Cers1 (ceramide synthase 1) - Rat Genome Database

Name: Cers1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Cers1 (ceramide synthase 1) Ictidomys tridecemlineatus

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Symbol:

Cers1

Name:

ceramide synthase 1

RGD ID:

12690091

Description:

ENCODES a protein that exhibits N-acyltransferase activity (ortholog); INVOLVED IN brain development (ortholog); negative regulation of D-glucose import (ortholog); ASSOCIATED WITH cerebellar ataxia (ortholog); congenital heart disease (ortholog); dextro-looped transposition of the great arteries (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CERS1 (ceramide synthase 1)	NCBI	Ortholog
Mus musculus (house mouse):	Cers1 (ceramide synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cers1 (ceramide synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cers1 (ceramide synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CERS1 (ceramide synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CERS1 (ceramide synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CERS1 (ceramide synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cers1 (ceramide synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,893,836 - 202,918,153 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,442,991 - 2,467,184 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,442,978 - 2,467,184 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebellar ataxia (ISO)

congenital heart disease (ISO)

dextro-looped transposition of the great arteries (ISO)

double outlet right ventricle (ISO)

genetic disease (ISO)

Insulin Resistance (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

multiple types of congenital heart defects 6 (ISO)

obesity (ISO)

oral squamous cell carcinoma (ISO)

Perinatal Asphyxia (ISO)

progressive myoclonus epilepsy (ISO)

progressive myoclonus epilepsy 8 (ISO)

right atrial isomerism (ISO)

situs inversus (ISO)

tetralogy of Fallot (ISO)

visceral heterotaxy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (ISO)

cellular response to dithiothreitol (IEA)

cellular response to mycotoxin (IEA)

cellular response to UV-A (IEA)

cellular response to xenobiotic stimulus (IEA)

ceramide biosynthetic process (IEA)

negative regulation of D-glucose import (ISO)

positive regulation of mitophagy (IEA)

sphingolipid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

intracellular membrane-bounded organelle (ISO)

membrane (IEA)

Molecular Function

N-acyltransferase activity (ISO)

protein binding (ISO)

sphingosine N-acyltransferase activity (IEA)

transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cers1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,893,836 - 202,918,153 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,442,991 - 2,467,184 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,442,978 - 2,467,184 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CERS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,868,545 - 18,896,982 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,868,545 - 18,896,727 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	18,979,354 - 19,007,791 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,842,117 - 18,867,953 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	18,849,726 - 18,867,953	NCBI
Celera	19	18,884,162 - 18,911,776 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,543,712 - 18,571,613 (-)	NCBI		HuRef
CHM1_1	19	18,979,170 - 19,006,647 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	19,004,162 - 19,032,606 (-)	NCBI		T2T-CHM13v2.0

Cers1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	70,768,425 - 70,784,238 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	70,768,425 - 70,784,242 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,315,775 - 70,331,588 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,315,775 - 70,331,592 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	72,839,674 - 72,855,487 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,244,776 - 73,260,576 (+)	NCBI		MGSCv36	mm8
Celera	8	72,872,244 - 72,888,065 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

Cers1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,131,271 - 19,146,480 (-)	NCBI		GRCr8
mRatBN7.2	16	19,097,309 - 19,112,519 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,104,466 - 19,112,519 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	19,137,150 - 19,152,310 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,269,455 - 20,284,820 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,190,111 - 19,205,271 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,845,580 - 20,860,789 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,845,576 - 20,860,789 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,698,122 - 20,712,564 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,580,807 - 19,596,415 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,588,709 - 19,596,385 (-)	NCBI
Celera	16	19,287,577 - 19,302,834 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Cers1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	2,788,653 - 2,796,370 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	2,788,672 - 2,798,068 (+)	NCBI	ChiLan1.0	ChiLan1.0

CERS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,731,595 - 23,758,078 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,737,809 - 22,764,286 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	18,308,265 - 18,334,892 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1 Ensembl	19	19,317,173 - 19,342,487 (-)	Ensembl	panpan1.1		panPan2

CERS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,216,568 - 44,231,820 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,131,420 - 44,140,737 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	44,702,943 - 44,712,260 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,701,496 - 44,718,307 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	43,940,230 - 43,949,547 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,350,440 - 44,359,760 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	44,625,909 - 44,635,225 (+)	NCBI		UU_Cfam_GSD_1.0

CERS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	17,331,021 - 17,351,542 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666074	1,972,193 - 1,994,871 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cers1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,941,393 - 1,949,760 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,937,007 - 1,949,780 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000020751 ⟹ ENSSTOP00000022895

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936596	2,442,991 - 2,467,184 (+)	Ensembl

RefSeq Acc Id:

