Drd2 (dopamine receptor D2) - Rat Genome Database

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Gene: Drd2 (dopamine receptor D2) Ictidomys tridecemlineatus
Analyze
Symbol: Drd2
Name: dopamine receptor D2
RGD ID: 12650199
Description: ENCODES a protein that exhibits dopamine binding (ortholog); dopamine neurotransmitter receptor activity, coupled via Gi/Go (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN acid secretion (ortholog); activation of protein kinase activity (ortholog); adenohypophysis development (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; ASSOCIATED WITH alcohol dependence (ortholog); Alcohol Withdrawal Seizures (ortholog); alcohol-induced mental disorder (ortholog); FOUND IN acrosomal vesicle (ortholog); axon (ortholog); axon terminus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: D(2) dopamine receptor; dopamine receptor D2, transcript variant X1; dopamine receptor D2, transcript variant X2; dopamine receptor D2, transcript variant X3; dopamine receptor D2, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366121,094,680 - 1,154,798 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (ISO)
Alcohol Withdrawal Seizures  (ISO)
alcohol-induced mental disorder  (ISO)
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
basal ganglia disease  (ISO)
Binge Drinking  (ISO)
Binge-Eating Disorder  (ISO)
Bradycardia  (ISO)
Brain Concussion  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Catalepsy  (ISO)
chromosome 11 partial duplication syndrome  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
dementia  (ISO)
depressive disorder  (ISO)
Developmental Disabilities  (ISO)
drug psychosis  (ISO)
Drug-Induced Dyskinesia  (ISO)
Dyskinesias  (ISO)
dystonia  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
fetal alcohol spectrum disorder  (ISO)
Gilles de la Tourette syndrome  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperkinesis  (ISO)
hyperprolactinemia  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
impulse control disorder  (ISO)
intellectual disability  (ISO)
Language Development Disorders  (ISO)
language disorder  (ISO)
Memory Disorders  (ISO)
migraine with aura  (ISO)
morphine dependence  (ISO)
movement disease  (ISO)
myoclonic dystonia 11  (ISO)
Neuralgia  (ISO)
nicotine dependence  (ISO)
obesity  (ISO)
opiate dependence  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pituitary Neoplasms  (ISO)
primary hyperaldosteronism  (ISO)
schizophrenia  (ISO)
stress-related disorder  (ISO)
substance-related disorder  (ISO)
Tachycardia  (ISO)
toxic encephalopathy  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
activation of protein kinase activity  (ISO)
adenohypophysis development  (IEA,ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IEA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
adult behavior  (IEA,ISO)
adult walking behavior  (IEA,ISO)
arachidonate secretion  (IEA)
associative learning  (IEA,ISO)
auditory behavior  (ISO)
autophagy  (ISO)
axonogenesis  (IEA,ISO)
behavioral response to cocaine  (IEA,ISO)
behavioral response to ethanol  (IEA,ISO)
branching morphogenesis of a nerve  (IEA,ISO)
cell migration  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to ethanol  (ISO)
cellular response to retinoic acid  (ISO)
cerebral cortex GABAergic interneuron migration  (IEA,ISO)
circadian regulation of gene expression  (IEA,ISO)
dopamine metabolic process  (IEA,ISO)
dopamine uptake involved in synaptic transmission  (IEA,ISO)
drinking behavior  (ISO)
epithelial cell proliferation  (IEA,ISO)
feeding behavior  (IEA,ISO)
forebrain development  (ISO)
G protein-coupled dopamine receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
grooming behavior  (IEA,ISO)
hyaloid vascular plexus regression  (IEA)
intracellular calcium ion homeostasis  (ISO)
intracellular signal transduction  (ISO)
locomotory behavior  (IEA,ISO)
long-term memory  (ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of adenylate cyclase activity  (ISO)
negative regulation of blood pressure  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cellular response to hypoxia  (ISO)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of cytosolic calcium ion concentration  (IEA,ISO)
negative regulation of dephosphorylation  (ISO)
negative regulation of dopamine receptor signaling pathway  (IEA,ISO)
negative regulation of dopamine secretion  (ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of innate immune response  (IEA)
negative regulation of insulin secretion  (ISO)
negative regulation of neuron migration  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein secretion  (IEA)
negative regulation of synaptic transmission  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IEA,ISO)
negative regulation of voltage-gated calcium channel activity  (ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (IEA,ISO)
neuroblast proliferation  (IEA,ISO)
neuron migration  (IEA,ISO)
neuron-neuron synaptic transmission  (IEA,ISO)
orbitofrontal cortex development  (ISO)
peristalsis  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
pigmentation  (IEA,ISO)
positive regulation of cytokinesis  (IEA)
positive regulation of dopamine uptake involved in synaptic transmission  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glial cell-derived neurotrophic factor production  (IEA)
positive regulation of growth hormone secretion  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of renal sodium excretion  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urine volume  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (IEA)
protein localization  (IEA,ISO)
regulation of dopamine secretion  (IEA)
regulation of dopamine uptake involved in synaptic transmission  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of MAPK cascade  (ISO)
regulation of neurotransmitter uptake  (IEA)
regulation of potassium ion transport  (IEA,ISO)
regulation of secretion by cell  (IEA)
regulation of sodium ion transport  (IEA,ISO)
regulation of synapse structural plasticity  (ISO)
regulation of synaptic transmission, GABAergic  (IEA,ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to amphetamine  (IEA,ISO)
