RGD Reference Report - Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. - Rat Genome Database

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Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.

Authors: Ohki-Hamazaki, H  Watase, K  Yamamoto, K  Ogura, H  Yamano, M  Yamada, K  Maeno, H  Imaki, J  Kikuyama, S  Wada, E  Wada, K 
Citation: Ohki-Hamazaki H, etal., Nature 1997 Nov 13;390(6656):165-9.
RGD ID: 734661
Pubmed: PMID:9367152   (View Abstract at PubMed)
DOI: DOI:10.1038/36568   (Journal Full-text)

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism and behaviour. They bind to G-protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors cloned so far include, gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R), and bombesin receptor subtype-3 (BRS-3). However, despite the molecular characterization of BRS-3, determination of its function has been difficult as a result of its low affinity for bombesin and its lack of an identified natural ligand. We have generated BRS-3-deficient mice in an attempt to determine the in vivo function of the receptor. Mice lacking functional BRS-3 developed a mild obesity, associated with hypertension and impairment of glucose metabolism. They also exhibited reduced metabolic rate, increased feeding efficiency and subsequent hyperphagia. Our data suggest that BRS-3 is required for the regulation of endocrine processes and metabolism responsible for energy balance and adiposity. BRS-3-deficient mice provide a useful new model for the investigation of human obesity and associated diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BRS3HumanHyperphagia  ISOBrs3 (Mus musculus) RGD 
Brs3RatHyperphagia  ISOBrs3 (Mus musculus) RGD 
Brs3MouseHyperphagia  IMP  RGD 
BRS3Humanhypertension  ISOBrs3 (Mus musculus) RGD 
Brs3Rathypertension  ISOBrs3 (Mus musculus) RGD 
Brs3Mousehypertension  IMP  RGD 
BRS3Humanobesity  ISOBrs3 (Mus musculus) RGD 
Brs3Ratobesity  ISOBrs3 (Mus musculus) RGD 
Brs3Mouseobesity  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Brs3  (bombesin receptor subtype 3)

Genes (Mus musculus)
Brs3  (bombesin-like receptor 3)

Genes (Homo sapiens)
BRS3  (bombesin receptor subtype 3)

Objects referenced in this article
Gene Nmbr neuromedin B receptor Mus musculus

Additional Information