XM_005332975 ⟹ XP_005333032

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	202,893,836 - 202,918,153 (+)	NCBI
SpeTri2.0	NW_004936596	2,442,978 - 2,467,184 (+)	NCBI

Sequence:

show sequence

GCGGCGCGTGACGCGGGGTGCGCGGCTCCGGCGGCCACCGCGGGCTGGCGCAGGCAGCAGGGGA
CAGCCAGAGAGCCGGCTGCATGGCGGCGGCAGGGACCGCAGCAGGGCCGGCGGGGCCCGAGCCC
ATGCCGAGCTACGCGCAGCTGGTGCAACGGAGCTGGGGCAGCGCGCTAGCAGCAGCGCGGGACT
GTGCGGACTGCGGCTGGGGACTGGCGCGCCGCGGCCTGGCCGAGCACGCGCACCTGGCGCCGCC
CGAGCTGCTGCTGCTGGCGCTTTGCGCGCTTGGCTGGACCGCGCTGCGCTCCGCGGCCACCGCG
CGCCTCTTTCGGCCCCTGGCCAAGCGATGCCGCCTTCAGCCCAGAGATGCTGCCAAGATGCCTG
AGAGCGCCTGGAAGTTTCTGTTCTACTTGGGCTGCTGGAGCTACAGTGCCTACCTGCTCTTTGG
CACGGACTACCCCTTCTTTCGTGACCCACCCTCTGTCTTCTACGATTGGACGCCGGGCATGGCG
GTGCCGCGGGACATTGCAGCCGCCTATCTGCTGCAGGGGAGTTTCTACGGCCACTCCATCTACG
CCACGCTGTACATGGACACCTGGCGCAAGGACTCGGTGGTCATGCTCATCCACCACGTGGTCAC
CTTGGTCCTCATCGTCTCCTCCTATGCCTTCCGATACCACAACGTGGGCATCCTTGTGCTCTTC
CTGCACGACATCAGCGATGTGCAGCTCGAGTTCACCAAGCTCAACATTTACTTCAAGGCCCGAG
GCGGCTCCTACCACCGGCTACACGCAGTGGTGGCAGACCTGGGCTGCCTCAGTTTCTGCTTCAG
TTGGTTCTGGTTCCGCCTCTACTGGTTCCCGCTTAAAGTGCTGTATGCCACGTTCCACTCCAGC
CTGCTCGCGGTGCCCGACATCCCCTTCTATTTCTTCTTCAATGCGCTCCTGCTGTTGCTCACCG
TCATGAACCTCTACTGGTTCCTGTACATCGTGGCCTTCGCTGCCAAGGTGCTGACTGGCCAGAT
GCGCGAGTTGAAGGACCTGCGGGAGTACGACATGGCAGAAGCCCAGAGCCCCAAGCCCAGCAAA
GCTGAGAAACCGCTGAGGAACGGACTGGTGAAGGACAAGCGCTTCTGAACCCCTGGACCCCCTT
CCCCACCTCCCAGATTCGGCCCCGTCCCCAAGACACCCACCGAGCCCCTGGAGACCTGGGTCCG
CCCCCTGTCGAGCCCTGTCTCTGGAGGCCCGGGTCCGCCCCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333032	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022895.1
GenBank Protein	KAG3279900	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333032 ⟸ XM_005332975

- UniProtKB:

I3NEU8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAAGTAAGPAGPEPMPSYAQLVQRSWGSALAAARDCADCGWGLARRGLAEHAHLAPPELLLLA
LCALGWTALRSAATARLFRPLAKRCRLQPRDAAKMPESAWKFLFYLGCWSYSAYLLFGTDYPFF
RDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLIHHVVTLVLIVS
SYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKARGGSYHRLHAVVADLGCLSFCFSWFWFRL
YWFPLKVLYATFHSSLLAVPDIPFYFFFNALLLLLTVMNLYWFLYIVAFAAKVLTGQMRELKDL
REYDMAEAQSPKPSKAEKPLRNGLVKDKRF

hide sequence

Ensembl Acc Id:

ENSSTOP00000022895 ⟸ ENSSTOT00000020751

Protein Domains

TLC

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000029010	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000020751.2	UniProtKB/TrEMBL
InterPro	Lag1/Lac1-like	UniProtKB/TrEMBL
	TLC-dom	UniProtKB/TrEMBL
NCBI Gene	Cers1	ENTREZGENE
PANTHER	CERAMIDE SYNTHASE 1	UniProtKB/TrEMBL
	LONGEVITY ASSURANCE FACTOR 1 LAG1	UniProtKB/TrEMBL
Pfam	TRAM_LAG1_CLN8	UniProtKB/TrEMBL
PROSITE	TLC	UniProtKB/TrEMBL
SMART	TLC	UniProtKB/TrEMBL
UniProt	I3NEU8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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