 - 18,093,799 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38517,781,690 - 17,888,959 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl517,781,690 - 17,888,801 (-)Ensemblmm10GRCm38
MGSCv37517,287,508 - 17,394,777 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36517,293,840 - 17,347,520 (-)NCBIMGSCv36mm8
Celera514,757,802 - 14,864,361 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map58.11NCBI
Cd36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8418,209,088 - 18,302,142 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2417,317,343 - 17,410,084 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl417,354,466 - 17,513,903 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx422,477,636 - 22,533,306 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0418,290,445 - 18,348,857 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0416,675,588 - 16,731,247 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0414,150,309 - 14,191,498 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl414,001,761 - 14,249,749 (+)Ensemblrn6Rnor6.0
Rnor_5.0414,125,297 - 14,166,434 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4413,534,582 - 13,554,416 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera412,880,238 - 12,941,086 (+)NCBICelera
Cytogenetic Map4q11NCBI
Cd36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554105,003,668 - 5,075,313 (-)Ensembl
ChiLan1.0NW_0049554105,003,720 - 5,120,903 (-)NCBIChiLan1.0ChiLan1.0
CD36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2698,337,667 - 98,528,488 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17146,740,194 - 146,795,378 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0772,566,478 - 72,643,517 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1786,228,856 - 86,305,865 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl786,265,114 - 86,305,865 (+)EnsemblpanPan2panpan1.1
CD36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11820,299,808 - 20,375,856 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1820,339,050 - 20,372,639 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1820,015,595 - 20,045,069 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01820,745,564 - 20,821,666 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1820,542,818 - 20,821,688 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11820,418,233 - 20,447,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01819,970,682 - 20,000,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01820,626,442 - 20,655,919 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CD36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl999,605,181 - 99,782,105 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1999,685,748 - 99,782,296 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29110,037,583 - 110,106,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12168,214,875 - 68,309,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2168,216,201 - 68,268,669 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604235,654,688 - 35,734,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473929,407,568 - 29,441,333 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473929,341,620 - 29,441,232 (+)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000008498   ⟹   ENSSTOP00000007617
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936810758,182 - 838,365 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000036004   ⟹   ENSSTOP00000025792
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936810808,678 - 838,365 (+)Ensembl
RefSeq Acc Id: XM_005340670   ⟹   XP_005340727
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,236,264 - 62,269,004 (+)NCBI
SpeTri2.0NW_004936810805,556 - 838,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013365366   ⟹   XP_013220820
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,236,247 - 62,269,004 (+)NCBI
SpeTri2.0NW_004936810805,551 - 838,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013365367   ⟹   XP_013220821
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,222,603 - 62,269,004 (+)NCBI
SpeTri2.0NW_004936810791,823 - 838,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013365368   ⟹   XP_013220822
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,222,618 - 62,269,004 (+)NCBI
SpeTri2.0NW_004936810791,835 - 838,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013365369   ⟹   XP_013220823
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,236,271 - 62,269,004 (+)NCBI
SpeTri2.0NW_004936810805,556 - 838,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040291695   ⟹   XP_040147629
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,222,643 - 62,269,004 (+)NCBI
RefSeq Acc Id: XM_040291696   ⟹   XP_040147630
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,188,852 - 62,269,004 (+)NCBI
RefSeq Acc Id: XM_040291697   ⟹   XP_040147631
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,188,853 - 62,269,004 (+)NCBI
RefSeq Acc Id: XM_040291698   ⟹   XP_040147632
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511862,188,869 - 62,269,004 (+)NCBI
RefSeq Acc Id: XP_013220821   ⟸   XM_013365367
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013220822   ⟸   XM_013365368
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013220820   ⟸   XM_013365366
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005340727   ⟸   XM_005340670
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013220823   ⟸   XM_013365369
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040147630   ⟸   XM_040291696
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040147631   ⟸   XM_040291697
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040147632   ⟸   XM_040291698
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040147629   ⟸   XM_040291695
- UniProtKB: I3MBR1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000025792   ⟸   ENSSTOT00000036004
Ensembl Acc Id: ENSSTOP00000007617   ⟸   ENSSTOT00000008498


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008485 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008498.3 UniProtKB/TrEMBL
  ENSSTOT00000036004.1 UniProtKB/TrEMBL
InterPro CD36/SCARB1/SNMP1 UniProtKB/TrEMBL
  CD36_fam UniProtKB/TrEMBL
KEGG Report iti:101961032 UniProtKB/TrEMBL
NCBI Gene Cd36 ENTREZGENE
PANTHER PTHR11923 UniProtKB/TrEMBL
  PTHR11923:SF12 UniProtKB/TrEMBL
Pfam CD36 UniProtKB/TrEMBL
PRINTS CD36ANTIGEN UniProtKB/TrEMBL
  CD36FAMILY UniProtKB/TrEMBL
UniProt I3MBR1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-30 Cd36  CD36 molecule (CD36 blood group)  Cd36  CD36 molecule  Symbol and/or name change 5135510 APPROVED