response to axon injury  (ISO)
response to cocaine  (IEA,ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to histamine  (IEA)
response to hypoxia  (ISO)
response to inactivity  (ISO)
response to iron ion  (ISO)
response to light stimulus  (IEA,ISO)
response to morphine  (IEA,ISO)
response to nicotine  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
sensory perception of smell  (IEA,ISO)
startle response  (IEA,ISO)
striatum development  (ISO)
synapse assembly  (ISO)
synaptic transmission, dopaminergic  (IEA)
temperature homeostasis  (IEA,ISO)
visual learning  (IEA,ISO)
Wnt signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Drd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366121,094,680 - 1,154,798 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,409,605 - 113,475,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,409,605 - 113,475,691 (-)EnsemblGRCh38hg38GRCh38
GRCh3711113,280,327 - 113,346,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,785,527 - 112,851,091 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411112,785,527 - 112,851,103NCBI
Celera11110,433,249 - 110,498,937 (-)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,208,766 - 109,274,420 (-)NCBIHuRef
CHM1_111113,163,302 - 113,228,980 (-)NCBICHM1_1
T2T-CHM13v2.011113,420,107 - 113,485,882 (-)NCBIT2T-CHM13v2.0
Drd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,251,703 - 49,319,468 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl949,251,927 - 49,319,477 (+)EnsemblGRCm39 Ensembl
GRCm38949,340,360 - 49,408,177 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,340,627 - 49,408,177 (+)EnsemblGRCm38mm10GRCm38
MGSCv37949,148,767 - 49,215,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36949,092,857 - 49,160,407 (+)NCBIMGSCv36mm8
Celera946,638,220 - 46,705,025 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.72NCBI
Drd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,605,403 - 58,669,339 (+)NCBIGRCr8
mRatBN7.2849,708,927 - 49,772,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,708,927 - 49,772,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx855,213,102 - 55,276,965 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,491,983 - 53,555,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,356,250 - 51,420,103 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
Drd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,054,038 - 15,114,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,054,255 - 15,114,558 (-)NCBIChiLan1.0ChiLan1.0
DRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,154,239 - 114,221,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,248,609 - 115,315,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,132,703 - 112,168,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,132,703 - 112,198,935 (-)Ensemblpanpan1.1panPan2
DRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,732,842 - 19,795,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,704,390 - 19,715,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,803,212 - 19,815,852 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,754,070 - 19,815,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,865,917 - 19,877,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,767,231 - 19,778,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,814,856 - 19,826,385 (+)NCBIUU_Cfam_GSD_1.0
DRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,068,779 - 41,133,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,883,054 - 45,897,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,774,632 - 104,843,417 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1104,774,180 - 104,842,736 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604321,144,996 - 21,236,456 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247848,827,006 - 8,865,529 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247848,828,589 - 8,906,617 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000003566   ⟹   ENSSTOP00000003194
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366121,094,680 - 1,154,798 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000033055   ⟹   ENSSTOP00000025934
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366121,094,680 - 1,154,798 (+)Ensembl
RefSeq Acc Id: XM_005334208   ⟹   XP_005334265
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBI
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021732379   ⟹   XP_021588054
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBI
SpeTri2.0NW_0049366121,094,686 - 1,154,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021732381   ⟹   XP_021588056
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBI
SpeTri2.0NW_0049366121,094,686 - 1,154,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040285237   ⟹   XP_040141171
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494795,551,429 - 95,610,285 (-)NCBI
RefSeq Acc Id: XR_005733736
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494795,551,429 - 95,610,929 (-)NCBI
RefSeq Acc Id: XP_005334265   ⟸   XM_005334208
- Peptide Label: isoform X1
- UniProtKB: I3M2I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021588054   ⟸   XM_021732379
- Peptide Label: isoform X1
- UniProtKB: I3M2I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021588056   ⟸   XM_021732381
- Peptide Label: isoform X2
- UniProtKB: A0A287CXF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040141171   ⟸   XM_040285237
- Peptide Label: isoform X1
- UniProtKB: I3M2I3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000025934   ⟸   ENSSTOT00000033055
Ensembl Acc Id: ENSSTOP00000003194   ⟸   ENSSTOT00000003566
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003570 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003566.3 UniProtKB/TrEMBL
  ENSSTOT00000033055.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Dopamine_D2_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Drd2 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  D(2) DOPAMINE RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED2R UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A287CXF0 ENTREZGENE, UniProtKB/TrEMBL
  I3M2I3 ENTREZGENE, UniProtKB/TrEMBL