Nr3c1 (nuclear receptor subfamily 3 group C member 1) - Rat Genome Database
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Gene: Nr3c1 (nuclear receptor subfamily 3 group C member 1) Ictidomys tridecemlineatus
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Symbol: Nr3c1
Name: nuclear receptor subfamily 3 group C member 1
RGD ID: 12660079
Description: ENCODES a protein that exhibits chromatin binding (ortholog); core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN adrenal gland development (ortholog); aging (ortholog); androgen metabolic process (ortholog); PARTICIPATES IN cortisol signaling pathway; forkhead class A signaling pathway; prednisolone pharmacodynamics pathway; ASSOCIATED WITH 46, XX Disorders of Sex Development (ortholog); anorexia nervosa (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: glucocorticoid receptor
Orthologs:
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46, XX Disorders of Sex Development  (ISO)
anorexia nervosa  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cataract  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cushing Syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
Glucocorticoid Receptor Deficiency  (ISO)
glucose metabolism disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
hypokalemia  (ISO)
interstitial lung disease  (ISO)
lipoid nephrosis  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Malocclusion  (ISO)
mental depression  (ISO)
mood disorder  (ISO)
muscular atrophy  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 2  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
obstructive lung disease  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
Perennial Allergic Rhinitis  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
primary biliary cholangitis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
aging  (ISO)
androgen metabolic process  (ISO)
brain development  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin remodeling  (ISO)
chromatin-mediated maintenance of transcription  (ISO)
circadian rhythm  (ISO)
female pregnancy  (ISO)
glucocorticoid metabolic process  (ISO)
glucocorticoid receptor signaling pathway  (ISO)
lung development  (ISO)
mammary gland duct morphogenesis  (ISO)
maternal behavior  (ISO)
muscle atrophy  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of glucocorticoid mediated signaling pathway  (ISO)
negative regulation of synaptic plasticity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of vascular permeability  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of glucocorticoid biosynthetic process  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of glucose metabolic process  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
response to dexamethasone  (ISO)
response to electrical stimulus  (ISO)
response to inactivity  (ISO)
response to insulin  (ISO)
response to mercury ion  (ISO)
response to radiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Nr3c1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR3C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5143,277,931 - 143,435,512 (-)EnsemblGRCh38hg38GRCh38
GRCh385143,277,931 - 143,435,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375142,657,496 - 143,113,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,637,689 - 142,795,270 (-)NCBINCBI36hg18NCBI36
Build 345142,639,324 - 142,763,087NCBI
Celera5138,738,770 - 138,896,297 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5137,804,733 - 137,962,312 (-)NCBIHuRef
CHM1_15142,091,205 - 142,248,804 (-)NCBICHM1_1
Nr3c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391839,543,598 - 39,652,485 (-)NCBI
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIGRCm37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBImm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
Nr3c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
Celera1830,905,394 - 30,993,522 (-)NCBICelera
Cytogenetic Map18p11NCBI
RH 3.4 Map18442.9RGD
Nr3c1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBIChiLan1.0ChiLan1.0
NR3C1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15144,741,452 - 144,865,341 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,741,452 - 144,865,269 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05138,634,278 - 139,089,171 (-)NCBIMhudiblu_PPA_v0panPan3
NR3C1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl238,123,190 - 38,240,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1238,124,568 - 38,242,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
NR3C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2144,822,937 - 144,956,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12144,822,937 - 144,956,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22151,051,816 - 151,185,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR3C1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2345,904,873 - 46,031,125 (-)Ensembl
ChlSab1.12345,904,926 - 46,031,804 (-)NCBI
Nr3c1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247742,496,276 - 2,603,894 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005324220   ⟹   XP_005324277
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493650410,961,783 - 11,056,834 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013358148   ⟹   XP_013213602
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725703   ⟹   XP_021581378
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005324277 (Get FASTA)   NCBI Sequence Viewer  
  XP_013213602 (Get FASTA)   NCBI Sequence Viewer  
  XP_021581378 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013213602   ⟸   XM_013358148
- Peptide Label: isoform X1
- UniProtKB: I3MRQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005324277   ⟸   XM_005324220
- Peptide Label: isoform X1
- UniProtKB: I3MRQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581378   ⟸   XM_021725703
- Peptide Label: isoform X2
- Sequence:
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000016527 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000014793 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000024034 UniProtKB/TrEMBL
  ENSSTOP00000027413 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016531 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOT00000035032 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOT00000036215 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro Glcrtcd_rcpt UniProtKB/TrEMBL
  NHR_like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Nr3c1 ENTREZGENE
Pfam GCR UniProtKB/TrEMBL
  Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS GLCORTICOIDR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/TrEMBL
UniProt A0A287D1I2_ICTTR UniProtKB/TrEMBL
  I3MRQ8 ENTREZGENE, UniProtKB/TrEMBL