Cers1 (ceramide synthase 1) - Rat Genome Database
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Gene: Cers1 (ceramide synthase 1) Mus musculus
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Symbol: Cers1
Name: ceramide synthase 1
RGD ID: 1622181
MGI Page MGI
Description: Exhibits sphingosine N-acyltransferase activity. Involved in brain development and ceramide biosynthetic process. Localizes to intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 8. Orthologous to human CERS1 (ceramide synthase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cer; L; LAG1 homolog, ceramide synthase 1; LAG1 longevity assurance homolog 1; Lass1; longevity assurance gene 1 protein homolog 1; longevity assurance homolog 1; t; to; Uog-; Uog-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,768,425 - 70,784,238 (+)NCBIGRCm39mm39
GRCm38870,315,775 - 70,331,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,315,775 - 70,331,592 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,839,674 - 72,855,487 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,244,776 - 73,260,576 (+)NCBImm8
Celera872,872,244 - 72,888,065 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1704486   PMID:2034669   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11353399   PMID:12105227   PMID:12466851   PMID:12477932   PMID:15248193   PMID:15823095  
PMID:16141072   PMID:16141073   PMID:16951403   PMID:17977534   PMID:19393694   PMID:19800881   PMID:21267068   PMID:21625621   PMID:21873635   PMID:23074226   PMID:23096701   PMID:23936132  
PMID:25269881   PMID:26398595   PMID:26620563   PMID:27162368   PMID:30605666  


Genomics

Comparative Map Data
Cers1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,768,425 - 70,784,238 (+)NCBIGRCm39mm39
GRCm38870,315,775 - 70,331,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,315,775 - 70,331,592 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,839,674 - 72,855,487 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,244,776 - 73,260,576 (+)NCBImm8
Celera872,872,244 - 72,888,065 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
CERS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,868,545 - 18,896,727 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,868,545 - 18,896,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,979,361 - 19,007,396 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,842,117 - 18,867,953 (-)NCBINCBI36hg18NCBI36
Build 341918,849,726 - 18,867,953NCBI
Celera1918,884,162 - 18,911,776 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,543,712 - 18,571,613 (-)NCBIHuRef
CHM1_11918,979,164 - 19,007,208 (-)NCBICHM1_1
Cers1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,845,580 - 20,860,789 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,845,576 - 20,860,789 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,698,122 - 20,712,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,580,807 - 19,596,415 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,588,709 - 19,596,385 (-)NCBI
Celera1619,287,577 - 19,302,834 (-)NCBICelera
Cytogenetic Map16p14NCBI
Cers1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,788,653 - 2,796,370 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,788,672 - 2,798,068 (+)NCBIChiLan1.0ChiLan1.0
GDF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,315,848 - 19,342,482 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,317,173 - 19,342,487 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,306,513 - 18,334,328 (-)NCBIMhudiblu_PPA_v0panPan3
CERS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,216,568 - 44,231,820 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cers1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,442,978 - 2,467,184 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1258,951,463 - 58,972,692 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,750,506 - 58,769,955 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CERS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,331,021 - 17,351,542 (-)NCBI
Cers1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,937,007 - 1,949,780 (-)NCBI

Position Markers
Gdf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,381 - 70,331,527UniSTSGRCm38
MGSCv37872,855,280 - 72,855,426UniSTSGRCm37
Celera872,887,858 - 72,888,004UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map8 UniSTS
AI385651  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,438 - 70,331,536UniSTSGRCm38
MGSCv37872,855,337 - 72,855,435UniSTSGRCm37
Celera872,887,915 - 72,888,013UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8743.32UniSTS
UniSTS:235917  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,749 - 70,331,854UniSTSGRCm38
MGSCv37872,855,648 - 72,855,753UniSTSGRCm37
Celera872,888,226 - 72,888,331UniSTS
Cytogenetic Map8B3.3UniSTS
RH139099  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,392 - 70,331,538UniSTSGRCm38
MGSCv37872,855,291 - 72,855,437UniSTSGRCm37
Celera872,887,869 - 72,888,015UniSTS
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_138647   ⟹   NP_619588
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,768,425 - 70,784,238 (+)NCBI
GRCm38870,315,775 - 70,331,588 (+)ENTREZGENE
MGSCv37872,839,674 - 72,855,487 (+)RGD
Celera872,872,244 - 72,888,065 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_619588 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37675 (Get FASTA)   NCBI Sequence Viewer  
  AAI32319 (Get FASTA)   NCBI Sequence Viewer  
  BAE37069 (Get FASTA)   NCBI Sequence Viewer  
  EDL28811 (Get FASTA)   NCBI Sequence Viewer  
  P27545 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_619588   ⟸   NM_138647
- UniProtKB: P27545 (UniProtKB/Swiss-Prot),   A2RT05 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
TLC

Promoters
RGD ID:8667301
Promoter ID:EPDNEW_M11681
Type:initiation region
Name:Gdf1_1
Description:Mus musculus growth differentiation factor 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,315,804 - 70,315,864EPDNEW
RGD ID:6843384
Promoter ID:MM_KWN:54695
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001163282,   UC009LZY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,838,831 - 72,840,102 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2136690 AgrOrtholog
Ensembl Genes ENSMUSG00000087408 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000120598 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000140239 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLC-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14559 UniProtKB/TrEMBL
  mmu:93898 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2136690 ENTREZGENE
NCBI Gene 93898 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TRAM_LAG1_CLN8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cers1 PhenoGen
PROSITE TLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.258280 ENTREZGENE
UniProt A2RT05 ENTREZGENE, UniProtKB/TrEMBL
  CERS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-06 Cers1  ceramide synthase 1  Lass1  LAG1 homolog, ceramide synthase 1  Symbol and/or name change 5135510 APPROVED
2011-08-17 Lass1  LAG1 homolog, ceramide synthase 1  Lass1  LAG1 homolog, ceramide synthase 1  Symbol and/or name change 5135510 APPROVED