Il10 (interleukin 10) - Rat Genome Database

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Gene: Il10 (interleukin 10) Ictidomys tridecemlineatus
Symbol: Il10
Name: interleukin 10
RGD ID: 12567926
Description: ENCODES a protein that exhibits interleukin-10 receptor binding (ortholog); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); cellular response to antibiotic (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN Interleukin-10 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Actinic Cheilitis (ortholog); Acute Experimental Pancreatitis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-10
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934468,594,566 - 68,598,867 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,834,874 - 5,838,502 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365575,834,874 - 5,838,502 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actinic Cheilitis  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (ISO)
acute pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
Airway Obstruction  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aphthous stomatitis  (ISO)
appendicitis  (ISO)
arteriosclerosis  (ISO)
Asthenopia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchus carcinoma  (ISO)
Burns  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
central nervous system lymphoma  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
Chagas Cardiomyopathy  (ISO)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
choroid disease  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
Chronic Periodontitis  (ISO)
colitis  (ISO)
colon cancer  (ISO)
common cold  (ISO)
common variable immunodeficiency 7  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cytomegalovirus retinitis  (ISO)
decubitus ulcer  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (ISO)
Dyspepsia  (ISO)
Eales Disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
Enterocolitis  (ISO)
Enterovirus Infections  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Eye Burns  (ISO)
factor VIII deficiency  (ISO)
familial adult myoclonic epilepsy 5  (ISO)
Fanconi anemia  (ISO)
fatty liver disease  (ISO)
Femoral Fractures  (ISO)
gallbladder carcinoma  (ISO)
gastric dilatation  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
Heat Stroke  (ISO)
Hemorrhagic Shock  (ISO)
Heparin-induced Thrombocytopenia  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Human Viral Hepatitis  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypokalemic Periodic Paralysis, Type 1  (ISO)
hypothyroidism  (ISO)
ileitis  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate uveitis  (ISO)
intestinal obstruction  (ISO)
irritable bowel syndrome  (ISO)
Kidney Reperfusion Injury  (ISO)
leishmaniasis  (ISO)
leprosy  (ISO)
lip cancer  (ISO)
liver benign neoplasm  (ISO)
liver cancer  (ISO)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoplasmacytic lymphoma  (ISO)
major depressive disorder  (ISO)
Malignant Pleural Effusions  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
mitral valve stenosis  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational dermatitis  (ISO)
Ocular Toxoplasmosis  (ISO)
ocular tuberculosis  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
Penetrating Wounds  (ISO)
pericardial effusion  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
plasmacytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
postpartum depression  (ISO)
Pregnancy-associated Malaria  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinal artery occlusion  (ISO)
retinal disease  (ISO)
retinopathy of prematurity  (ISO)
Retroviridae Infections  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
shigellosis  (ISO)
Shwartzman phenomenon  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Staphylococcal Infections  (ISO)
Staphylococcal Pneumonia  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
thyrotoxicosis  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
trichinosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Weight Loss  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in labyrinthine layer morphogenesis  (IEA,ISO)
cellular response to antibiotic  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to virus  (ISO)
chronic inflammatory response to antigenic stimulus  (IEA,ISO)
defense response to bacterium  (IEA,ISO)
defense response to protozoan  (IEA,ISO)
immune response  (IEA,ISO)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (IEA)
negative regulation of B cell proliferation  (IEA,ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of chronic inflammatory response to antigenic stimulus  (IEA,ISO)
negative regulation of cytokine production  (IEA,ISO)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of heterotypic cell-cell adhesion  (IEA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA)
negative regulation of membrane protein ectodomain proteolysis  (IEA)
negative regulation of MHC class II biosynthetic process  (IEA)
negative regulation of myeloid dendritic cell activation  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type II interferon production  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA)
positive regulation of B cell apoptotic process  (IEA,ISO)
positive regulation of cell cycle  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of immunoglobulin production  (IEA,ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of plasma cell differentiation  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA)
positive regulation of sprouting angiogenesis  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of cytokine production  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of response to wounding  (IEA)
regulation of synapse organization  (ISO)
response to activity  (ISO)
response to carbon monoxide  (ISO)
response to glucocorticoid  (IEA,ISO)
response to inactivity  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to molecule of bacterial origin  (IEA)
response to organic substance  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934468,594,566 - 68,598,867 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,834,874 - 5,838,502 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365575,834,874 - 5,838,502 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381206,767,602 - 206,772,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,767,602 - 206,774,541 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,940,947 - 206,945,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,007,571 - 205,012,462 (-)NCBINCBI36Build 36hg18NCBI36
Build 341203,329,342 - 203,334,234NCBI
Celera1180,192,396 - 180,197,294 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,639,274 - 177,644,165 (-)NCBIHuRef
CHM1_11208,213,574 - 208,218,465 (-)NCBICHM1_1
T2T-CHM13v2.01206,031,803 - 206,036,695 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391130,947,459 - 130,952,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,947,582 - 130,952,711 (+)EnsemblGRCm39 Ensembl
GRCm381131,019,845 - 131,024,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,019,845 - 131,024,974 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,916,422 - 132,921,547 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,847,393 - 132,852,516 (+)NCBIMGSCv36mm8
Celera1133,642,456 - 133,647,581 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21342,472,625 - 42,477,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,472,839 - 42,477,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,079,495 - 45,083,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,367,625 - 46,371,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,631,889 - 43,635,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,738,933 - 47,743,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,739,526 - 47,743,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,824,594 - 52,828,560 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,953,900 - 43,957,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,967,906 - 43,972,374 (+)NCBI
Celera1342,821,569 - 42,825,416 (+)NCBICelera
Cytogenetic Map13q13NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540642,307,664 - 42,312,779 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,307,789 - 42,312,255 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1142,567,540 - 42,575,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,369,234 - 182,374,207 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,648,289 - 186,653,155 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,648,289 - 186,653,371 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.175,933,285 - 5,937,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,933,285 - 5,937,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,497,391 - 5,501,163 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,622,589 - 5,626,365 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,622,079 - 5,626,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,557,139 - 5,560,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,658,009 - 5,661,775 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,697,728 - 5,701,500 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl967,400,728 - 67,405,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,400,727 - 67,405,941 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,757,707 - 73,762,925 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12522,590,389 - 22,595,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,590,962 - 22,594,836 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,288,754 - 23,293,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248074,687,176 - 4,691,732 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,687,249 - 4,691,658 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2



Nucleotide Sequences
RefSeq Transcripts XM_005329480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010004404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000006394   ⟹   ENSSTOP00000005716
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365575,834,874 - 5,838,502 (+)Ensembl
RefSeq Acc Id: XM_005329480   ⟹   XP_005329537
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934468,594,566 - 68,598,867 (+)NCBI
SpeTri2.0NW_0049365575,834,874 - 5,838,502 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005329537 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000005716.1
GenBank Protein KAG3258252 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005329537   ⟸   XM_005329480
- UniProtKB: I3M7U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000005716   ⟸   ENSSTOT00000006394

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006397 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006394.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-10 UniProtKB/TrEMBL
  IL-10/19/20/22/24/26_fam UniProtKB/TrEMBL
  IL-10_CS UniProtKB/TrEMBL
Pfam IL10 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL